Kazuaki Chayama

Last Updated :2021/01/20

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
Web Site
E-mail
chayamahiroshima-u.ac.jp
Self-introduction
Since I became a Professor of the Faculty of Medicine, Hiroshima University, in September, 2000 and the head Professor of the Division of Gastroenterology of Hiroshima University Hospital in April 2002, our laboratory has evolved steadily as the result of the hard work of its doctors, staff and graduate students in the field of medical examination, education and research. We really appreciate the support of persons concerned with these activities.

Basic Information

Educational Backgrounds

  • Hiroshima University, Faculty of Medicine, Japan, 1974/04, 1981/03

Academic Degrees

  • Doctor of Philosophy in Medical Sciences, The University of Tokyo

Educational Activity

  • 【Bachelor Degree Program】School of Medicine : Program of Medicine
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

In Charge of Primary Major Programs

  • Dentistry
  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Gastroenterology

Research Keywords

  • nucleotide sequence|Hepatitis-B
  • epigenetics
  • liver cirrhosis
  • driver mutation
  • deep sequence
  • whole genome analysisi
  • Hepatitis-C
  • whole genome sequencing
  • hepatitis
  • hepatocellular carcinoma

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2020, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2020, Undergraduate Education, Intensive, Practice for medical research
  3. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Gastroenterology and Metabolism
  4. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Gastroenterology and Metabolism
  5. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced research on Gastroenterology and Metabolism
  6. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Gastroenterology and Metabolism
  7. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Gastroenterology and Metabolism
  8. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Gastroenterology and Metabolism
  9. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Gastroenterology and Metabolism
  10. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Gastroenterology and Metabolism

Research Activities

Academic Papers

  1. Regression of Idiopathic Thrombocytopenic Purpura in a Patient With Eradication of Hepatitis C Virus by Direct-Acting Antivirals, HEPATOLOGY, 71(1), 389-391, 202001
  2. Clinical Usefulness of Dual Red Imaging in Gastric Endoscopic Submucosal Dissection: A Pilot Study, CLINICAL ENDOSCOPY, 53(1), 54-59, 202001
  3. A Cost-Effectiveness Analysis of Glecaprevir/Pibrentasvir Versus Existing Direct-Acting Antivirals to Treat Chronic Hepatitis C in Japan, ADVANCES IN THERAPY, 37(1), 457-476, 202001
  4. Management of refractory ascites attenuates muscle mass reduction and improves survival in patients with decompensated cirrhosis, JOURNAL OF GASTROENTEROLOGY, 55(2), 217-226, 202002
  5. Preoperative PET-CT is useful for predicting recurrent extrahepatic metastasis of hepatocellular carcinoma after resection, EUROPEAN JOURNAL OF RADIOLOGY, 124, 202003
  6. Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 9(2), 20200121
  7. Clinical outcomes of endoscopic resection for superficial non-ampullary duodenal tumors, ENDOSCOPY INTERNATIONAL OPEN, 8(3), E354-E359, 202003
  8. Clinical usefulness of the S-O clip during colorectal endoscopic submucosal dissection in difficult-to-access submucosal layer, ENDOSCOPY INTERNATIONAL OPEN, 8(3), E437-E444, 202003
  9. Successful retreatment with 12 weeks of glecaprevir and pibrentasvir for a genotype 2a HCV-infected hemodialysis patient who failed to respond to 8 weeks of prior glecaprevir and pibrentasvir therapy, CLINICAL JOURNAL OF GASTROENTEROLOGY, 13(2), 267-270, 202004
  10. The Evaluation of Esophageal Motility Using Infusion Manometry with a Trans-nasal Endoscope: A Preliminary Study, INTERNAL MEDICINE, 59(7), 887-890, 2020
  11. Three Children Treated with Direct-acting Antivirals for Chronic Hepatitis C Virus Genotype 1b Infection, INTERNAL MEDICINE, 59(7), 941-944, 2020
  12. Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission, BMC GASTROENTEROLOGY, 20(1), 20200403
  13. Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations, EBIOMEDICINE, 53, 202003
  14. Genomic Characterization of Non-Invasive Differentiated-Type Gastric Cancer in the Japanese Population, CANCERS, 12(2), 202002
  15. Sinusoidal obstruction syndrome post-treatment with trastuzumab emtansine (T-DM1) in advanced breast cancer, INTERNATIONAL CANCER CONFERENCE JOURNAL, 9(1), 18-23, 202001
  16. Comparative study on the replication of HCV1b genome between wild-type and cell culture-adaptive mutant in regard to sensitivities against anti-HCV drugs, MICROBIOLOGY AND IMMUNOLOGY, 64(4), 296-303, 202004
  17. Skeletal Muscle Loss during Tyrosine Kinase Inhibitor Treatment for Advanced Hepatocellular Carcinoma Patients, LIVER CANCER, 9(2), 148-155, 202004
  18. Predicting atrial fibrillation using a combination of genetic risk score and clinical risk factors, HEART RHYTHM, 17(5), 699-705, 202005
  19. Pan-cancer analysis of whole genomes, NATURE, 578(7793), 82-+, 20200206
  20. Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV-infected Japanese Subjects in Phase 3 CERTAIN-1 and CERTAIN-2 Trials, JOURNAL OF CLINICAL PHARMACOLOGY, 60(3), 331-339, 202003
  21. Isolated cardiac metastases of hepatocellular carcinoma after resection: a case report, CLINICAL JOURNAL OF GASTROENTEROLOGY, 13(3), 421-427, 202006
  22. JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study, JOURNAL OF GASTROENTEROLOGY, 55(6), 640-652, 202006
  23. Serum miR-379 expression is related to the development and progression of hypercholesterolemia in non-alcoholic fatty liver disease, PLOS ONE, 15(2), 20200227
  24. Diagnostic Yield of Colon Capsule Endoscopy in Detection of Superficial Colorectal Lesions, DIGESTION, 101(3), 262-269, 202005
  25. Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receiving lenvatinib, THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 12, 202005
  26. Discordant pathological diagnosis of non-alcoholic fatty liver disease: A prospective multicenter study, JGH OPEN, 4(3), 497-502, 202006
  27. Impact of the introduction of direct-acting anti-viral drugs on hepatocarcinogenesis: a prospective serial follow-up MRI study, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 52(2), 359-370, 202007
  28. Renal metastasis from primary hepatocellular carcinoma: a case report, INTERNATIONAL CANCER CONFERENCE JOURNAL, 9(3), 141-145, 202007
  29. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases, NATURE GENETICS, 52(7), 669-+, 202007
  30. Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection, JOURNAL OF CLINICAL INVESTIGATION, 130(6), 3205-3220, 20200601
  31. Incidence of microsatellite instability-high hepatocellular carcinoma among Japanese patients and response to pembrolizumab, HEPATOLOGY RESEARCH, 50(7), 885-888, 202007
  32. Increased arterial stiffness and cardiovascular risk prediction in controlled hypertensive patients with coronary artery disease: post hoc analysis of FMD-J (Flow-mediated Dilation Japan) Study A, HYPERTENSION RESEARCH, 43(8), 781-790, 202008
  33. Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men, SCIENTIFIC REPORTS, 10(1), 20200710
  34. Risk factors for histological progression of non-alcoholic steatohepatitis analyzed from repeated biopsy cases, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 35(8), 1412-1419, 202008
  35. Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma, CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, 11, 202005
  36. Vascular function is further impaired in subjects aged 80 years or older, HYPERTENSION RESEARCH, 43(9), 914-921, 202009
  37. Clinical and genomic characteristics of mucosal signet-ring cell carcinoma in Helicobacter pylori-uninfected stomach, BMC GASTROENTEROLOGY, 20(1), 20200729
  38. Modifying Effect of Chronic Atrophic Gastritis on Radiation Risk for Noncardia Gastric Cancer According to Histological Type, RADIATION RESEARCH, 194(2), 180-187, 202008
  39. Metabolomic/lipidomic-based analysis of plasma to diagnose hepatocellular ballooning in patients with non-alcoholic fatty liver disease: A multicenter study, HEPATOLOGY RESEARCH, 50(8), 955-965, 202008
  40. PD1 gene polymorphism is associated with a poor prognosis in hepatocellular carcinoma following liver resection, cohort study, INTERNATIONAL JOURNAL OF SURGERY, 80, 84-90, 202008
  41. Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study, BMJ OPEN, 10(7), 2020
  42. Treatment outcomes after splenectomy with gastric devascularization or balloon-occluded retrograde transvenous obliteration for gastric varices: a propensity score-weighted analysis from a single institution, JOURNAL OF GASTROENTEROLOGY, 55(9), 877-887, 202009
  43. Japan Society of Hepatology Guidelines for the Management of Hepatitis B Virus Infection: 2019 update, HEPATOLOGY RESEARCH, 50(8), 892-923, 202008
  44. Real-world learning curve analysis of colorectal endoscopic submucosal dissection: a large multicenter study, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 34(8), 3344-3351, 202008
  45. Range of Normal Liver Stiffness and Factors Associated With Increased Stiffness Measurements in Apparently Healthy Individuals, CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 17(1), 54-+, 201901
  46. Dual Red Imaging Maintains Clear Visibility During Colorectal Endoscopic Submucosal Dissection, DIGESTIVE DISEASES AND SCIENCES, 64(1), 224-231, 201901
  47. Efficacy and safety of sofosbuvir-velpatasvir with or without ribavirin in HCV-infected Japanese patients with decompensated cirrhosis: an open-label phase 3 trial, JOURNAL OF GASTROENTEROLOGY, 54(1), 87-95, 201901
  48. Gastric Cancer with Submucosal Invasion after Successful Helicobacter pylori Eradication: A Propensity Score-Matched Analysis of Patients with Annual Patient Endoscopic Survey, DIGESTION, 99(1), 59-65, 2019
  49. The utility of a novel colonoscope with retroflexion for colorectal endoscopic submucosal dissection, ENDOSCOPY INTERNATIONAL OPEN, 7(2), E130-E137, 201902
  50. The impact of interferon-free direct-acting antivirals on clinical outcome after curative treatment for hepatitis C virus-associated hepatocellular carcinoma: Comparison with interferon-based therapy, JOURNAL OF MEDICAL VIROLOGY, 91(4), 650-658, 201904
  51. Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor, PLOS ONE, 14(2), 20190219
  52. Early-stage serrated adenocarcinomas are divided into several molecularly distinct subtypes, PLOS ONE, 14(2), 20190220
  53. Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures, JOURNAL OF GASTROENTEROLOGY, 54(3), 291-296, 201903
  54. Levocarnitine Use Is Associated With Improvement in Sarcopenia in Patients With Liver Cirrhosis, HEPATOLOGY COMMUNICATIONS, 3(3), 348-355, 201903
  55. Rectal Lymphoid Follicle Aphthous Lesions Frequently Progress to Ulcerative Colitis with Proximal Extension, INTERNAL MEDICINE, 58(5), 625-631, 201903
  56. Ser96Ala genetic variant of the human histidine-rich calcium-binding protein is a genetic predictor of recurrence after catheter ablation in patients with paroxysmal atrial fibrillation, PLOS ONE, 14(3), 20190306
  57. Epidemiological survey of hemoglobin A1c and liver fibrosis in a general population with non-alcoholic fatty liver disease, HEPATOLOGY RESEARCH, 49(3), 296-303, 201903
  58. Construction of a risk model for the development of metachronous squamous cell carcinoma after endoscopic resection of esopahageal squamous cell carcinoma, ESOPHAGUS, 16(2), 141-146, 201904
  59. A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011-2015 update, JOURNAL OF GASTROENTEROLOGY, 54(4), 367-376, 201904
  60. Long-term prognosis after treatment for T1 carcinoma of laterally spreading tumors: a multicenter retrospective study, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 34(3), 481-490, 201903
  61. Early Multiphasic HBV Infection Initiation Kinetics Is Not Clone-Specific and Is Not Affected by Hepatitis D Virus (HDV) Infection, VIRUSES-BASEL, 11(3), 20190315
  62. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension, EUROPEAN JOURNAL OF NUTRITION, 58(3), 989-996, 201904
  63. Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease - Post Hoc Analysis of the FMD-J Study A, CIRCULATION JOURNAL, 83(5), 1064-+, 201905
  64. The Clinical Usefulness of the PillCam Progress Indicator for Route Selection in Double Balloon Endoscopy, INTERNAL MEDICINE, 58(10), 1375-1381, 2019
  65. HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response, GASTROENTEROLOGY, 156(8), 2313-+, 201906
  66. Experience with Balloon Dilatation in Crohn's and Non-Crohn's Benign Small-Bowel Strictures: Is There a Difference?, GASTROENTEROLOGY RESEARCH AND PRACTICE, 2019
  67. Impact of sclerosing dacryoadenitis/sialadenitis on relapse during steroid therapy in patients with type 1 autoimmune pancreatitis, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 54(2), 259-264, 20190201
  68. Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes, CANCER CELL, 35(6), 932-+, 20190610
  69. Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP, SCIENTIFIC REPORTS, 9, 20190611
  70. Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis, JOURNAL OF BIOMEDICAL SCIENCE, 26, 20190606
  71. Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice, JOURNAL OF GASTROENTEROLOGY, 54(7), 650-659, 201907
  72. Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study, JOURNAL OF HYPERTENSION, 37(5), 1083-1095, 201905
  73. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study, SCIENTIFIC REPORTS, 9, 20190715
  74. Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice, JOURNAL OF GENERAL VIROLOGY, 100(7), 1123-1131, 201907
  75. Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus-Infected Cells and Liver to Identify Pathways Associated With Disease Development, GASTROENTEROLOGY, 157(2), 537-+, 201908
  76. Real-world virological efficacy and safety of daclatasvir/asunaprevir/beclabuvir in patients with chronic hepatitis C virus genotype 1 infection in Japan, JOURNAL OF GASTROENTEROLOGY, 54(8), 742-751, 201908
  77. y Integrated analysis of 8-week glecaprevir/pibrentasvir in Japanese and overseas patients without cirrhosis and with hepatitis C virus genotype 1 or 2 infection, JOURNAL OF GASTROENTEROLOGY, 54(8), 752-761, 201908
  78. Can surveillance colonoscopy be discontinued in an elderly population with diminutive polyps?, JOURNAL OF THE ANUS RECTUM AND COLON, 3(3), 128-135, 201907
  79. Helicobacter suis infection is associated with nodular gastritis-like appearance of gastric mucosa-associated lymphoid tissue lymphoma, CANCER MEDICINE, 8(9), 4370-4379, 201908
  80. Relationship between home blood pressure and vascular function in patients receiving antihypertensive drug treatment, HYPERTENSION RESEARCH, 42(8), 1175-1185, 201908
  81. Percutaneous transvenous shunt occlusion for portosystemic encephalopathy due to lenvatinib administration to a patient with hepatocellular carcinoma and portosystemic shunt, CLINICAL JOURNAL OF GASTROENTEROLOGY, 12(4), 341-346, 201908
  82. Correlation between Early Tumor Marker Response and Imaging Response in Patients with Advanced Hepatocellular Carcinoma Treated with Lenvatinib, ONCOLOGY, 97(2), 75-81, 2019
  83. Management of HCV patients in cases of direct-acting antiviral failure, EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 13(9), 839-848, 20190902
  84. Early changes in ammonia levels and liver function in patients with advanced hepatocellular carcinoma treated by lenvatinib therapy, SCIENTIFIC REPORTS, 9, 20190820
  85. Alcohol Use Disorders Identification Test-consumption Predicts the Risk of Excessive Alcohol Consumption After Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 51(6), 1934-1938, 2019
  86. HOMA-IR: An independent predictor of advanced liver fibrosis in nondiabetic non-alcoholic fatty liver disease, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 34(8), 1390-1395, 201908
  87. Preceding endoscopic submucosal dissection for T1 colorectal carcinoma does not affect the prognosis of patients who underwent additional surgery: a large multicenter propensity score-matched analysis, JOURNAL OF GASTROENTEROLOGY, 54(10), 897-906, 201910
  88. Genomic landscape of epithelium with low-grade atypia on gastric cancer after Helicobacter pylori eradiation therapy, JOURNAL OF GASTROENTEROLOGY, 54(10), 907-915, 201910
  89. Clinical features of hepatocellular carcinoma in nonalcoholic fatty liver disease patients without advanced fibrosis, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 34(9), 1626-1632, 201909
  90. Relationships Between Calcium Channel Blockers and Vascular Function Tests, AMERICAN JOURNAL OF HYPERTENSION, 32(7), 640-648, 201907
  91. Effects of the Dipeptidyl Peptidase 4 Inhibitor Alogliptin on Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus, AMERICAN JOURNAL OF HYPERTENSION, 32(7), 695-702, 201907
  92. Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men, JOURNAL OF CLINICAL LIPIDOLOGY, 13(4), 664-672, 201908
  93. eVIDENCE: a practical variant filtering for low-frequency variants detection in cell-free DNA, SCIENTIFIC REPORTS, 9, 20191022
  94. Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis, BMC GASTROENTEROLOGY, 19(1), 20191024
  95. Potential of Helicobacter pylori-uninfected signet ring cell carcinoma to invade the submucosal layer, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 34(11), 1955-1962, 201911
  96. Clinical Utility of Emergency Capsule Endoscopy for Diagnosing the Source and Nature of Ongoing Overt Obscure Gastrointestinal Bleeding, GASTROENTEROLOGY RESEARCH AND PRACTICE, 2019, 20191201
  97. Investigation of Fluorodeoxyglucose Positron Emission Tomography for the Diagnosis of Solid Pseudopapillary Neoplasm of the Pancreas A Study Associated With a National Survey of Solid Pseudopapillary Neoplasms, PANCREAS, 48(10), 1312-1320, 2019
  98. A case of primary malignant melanoma of the esophagus with a widely expanded surface area, CLINICAL JOURNAL OF GASTROENTEROLOGY, 12(5), 424-428, 201910
  99. Efficacy of a self-management program in patients with chronic viral hepatitis in China, BMC NURSING, 18(1), 20190918
  100. Advanced liver fibrosis effects on the response to sofosbuvir-based antiviral therapies for chronic hepatitis C, JOURNAL OF MEDICAL VIROLOGY, 90(12), 1834-1840, 201812
  101. CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients, JOURNAL OF VIRAL HEPATITIS, 25(12), 1555-1564, 201812
  102. The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study, JOURNAL OF GASTROENTEROLOGY, 53(11), 1216-1224, 201811
  103. Early experience of seven hepatocellular carcinoma cases treated with regorafenib, CLINICAL CASE REPORTS, 6(11), 2217-2223, 201811
  104. Chromosome 4q25 Variant rs6817105 Bring Sinus Node Dysfunction and Left Atrial Enlargement, SCIENTIFIC REPORTS, 8, 20181001
  105. Comparison of clinical outcome of hepatic arterial infusion chemotherapy and sorafenib for advanced hepatocellular carcinoma according to macrovascular invasion and transcatheter arterial chemoembolization refractory status, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33(10), 1780-1786, 201810
  106. Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure, RADIATION RESEARCH, 190(4), 424-432, 201810
  107. Molecular Mechanisms of Hepatocarcinogenesis Following Sustained Virological Response in Patients with Chronic Hepatitis C Virus Infection, VIRUSES-BASEL, 10(10), 201810
  108. IL-1 beta/ATF3-mediated induction of Ski2 expression enhances hepatitis B virus x mRNA degradation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 503(3), 1854-1860, 20180910
  109. Maintenance of low inflammation level by the ZFHX3 SNP rs2106261 minor allele contributes to reduced atrial fibrillation recurrence after pulmonary vein isolation, PLOS ONE, 13(9), 20180904
  110. Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection, JOURNAL OF GASTROENTEROLOGY, 53(9), 1089-1097, 201809
  111. Clinical outcomes of sorafenib treatment failure for advanced hepatocellular carcinoma and candidates for regorafenib treatment in real-world practice, HEPATOLOGY RESEARCH, 48(10), 814-820, 201809
  112. New assessment of endothelial function measured by short time flow-mediated vasodilation: Comparison with conventional flow-mediated vasodilation measurement, INTERNATIONAL JOURNAL OF CARDIOLOGY, 265, 24-29, 20180815
  113. Watch-and-wait policy versus rituximab-combined chemotherapy in Japanese patients with intestinal follicular lymphoma, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33(8), 1461-1468, 201808
  114. Long-term outcome of stereotactic body radiotherapy for patients with small hepatocellular carcinoma, HEPATOLOGY RESEARCH, 48(9), 701-707, 201808
  115. Limitations of daclatasvir/asunaprevir plus beclabuvir treatment in cases of NS5A inhibitor treatment failure, JOURNAL OF GENERAL VIROLOGY, 99(8), 1058-1065, 201808
  116. Hepatectomy versus stereotactic body radiotherapy for primary early hepatocellular carcinoma: A propensity-matched analysis in a single institution, SURGERY, 164(2), 219-226, 201808
  117. Acute hepatitis B virus infection in humanized chimeric mice has multiphasic viral kinetics, HEPATOLOGY, 68(2), 473-484, 201808
  118. Management of occult obscure gastrointestinal bleeding patients based on long-term outcomes, THERAPEUTIC ADVANCES IN GASTROENTEROLOGY, 11, 20180716
  119. A Data Mining-based Prognostic Algorithm for NAFLD-related Hepatoma Patients: A Nationwide Study by the Japan Study Group of NAFLD, SCIENTIFIC REPORTS, 8, 20180711
  120. Comparison of Stereotactic Body Radiation Therapy Combined With or Without Transcatheter Arterial Chemoembolization for Patients With Small Hepatocellular Carcinoma Ineligible for Resection or Ablation Therapies, TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 17, 20180701
  121. Use of anticoagulants increases risk of bleeding after colorectal endoscopic submucosal dissection, ENDOSCOPY INTERNATIONAL OPEN, 6(7), E857-E864, 201807
  122. Sofosbuvir-velpatasvir plus ribavirin in Japanese patients with genotype 1 or 2 hepatitis C who failed direct-acting antivirals, HEPATOLOGY INTERNATIONAL, 12(4), 356-367, 201807
  123. HCN4 Gene Polymorphisms Are Associated With Occurrence of Tachycardia-Induced Cardiomyopathy in Patients With Atrial Fibrillation, CIRCULATION-GENOMIC AND PRECISION MEDICINE, 11(7), 201807
  124. Diagnosis of superficial esophageal squamous cell carcinoma invasion depth before endoscopic submucosal dissection, DISEASES OF THE ESOPHAGUS, 31(7), 201807
  125. Endothelial dysfunction, abnormal vascular structure and lower urinary tract symptoms in men and women, INTERNATIONAL JOURNAL OF CARDIOLOGY, 261, 196-203, 20180615
  126. Hepatic arterial infusion chemotherapy followed by sorafenib in patients with advanced hepatocellular carcinoma (HICS 55): an open label, non-comparative, phase II trial, BMC CANCER, 18, 20180604
  127. Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 500(2), 152-157, 20180602
  128. Reactive hyperemia-peripheral arterial tonometry is useful for assessment of not only endothelial function but also stenosis of the digital artery, INTERNATIONAL JOURNAL OF CARDIOLOGY, 260, 178-183, 20180601
  129. Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection, JOURNAL OF INFECTIOUS DISEASES, 217(11), 1761-1769, 20180601
  130. Curative Criteria After Endoscopic Resection for Superficial Esophageal Squamous Cell Carcinomas, DIGESTIVE DISEASES AND SCIENCES, 63(6), 1605-1612, 201806
  131. Cost-effectiveness analyses of anti-hepatitis C virus treatments using quality of life scoring among patients with chronic liver disease in Hiroshima prefecture, Japan, HEPATOLOGY RESEARCH, 48(7), 509-520, 201806
  132. Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts the development of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease, HEPATOLOGY RESEARCH, 48(7), 521-528, 201806
  133. Silencing of Discoidin Domain Receptor-1 (DDR1) Concurrently Inhibits Multiple Steps of Metastasis Cascade in Gastric Cancer, TRANSLATIONAL ONCOLOGY, 11(3), 575-584, 201806
  134. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction, PLOS ONE, 13(5), 20180521
  135. Short-term outcomes of endoscopic submucosal dissection for superficial cecal tumors: a comparison between extension and nonextension into the appendiceal orifice, THERAPEUTIC ADVANCES IN GASTROENTEROLOGY, 11, 20180501
  136. miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis, GUT, 67(5), 953-962, 201805
  137. Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations, JOURNAL OF HEPATOLOGY, 68(5), 959-969, 201805
  138. Long-term follow-up of clinical trial patients treated for chronic HCV infection with daclatasvir-based regimens, LIVER INTERNATIONAL, 38(5), 821-833, 201805
  139. In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors, GENOME RESEARCH, 28(5), 654-665, 201805
  140. Evaluation of glycemic variability in chronic liver disease patients with type 2 diabetes mellitus using continuous glucose monitoring, PLOS ONE, 13(4), 20180403
  141. Serial profiling of circulating tumor DNA for optimization of anti-VEGF chemotherapy in metastatic colorectal cancer patients, INTERNATIONAL JOURNAL OF CANCER, 142(7), 1418-1426, 20180401
  142. Clinical significance of small-bowel villous edema in patients with liver cirrhosis: A capsule endoscopy study, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33(4), 825-830, 201804
  143. Efficacy and safety of ledipasvir/sofosbuvir with ribavirin in chronic hepatitis C patients who failed daclatasvir/asunaprevir therapy: pilot study, JOURNAL OF GASTROENTEROLOGY, 53(4), 548-556, 201804
  144. Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 1 hepatitis C virus infection with and without cirrhosis, JOURNAL OF GASTROENTEROLOGY, 53(4), 557-565, 201804
  145. Efficacy and safety of glecaprevir/pibrentasvir in HCV-infected Japanese patients with prior DAA experience, severe renal impairment, or genotype 3 infection, JOURNAL OF GASTROENTEROLOGY, 53(4), 566-575, 201804
  146. Chronic kidney disease is associated with vascular smooth muscle dysfunction but not with endothelial dysfunction, INTERNATIONAL JOURNAL OF CARDIOLOGY, 254, 284-290, 20180301
  147. Clinical outcomes of endoscopic submucosal dissection for colorectal tumors: a large multicenter retrospective study from the Hiroshima GI Endoscopy Research Group, GASTROINTESTINAL ENDOSCOPY, 87(3), 714-722, 201803
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  358. Major predictors of portal hypertensive enteropathy in patients with liver cirrhosis, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 30(1), 124-130, 201501
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  360. Ratio of Serum Levels of AGEs to Soluble Form of RAGE Is a Predictor of Endothelial Function, DIABETES CARE, 38(1), 119-125, 201501
  361. Evaluation of Antibiotic Use to Prevent Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis and Cholangitis, HEPATO-GASTROENTEROLOGY, 62(138), 417-424, 2015
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  368. A Computer System To Be Used With Laser-based Endoscopy for Quantitative Diagnosis of Early Gastric Cancer, JOURNAL OF CLINICAL GASTROENTEROLOGY, 49(2), 108-115, 2015
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  370. mTOR and PDGF Pathway Blockade Inhibits Liver Metastasis of Colorectal Cancer by Modulating the Tumor Microenvironment, AMERICAN JOURNAL OF PATHOLOGY, 185(2), 399-408, 2015
  371. Optimizing triple therapy and IFN/RBV-free regimens for hepatitis C virus infection, EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 9(1), 21-30, 2015
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  374. Endoscopic Submucosal Dissection as Total Excisional Biopsy for Clinical T1 Colorectal Carcinoma, DIGESTION, 91(1), 64-69, 2015
  375. Differences in serum microRNA profiles in hepatitis B and C virus infection, JOURNAL OF INFECTION, 70(3), 273-287, 2015
  376. The effects of bisphosphonate zoledronic acid in hepatocellular carcinoma, depending on mevalonate pathway, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 30(3), 619-627, 2015
  377. Emerging treatments for chronic hepatitis C, JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 114(3), 204-215, 2015
  378. Rate of Unintended Helicobacter pylori Eradication in the Vietnamese, HELICOBACTER, 20(2), 156-157, 2015
  379. Evaluation of early response to hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma using the combination of Response Evaluation Criteria in Solid Tumors and tumor markers, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 30(4), 726-732, 2015
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  382. Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection, SCIENCE TRANSLATIONAL MEDICINE, 7(282), 2015
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  385. Eicosapentaenoic acid/arachidonic acid ratio as a possible link between non-alcoholic fatty liver disease and cardiovascular disease, HEPATOLOGY RESEARCH, 45(5), 533-539, 2015
  386. Novel Robust in Vitro Hepatitis B Virus Infection Model Using Fresh Human Hepatocytes Isolated from Humanized Mice, AMERICAN JOURNAL OF PATHOLOGY, 185(5), 1275-1285, 2015
  387. Role of 3-D conformal radiotherapy for major portal vein tumor thrombosis combined with hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma, HEPATOLOGY RESEARCH, 45(6), 607-617, 2015
  388. Efficacy and safety of the anticoagulant drug, danaparoid sodium, in the treatment of portal vein thrombosis in patients with liver cirrhosis, HEPATOLOGY RESEARCH, 45(6), 656-662, 2015
  389. Disseminated carcinomatosis of the bone marrow originating from hepatocellular carcinoma. A case report, HEPATOLOGY RESEARCH, 45(6), 705-710, 2015
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  436. Characteristic Features of Cholangiocarcinoma Complicating Primary Sclerosing Cholangitis, HEPATO-GASTROENTEROLOGY, 61(131), 567-573, 201405
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  451. Is It Possible to Discriminate Between Neoplastic and Nonneoplastic Lesions in Ulcerative Colitis by Magnifying Colonoscopy?, INFLAMMATORY BOWEL DISEASES, 20(3), 508-513, 201403
  452. Is small-bowel capsule endoscopy effective for diagnosis of esophagogastric lesions related to portal hypertension?, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 29(3), 511-516, 201403
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  456. Transarterial Therapy of Hepatocellular Carcinoma Fed by the Right Renal Capsular Artery, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 25(3), 389-395, 201403
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  464. Pilot Study of Stereotactic Body Radiation Therapy Combined with Transcatheter Arterial Chemoembolization for Small Hepatocellular Carcinoma, HEPATO-GASTROENTEROLOGY, 61(129), 31-36, 2014
  465. The effect of respiratory-gated positron emission tomography/computed tomography in patients with pancreatic cancer, HELLENIC JOURNAL OF NUCLEAR MEDICINE, 17(1), 31-36, 2014
  466. A randomized trial of daclatasvir with peginterferon alfa-2b and ribavirin for HCV genotype 1 infection, ANTIVIRAL THERAPY, 19(5), 491-499, 2014
  467. Characteristics of Metachronous Gastric Tumors after Endoscopic Submucosal Dissection for Gastric Intraepithelial Neoplasms, GASTROENTEROLOGY RESEARCH AND PRACTICE, 2014
  468. Comparison of Small-Bowel Mucosal Injury between Low-Dose Aspirin and Non-Aspirin Non-Steroidal Anti-Inflammatory Drugs: A Capsule Endoscopy Study, DIGESTION, 89(3), 225-231, 2014
  469. Hepatitis C Virus (HCV) Reactivation Caused by Steroid Therapy for Dermatomyositis, INTERNAL MEDICINE, 53(23), 2689-2693, 2014
  470. Occupational Radiation Exposure during Endoscopic Retrograde Cholangiopancreatography and Usefulness of Radiation Protective Curtains, GASTROENTEROLOGY RESEARCH AND PRACTICE, 2014
  471. Telaprevir is effective given every 12 h at 750 mg with pegylated interferon-alpha 2b and ribavirin to Japanese patients with HCV-1b IL28B rs8099917 TT, ANTIVIRAL THERAPY, 19(3), 277-285, 2014
  472. Virological escape in HCV genotype-1-infected patients receiving daclatasvir plus ribavirin and peginterferon alfa-2a or alfa-2b, ANTIVIRAL THERAPY, 19(5), 479-490, 2014
  473. The IL28B SNP has a stronger regulatory effect on the expression of OAS1 than a nearby SNP located downstream of OAS1 in chronic HCV patients, HEPATOLOGY, 60, 1077A-1077A, 2014
  474. Pretreatment induction of ISGs in the presence of IFNL4 in hepatocytes but not in white blood cells is related with poor induction of ISGs following IFN-alpha therapy, HEPATOLOGY, 60, 1077A-1078A, 2014
  475. Hepatocellular carcinoma development of hepatitis C virus patients with eradication to interferon therapy: a large scale, long-term study of 2266 patients, HEPATOLOGY, 60, 1162A-1163A, 2014
  476. Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients, JOURNAL OF GASTROENTEROLOGY, 49(11), 1477-1484, 2014
  477. Usefulness of transabdominal ultrasonography for improved safety of capsule endoscopy in patients with crohn's disease, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 29, 89-89, 2014
  478. Endocannabinoid CB1 antagonists inhibit hepatitis C virus production, providing a novel class of antiviral host-targeting agents, JOURNAL OF GENERAL VIROLOGY, 95, 2468-2479, 2014
  479. Clinical outcome and prognostic factors of patients with hepatocellular carcinoma and extrahepatic metastasis treated with sorafenib, HEPATOLOGY RESEARCH, 44(13), 1320-1328, 2014
  480. Impact of alloimmune T cell responses on hepatitis C virus replication in liver transplant recipients, HUMAN IMMUNOLOGY, 75(12), 1259-1267, 2014
  481. Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C, JOURNAL OF GASTROENTEROLOGY, 49(12), 1548-1556, 2014
  482. Quantitative Effect of Natural Killer-Cell Licensing on Hepatocellular Carcinoma Recurrence after Curative Hepatectomy, CANCER IMMUNOLOGY RESEARCH, 2(12), 1142-1147, 2014
  483. Non-invasive assessment of liver steatosis in non-alcoholic fatty liver disease, HEPATOLOGY RESEARCH, 44(14), E420-E427, 2014
  484. Interferon lambda 4 polymorphism affects on outcome of telaprevir, pegylated interferon and ribavirin combination therapy for chronic hepatitis C, HEPATOLOGY RESEARCH, 44(14), E447-E454, 2014
  485. Hepatitis C Virus (HCV) Reactivation Caused by Steroid Therapy for Dermatomyositis, INTERNAL MEDICINE, 53(23), 2689-2693, 2014
  486. Differences in K-ras and mitochondrial DNA mutations and microsatellite instability between colorectal cancers of Vietnamese and Japanese patients, BMC GASTROENTEROLOGY, 14, 2014
  487. Integrated Analysis of Whole Genome and Transcriptome Sequencing Reveals Diverse Transcriptomic Aberrations Driven by Somatic Genomic Changes in Liver Cancers, PLOS ONE, 9(12), 2014
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  489. Interaction between bone marrow-derived mesenchymal stem cells and tumor cells induces expression of fibronectin in human colon cancer cells, CANCER RESEARCH, 74(19), 2014
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  493. The upper limit of normal serum alanine aminotransferase levels in Japanese subjects, Hepatol Res, 20131201
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  495. Combining Molecular Targeted Drugs to Inhibit Both Cancer Cells and Activated Stromal Cells in Gastric Cancer, NEOPLASIA, 15(12), 1391-1399, 201312
  496. sRAGE is associated with low waist circumference and Hb levels in NAFLD, CENTRAL EUROPEAN JOURNAL OF MEDICINE, 8(6), 830-834, 201312
  497. A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441(1), 230-235, 20131108
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  500. Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice, JOURNAL OF GASTROENTEROLOGY, 48(11), 1259-1270, 201311
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  504. Serum HBV RNA and HBeAg are useful markers for the safe discontinuation of nucleotide analogue treatments in chronic hepatitis B patients, JOURNAL OF GASTROENTEROLOGY, 48(10), 1188-1204, 201310
  505. A Translational Study of Resistance Emergence Using Sequential Direct-Acting Antiviral Agents for Hepatitis C Using Ultra-Deep Sequencing, AMERICAN JOURNAL OF GASTROENTEROLOGY, 108(9), 1464-1472, 201309
  506. Clinical usefulness of classification by transabdominal ultrasonography for detection of small-bowel stricture, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 48(9), 1041-1047, 201309
  507. Noninvasive scoring systems in patients with nonalcoholic fatty liver disease with normal alanine aminotransferase levels, JOURNAL OF GASTROENTEROLOGY, 48(9), 1051-1060, 201309
  508. Risk factors for vertical incomplete resection in endoscopic submucosal dissection as total excisional biopsy for submucosal invasive colorectal carcinoma, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 28(9), 1247-1256, 201309
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  516. Dynamic computed tomography appearance of tumor response after stereotactic body radiation therapy for hepatocellular carcinoma: How should we evaluate treatment effects?, HEPATOLOGY RESEARCH, 43(7), 717-727, 201307
  517. Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan, HUMAN GENETICS, 132(7), 783-792, 201307
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  519. Risk factors for the exacerbation of esophageal varices or portosystemic encephalopathy after sustained virological response with IFN therapy for HCV-related compensated cirrhosis, JOURNAL OF GASTROENTEROLOGY, 48(7), 847-855, 201307
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  523. Genetic Analyses Reveal a Role for Vitamin D Insufficiency in HCV-Associated Hepatocellular Carcinoma Development, PLOS ONE, 8(5), 20130529
  524. A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region, JOURNAL OF HEPATOLOGY, 58(5), 875-882, 201305
  525. Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B, JOURNAL OF MEDICAL VIROLOGY, 85(5), 789-798, 201305
  526. Left atrial thickness under the catheter ablation lines in patients with paroxysmal atrial fibrillation: insights from 64-slice multidetector computed tomography, HEART AND VESSELS, 28(3), 360-368, 201305
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  528. Risk analysis of submucosal invasive rectal carcinomas for lymph node metastasis to expand indication criteria for endoscopic resection, DIGESTIVE ENDOSCOPY, 25, 21-25, 201305
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  530. Identification of a Functional Variant in the MICA Promoter Which Regulates MICA Expression and Increases HCV-Related Hepatocellular Carcinoma Risk, PLOS ONE, 8(4), 20130411
  531. A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation, PLOS GENETICS, 9(4), 201304
  532. Airway Stenting for Tracheal Obstruction Due to Lymph Node Metastasis of Hepatocellular Carcinoma, ANTICANCER RESEARCH, 33(4), 1761-1764, 201304
  533. Characteristic magnifying narrow-band imaging features of colorectal tumors in each growth type, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 28(4), 459-468, 201304
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  536. Flow-Mediated Vasodilation and Anatomical Variation of the Brachial Artery (Double Brachial Artery) in Healthy Subjects and Patients With Cardiovascular Disease, CIRCULATION JOURNAL, 77(4), 1073-1080, 201304
  537. Endoscopic assessment of colorectal cancer with superficial or deep submucosal invasion using magnifying colonoscopy., Clin Endosc., 46, 138-146, 20130301
  538. High Expression of Gastrin Receptor Protein in Injured Mucosa of Helicobacter pylori-Positive Gastritis, DIGESTIVE DISEASES AND SCIENCES, 58(3), 634-640, 201303
  539. Inhibition of hepatocellular carcinoma by PegIFN alpha-2a in patients with chronic hepatitis C: a nationwide multicenter cooperative study, JOURNAL OF GASTROENTEROLOGY, 48(3), 382-390, 201303
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  543. Virological response and safety of 24-week telaprevir alone in Japanese patients infected with hepatitis C virus subtype 1b, JOURNAL OF VIRAL HEPATITIS, 20(3), 167-173, 201303
  544. Warning for unprincipled colorectal endoscopic submucosal dissection: Accurate diagnosis and reasonable treatment strategy, DIGESTIVE ENDOSCOPY, 25(2), 107-116, 201303
  545. Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer, INTERNATIONAL JOURNAL OF CANCER, 132(4), 813-823, 20130215
  546. Response to "Treatment guidelines for HCV genotype 1: mono for low, triple for high, and dual for 'middle'?"., J Gastroenterol., 20130201
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  548. Interleukin-28B polymorphisms and hepatitis C virus clearance, GENOME MEDICINE, 5, 20130129
  549. Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C, JOURNAL OF GENERAL VIROLOGY, 94, 81-89, 201301
  550. Treatment of chronic hepatitis C virus infection in Japan: update on therapy and guidelines, JOURNAL OF GASTROENTEROLOGY, 48(1), 1-12, 201301
  551. Relationship between Narrow-Band Imaging Magnifying Observation and Pit Pattern Diagnosis in Colorectal Tumors, DIGESTION, 87(1), 53-58, 2013
  552. Replication Study of 15 Recently Published Loci for Body Fat Distribution in the Japanese Population, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 20(4), 336-350, 2013
  553. Clinical Characteristics of Patients who Developed Hepatocellular Carcinoma after Hepatitis C Virus Eradication with Interferon Therapy: Current Status in Japan, INTERNAL MEDICINE, 52(24), 2701-2706, 2013
  554. Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women, BMJ OPEN, 3(11), 2013
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  558. Clinical features of pharyngeal intraepithelial neoplasias and outcomes of treatment by endoscopic submucosal dissection, GASTROINTESTINAL ENDOSCOPY, 76(6), 1095-1103, 201212
  559. Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma according to Child-Pugh classification, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 27(12), 1850-1857, 201212
  560. Serum levels of pigment epithelium-derived factor (PEDF) are independently associated with procollagen III N-terminal peptide levels in patients with nonalcoholic fatty liver disease, CLINICAL BIOCHEMISTRY, 45(18), 1554-1557, 201212
  561. Bile Acid Promotes Intestinal Metaplasia and Gastric Carcinogenesis, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 21(11), 2101-2107, 201211
  562. Efficacy of rosuvastatin for the treatment of non-alcoholic steatohepatitis with dyslipidemia: An open-label, pilot study, HEPATOLOGY RESEARCH, 42(11), 1065-1072, 201211
  563. Increased insulinogenic index is an independent determinant of nonalcoholic fatty liver disease activity score in patients with normal glucose tolerance, DIGESTIVE AND LIVER DISEASE, 44(11), 935-939, 201211
  564. Hepatitis B Virus-Specific miRNAs and Argonaute2 Play a Role in the Viral Life Cycle, PLOS ONE, 7(10), 20121016
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  576. ★, Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators, NATURE GENETICS, 44(7), 760-U182, 201207
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  584. Association of two polymorphisms of the IL28B gene with viral factors and treatment response in 1,518 patients infected with hepatitis C virus, JOURNAL OF GASTROENTEROLOGY, 47(5), 596-605, 201205
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  590. Value of Cytodiagnosis Using Endoscopic Nasopancreatic Drainage for Early Diagnosis of Pancreatic Cancer Establishing a New Method for the Early Detection of Pancreatic Carcinoma In Situ, PANCREAS, 41(4), 523-529, 201205
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  774. G-to-A Hypermutation in Hepatitis B Virus (HBV) and Clinical Course of Patients with Chronic HBV Infection, JOURNAL OF INFECTIOUS DISEASES, 199(11), 1599-1607, 200906
  775. Predicting the clinical response to cytapheresis in steroid-refractory or -dependent ulcerative colitis using contrast-enhanced ultrasonography, Scand J Gastroenterol, 44(5), 405-411, 20090501
  776. ★, A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians, NATURE GENETICS, 41(5), 591-595, 200905
  777. A Polymorphism in MAPKAPK3 Affects Response to Interferon Therapy for Chronic Hepatitis C, GASTROENTEROLOGY, 136(5), 1796-1805, 200905
  778. Clinical prevention of gastric cancer by Helicobacter pylori eradication therapy: a systematic review, JOURNAL OF GASTROENTEROLOGY, 44(5), 365-371, 200905
  779. Evaluation and validation of computed virtual chromoendoscopy in early gastric cancer, GASTROINTESTINAL ENDOSCOPY, 69(6), 1052-1058, 200905
  780. Intra-arterial 5-fluorouracil/interferon combination therapy for advanced hepatocellular carcinoma with or without three-dimensional conformal radiotherapy for portal vein tumor thrombosis, JOURNAL OF GASTROENTEROLOGY, 44(5), 492-502, 200905
  781. Pathogenetic role of the tyrosine-phosphorylated CagA EPIYA sequence of Helicobacter pylori in histological gastritis in Japanese patients, JOURNAL OF GASTROENTEROLOGY, 44(5), 405-411, 200905
  782. Cigarette Smoking Abolishes Ischemic Preconditioning-Induced Augmentation of Endothelium-Dependent Vasodilation, HYPERTENSION, 53(4), 674-U151, 200904
  783. Comparison of detectability of small-bowel lesions between capsule endoscopy and double-balloon endoscopy for patients with suspected small-bowel disease, GASTROINTESTINAL ENDOSCOPY, 69(4), 857-865, 200904
  784. Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 24(4), 537-546, 200904
  785. Metachronous multiple esophageal squamous cell carcinomas and Lugol-voiding lesions after endoscopic mucosal resection, ENDOSCOPY, 41(4), 304-309, 200904
  786. Randomized Trial of High-Dose Interferon-alpha-2b Combined With Ribavirin in Patients With Chronic Hepatitis C: Correlation Between Amino Acid Substitutions in the Core/NS5A Region and Virological Response to Interferon Therapy, JOURNAL OF MEDICAL VIROLOGY, 81(4), 640-649, 200904
  787. Successful treatment of pulmonary metastases associated with advanced hepatocellular carcinoma by systemic 5-fluorouracil combined with interferon-alpha in a hemodialysis patient, HEPATOLOGY RESEARCH, 39(4), 415-420, 200904
  788. Usefulness of Endoscopic Ultrasonography in Determining the Depth of Invasion and Indication for Endoscopic Treatment of Early Gastric Cancer, JOURNAL OF CLINICAL GASTROENTEROLOGY, 43(4), 318-322, 200904
  789. Dose comparison study of pegylated interferon-alpha-2b plus ribavirin in naive Japanese patients with hepatitis C virus genotype 2: A randomized clinical trial, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 24(3), 366-371, 200903
  790. Narrow-band imaging magnification predicts the histology and invasion depth of colorectal tumors, GASTROINTESTINAL ENDOSCOPY, 69(3), 631-636, 200903
  791. The first Japanese case of COACH syndrome, HEPATOLOGY RESEARCH, 39(3), 318-323, 200903
  792. FDG positron emission tomography/computed tomography for the detection of extrahepatic metastases from hepatocellular carcinoma, HEPATOLOGY RESEARCH, 39(2), 134-142, 200902
  793. Significant Correlation Between Spleen Volume and Thrombocytopenia in Liver Transplant Patients: A Concept for Predicting Persistent Thrombocytopenia, LIVER TRANSPLANTATION, 15(2), 208-215, 200902
  794. Involvement of Epithelial Cell Transforming Sequence-2 Oncoantigen in Lung and Esophageal Cancer Progression, CLINICAL CANCER RESEARCH, 15(1), 256-266, 20090101
  795. Trend in Japanese malpractice litigation involving gastrointestinal endoscopy, Am J Gastroenterol, 104(1), 251-252, 20090101
  796. Evaluation of Patients with Esophageal Varices After Endoscopic Injection Sclerotherapy Using Multiplanar Reconstruction MDCT Images, AMERICAN JOURNAL OF ROENTGENOLOGY, 192(1), 122-130, 200901
  797. Little Necessity of Acid Inhibition against Proton Pump Inhibitor Rebound Effects and Prior Helicobacter pylori Eradication Therapy in Gastric Ulcer Patients: A Randomized Prospective Study, HEPATO-GASTROENTEROLOGY, 56(91-92), 624-628, 2009
  798. Usefulness and limitations of transabdominal ultrasonography for detecting small-bowel tumors, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 44(3), 332-338, 2009
  799. Rapid progression of Epstein -Barr-virus-positive gastric diffuse large B-cell lymphoma during chemoradiotherapy: a case report, Clin J Gastroenterol, 1, 105-109, 20081218
  800. Beneficial effects of living-donor liver transplantation on esophageal varices, JOURNAL OF GASTROENTEROLOGY, 43(12), 982-989, 200812
  801. Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia, METABOLISM-CLINICAL AND EXPERIMENTAL, 57(12), 1711-1718, 200812
  802. Expression of multidrug resistance-associated protein 2 is involved in chemotherapy resistance in human pancreatic cancer, INTERNATIONAL JOURNAL OF ONCOLOGY, 33(6), 1187-1194, 200812
  803. Vascular Endothelial Growth Factor C Stimulates Progression of Human Gastric Cancer via Both Autocrine and Paracrine Mechanisms, CLINICAL CANCER RESEARCH, 14(22), 7205-7214, 20081115
  804. Aging and Hypertension Are Independent Risk Factors for Reduced Number of Circulating Endothelial Progenitor Cells, AMERICAN JOURNAL OF HYPERTENSION, 21(11), 1203-1209, 200811
  805. Colorectal endoscopic submucosal dissection: present status and future perspective, including its differentiation from endoscopic mucosal resection, JOURNAL OF GASTROENTEROLOGY, 43(9), 641-651, 200809
  806. Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice, JOURNAL OF GENERAL VIROLOGY, 89, 2108-2113, 200809
  807. Strategy of endoscopic treatment for colorectal tumor: recent progress and perspective, 353-366, 20080815
  808. Etiology and outcome of acute liver failure: Retrospective analysis of 50 patients treated at a single center, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 23(8), 1216-1222, 200808
  809. Endoscopic ultrasonography with double baloon enteroscopy for small bowel diseases, Techniques in Gastrointestinal Endoscopy, 10(3), 113-118, 20080724
  810. Clinicopathological features of elderly patients with hepatitis C virus-related hepatocellular carcinoma, JOURNAL OF GASTROENTEROLOGY, 43(7), 550-557, 200807
  811. Coronary vasospasm produces reversible perfusion defects observed during adenosine triphosphate stress myocardial single-photon emission computed tomography, CLINICAL CARDIOLOGY, 31(7), 310-316, 200807
  812. Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 23(7), E198-E206, 200807
  813. Evaluation of gastric cancer risk using topography of histological gastritis: A large-scaled cross-sectional study, DIGESTIVE DISEASES AND SCIENCES, 53(7), 1818-1823, 200807
  814. Relationship between Augmentation Index and Flow-Mediated Vasodilation in the Brachial Artery, HYPERTENSION RESEARCH, 31(7), 1293-1298, 200807
  815. A Case of Fulminant Hepatic Failure Caused by Hepatitis E virus79117, Clinical Journal of gastroenterology, 1, 69-74, 20080603
  816. Role of the angiotensin II type 2 receptor in arterial remodeling after wire injury in mice, HYPERTENSION RESEARCH, 31(6), 1241-1249, 200806
  817. Strategy for treatment of nonerosive reflux disease in Asia, WORLD JOURNAL OF GASTROENTEROLOGY, 14(20), 3123-3128, 20080528
  818. Angiotensin II-Induced osteopontin expression in vascular smooth muscle cells involves G(q/11), Ras, ERK, Src and Ets-1, HYPERTENSION RESEARCH, 31(5), 987-998, 200805
  819. Genetic polymorphisms and head and neck cancer risk (Review), INTERNATIONAL JOURNAL OF ONCOLOGY, 32(5), 945-973, 200805
  820. Systemic gemcitabine combined with intra-arterial low-dose cisplatin and 5-fluorouracil for advanced hepatocellular carcinoma: Seven cases, WORLD JOURNAL OF GASTROENTEROLOGY, 14(16), 2602-2608, 20080428
  821. Ablation of the Bach1 gene leads to the suppression of atherosclerosis in Bach1 and apolipoprotein E double knockout mice, HYPERTENSION RESEARCH, 31(4), 783-792, 200804
  822. Prospective study of short-term peginterferon-alpha-2a monotherapy in patients who had a virological response at 2 weeks after initiation of interferon therapy, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 23(4), 541-545, 200804
  823. Risk factors for hepatocellular carcinoma in a Japanese population: A nested case-control study, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 17(4), 846-854, 200804
  824. Long-term ultrasonographic follow-up study of gastric motility in patients with functional dyspepsia, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 42(2), 144-149, 200803
  825. Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients, HYPERTENSION, 51(2), 446-453, 20080201
  826. Susceptibility of chimeric mice with livers repopulated by serially subcultured human hepatocytes to hepatitis B virus, HEPATOLOGY, 47(2), 435-446, 200802
  827. The number of criminal prosecutions against physicians due to medical negligence is on the rise in Japan, Am J Emerg Med, 26(1), 105-106, 20080117
  828. Clinical significance of type V-I pit pattern subclassification in determining the depth of invasion of colorectal neoplasms, WORLD JOURNAL OF GASTROENTEROLOGY, 14(2), 211-217, 20080114
  829. Presence of Poorly Differentiated Component Correlated with Submucosal Invasion in the Early Diffuse-type Gastric Cancer, HEPATO-GASTROENTEROLOGY, 55(88), 2264-2268, 2008
  830. Optical biopsy of early gastroesophageal cancer by catheter-based reflectance-type laser-scanning confocal microscopy, JOURNAL OF BIOMEDICAL OPTICS, 13(5), 2008
  831. Prophylaxis against Recurrence of HBV Hepatitis after Living-donor Liver Transplantation, HEPATO-GASTROENTEROLOGY, 55(86-87), 1746-1749, 2008
  832. Advanced glycation end products enhance the proliferation and activation of hepatic stellate cells, JOURNAL OF GASTROENTEROLOGY, 43(4), 298-304, 2008
  833. Combination therapy of oral fluoropyrimidine anticancer drug S-1 and interferon alpha for HCC patients with extrahepatic metastases, ONCOLOGY, 75(1-2), 8-16, 2008
  834. Evaluation of colon cancer vascularity by flash echo imaging, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 43(2), 223-228, 2008
  835. Predictors and long-term prognostic implications of angiographic slow/no-flow during percutaneous coronary intervention for acute myocardial infarction, INTERNAL MEDICINE, 47(10), 899-906, 2008
  836. Relation between histologic gastritis and gastric motility in Japanese patients with functional dyspepsia: evaluation by transabdominal ultrasonography, JOURNAL OF GASTROENTEROLOGY, 43(5), 332-337, 2008
  837. Role of the Gastrin-Gastrin Receptor System in the Expansive Growth of Human Gastric Neoplasms, DIGESTION, 78(2-3), 163-170, 2008
  838. Validating a Markov Model of Treatment for Hepatitis C Virus-related Hepatocellular Carcinoma, METHODS OF INFORMATION IN MEDICINE, 47(6), 529-540, 2008
  839. Selective decrease in colonic CD56(+) T and CD161(+) T cells in the inflamed mucosa of patients with ulcerative colitis, WORLD JOURNAL OF GASTROENTEROLOGY, 13(45), 5995-6002, 20071207
  840. Primary follicular lymphoma of the gastrointestinal tract: a retrospective case series, Endoscopy, 20071201
  841. Single lymphocyte analysis with a microwell array chip, CYTOMETRY PART A, 71A(12), 1003-1010, 200712
  842. Successful treatment of an entecavir-resistant hepatitis B virus variant, JOURNAL OF MEDICAL VIROLOGY, 79(12), 1811-1817, 200712
  843. Images in cardiovascular medicine. Corkscrew collaterals in thromboangitis obliterans (Buerger's disease)., CIRCULATION, E539-E540, 20071120
  844. Biliary complications after duct-to-duct biliary reconstruction in living-donor liver transplantation: Causes and treatment, WORLD JOURNAL OF SURGERY, 31(11), 2222-2229, 200711
  845. Evaluation of microvessels in colorectal tumors by narrow band imaging magnification, GASTROINTESTINAL ENDOSCOPY, 66(5), 945-952, 200711
  846. Similar effects of recombinant interferon-alpha-2b and natural interferon-alpha when combined with intra-arterial 5-fluorouracil for the treatment of advanced hepatocellular carcinoma, LIVER INTERNATIONAL, 27(9), 1209-1216, 200711
  847. Effects of a 24-week course of interferon-a therapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma, WORLD JOURNAL OF GASTROENTEROLOGY, 13(40), 5343-5350, 20071028
  848. Low-dose intermittent interferon-alpha therapy for HCV-related liver cirrhosis after curative treatment of hepatocellular carcinoma, WORLD JOURNAL OF GASTROENTEROLOGY, 13(39), 5188-5195, 20071021
  849. Genetic polymorphisms and esophageal cancer risk, INTERNATIONAL JOURNAL OF CANCER, 121(8), 1643-1658, 20071015
  850. Nodular gastritis with Helicobacter pylori infection is strongly associated with diffuse-type gastric cancer in young patients, DIGESTIVE ENDOSCOPY, 19(4), 180-184, 200710
  851. Pretreatment predictor of response, time to progression, and survival to intraarterial 5-fluorouracil/interferon combination therapy in patients with advanced hepatocellular carcinoma, JOURNAL OF GASTROENTEROLOGY, 42(10), 845-853, 200710
  852. Treatment of functional dyspepsia with serotonin agonists: A meta-analysis of randomized controlled trials, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 22(10), 1566-1570, 200710
  853. Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans., HYPERTENSION RESEARCH, 775-780, 20070901
  854. Pycnogenol (R), French maritime pine bark extract, augments endothelium-dependent vasodilation in humans, HYPERTENSION RESEARCH, 30(9), 775-780, 200709
  855. Serum pepsinogen levels in the Japanese population: Prospective study of 9 years of follow-up, HEPATO-GASTROENTEROLOGY, 54(78), 1887-1890, 200709
  856. Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma, WORLD JOURNAL OF GASTROENTEROLOGY, 13(29), 3932-3938, 20070807
  857. Acute moderate-intensity exercise induces vasodilation through oxide bioavailiability an increase in nitric in humans, AMERICAN JOURNAL OF HYPERTENSION, 20(8), 825-830, 200708
  858. Low serum level of hepatitis B indicates unlikely reactivation core-related antigen of hepatitis after cessation of lamivudine therapy, HEPATOLOGY RESEARCH, 37(8), 661-666, 200708
  859. The long-term outcome of patients with bleeding gastric varices after balloon-occluded retrograde transvenous obliteration, JOURNAL OF GASTROENTEROLOGY, 42(8), 663-672, 200708
  860. Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer, WORLD JOURNAL OF GASTROENTEROLOGY, 13(28), 3829-3835, 20070728
  861. Elevated levels of serum advanced glycation end products in patients with non-alcoholic steatohepatitis, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 22(7), 1112-1119, 200707
  862. Endoscopic submucosal dissection for colorectal neoplasia: possibility of standardization, GASTROINTESTINAL ENDOSCOPY, 66(1), 100-107, 200707
  863. Optical biopsy of GI lesions by reflectance-type laser-scanning confocal microscopy, GASTROINTESTINAL ENDOSCOPY, 66(1), 144-149, 200707
  864. Techniques and pitfalls of endoscopic submucosal dissection for colorectal tumors, DIGESTIVE ENDOSCOPY, 19, S30-S33, 200707
  865. Clinical significance of mucosal suppressors of cytokine signaling 3 expression in ulcerative colitis, WORLD JOURNAL OF GASTROENTEROLOGY, 13(21), 2939-2944, 20070607
  866. Predicting the need for surgery in Crohn's disease with contrast harmonic ultrasound, Scand J Gastroenterol, 42, 577-585, 20070601
  867. Should splenectomy be performed for hepatitis C patients undergoing living-donor liver transplantation, J Gastroenterol Hepatol, 22(6), 959-960, 20070601
  868. Magnifying endoscopy with narrow band imaging for diagnosis of colorectal tumors, GASTROINTESTINAL ENDOSCOPY, 65(7), 988-995, 200706
  869. Repetition of ischemic preconditioning augments endothelium-dependent vasodilation in humans - Role of endothelium-derived nitric oxide and endothelial progenitor cells, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 27(6), 1403-1410, 200706
  870. Earthworm fibrinolytic enzyme: anti-tumor activity on human hepatoma cells in vitro and in vivo, CHINESE MEDICAL JOURNAL, 120(10), 898-904, 20070520
  871. Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon, FEBS LETTERS, 581(10), 1983-1987, 20070515
  872. Measurement of flow-mediated vasodilation of the brachial artery - A comparison of measurements in the seated and supine positions, CIRCULATION JOURNAL, 71(5), 736-740, 200705
  873. Role of Helicobacter pylori infection and chronic inflammation in gastric cancer in the cardia, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 37(5), 365-369, 200705
  874. Serum HBV RNA is a predictor of early emergence of the YMDD mutant in patients treated with lamivudine, HEPATOLOGY, 45(5), 1179-1186, 200705
  875. Helicobacter pylori-associated gastritisis related to babA2expression without heterogeneity of the 3' region of the cagA genotype in Gastric Biopsy Specimens, Pathobiology, 74(5), 1-7, 20070401
  876. Reduced expression of heme oxygenase-1 in patients with coronary atherosclerosis, HYPERTENSION RESEARCH, 30(4), 341-348, 200704
  877. Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 49(4), 221-227, 200704
  878. Host factors contributing to the discovery of gastric cancer after successful eradication therapy of Helicobacter pylori: Preliminary report, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 22(4), 571-576, 200704
  879. New method of evaluating gastric mucosal blood flow by ultrasound, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 42(4), 513-518, 200704
  880. Usefulness of EUS with double-balloon enteroscopy for diagnosis of small-bowel diseases, GASTROINTESTINAL ENDOSCOPY, 65(3), 412-420, 200703
  881. Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 22(3), 304-310, 200703
  882. The effects of different intensities of acute exercise on systemic hemodynamics and forearm vascular function in humans., AMERICAN JUORNAL OF HYPERTENSION, 825-830, 20070214
  883. Roles of Rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 49(6), 698-705, 20070213
  884. Carvedilol improves endothelium-dependent vasodilation in patients with dilated cardiomyopathy., HEART, 247-248, 20070201
  885. Cavernous hemangioma in the ascending colon treated by endoscopic mucosal resection, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 22(2), 280-281, 200702
  886. Dual effect of APOBEC3G on Hepatitis B virus, JOURNAL OF GENERAL VIROLOGY, 88, 432-440, 200702
  887. Immune response to CagA protein is associated with improved platelet count after Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura, HELICOBACTER, 12(1), 36-42, 200702
  888. Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma, WORLD JOURNAL OF GASTROENTEROLOGY, 13(3), 414-420, 20070121
  889. Basis of decreased risk of gastric cancer in severe atrophic gastritis with eradication of Helicobacter pylori, DIGESTIVE DISEASES AND SCIENCES, 52(1), 232-239, 200701
  890. Gene delivery of paraoxonase-1 inhibits neointimal hyperplasia after arterial balloon-injury in rabbits fed a high-fat diet, HYPERTENSION RESEARCH, 30(1), 85-91, 200701
  891. Lymphatic vessel density at the site of deepest penetration as a predictor of lymph node metastasis in submucosal colorectal cancer, DISEASES OF THE COLON & RECTUM, 50(1), 13-21, 200701
  892. Non-SCN5A related Brugada syndromes: Verification of normal splicing and trafficking of SCN5A without exonic mutations, ANNALS OF HUMAN GENETICS, 71, 8-17, 200701
  893. Balloon-occluded retrograde transvenous obliteration for portal-systemic encephalopathy due to superior mesenteric-caval shunt via the right gonadal vein, INTERNAL MEDICINE, 46(17), 1479-1480, 2007
  894. Efficacy of percutaneous cementoplasty for bone metastasis from hepatocellular carcinoma, ONCOLOGY, 72(5-6), 285-292, 2007
  895. Eicosapentaenoic acid could permit maintenance of the original ribavirin dose in chronic hepatitis C virus patients during the first 12 weeks of combination therapy with pegylated interferon-alpha and ribavirin, INTERVIROLOGY, 50(6), 439-446, 2007
  896. Helicobacter pylori - Associated gastritis is related to babA2 expression without heterogeneity of the 3 ' region of the cagA genotype in gastric biopsy specimens, PATHOBIOLOGY, 74(5), 309-316, 2007
  897. Predicting the need for surgery in Crohn's disease with contrast harmonic ultrasound, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 42(5), 577-585, 2007
  898. Defensive medicine practices among gastroenterologists in Japan, WORLD JOURNAL OF GASTROENTEROLOGY, 12(47), 7671-7675, 20061221
  899. Effects of acute administration of caffeine on vascular function, AMERICAN JOURNAL OF CARDIOLOGY, 98(11), 1538-1541, 20061201
  900. Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer, GASTROINTESTINAL ENDOSCOPY, 64(6), 877-883, 200612
  901. Feasibility of freeze-dried sera for serological and molecular biological detection of hepatitis B and C viruses, JOURNAL OF CLINICAL MICROBIOLOGY, 44(12), 4593-4595, 200612
  902. Genetic and pathologic characteristics of gastrointestinal stromal tumors in extragastric lesions, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 18(6), 1067-1071, 200612
  903. Small-intestinal Peutz-Jeghers polyps resected by endoscopic polypectomy with double-balloon enteroscopy and removal confirmed by ultrasonography, DIGESTIVE DISEASES AND SCIENCES, 51(12), 2337-2340, 200612
  904. Medical malpractice litigation related to gastrointestinal endoscopy in Japan: A two-decade review of civil court cases, WORLD JOURNAL OF GASTROENTEROLOGY, 12(42), 6857-6860, 20061114
  905. Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 50(11), 3867-3874, 200611
  906. High-magnification colonoscopy (with Videos), Gastrointest Endosc, 64(4), 604-613, 20061001
  907. Management of Intraductal Papillary -mucinous Neoplasm of the Pancreas, J Clin Gastroenterol, 40(9), 856-862, 20061001
  908. Autologous bone marrow mononuclear cell implantation induces angiogenesis and bone regeneration in a patient with compartment syndrome, CIRCULATION JOURNAL, 70(10), 1362-1364, 200610
  909. Endoscopic submucosal dissection for residual/local recurrence of early gastric cancer after endoscopic mucosal resection, ENDOSCOPY, 38(10), 996-1000, 200610
  910. Genetic progression and divergence in superficial esophageal squamous cell carcinoma by loss of heterozygosity analysis, ONCOLOGY REPORTS, 16(4), 685-691, 200610
  911. High-magnification colonoscopy (with videos), GASTROINTESTINAL ENDOSCOPY, 64(4), 604-613, 200610
  912. Management of intraductal papillary-mucinous neoplasm of the pancreas - Treatment strategy based on morphologic classification, JOURNAL OF CLINICAL GASTROENTEROLOGY, 40(9), 856-862, 200610
  913. Suppression of interferon-related promoter activation by hepatitis C virus proteins expressed in cultured cells., Hiroshima Journal of Medical Sciences, 55(3), 71-77, 20060901
  914. A case of Crohn's disease with hydronephrosis caused by ureteropelvic junction obstruction, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 18(9), 1015-1018, 200609
  915. A ligand for peroxisome proliferator-activated receptor gamma inhibits human cholangiocarcinoma cell growth: Potential molecular targeting strategy for cholangioma, DIGESTIVE DISEASES AND SCIENCES, 51(9), 1650-1657, 200609
  916. Helicobacter pylori infection is the major risk factor for gastric inflammation in the cardia, DIGESTIVE DISEASES AND SCIENCES, 51(9), 1582-1588, 200609
  917. Medical malpractice litigation in gastroenterological practice in Japan: A 22-yr review of civil court cases, AMERICAN JOURNAL OF GASTROENTEROLOGY, 101(9), 1951-1953, 200609
  918. Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 346(3), 658-664, 20060804
  919. Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 346(1), 67-73, 20060721
  920. Pit pattern diagnosis for colorectal neoplasia using narrow band imaging magnification, Dig Endosc, 18, S52-S56, 20060701
  921. A case of multiple hepatic peribiliary cysts which contributed to the obstructive jaundice and led to liver failure at the young man with von Recklinghausen's disease, HEPATOLOGY RESEARCH, 35(3), 222-227, 200607
  922. Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients, ONCOLOGY REPORTS, 16(1), 11-15, 200607
  923. Double-balloon enteroscopy in patients with GI bleeding of obscure origin, GASTROINTESTINAL ENDOSCOPY, 64(1), 135-140, 200607
  924. Gastrointestinal stromal tumor in jejunum: Diagnosis using contrast-enhanced ultrasonography and double-balloon enteroscopy, DIGESTIVE DISEASES AND SCIENCES, 51(7), 1236-1240, 200607
  925. Neuropilin-1 is involved in regulation of apoptosis and migration of human colon cancer, INTERNATIONAL JOURNAL OF ONCOLOGY, 29(1), 105-116, 200607
  926. Real-time visualization and quantitation of canine gastric mucosal blood flow by contrast-enhanced ultrasonography, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 41(7), 856-861, 200607
  927. Delection of the KIT gene is associated with liver metastasis and poor prognosis in patients with gastrointestinal stromal tumor in the stomach., Int J Oncology, 28, 1361-1367, 20060601
  928. Deletion of the KIT gene is associated with liver metastasis and poor prognosis in patients with gastrointestinal stromal tumor in the stomach, INTERNATIONAL JOURNAL OF ONCOLOGY, 28(6), 1361-1367, 200606
  929. Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production, ATHEROSCLEROSIS, 186(2), 390-395, 200606
  930. Surface structure of antral gastric mucosa represents the status of histologic gastritis: Fundamental evidence for the evaluation of antral gastritis by magnifying endoscopy, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 21(5), 837-841, 200605
  931. The usefulness of transabdominal ultrasound for the diagnosis of lower gastrointestinal bleeding, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 23(8), 1267-1272, 20060415
  932. Ablation of indiopathic ventricular tachycardia with a left Bundle-Branch block morphology originating from the pulmonary artery., J Arrthmia, 22(3), 180-186, 20060401
  933. Coronary sinus Morphology in Patients with Posteroseptal Atrioventricular Accessory Pathways., J Arrthmia, 22(3), 149-154, 20060401
  934. Edaravone(3-Methyl-1-Phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases., Recent Patents on Cardiovascular Drug Discovery, 1, 85-93, 20060401
  935. Oxidative stress, endothelial function and angiogenesis induced by cell therapy and gene therapy, CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 7(2), 109-116, 200604
  936. The effect of Helicobacter pylori eradication therapy on gastric ulcer healing after endoscopic mucosal resection, JOURNAL OF CLINICAL GASTROENTEROLOGY, 40(4), 293-296, 200604
  937. The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines, INTERNATIONAL JOURNAL OF ONCOLOGY, 28(4), 915-921, 200604
  938. Helicobacter pylori infection is the major risk factor for atrophic gastritis, San Diego, 20060301
  939. Aged garlic extract has potential suppressive effect on colorectal adenomas in humans, JOURNAL OF NUTRITION, 136(3), 821S-826S, 200603
  940. Measurement of hepatitis B virus core-related antigen is valuable for identifying patients who are at low risk of lamivudine resistance, LIVER INTERNATIONAL, 26(1), 90-96, 200602
  941. Nonpolypoid (flat and depressed) colorectal neoplasms, GASTROENTEROLOGY, 130(2), 566-576, 200602
  942. Suppression of STAT3 activity by duplin, which is a negative regulator of the Wnt signal, JOURNAL OF BIOCHEMISTRY, 139(2), 305-314, 200602
  943. Causal role of Helicobacter pylori infection and eradication therapy in gastric carcinogenesis., World J Gastroenterol, 12(1), 10-16, 20060101
  944. Evaluation of endoscopic and histological findings in Helicobacter pylori-positive Japanese young adults, J Gastroenterol Hepatol, 21, 258-261, 20060101
  945. dEvaluation of endoscopic and histological findings in Helicobacter pylori-positive Japanese young adults, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 21(1), 258-261, 200601
  946. Development of a novel method to detect Helicobacter pylori cagA genotype from paraffin-embedded materials: Comparison between patients with duodenal ulcer and gastric cancer in young Japanese, DIGESTION, 73(1), 47-53, 2006
  947. Evolution of hepatitis C virus quasispecies during ribavirin and interferon-alpha-2b combination therapy and interferon-alpha-2b monotherapy, INTERVIROLOGY, 49(6), 352-361, 2006
  948. Nuclear and mitochondrial DNA microsatellite instability in gastrointestinal stromal tumors, PATHOBIOLOGY, 73(2), 93-97, 2006
  949. Prolonged negative HCV-RNA status led to a good outcome in chronic hepatitis C patients with genotype 1b and super-high viral load, INTERVIROLOGY, 49(6), 362-369, 2006
  950. Successive, rapid recurrences of in-stent restenoses in a woman with angina pectoris, INTERNAL MEDICINE, 45(19), 1093-1096, 2006
  951. Glycochenodeoxycholate plays a carcinogenic role in immortalized mouse cholanglocytes via oxidative DNA damage, FREE RADICAL BIOLOGY AND MEDICINE, 39(11), 1418-1427, 20051201
  952. Biphasic effect of HMG-CoA reductase inhibitor, pitavastatin, on vascular endothelial cells and angiogenesis, CIRCULATION JOURNAL, 69(12), 1547-1555, 200512
  953. Smoking, endothelial function, and Rho-kinase in humans, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 25(12), 2630-2635, 200512
  954. Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment, CLINICAL CANCER RESEARCH, 11(21), 7629-7636, 20051101
  955. Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells, CARDIOVASCULAR RESEARCH, 68(2), 289-298, 20051101
  956. Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis B virus, HEPATOLOGY, 42(5), 1046-1054, 200511
  957. Reliable and cost-effective screening of inherited heterozygosity by Zn2+-cyclen polyacrylamide gel electrophoresis, CLINICAL CHEMISTRY, 51(11), 2195-2198, 200511
  958. Somatic mutations of mitochondrial DNA in digestive tract cancers, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 20(11), 1679-1684, 200511
  959. ★, A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5 ' flanking region of SMYD3 is a risk factor for human cancers, NATURE GENETICS, 37(10), 1104-1107, 200510
  960. Adrenomedullin causes coronary vasodilation in humans - Effects of inhibition of nitric oxide synthesis, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 46(4), 534-539, 200510
  961. Diagnostic ability of high-frequency ultrasound probe sonography in staging early gastric cancer, especially for submucosal invasion, ABDOMINAL IMAGING, 30(5), 518-523, 200510
  962. Relationship between endothelial function in the coronary and brachial arteries, CLINICAL CARDIOLOGY, 28(10), 460-466, 200510
  963. Therapeutic effect of repeated natural killer T cell stimulation in mouse cholangitis complicated by colitis, DIGESTIVE DISEASES AND SCIENCES, 50(10), 1844-1851, 200510
  964. Expression of p53 protein in esophageal squamous cell carcinoma: relation to hypoxia-inducible factor-1alpha, angiogenesis and apoptosis., Pathobiology, 72, 179-185, 20050901
  965. Cardiac glands hyperplastic polyp of the stomach, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 20(9), 1461-1463, 200509
  966. A nuclear receptor-mediated choleretic action of fibrates is associated with enhanced canalicular membrane fluidity and transporter activity mediating bile acid-independent bile secretion, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 12(4), 211-217, 20050825
  967. Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in early gastric carcinoma: correlation with clinicopathological parameters, CANCER LETTERS, 226(1), 85-90, 20050808
  968. A combination of the Helicobacter pylori stool antigen test and urea breath test is useful for clinical evaluation of eradication therapy: A multicenter study, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 20(8), 1241-1245, 200508
  969. Multiple carcinoid tumors of the ileum preoperatively diagnosed by enteroscopy with the double-balloon technique, GASTROINTESTINAL ENDOSCOPY, 62(2), 315-318, 200508
  970. Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver, DIGESTIVE DISEASES AND SCIENCES, 50(7), 1361-1371, 200507
  971. Quantitative analysis of lymphangiogenic markers for predicting metastasis of human gastric carcinoma to lymph nodes, INTERNATIONAL JOURNAL OF CANCER, 115(3), 388-392, 20050620
  972. Effect of famotidine on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 21, 73-78, 200506
  973. Effect of long-term half-dose famotidine therapy on corpus gastritis in peptic ulcer disease, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 21, 99-104, 200506
  974. Clinical features of gastric cancer discovered after successful eradication of Helicobacter pylori: results from a 9-year prospective follow-up study in Japan, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 21(9), 1121-1126, 20050501
  975. Angiotensin II participates in hepatic inflammation and fibrosis through MCP-1 expression, DIGESTIVE DISEASES AND SCIENCES, 50(5), 942-948, 200505
  976. Ablation of ventricular tachycardia originating from the right ventricle associated with scleroderma cardiomyopathy., J Arrhythmia, 21(5), 542-545, 20050401
  977. Angiotensin II type I receptor blocker and endothelial function in humans: role of nitric oxide and oxidative stress., Curr.Med.Chem, 3(2), 133-148, 20050401
  978. Relationship between histopathological features and type V pit pattern determined by magnifying videocolonoscopy in early colorectal carcinoma, Dig Endos, 17, 117-122, 20050401
  979. The nicorandil-induced vasodilation in humans is inhibited by miconazole, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 45(4), 290-294, 200504
  980. Morphological changes in human gastric tumours after eradication therapy of Helicobacter pylori in a short-term follow-up, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 21(5), 559-566, 20050301
  981. A nuclear receptor ligand down-regulates cytosolic phospholipase A(2) expression to reduce bile acid-induced cyclooxygenase 2 activity in cholangiocytes: Implications of anticarcinogenic action of farnesoid X receptor agonists, DIGESTIVE DISEASES AND SCIENCES, 50(3), 514-524, 200503
  982. G to A hypermutation of hepatitis B virus, HEPATOLOGY, 41(3), 626-633, 200503
  983. Ubquitin-interacting motifs of epsin are involved in the regulation of insulin-dependent endocytosis, JOURNAL OF BIOCHEMISTRY, 137(3), 355-364, 200503
  984. Effects of angiotensin II on the expression of MCP-1 in hepatic stellate line LI90, Japanese Pharmaology and Therapeutics, 32, 143-5, 20050201
  985. Molecular evolutionaly analyses implicate injecthion treatment for schistosomiasis in the initial hepatitis C epidemics in japan, Journal of Hepatology, 42, 47-53, 20050101
  986. Superficial type serrated adenoma in ulcerative colitis resected by endoscopic submucosal dissection, Dig Endosc, 17, S49-S52, 20050101
  987. A case of congenital absence of the portal vein, HEPATOLOGY RESEARCH, 31(1), 43-47, 200501
  988. A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer, JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 131(1), 19-25, 200501
  989. Eradication of Helicobacter pylori increases the incidence of hyperlipidaemia and obesity in peptic ulcer patients, DIGESTIVE AND LIVER DISEASE, 37(1), 39-43, 200501
  990. Infliximab therapy for Crohn's disease in a patient with chronic hepatitis B, DIGESTIVE DISEASES AND SCIENCES, 50(1), 163-166, 200501
  991. Molecular evolutionary analyses implicate injection treatment for schistosomiasis in the initial hepatitis C epidemics in Japan, JOURNAL OF HEPATOLOGY, 42(1), 47-53, 200501
  992. Single dose of OCH improves mucosal T helper type 1/T helper type 2 cytokine balance and prevents experimental colitis in the presence of v alpha 14 natural killer T cells in mice, INFLAMMATORY BOWEL DISEASES, 11(1), 35-41, 200501
  993. Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats, GASTROENTEROLOGY, 128(1), 138-146, 200501
  994. Vascular function in patients with lower extremity peripheral arterial disease: a comparison of functions in upper and lower extremities, ATHEROSCLEROSIS, 178(1), 179-185, 200501
  995. A classification system of echogenicity for gastrointestinal neoplasms, DIGESTION, 72(1), 8-12, 2005
  996. Expression of p53 protein in esophageal squamous cell carcinoma: Relation to hypoxia-inducible factor-1 alpha, angiogenesis and apoptosis, PATHOBIOLOGY, 72(4), 179-185, 2005
  997. Involvement of proinflammatory cytokines IL-1 beta and IL-6 in progression of human gastric carcinoma, ANTICANCER RESEARCH, 25(2A), 709-713, 2005
  998. Loss of heterozygosity on chromosome 10p14-p15 in colorectal carcinoma, PATHOBIOLOGY, 72(4), 220-224, 2005
  999. Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma, INTERNATIONAL JOURNAL OF CANCER, 112(6), 1003-1009, 20041220
  1000. Single nucleotide polymorphism in the hypoxia-inducible factor-1 alpha gene in colorectal carcinoma, ONCOLOGY REPORTS, 12(5), 1033-1037, 200411
  1001. Apolipoprotein E phenotype affects the malondialdehyde-modified LDL concentration and forearm endothelial function in postmenopausal women, CLINICAL ENDOCRINOLOGY, 61(5), 619-625, 200411
  1002. Magnifying colonoscopic features of ulcerative colitis reflect histologic inflammation, INFLAMMATORY BOWEL DISEASES, 10(6), 737-744, 200411
  1003. Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers, AMERICAN JOURNAL OF CARDIOLOGY, 94(8), 1070-1073, 20041015
  1004. Partial characterization of cytoprotective mechanisms of lecithin against bile salt-induced bile duct damage, JOURNAL OF GASTROENTEROLOGY, 39(10), 955-960, 200410
  1005. Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes, INTERNATIONAL JOURNAL OF CANCER, 111(4), 617-626, 20040910
  1006. Improvement of atrial signal-averaged electrocardiographic abnormalities after radiofrequency catheter ablation in persistent atrial flutter, JAPANESE HEART JOURNAL, 45(5), 761-770, 200409
  1007. Expression of hypoxia-inducible factor (HIF)-1alpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma., Eur J Cancer, 40, 1904-1912, 20040801
  1008. Expression of hypoxia-inducible factor (HIF)-1 alpha is associated with vascular endothelial growth factor expression and tumour anglogenesis in human oesophageal squamous cell carcinoma, EUROPEAN JOURNAL OF CANCER, 40(12), 1904-1912, 200408
  1009. Frequent loss of heterozygosity on chromosome 10p14-p15 in esophageal dysplasia and squamous cell carcinoma, ONCOLOGY REPORTS, 12(2), 333-337, 200408
  1010. Immune response in mouse experimental cholangitis associated with colitis induced by dextran sulfate sodium, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 19(8), 910-915, 200408
  1011. Relationship between C-reactive protein concetrations and coronary microvascular endothelial function0, Heart, 90, 750-754, 20040701
  1012. Chromosomal and microsatellite instability in sporadic gastric cancer, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 19(7), 756-760, 200407
  1013. Regulation of vascular endothelial growth factor (VEGF)-C and VEGF-D expression by the organ microenvironment in human colon carcinoma, EUROPEAN JOURNAL OF CANCER, 40(10), 1604-1609, 200407
  1014. Relation between C reactive protein concentrations and coronary microvascular endothelial function, HEART, 90(7), 750-754, 200407
  1015. Induction of apoptosis by ionizing radiation and CI-1033 in HuCCT-1 cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 319(1), 114-119, 20040618
  1016. Chronic gastritis with expression of inducible nitric oxide synthase is associated with high expression of interleukin-6 and hypergastrinaemia, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 19(12), 1309-1314, 20040615
  1017. Frequent epigenetic inactivation of RIZ1 by promoter hypermethylation in human gastric carcinoma, INTERNATIONAL JOURNAL OF CANCER, 110(2), 212-218, 20040610
  1018. Fas and Fas ligand: Expression and soluble circulating levels in bile duct carcinoma, ONCOLOGY REPORTS, 11(6), 1183-1186, 200406
  1019. Initial experience with catheter probe US when using a multibending endoscope, GASTROINTESTINAL ENDOSCOPY, 59(7), 889-894, 200406
  1020. A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer, JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 130(5), 259-265, 200405
  1021. Effects of aged garlic extract (AGE) on colorectal adenomas: a double-blinded study, Hiroshima J Med Sci, 53(3--4), 39-45, 20040401
  1022. Identification of rare polymerase variants of hepatitis B virus using a two-stage PCR with peptide nucleic acid clamping, JOURNAL OF MEDICAL VIROLOGY, 72(4), 558-565, 200404
  1023. Magnifying gastroendoscopy for diagnosis of histologic gastritis in the gastric antrum, DIGESTIVE AND LIVER DISEASE, 36(4), 286-291, 200404
  1024. Sonographic detection of longitudinal ulcers in Crohn disease, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 39(4), 322-326, 200404
  1025. Autologous bone-marrow mononuclear cell implantation improves endothelium-dependent vasodilation in patients with limb ischemia, CIRCULATION, 109(10), 1215-1218, 20040316
  1026. Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 43(5), 818-825, 20040303
  1027. A case of latent primary biliary cirrhosis, HEPATOLOGY RESEARCH, 28(3), 166-169, 200403
  1028. Atrial contraction after surgical isolation of the left atrial posterior wall concomitant with mitral valve replacement, CIRCULATION JOURNAL, 68(3), 204-207, 200403
  1029. Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma, INTERNATIONAL JOURNAL OF ONCOLOGY, 24(3), 539-547, 200403
  1030. Pathophysiology of nonalcoholic steatohepatitis (NASH)-Relation to adipocytokine and advanced glycation end products., Japanese Pharmaology & Therapeutics, 32, 107-9, 20040201
  1031. Angiogenic switch occurs during the precancerous stage of human esophageal squamous cell carcinoma, ONCOLOGY REPORTS, 11(2), 315-319, 200402
  1032. Clinicopathologic and endoscopic features of colorectal serrated adenoma: differences between polypoid and superficial types, GASTROINTESTINAL ENDOSCOPY, 59(2), 213-219, 200402
  1033. Mutation of the von Hippel-Lindau (VHL) gene in human colorectal carcinoma: Association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1 alpha, CANCER SCIENCE, 95(2), 149-153, 200402
  1034. Clinical usefulness of high-frequency ultrasound probes for new invasion depth diagnosis in submucosal colorectal carcinoma, Dig Endosc, 16, S49-S52, 20040101
  1035. Expression of human telomerase reverse transcriptase mRNA in esophageal cancers and precancerous lesions, ONCOLOGY REPORTS, 11(1), 51-55, 200401
  1036. Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma, CANCER SCIENCE, 95(1), 32-39, 200401
  1037. Gemcitabine suppresses malignant ascites of human pancreatic cancer: Correlation with VEGF expression in ascites, ONCOLOGY REPORTS, 11(1), 73-80, 200401
  1038. Characteristics and trends of clarithromycin-resistant Helicobacter pylori isolates in Japan over a decade, PATHOBIOLOGY, 71(3), 159-163, 2004
  1039. Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma, PATHOBIOLOGY, 71(3), 137-143, 2004
  1040. Mucin phenotype and background mucosa of intramucosal differentiated-type adenocarcinoma of the stomach, ONCOLOGY, 66(5), 379-387, 2004
  1041. Response of the left anterior descending coronary artery to Acetylcholine in patients with chest pain and angiographically normal coronary arteries, AMERICAN JOURNAL OF CARDIOLOGY, 92(12), 1394-1398, 20031215
  1042. Mnk1 is required for angiotensin II - Induced protein synthesis in vascular smooth muscle cells, CIRCULATION RESEARCH, 93(12), 1218-1224, 20031212
  1043. Promoter methylation of cyclin D2 gene in gastric carcinoma, INTERNATIONAL JOURNAL OF ONCOLOGY, 23(6), 1663-1670, 200312
  1044. Unique inhibition of bile salt-induced apoptosis by lecithins and cytoprotective bile salts in immortalized mouse cholangiocytes, DIGESTIVE DISEASES AND SCIENCES, 48(12), 2315-2322, 200312
  1045. Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 311(4), 809-814, 20031128
  1046. Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 12(4), 437-442, 200310
  1047. Clinical significance of thrombospondin-1 expression in relation to vascular endothelial growth factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal carcinoma, INTERNATIONAL JOURNAL OF ONCOLOGY, 23(4), 901-911, 200310
  1048. Disruption of the type 2 dopamine receptor gene causes a sodium-dependent increase in blood pressure in mice, AMERICAN JOURNAL OF HYPERTENSION, 16(10), 853-858, 200310
  1049. Prevalence of Helicobacter pylori resistance to clarithromycin and metronidazole determined by 23S ribosomal RNA and rdxA gene analyses in Hiroshima, Japan, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 18(10), 1202-1207, 200310
  1050. The promoter methylation status of the DNA repair gene O-6-methylguanine-DNA methyltransferase in ulcerative colitis, VIRCHOWS ARCHIV, 443(4), 518-523, 200310
  1051. Does intragastric nitrite concentration reflect gastric carcinogenesis in Japanese Helicobacter pylori-infected patients?, DIGESTIVE DISEASES AND SCIENCES, 48(9), 1730-1736, 200309
  1052. Gastric juice nitrite and vitamin C in patients with gastric cancer and atrophic gastritis: is low acidity solely responsible for cancer risk?, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 15(9), 987-993, 200309
  1053. Necessity of multiple gastric biopsies from different sites for detection of clarithromycin-resistant Helicobacter pylori strains, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 38(9), 942-946, 200309
  1054. p53 expression, K-ras gene mutation and microsatellite instability in gastric B-cell lymphomas, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 18(9), 1047-1053, 200309
  1055. AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl4, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 308(1), 177-183, 20030815
  1056. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans - Role of endothelium-dependent nitric oxide and oxidative stress, CIRCULATION, 108(5), 530-535, 20030805
  1057. Impact of aging on the development of hepatocellular carcinoma in patients with hepatitis C virus infection in Japan, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 38(8), 894-900, 200308
  1058. Myocardial bridging increases the risk of coronary spasm, CLINICAL CARDIOLOGY, 26(8), 377-383, 200308
  1059. Somatic mutation of mitochondrial DNA in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 12(2), 169-174, 200308
  1060. Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: Role of nitric oxide and oxidative stress, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 42(2), 256-263, 20030716
  1061. Food deprivation enhances somatostatin and somatostatin receptor subtype expression in rat colon, REGULATORY PEPTIDES, 114(2-3), 167-173, 20030715
  1062. The specific expression of Hypoxia Inducible Factor-1 alpha in human gastric mucosa induced by nonsteroidal anti-inflammatory drugs, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 18, 90-98, 200307
  1063. Natural histories of hepatitis C virus infection in men and women simulated by the Markov model, JOURNAL OF MEDICAL VIROLOGY, 70(3), 378-386, 200307
  1064. Long-term observation of reflux oesophagitis developing after Helicobacter pylori eradication therapy, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 17(12), 1529-1534, 20030615
  1065. Expression of hypoxia-inducible factor-l alpha is associated with tumor vascularization in human colorectal carcinoma, INTERNATIONAL JOURNAL OF CANCER, 105(2), 176-181, 20030610
  1066. Inhibition of cholesterol crystallization under bilirubin deconjugation: partial characterization of mechanisms whereby infected bile accelerates pigment stone formation, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1632(1-2), 48-54, 20030610
  1067. Unique reciprocal changes of hepatocellular membrane transporter expression and fluidity in rats with selective biliary obstruction, HEPATOLOGY RESEARCH, 26(2), 157-163, 200306
  1068. Expressions of angiogenic factors in pancreatic ductal carcinoma: A correlative study with clinicopathologic parameters and patient survival, PANCREAS, 26(4), 344-349, 200305
  1069. Nodular gastritis in adults is caused by Helicobacter pylori infection, DIGESTIVE DISEASES AND SCIENCES, 48(5), 968-975, 200305
  1070. PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers, HYPERTENSION, 41(5), 1106-1110, 200305
  1071. Smoking activates Rho-kinase in smooth muscle cells of forearm vasculature in humans, HYPERTENSION, 41(5), 1102-1105, 200305
  1072. Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia, MATURITAS, 44(4), 307-315, 20030425
  1073. Depressed-type, early duodenal carcinoma(carcinoma in situ) treated by endoscopic mucosal resection, J. Gastroenterol., 38(8), 813-815, 20030401
  1074. Expression of hyposia-inducible factor-1 alpha is associated with tumor vascularization in human colorectal carcinoma, Int J Cancer, 105(2), 176-181, 20030401
  1075. Expression of vascular endothelial growth facter and angiogenesis in gastrointestinal stromal tumor of the stomach, Oncology, 64(3), 266-274, 20030401
  1076. Minute depressed colon cancer with submucosal invasion, Gastrointest Endosc, 57(4), 564-565, 20030401
  1077. Nondular gastritis in adults is caused by Helicobacter pylori ingfection, Dig Dis Sci, 48(5), 968-975, 20030401
  1078. Prominent J wave and ST segment elevation: Serial electrocardiographic changes in accidental hypothermia, Journal of cardiovasuclar electrophysiology, 14(2), 223, 20030401
  1079. Isolated granulomatous gastritis successfully treated by Helicobacter pylori eradication: a possible association between granulomatous gastritis and Helicobacter pylori, JOURNAL OF GASTROENTEROLOGY, 38(4), 371-375, 200304
  1080. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas, INTERNATIONAL JOURNAL OF ONCOLOGY, 22(4), 773-778, 200304
  1081. Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 22(4), 765-771, 200304
  1082. Serum pepsinogen concentration as a marker of Helicobacter pylori infection and the histologic grade of gastritis; evaluation of gastric mucosa by serum pepsinogen levels, JOURNAL OF GASTROENTEROLOGY, 38(4), 332-338, 200304
  1083. Significance of an exaggerated meal-stimulated gastrin response in pathogenesis of Helicobacter pylori-negative duodenal ulcer, DIGESTIVE DISEASES AND SCIENCES, 48(4), 644-651, 200304
  1084. A comparison of low-dose and standard-dose oral estrogen on forearm endothelial function in early postmenopausal women, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 88(3), 1303-1309, 200303
  1085. Choleretic action of diosgenin is based upon the increases in canalicular membrane fluidity and transporter activity mediating bile acid independent bile flow, HEPATOLOGY RESEARCH, 25(3), 287-295, 200303
  1086. Giant gastric folds: Differential diagnosis at US, RADIOLOGY, 226(3), 686-690, 200303
  1087. Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma, CANCER SCIENCE, 94(3), 263-270, 200303
  1088. Autonomic nerve dysfunction is closely associated with the abnormalities of esophageal motility in reflux esophagitis, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 38(2), 159-163, 200302
  1089. Helicobacter pylori infection influences tumor growth of human gastric carcinomas, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 38(2), 153-158, 200302
  1090. Impaired gallbladder mucosal function in aged gallstone patients suppresses gallstone recurrence after successful extracorporeal shockwave lithotripsy, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 18(2), 157-161, 200302
  1091. Leptin causes nitric-oxide independent coronary artery vasodilation in humans, HYPERTENSION RESEARCH, 26(2), 147-152, 200302
  1092. Small rectal carcinoid with lymph node metastasis diagnosed prior to treatment, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 15(2), 195-197, 200302
  1093. Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis, HYPERTENSION, 41(1), 99-107, 200301
  1094. Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity, HEPATOLOGY RESEARCH, 25(1), 38-47, 200301
  1095. Frequent loss of heterozygosity on chromosome 10p15, a putative telomerase repressor/senescence gene locus, in gastric cancer, ONCOLOGY REPORTS, 10(5), 1297-1299, 2003
  1096. Prognostic value of p53 and Ki-67 expression in resected or biopsy specimens of bile duct carcinoma, ONCOLOGY REPORTS, 10(5), 1091-1096, 2003
  1097. Clinicopathologic features and endoscopic resection of early primary nonampullary duodenal carcinoma, JOURNAL OF CLINICAL GASTROENTEROLOGY, 37(5), 381-386, 2003
  1098. Somatic mutation in mitochondrial DNA and nuclear microsatellite instability in gastric cancer, ONCOLOGY REPORTS, 10(6), 1837-1841, 2003
  1099. Expression of fibroblast growth factor receptor genes in human hepatoma-derived cell lines, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 39(7), 321-328, 2003
  1100. Hypoxia-inducible factor-1 alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach, ONCOLOGY REPORTS, 10(4), 797-802, 2003
  1101. Clinical significance of angiogenic factor expression at the deepest invasive site of advanced colorectal carcinoma, ONCOLOGY, 64(1), 61-73, 2003
  1102. Expression of vascular endothelial growth factor and angiogenesis in gastrointestinal stromal tumor of the stomach, ONCOLOGY, 64(3), 266-274, 2003
  1103. Rare quasispecies in the YMDD motif of hepatitis B virus detected by polymerase chain reaction with peptide nucleic acid clamping, INTERVIROLOGY, 46(6), 355-361, 2003
  1104. Circadian variation of blood pressure and endothelial function in patients with essential hypertension: A comparison of dippers and non-dippers, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 40(11), 2039-2043, 20021204
  1105. A frameshift mutation of beta subunit of epithelial sodium channel in a case of isolated Liddle syndrome, JOURNAL OF HYPERTENSION, 20(12), 2379-2382, 200212
  1106. Mechanisms responsible for vasodilation upon magnesium infusion in vivo: Clinical evidence, MAGNESIUM RESEARCH, 15(3-4), 241-246, 200212
  1107. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas, INTERNATIONAL JOURNAL OF CANCER, 102(3), 220-224, 20021120
  1108. Effect of alcohol consumption on endothelial function in men with coronary artery disease, ATHEROSCLEROSIS, 165(1), 145-152, 200211
  1109. Irsogladine malate up-regulates gap junctional intercellular communication between pancreatic cancer cells via PKA pathway, PANCREAS, 25(4), 373-377, 200211
  1110. Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 87(10), 4634-4641, 200210
  1111. Human telomerase reverse transcriptase, p53 and Ki-67 expression and apoptosis in colorectal serrated adenoma, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 37(10), 1194-1200, 200210
  1112. Clinical characteristics and natural history of patients with low-grade reflux esophagitis, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 17(9), 949-954, 200209
  1113. Combination of transcatheter arterial chemoembolization using cisplatin-lipiodol suspension and percutaneous ethanol injection for treatment of advanced small hepatocellular carcinoma, AMERICAN JOURNAL OF SURGERY, 184(3), 284-290, 200209
  1114. Nicorandil-induced preconditioning as evidenced by troponin T measurements after coronary angioplasty in patients with stable angina pectoris, JAPANESE HEART JOURNAL, 43(5), 443-453, 200209
  1115. Advanced colorectal carcinoma smaller than 10 mm in maximum diameter with special reference to clinicopathologic and molecular features: a report of 3 cases, GASTROINTESTINAL ENDOSCOPY, 56(2), 299-303, 200208
  1116. Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 16(8), 1449-1456, 200208
  1117. p53 codon 72 polymorphism in gastric cancer susceptibility in patients with Helicobacter pylori-associated chronic gastritis, INTERNATIONAL JOURNAL OF CANCER, 100(3), 304-308, 20020720
  1118. Vascular endothelial growth factor-C expression predicts lymph node metastasis of human gastric carcinomas invading the submucosa, EUROPEAN JOURNAL OF CANCER, 38(10), 1413-1419, 200207
  1119. Preconditioning effect during coronary angioplasty in patients with stable angina pectoris, INTERNAL MEDICINE, 41(7), 509-515, 200207
  1120. ★, Endothelial function and oxidative stress in renovascular hypertension, NEW ENGLAND JOURNAL OF MEDICINE, 346(25), 1954-1962, 20020620
  1121. Evaluation of esophageal motility by endosonography using a miniature ultrasonographic probe in patients with reflux esophagitis, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 37(6), 674-678, 20020601
  1122. Evaluation of gastric emptying measured with the C-13-octanoic acid breath test in patients with functional dyspepsia comparison with ultrasonography, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 37(6), 662-666, 20020601
  1123. Management of chronic hepatitis C and prevention of hepatocellular carcinoma, JOURNAL OF GASTROENTEROLOGY, 37, 69-73, 200206
  1124. Balloon-occluded retrograde transvenous obliteration of gastric fundal varices with hemorrhage, AMERICAN JOURNAL OF ROENTGENOLOGY, 178(5), 1167-1174, 200205
  1125. Implication of anti-parietal cell antibody levels in gastrointestinal diseases, including gastric carcinogenesis, DIGESTIVE DISEASES AND SCIENCES, 47(5), 1080-1085, 200205
  1126. Preoperative assessment of gastric cancer vascularity by flash echo imaging, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 37(5), 608-612, 200205
  1127. Severity of hypertension affects improved resistance artery endothelial function by angiotensin-converting enzyme inhibition, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 39(5), 668-676, 200205
  1128. Hepatic hydroxylation of bile acids and chronic liver diseases: do transporters play a mechanistic role?, 20020401
  1129. Single administration of ecabet sodium diminishes the level of delta-(13) Co(2) in urea breath test, J GastroenterolM., 37(8), 674-675, 20020401
  1130. A low-calorie diet improves endothelium-dependent vasodilation in obese patients with essential hypertension, AMERICAN JOURNAL OF HYPERTENSION, 15(4), 302-309, 200204
  1131. High incidence of B-cell monoclonality in follicular gastritis: a possible association between follicular gastritis and MALT lymphoma, VIRCHOWS ARCHIV, 440(4), 376-380, 200204
  1132. Long-term rebamipide therapy improves Helicobacter pylori-associated chronic gastritis, DIGESTIVE DISEASES AND SCIENCES, 47(4), 862-867, 200204
  1133. Nicorandil enhances myocardial tolerance to ischemia without progressive collateral recruitment during coronary angioplasty, CIRCULATION JOURNAL, 66(4), 317-322, 200204
  1134. Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals, AMERICAN JOURNAL OF HYPERTENSION, 15(4), 326-332, 200204
  1135. Cigarette smoking promotes atrophic gastritis in Helicobacter pylori-positive subjects, DIGESTIVE DISEASES AND SCIENCES, 47(3), 675-681, 200203
  1136. Leptin causes vasodilation in humans, HYPERTENSION RESEARCH, 25(2), 161-165, 200203
  1137. Role of anti-parietal cell antibody in Helicobacter pylori-associated atrophic gastritis: Evaluation in a country of high prevalence of atrophic gastritis, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 37(3), 287-293, 200203
  1138. Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia, HEART, 87(3), 264-269, 200203
  1139. Estrogen replacement suppresses function of thrombin stimulated platelets by inhibiting Ca2+ influx and raising cyclic adenosine monophosphate, CARDIOVASCULAR RESEARCH, 53(3), 634-641, 20020215
  1140. Less hydrophobic phosphatidylcholine species simplify biliary vesicle morphology, but induce bile metastability with a broad spectrum of crystal forms, BIOCHEMICAL JOURNAL, 362, 105-112, 20020215
  1141. K-ras mutation in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer, INTERNATIONAL JOURNAL OF CANCER, 97(5), 562-566, 20020210
  1142. Excess norepinephrine impairs both endothelium-dependent and -independent vasodilation in patients with pheochromocytoma, HYPERTENSION, 39(2), 513-518, 200202
  1143. Helicobacter pylori infection increases serum nitrate and nitrite more prominently than serum pepsinogens, HELICOBACTER, 7(1), 9-13, 200202
  1144. Serological comparison of serum pepsinogen and antiparietal cell antibody levels between Japanese and German patients, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 14(2), 123-127, 200202
  1145. Tetrahydrobiopterin improves coronary endothelial function, but does not prevent coronary spasm in patients with vasospastic angina, CIRCULATION JOURNAL, 66(1), 58-62, 200201
  1146. Combination therapy of low-dose medroxyprogesterone acetate and oral estrogen does not affect endothelial function in the forearms of postmenopausal women, MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 9(5), 360-366, 2002
  1147. Determining depth of invasion by VN pit pattern analysis in submucosal colorectal carcinoma, ONCOLOGY REPORTS, 9(5), 1005-1008, 2002
  1148. Clinical significance of angiogenesis in rectal carcinoid tumors, ONCOLOGY REPORTS, 9(3), 489-494, 2002
  1149. Renal endothelial dysfunction and hypertension, JOURNAL OF DIABETES AND ITS COMPLICATIONS, 16(1), 103-107, 2002
  1150. Clinical significance of vascular endothelial growth factor C expression and angiogenesis at the deepest invasive site of advanced colorectal carcinoma, ONCOLOGY, 62(2), 157-166, 2002
  1151. Does bilirubin play a role in the pathogenesis of both cholesterol and pigment gallstone formation? Direct and indirect influences of bilirubin on bile lithogenicity, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1534(2-3), 78-84, 20011230
  1152. Endothelial dysfunction is an independent factor responsible for vasospastic angina, CLINICAL SCIENCE, 101(6), 707-713, 200112
  1153. Microsatellite instability is a genetic marker for the development of multiple gastric cancers, INTERNATIONAL JOURNAL OF CANCER, 95(6), 350-353, 20011120
  1154. Usefulness of flow-mediated dilation of the brachial artery and/or the intima-media thickness of the carotid artery in predicting coronary narrowing in patients suspected of having coronary artery disease, AMERICAN JOURNAL OF CARDIOLOGY, 88(10), 1147-1151, 20011115
  1155. Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function, BIOCHEMICAL JOURNAL, 359, 605-610, 20011101
  1156. Extracorporeal ultrasound is an effective diagnostic alternative to endoscopic ultrasound for gastric submucosal tumours, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 36(11), 1222-1226, 200111
  1157. Sodium chloride loading does not alter endothelium-dependent vasodilation of forearm vasculature in either salt-sensitive or salt-resistant patients with essential hypertension, HYPERTENSION RESEARCH, 24(6), 711-716, 200111
  1158. Calorie restriction reduced blood pressure in obesity hypertensives by improvement of autonomic nerve activity and insulin sensitivity, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 38, S69-S74, 200110
  1159. Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension, AMERICAN JOURNAL OF HYPERTENSION, 14(10), 1038-1045, 200110
  1160. MUC1 and cathepsin D expression in early colorectal carcinoma showing V type pit pattern, INTERNATIONAL JOURNAL OF ONCOLOGY, 19(4), 665-672, 200110
  1161. Clinicopathological significance of vascular endothelial growth factor (VEGF)-C in human esophageal squamous cell carcinomas, INTERNATIONAL JOURNAL OF CANCER, 93(5), 662-666, 20010901
  1162. A low C-13-urea breath test value is associated with increased risk of gastric cancer, JOURNAL OF GASTROENTEROLOGY, 36(9), 601-605, 200109
  1163. Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas, INTERNATIONAL JOURNAL OF ONCOLOGY, 19(3), 507-512, 200109
  1164. Randomized controlled clinical trial of lymphoblastoid interferon-alpha for chronic hepatitis C, HEPATOLOGY RESEARCH, 21(1), 55-66, 200109
  1165. Interleukin 8 and vascular endothelial growth factor - prognostic factors in human gastric carcinomas?, EUROPEAN JOURNAL OF CANCER, 37(12), 1482-1487, 200108
  1166. Nonselective cation channel as a Ca2+ influx pathway in pepsinogen-secreting cells of bullfrog esophagus, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 281(2), G333-G341, 200108
  1167. Clinicopathologic features and endoscopic treatment of superficially spreading colorectal neoplasms larger than 20 mm, GASTROINTESTINAL ENDOSCOPY, 54(1), 62-66, 200107
  1168. Clinicopathological features of gastric mucosa-associated lymphoid tissue lymphoma: A comparison with diffuse large B-cell lymphoma without a mucosa-associated lymphoid tissue lymphoma component, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 16(7), 734-739, 200107
  1169. Dose-dependent conjugation of sulfobromophthalein and hepatic transit time in bile fistula rats - Role of the microtubule-dependent vesicle pathway, DIGESTIVE DISEASES AND SCIENCES, 46(6), 1285-1289, 200106
  1170. Evaluation of quantitative measurements of hepatitis C virus RNA to predict sustained response to interferon by genotype, JOURNAL OF VIROLOGICAL METHODS, 95(1-2), 33-45, 200106
  1171. Helicobacter pylori eradication therapy for high-grade mucosa-associated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability, INTERNATIONAL JOURNAL OF ONCOLOGY, 18(6), 1207-1212, 200106
  1172. Risk factors of hepatitis C virus-related liver cirrhosis in young adults: Positive family history of liver disease and transporter associated with antigen processing 2 (TAP2)*0201 allele, JOURNAL OF MEDICAL VIROLOGY, 64(2), 109-116, 200106
  1173. Is a role of phospholipase A(2) in cholesterol gallstone formation phospholipid species-dependent?, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1532(1-2), 51-59, 20010531
  1174. Non-dipper phenomenon in essential hypertension is related to blunted nocturnal rise and fall of sympatho-vagal nervous activity and progress in retinopathy, AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 88(3), 181-186, 20010514
  1175. Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist, FEBS LETTERS, 495(3), 197-200, 20010427
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  1177. Diagnosis of invasion depth in early colorectal carcinoma by pit pattern analysis with magnifying endoscopy, Digestive Endoscopy, 13, S2-S5, 20010401
  1178. Effect of for antihypertensives on reactive hypermia in essential hypertension, Cardiology Review, 18(4), 31-39, 20010401
  1179. Efficacy of IFN therapy based on duration period of negative HCV-RNA during IFN administration, Hepatol Res, 19, 22-300, 20010401
  1180. Long-term interferon therapy for 1 year or longer reduces the hepatocellular carcinogenesis rate in patients with liver cirrhosis caused by hepatitis C virus: a pilot study, J Gastroenterol Hepatol., 16(4), 406-415, 20010401
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  1182. Twice-daily administration of interferon-beta for chronic hepatitis C is not superior to a once-daily regimen, J. Gastroenterol, 36, 242-247, 20010401
  1183. Cyclosporin A reduces canalicular membrane fluidity and regulates transporter function in rats, BIOCHEMICAL JOURNAL, 354, 591-596, 20010315
  1184. Effect of estrogen replacement therapy on endothelial function in peripheral resistance arteries in normotensive and hypertensive postmenopausal women, HYPERTENSION, 37(2), 651-657, 200102
  1185. Lamivudine therapy for spontaneously occurring severe acute exacerbation in chronic hepatitis B virus infection: A preliminary study, AMERICAN JOURNAL OF GASTROENTEROLOGY, 96(2), 557-562, 200102
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  1187. Reduction in the incidence of Helicobacter pylori-associated carcinoma in Japanese young adults, ONCOLOGY REPORTS, 8(3), 633-636, 2001
  1188. c-myc gene mutation in gastric mucose-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma, ONCOLOGY REPORTS, 8(2), 289-292, 2001
  1189. Microsatellite instability at D18S61 is associated with no regression of gastric mucosa-associated lymphoid tissue lymphoma after Helicobacter pylori eradication, ONCOLOGY REPORTS, 8(2), 293-297, 2001
  1190. Activation of peroxisome proliferator-activated receptor gamma inhibits the growth of human pancreatic cancer, PATHOBIOLOGY, 69(5), 258-265, 2001
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  1192. Association of amino acid sequence in the PKR-eIF2 phosphorylation homology domain and response to interferon therapy, HEPATOLOGY, 32(5), 1138-1144, 200011
  1193. Distinction between chronic hepatitis and liver cirrhosis in patients with hepatitis C virus infection. Practical discriminant function using common laboratory data, Hepatol Res, 18(3), 252-266, 20000401
  1194. Fluctuation patterns of HCV-RNA serum level in patients with chronic hepatitis C, J. Gastroenterol., 35(3), 221-225, 20000401
  1195. Incidence of primary liver cancer-cholangiocellular type in Japanese patients with hepatitis C virus related cirrhosis, Cancer, 88, 2471-2477, 20000401
  1196. Interferon beta prevents recurrence of hepatocellular carcinoma after complete resection or ablation of the primary tumor-A prospective randomized study of hepatitis C virus-related liver cancer., Hepatology, 32(2), 436-438, 20000401
  1197. Progressive and sufficient decrease of hepatitis B core antibody can predict the disappearance of hepatitis B virus DNA in Japanese patients with hepatitis B surface antigen clearance, J. Gastroenterol., 35(10), 753-757, 20000401
  1198. Relationship between five-year histological outcome and serial changes in serum alanine aminotransferase in patients with biochemical and virological relapse after interferon treatment for chronic hepatitis C, Intervirol, 43, 174-179, 20000401
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  1271. Modeling-Based Response-Guided Glecaprevir-Pibrentasvir Therapy for Chronic Hepatitis C to Identify Patients for Ultrashort Treatment Duration, JOURNAL OF INFECTIOUS DISEASES, 222(7), 1165-1169, 20201001
  1272. Pre-impaired fasting glucose state is a risk factor for endothelial dysfunction: Flow-mediated Dilation Japan (FMD-J) study, BMJ OPEN DIABETES RESEARCH & CARE, 8(1), 2020
  1273. Analysis of Post-Progression Survival in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib, ONCOLOGY, 98(11), 787-797, 202011
  1274. Impact of viral eradication by direct-acting antivirals on the risk of hepatocellular carcinoma development, prognosis, and portal hypertension in hepatitis C virus-related compensated cirrhosis patients, HEPATOLOGY RESEARCH, 50(11), 1222-1233, 202011
  1275. Decrease in fasting insulin secretory function correlates with significant liver fibrosis in Japanese non-alcoholic fatty liver disease patients, JGH OPEN, 4(5), 929-936, 202010
  1276. Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion, NATURE MICROBIOLOGY, 5(12), 1532-+, 202012
  1277. Pilot study of tenofovir disoproxil fumarate and pegylated interferon-alpha 2a add-on therapy in Japanese patients with chronic hepatitis B, JOURNAL OF GASTROENTEROLOGY, 55(10), 977-989, 202010
  1278. Real-word efficacy of sofosbuvir, velpatasvir plus ribavirin therapy for chronic hepatitis patients who failed to prior DAA therapy with NS5A-P32 deletion mutated HCV infection, CLINICAL JOURNAL OF GASTROENTEROLOGY, 13(6), 1233-1238, 202012
  1279. A Comparison of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 105(11), 202011

Publications such as books

  1. 2006, Molecular pathologic application as a predictor of lymph node metastasis in submucosal colorectal carcinoma:implication of immunohistochemical alterations at the deepest invasive margin , 2006, 04, Scholarly Book, Joint work, 171
  2. 2005, Role of invariant natural killer T cells in the regulation of the inflammatory response in experimental colitis in mice , 2005, 12, Scholarly Book, Joint work, 35
  3. 1998, Methods in molecular medicine-hepatitis C protocols. Genotyping hepatitis C virus by type-specific primers for PCR based on NS5 region. , Humana Press, 1998
  4. 1998, Hepatitis C protocols; Genotyping hepatitis C virus by type-specific primers or PCR based on NS5 region , Humana Press, 1998, Scholarly Book, Single work
  5. 1994, Viral hepatitis and liver disease. High virus titer, slow virus decrease, genotype(]G0002[), and sequence variability of E2/NS1 HVR predict poor response to interferon therapy in chronic hepatitis C. , Springer Verlag, 1994
  6. 1994, High virus titer, slow virus decrease, genotypeII, and sequence variability of E2/NS1 HVR predict poor response to interferon therapy in chronic hepatitis C Viral hepatitis and liver disease , Springer Verlag, 1994
  7. 2017, Hepatotos C Virus Treatment, Highly Effective Therapy with Direct Acting Antivirals and Associated Viral Resistance, Springer, 2017, Scholarly Book, Compilation
  8. 2017/09/05, Hepatitis B Virus and Liver Desease, Unmet Needs in Basic Research: In Vitro and In Vivo Models, Springer Nature Singapore Pre Ltd., 2018, 2018, Scholarly Book, Cocompilation, Kazuaki Chayama, Nelson Hayes.
  9. 2017/09/30, Management for DAA resistant-associated variants, Management for DAA resistant-associated variants, 2017, 9月
  10. 2017/12, The Liver Cancer Journal, Meeting Report
  11. 2018, Clinics in Gastroenterology, 2018, Book(general), Supervisor

Invited Lecture, Oral Presentation, Poster Presentation

  1. chronic hepatitis virus infection and interferon, 2017/10/30, Without Invitation, Japanese
  2. Baselin RAS Test: Clinical practice, The Liver Week 2017, 2017/06/23, With Invitation, Japanese, Korea
  3. Efficacy and safety of Glecaprevir/Pibrentasvir in Japanese Patients with Chronic GT1 Hepatitis C Virus Infection with and without Cirrhosis, 2017/06/09, Without Invitation, English, Hiroshima city
  4. Recent Progress in Treatment for Chronic Hepatitis C for Genotype 1, Asian Pacific Association for the Study of the Liver Single Topic Conference(APASL STC), 2017/04/11, Without Invitation, English, Nagasaki city
  5. Targeting Host and Viral Interactions: Insights from Mice Model, Asian Pacific Association for the Study of the Liver 2017(APASL 2017), 2017/02/17, With Invitation, English, Shanghai
  6. Recent Progress in Treatment for Chronic Hepatitis C, APDW2016, 2016/11/05, Without Invitation, English
  7. Practical Therapy of Chronic Hepatitis C, 2016/10/12, Without Invitation, English, Kyoto
  8. Integrated safety and Tolerability of DCV+ASV in Patients with Chronic HCV Genotype 1b Infection, 2016 APASL Single Topic Conference on Hepatitis C, 2016/06/12, Without Invitation, English, Kaohsiung (Taiwan)
  9. Best Strategy for Curing HCV Genotype 1 and 4: East vs. West, 2016 APASL Single Topic Conference on Hepatitis C, 2016/06/11, Without Invitation, Japanese, Kaohsiung city (Taiwan)
  10. A mouse model of human CTL mediated severe acute hepatitis B, 2016/05/20, Without Invitation, English, Makuhari
  11. HCV Treatiment Update-a New Era of All-oral HCV Treatment, The 46th Annual Meeting of GEST and The 25th Annual Meeting of DEST, 2016/03/26, With Invitation, English, Taipei
  12. GIFT-1:Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir in Elderly Japanese Patients, Asian Pacific Association for the Study of the Liver 2016(APASL 2016) (アジア太平洋肝臓病学会議), 2016/02/22, Without Invitation, Japanese, Tokyo
  13. Chimeric Animal Model, Asian Pacific Association for the Study of the Liver 2016(APASL 2016) (アジア太平洋肝臓病学会議), 2016/02/22, Without Invitation, Japanese, Tokyo
  14. DAA/PR therapy in Asian HCV patients, 2015/12/04, With Invitation, Japanese
  15. Circulating Tumor DNA Analysis for HCC., 2015/10/26, With Invitation, English
  16. Circulating Tumor DNA Analysis for HCC., 2015/10/26, Without Invitation, Japanese
  17. All Oral Direct Acting Antiviral Therapy for Chronic Hepatitis C, 2015/10/17, With Invitation, English
  18. Ombitasvir/Paritaprevir/Ritonavir for treatment of HCV genotype 1b in Japanese patients with or without Cirrhosis: results from GIFT-1, 2015/05/22, Without Invitation, English
  19. Hepatitis B mouse model involving CTL, 2015/04/23, Without Invitation, English, other
  20. All-oral Dual Combination of Daclatasvir plus Asunaprevir Compared with Telaprevir plus Peginterferon Alfa/Ribavirin in Treatment-maive Japanese Patients ChronicallyInfected with HCV Genotype 1b:Results from a Phase 3 Study, chayama kazuaki, 2014/11/11, Without Invitation
  21. Optimizing triple therapy, and IFN/RBV free regimens, chayama kazuaki, 2014/03/12, Without Invitation, Japanese
  22. Recent Progress in Treatment for Chronic Hepatitis C for Genotype 1, Asian Pacific Association for the Study of the Liver Single Topic Conference(APASL STC), Without Invitation, English, Nagasaki city
  23. Recent Progress in Treatment for Chronic Hepatitis C for Genotype 1, Asian Pacific Association for the Study of the Liver Single Topic Conference(APASL STC), Without Invitation, English, Nagasaki

Patented

  1. Patent, JP5152745, 2012/12/14
  2. Patent
  3. Patent, JP2869759, 1999/01/08
  4. Patent, JP5656159, 2014/12/05
  5. Patent, JP5696317, 2015/02/20
  6. Patent, JP5888668, 2016/02/26
  7. Patent, JP5924644, 2016/04/28
  8. Patent
  9. Patent
  10. Patent
  11. Patent
  12. Patent
  13. Patent
  14. Patent
  15. Patent, 2014/12/05
  16. Patent
  17. Patent
  18. Patent
  19. Patent

Works, etc.

  1. 広島大学ラグビー部顧問,第32回中国四国医科学生ラグビーフットボール大会 広島大学優勝

External Funds

Acceptance Results of Competitive Funds

  1. Research Program on Hepatitis, 2015/04/01, 2016/03/31
  2. Research Program on Hepatitis, 2015/04/01, 2016/03/31
  3. Health and Labour Sciences Research Grants, 2011, 2013
  4. Health and Labour Sciences Research Grants, 2012, 2016
  5. 2001
  6. 2003
  7. 2004
  8. 2004
  9. 2004
  10. 2006
  11. 2005
  12. 2007
  13. 2007
  14. 2008
  15. 2009
  16. 2009
  17. 2010
  18. 2010
  19. KAKENHI, 2014, 2014
  20. KAKENHI, Identification of SNPs on mature micro RNA to analyze origin of miRNA, 2013, 2013
  21. KAKENHI, Analysis of unknown pathogen using human hepatocyte chimeric mouseand massive parallel sequencing, 2012, 2012
  22. KAKENHI, Generation of a mouse model that shows specific features of human diseases., 2010, 2011
  23. KAKENHI, A comprehensive transcriptome analysis of humanized mouse liver using ultra high density cDNA micro array, 2009, 2011
  24. KAKENHI, 2007, 2007
  25. KAKENHI, Production of interferon stimulated gene library and screening of new therapeutic drug for hepatitis viruses, 2006, 2007
  26. KAKENHI, 2003, 2005
  27. KAKENHI, Specification of the factor in a liver cell required for multiplication of hepatitis C virus, 2001, 2003
  28. KAKENHI, Analysis of lamivudine resistance acquisition by hepatitis B virus., 2001, 2003
  29. KAKENHI, Detection of drug resistant mutant hepatitis B virus strain and its clinical application., 1998, 2000
  30. KAKENHI, Interferon resistance of hepatitis C virus, 1994, 1995
  31. Health and Labour Sciences Research Grants, 2014/04/01, 2015/03/31
  32. KAKENHI, 2015, 2016
  33. Research Program on Hepatitis , 2016/04/01, 2017/03/31
  34. Research Program on Hepatitis , 2016/04/01, 2017/03/31
  35. KAKENHI(Grant-in-Aid for Challenging Research (Pioneering)), 2017, 2019
  36. Research Program on Hepatitis , 2017/04/01, 2018/03/31
  37. Research Program on Hepatitis , 2017/04/01, 2018/03/31
  38. 2004/04/01
  39. 2017

Social Activities

Organizing Academic Conferences, etc.

  1. 2000/11
  2. 2001/10
  3. 2001/05
  4. 2001/10
  5. 2001/11
  6. 2001/02
  7. 2001/11
  8. 2001/02
  9. 2001/07
  10. 2001/07
  11. 2001/04
  12. 2001/05
  13. 2001/09
  14. 2001/12
  15. 2001/01
  16. 2009/09
  17. 2011/10
  18. 2012/02
  19. The 2nd Japan-Italy Liver Workshop, 2014/11, 2014/11
  20. The 11th JSH Single Topic Conference, 2014/11
  21. 2014/07
  22. 2016/11
  23. 2015/11, 2015/11
  24. 2017/06, 2017/06
  25. 2016/06, 2016/06
  26. 2017/07, 2017/07

Other Social Contributions

  1. Pancreatic Cancer Expert Meeting, 2017/05/26, 2017/05/26, Others
  2. Academic Workshop by Hiroshima University and Cairo University, Human hepatocyte chimeric mouse model for hepatitis virus studies, 2017/02/21, 2017/02/21