Hiroyuki Morino

Last Updated :2021/01/05

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Associate Professor
E-mail
morinohiroshima-u.ac.jp

Basic Information

Educational Backgrounds

  • Hiroshima University, Japan, 1994/04, 2000/02
  • Hiroshima University, Japan, 1988/04, 1994/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Educational Activity

  • 【Bachelor Degree Program】School of Medicine : Program of Medicine
  • 【Master's Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Pathological medical chemistry
  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Neurology

Research Keywords

  • Neurodegenerative disease
  • Clinical genetics

Affiliated Academic Societies

  • Japanese Society of Neurology
  • The Japanese Society of Internal Medicine
  • The Japan Society of Human Genetics
  • The Japan Geriatrics Society
  • The Japan Neuroscience Society

Educational Activity

Course in Charge

  1. 2020, Undergraduate Education, First Semester, Human genetics
  2. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  3. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  4. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  5. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  6. 2020, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  7. 2020, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  8. 2020, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science

Research Activities

Academic Papers

  1. Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease, JAMA, 296(6), 661-670, 20060809
  2. Retinitis pigmentosa prior to familial ALS caused by a homozygous cilia and flagella-associated protein 410 mutation, J Neurol Neurosurg Psychiatry, 91(2), 220-222
  3. Genetic screening for potassium channel mutations in Japanese autosomal dominant spinocerebellar ataxia, JOURNAL OF HUMAN GENETICS, 65(4), 363-369, 202004
  4. Middle-age-onset cerebellar ataxia caused by a homozygous TWNK variant: a case report, BMC MEDICAL GENETICS, 21(1), 20200331
  5. Optineurin regulates osteoblastogenesis through STAT1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4), 889-894, 20200514
  6. Biallelic mutation of HSD17B4 induces middle age-onset spinocerebellar ataxia, NEUROLOGY-GENETICS, 6(1), 202002
  7. The first Japanese case of primary familial brain calcification caused by an MYORG variant, JOURNAL OF HUMAN GENETICS, 65(10), 917-920, 202010
  8. Aggressive periodontitis and NOD2 variants, JOURNAL OF HUMAN GENETICS, 65(10), 841-846, 202010
  9. Treatment of intractable resting tremor of spinocerebellar ataxia 42 with zonisamide, J Neurol Sci, 15(396), 119-120, 20190115
  10. C-terminal mutations in SYNE1 are associated with motor neuron disease in patients with SCAR8, J Neurol Sci, 15(402), 118-120, 20190715
  11. Co-morbidity of progressive supranuclear palsy and amyotrophic lateral sclerosis: a clinical-pathological case report, BMC Neurol, 19(1), 168-168, 20190718
  12. Amyotrophic lateral sclerosis of long clinical course clinically presenting with progressive muscular atrophy, NEUROPATHOLOGY, 39(1), 47-53, 201902
  13. Mitochondrial DNA haplogroups and age at onset of Machado-Joseph disease/spinocerebellar ataxia type 3: a study in patients from multiple populations, EUROPEAN JOURNAL OF NEUROLOGY, 26(3), 506-512, 201903
  14. Compound heterozygote mutations in the SIGMAR1 gene in an oldest old patient with amyotrophic lateral sclerosis, Geriatr Gerontol Int, 18(10), 1519-1520
  15. First report of a Japanese family with spinocerebellar ataxia type 10: The second report from Asia after a report from China, PLOS ONE, 12(5), 20170519
  16. PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation, HUMAN MOLECULAR GENETICS, 26(22), 4429-4440, 20171115
  17. Causative Genes for Amyotrophic Lateral Sclerosis, Brain Nerve, 68(9), 1081-1086, 2016
  18. Exome sequencing identifies a novel intronic mutation in ENG that causes recurrence of pulmonary arteriovenous malformations, JOURNAL OF THE NEUROLOGICAL SCIENCES, 352(1-2), 29-33, 20150515
  19. ★, A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia, MOLECULAR BRAIN, 8, 20151229
  20. Exome sequencing reveals a novel TTC19 mutation in an autosomal recessive spinocerebellar ataxia patient, BMC NEUROLOGY, 14, 20140107
  21. Exome sequencing reveals a novel MRE11 mutation in a patient with progressive myoclonic ataxia, JOURNAL OF THE NEUROLOGICAL SCIENCES, 337(1-2), 219-223, 20140215
  22. Exome sequencing reveals a novel ANO10 mutation in a Japanese patient with autosomal recessive spinocerebellar ataxia., Clinical Genetics, 85(3), 296-297, 20140301
  23. DYT6 in Japan - genetic screening and clinical characteristics of the patients., Movement Disorders, 29(2), 278-280, 20140201
  24. Detecting gene mutations in Japanese Alzheimer's patients by semiconductor sequencing, NEUROBIOLOGY OF AGING, 35(7), 201407
  25. ★, Mutations in Twinkle primase-helicase cause Perrault syndrome with neurologic features, NEUROLOGY, 83(22), 2054-2061, 20141125
  26. Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant, ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2, 2014
  27. Detecting gene mutations in Japanese Alzheimer's patients by semiconductor sequencing, NEUROBIOLOGY OF AGING, 35(7), 2014
  28. Autosomal recessive Andersen–Tawil syndrome with a novel mutation L94P in Kir2.1, Neurol Clin Neurosci, 1(4), 131-137
  29. Cerebellar ataxia with SYNE1 mutation accompanying motor neuron diesease., Neurology, 80(2), 600-601, 20130201
  30. Convenient diagnosis of spinal and bulbar muscular atrophy using a microchip electrophoresis system, American Journal of Neurodegenerative Disease, 2(1), 35-39, 20130301
  31. Oromandibular Dystonia associated with SCA36, Movement Disorders, 28(4), 557-559, 20130401
  32. The clinical characteristics of spinocerebellar ataxia 36: A study of 2121 Japanese ataxia patients, MOVEMENT DISORDERS, 27(9), 1158-1163, 201208
  33. Screening for OPTN mutations in amyotrophic lateral sclerosis in a mainly Caucasian population, NEUROBIOLOGY OF AGING, 32(10), 201110
  34. The UCHL1 polymorphism and parkinson's disease in a Japanese population, Parkinsonism and Related Disorders, 17, 473-475, 20110701
  35. Detection of large expansions in SCA8 using a fluorescent repeat-primed PCR assay., Hiroshima Journal of Mediacal Science, 60(3), 63-66, 20110901
  36. Severe brain atrophy after long-term survival seen in siblings with familial amyotrophic lateral sclerosis and a mutation in the optineurin gene: a case series, Journal of Medical Case Reports, 5(12), 573, 20111201
  37. The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population, PARKINSONISM & RELATED DISORDERS, 17(6), 473-475, 201107
  38. ★, Homozygosity Mapping on Homozygosity Haplotype Analysis to Detect Recessive Disease-Causing Genes from a Small Number of Unrelated, Outbred Patients, PLOS ONE, 6(9), 20110920
  39. ★, Mutations of optineurin in amyotrophic lateral sclerosis, Nature, 465(5), 223-226, 20100501
  40. A quantitatively-modeled homozygosity mapping algorithm, qHomozygosityMapping, utilizing whole genome single nucleotide polymorphism genotyping data, BMC BIOINFORMATICS, 11, 20101015
  41. LRRK2 Mutations and Risk Variants in Japanese Patients with Parkinson's Disease, MOVEMENT DISORDERS, 24(7), 1034-1041, 20090515
  42. Screening for TARDBP mutations in Japanese familial amyotrophic lateral sclerosis, Journal of the Neurological Sciences, 284, 69-71, 20090820
  43. The CNTN4 c.4256C>T mutation is rare in Japanese with inherited spinocerebellar ataxia, Journal of the Neurological Sciences, 266, 180-181, 20080201
  44. Pathogenic expansions of the SCA6 locus are associated with a common CACNA1A haplotype across the globe: founder effect or predisposing chromosome?, European Journal of Human Genetics, 16(7), 841-847, 20080701
  45. Cytotoxic edema in neuro-Behcet's disease ?, Intern Med., 47, 2073-2076, 20081201
  46. Pathogenic expansions of the SCA6 locus are associated with a common CACNA1A haplotype across the globe: founder effect or predisposing chromosome?, EUROPEAN JOURNAL OF HUMAN GENETICS, 16(7), 841-847, 200807
  47. Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study, Lancet Neurol, 5(11), 917-923
  48. Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease., Neurology, 67(4), 697-699, 20060801
  49. Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4., Mov Disord., 21, 1355-1360, 20060401
  50. Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4, MOVEMENT DISORDERS, 21(9), 1355-1360, 200609
  51. Possible Reduced Penetrance of Expansion of 44 to 47 CAG/CAA Repeats in the TATA-Binding Protein Gene in Spinocerebellar Ataxia Type 17., Arch Neurol, 61, 209-212, 20040401
  52. A novel haplotype of spinocerebellar ataxia type 6 contributes to the highest prevalence in Western Japan, Neurosci Lett, 358, 107-110, 20040401
  53. Possible reduced penetrance of expansion of 44 to 47 CAG/CAA repeats in the TATA-binding protein gene in spinocerebellar ataxia type 17, ARCHIVES OF NEUROLOGY, 61(2), 209-212, 200402
  54. Dinucleotide repeat polymorphism in interferon-gamma gene is not associated with sporadic Alzheimer's disease, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 124B(1), 48-49, 20040101
  55. A novel haplotype of spinocerebellar ataxia type 6 contributes to the highest prevalence in Western Japan, NEUROSCIENCE LETTERS, 358(2), 107-110, 20040325
  56. SCA8 repeat expansion-large CTA/CTG repeat alleles are more common in ataxic patients, including those with SCA6., American Journal of Human Genetics, 72, 704-709, 20030401
  57. SCA8 repeat expansion: Large CTA/CTG repeat alleles are more common in ataxic patients, including those with SCA6, AMERICAN JOURNAL OF HUMAN GENETICS, 72(3), 704-709, 200303
  58. Contribution of the interleukin-1beta gene polymorphism in multiple system atrophy., Mov. Disord., 17(4), 808-811, 20020701
  59. Difference in disease-free survival curve and regional distribution according to subtype of spinocerebellar ataxia: a study of 1,286 Japanese patients., Am J Med Genet, 114(5), 578-583, 20020701
  60. Dinucleotide repeat polymorphisms in the neprilysin gene are not associated with sporadic Alzheimer's disease, NEUROSCIENCE LETTERS, 320(1-2), 105-107, 20020301
  61. Difference in disease-free survival curve and regional distribution according to subtype of spinocerebellar ataxia: A study of 1,286 Japanese patients, AMERICAN JOURNAL OF MEDICAL GENETICS, 114(5), 578-583, 20020708
  62. Contribution of the interleukin-1 beta gene polymorphism in multiple system atrophy, MOVEMENT DISORDERS, 17(4), 808-811, 200207
  63. Genetic studies in Parkinson's disease with an alpha-synuclein/NACP gene polymorphism in Japan, NEUROSCIENCE LETTERS, 300(2), 125-127, 20010309
  64. Lack of an association between cystatin C gene polymorphisms in Japanese patients with Alzheimer's disease, NEUROLOGY, 57(2), 337-339, 20010724
  65. A single nucleotide polymorphism of dopamine transporter gene is associated with Parkinson's disease, ANNALS OF NEUROLOGY, 47(4), 528-531, 200004
  66. Antiglycolipid antibody in autoimmune neuropathy associated with chronic renal failure on dialysis, Neuroimmunology, 6, 108-109, 19980401
  67. Antiglycolipid antibody in autoimmune neuropathy associated with chronic renal failure on dialysis., Neuroimmunology, 6, 108-109, 19980401

Publications such as books

  1. Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Association study in alpha-synuclein polymorphism in sporadic amyotrophic lateral sclerosis, Elsevier Science, 2001, Scholarly Book, Joint work
  2. In Catecholamine Research from Molecular Insights to Clinical medicine, Dopamine transporter and Parkinson's disease, Kluwer Academic/Plenum Publishers, 2002, Scholarly Book, Joint work
  3. Handbook of the Cerebellum and Cerebellar Disorders, Channelopathies and Cerebellar Disease, Springer, 2019, Scholarly Book, Joint work, 978-3-319-97911-3

Invited Lecture, Oral Presentation, Poster Presentation

  1. A mutation in CACNA1G causes spinocerebellar ataxia, Hiroyuki Morino, Yukiko Matsuda, Keiko Muguruma, Ryosuke Miyamoto, Ryosuke Ohsawa, Toshiyuki Ohtake, Reiko Otobe, Masahiko Watanabe, Hirofumi Maruyama, Kouichi Hashimoto, Hideshi Kawakami, 2016/07/20, With Invitation, English
  2. A mutation in CACNA1G causes autosomal dominant spinocerebellar ataxia, Hiroyuki Morino, Matsuda Yukiko, Muguruma Keiko, Miyamoto Ryosuke, Ohsawa Ryosuke, Ohtake Toshiyuki, Otobe Reiko, Watanabe Masahiko, Maruyama Hirofumi, Hashimoto Kouichi, Kawakami Hideshi, 2016/05/21, Without Invitation, English
  3. A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia, Hiroyuki Morino, Hideshi Kawakami, 2016/01/08, Without Invitation, English
  4. Causative gene screening of ALS using a next-generation sequencer, 2015/05/23, Without Invitation, Japanese
  5. Novel C10orf2 mutations cause Perrault syndrome, Hiroyuki Morino1, Yukiko Matsuda1, Keiko Hiraki1 and Hideshi Kawakami1, 2015/02/02, Without Invitation, English
  6. A novel insertion mutation of MAPT causes FTDP-17 with distinct pathology. ASHG 64th Annual Meeting, Hiroyuki Morino, Yukiko Matsuda, Ryosuke Ohsawa, Keiko Hiraki, Takashi Kurashige*1, Yuishin Izumi*2, Yu Yamazaki*1, Tetsuya Takahashi*1, Akihiko Takashima*3, Yoshiyuki Soeda*3, Tomohiro Miyasaka*4, Makoto Higuchi*5, Naruhiko Sahara*5, Tetsuya Suhara*5, Hitoshi Shimada*5, Hirofumi Maruyama*1, Hidefumi Ito*6, Hideshi Kawakami, 2014/10/20, Without Invitation, Japanese, San Diego, USA