SHIRO AOKI
Last Updated :2025/02/05
- Affiliations, Positions
- Hiroshima University Hospital(Medical), Associate Professor or Lecturer
- E-mail
- shirou
hiroshima-u.ac.jp
- Self-introduction
- I am engaged in treatment and prevention of stroke.
Basic Information
Major Professional Backgrounds
- 2003/05/16, 2003/09/30, Hiroshima University, Medical Hospital, Clinical Resident
- 2003/10/01, 2003/12/31, Hiroshima University, Hospital, Clinical Resident
- 2004/01/01, 2004/03/31, Kajikawa Hospital, Doctor
- 2004/04/01, 2005/03/31, Hiroshima University, Hospital, Clinical Resident
- 2005/04/01, 2007/03/31, Brain Attack Center Ota Memorial Hospital, Doctor
- 2007/04/01, 2012/06/30, Hiroshima University Hospital, Advanced Emergency and Critical Care Center, Clinical Fellow
- 2012/07/01, 2013/06/30, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor (Special Appointment)
- 2013/07/01, 2022/03/31, Hiroshima University, Hospital, Assistant Professor
- 2022/04/01, Hiroshima University, Hospital, Lecturer
Educational Backgrounds
- Hiroshima University, Japan, 1997/04, 2003/03
- Hiroshima university graduate school, clinical neuroscience and therapeutics, Japan, 2007/04, 2011/03
Academic Degrees
In Charge of Primary Major Programs
Research Fields
- Medicine,dentistry, and pharmacy;Clinical internal medicine;Neurology
Research Keywords
- stroke/cerebral circulation/neurology
Affiliated Academic Societies
- Japanese Society of Interanl Medicine
- Japanese Society of Neurology
- Japan Stroke Society
Educational Activity
Course in Charge
- 2024, Undergraduate Education, Intensive, Introduction to clinical clerkship
- 2024, Undergraduate Education, Year, Medical Neuroscience III
- 2024, Undergraduate Education, Intensive, Practice of Medicine I
- 2024, Undergraduate Education, Intensive, Practice of Medicine II
- 2024, Undergraduate Education, First Semester, Internal Medicine I
Research Activities
Academic Papers
- Positional Relationship between Recurrent Intracerebral Hemorrhage/Lacunar Infarction and Previously Detected Microbleeds, AMERICAN JOURNAL OF NEURORADIOLOGY, 31(8), 1498-1503, 201009
- Blood pressure variability and prognosis in acute ischemic stroke with vascular compression on the rostral ventrolateral medulla (RVLM), HYPERTENSION RESEARCH, 34(5), 617-622, 201105
- Association of Serum Anti-Periodontal Pathogen Antibody with Ischemic Stroke, CEREBROVASCULAR DISEASES, 34(5-6), 385-392, 2012
- Cancer-associated ischemic stroke is associated with elevated d-dimer and fibrin degradation product levels in acute ischemic stroke with advanced cancer, GERIATRICS & GERONTOLOGY INTERNATIONAL, 12(3), 468-474, 201207
- Alpha2-macroglobulin as a promising biomarker for cerebral small vessel disease in acute ischemic stroke patients, JOURNAL OF NEUROLOGY, 260(10), 2642-2649, 201310
- The Association between Hyperintense Vessel Sign and Final Ischemic Lesion Differ in Its Location, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 23(6), 1337-1343, 201407
- Safety Evaluation of Substituting Clopidogrel for Ticlopidine in Japanese Patients with Ischemic Stroke-Hiroshima Ticlopidine, Clopidogrel Safe Exchange Trial, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 23(6), 1485-1490, 201407
- Changes over Time in Intracranial Air in Patients with Cerebral Air Embolism: Radiological Study in Two Cases, CASE REPORTS IN NEUROLOGICAL MEDICINE, 2015
- CD34+/CD144+Circulating Endothelial Cells as an Indicator of Carotid Atherosclerosis, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(3), 583-590, 201503
- Endothelial dysfunction is associated with the severity of cerebral small vessel disease, HYPERTENSION RESEARCH, 38(4), 291-297, 201504
- Effects of Meteorological Conditions on the Risk of Ischemic Stroke Events in Patients Treated with Alteplase-HEWS-tPA, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(7), 1500-1505, 201507
- Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study, EBIOMEDICINE, 2(8), 960-967, 201508
- The Japan Statin Treatment Against Recurrent Stroke (J-STARS): A Multicenter, Randomized, Open-label, Parallel-group Study, EBIOMEDICINE, 2(9), 1071-1078, 201509
- A Case of Recurrent Ischemic Stroke Involving Subacute, Progressive Intracranial Cerebral Arterial Sclerosis Prior to Diagnosis with JAK2-mutated Polycythemia Vera, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(12), E4-E6, 201512
- Multicenter Study of Intravenous Recombinant Tissue Plasminogen Activator Infusion around Hiroshima, Japan: The Hiroshima Acute Stroke Retrospective and Prospective Registry Study, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(12), 2747-2753, 201512
- Greater Severity of Neurological Defects in Women Admitted With Atrial Fibrillation-Related Stroke, CIRCULATION JOURNAL, 80(1), 250-+, 201512
- Carotid Intima-Media Thickness for Atherosclerosis, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 23(1), 18-31, 2016
- Temporal Trends in Stroke Severity and Prior Antithrombotic Use Among Acute Ischemic Stroke Patients in Japan, CIRCULATION JOURNAL, 80(9), 2033-2036, 201609
- Warfarin-Resistant Deep Vein Thrombosis during the Treatment of Acute Ischemic Stroke in Lung Adenocarcinoma, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 25(9), E141-E145, 201609
- The Multidisciplinary Swallowing Team Approach Decreases Pneumonia Onset in Acute Stroke Patients, PLOS ONE, 11(5), 20160503
- Blood pressure control with cilnidipine treatment in Japanese post-stroke hypertensive patients: The CA-ATTEND study, CLINICAL AND EXPERIMENTAL HYPERTENSION, 39(3), 225-234, 2017
- Various meteorological conditions exhibit both immediate and delayed influences on the risk of stroke events: The HEWS-stroke study, PLOS ONE, 12(5), 20170602
- Pravastatin Reduces the Risk of Atherothrombotic Stroke when Administered within Six Months of an Initial Stroke Event, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(3), 262-268, 2018
- Blood Pressure Variability in Acute Ischemic Stroke: Influence of Infarct Location in the Insular Cortex, EUROPEAN NEUROLOGY, 79(1-2), 90-99, 2018
- Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(4), 350-358, 2018
- Factors Associated with Intima-Media Complex Thickness of the Common Carotid Artery in Japanese Noncardioembolic Stroke Patients with Hyperlipidemia: The J-STARS Echo Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(4), 359-373, 2018
- Effects of Cilnidipine, an L/N-Type Calcium Channel Blocker, on Carotid Atherosclerosis in Japanese Post-Stroke Hypertensive Patients: Results from the CA-ATTEND Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(6), 490-504, 2018
- Controlling nutritional status score for predicting 3-mo functional outcome in acute ischemic stroke, NUTRITION, 55-56, 1-6, 2018
- Long-Term Effect of Pravastatin on Carotid Intima-Media Complex Thickness The J-STARS Echo Study (Japan Statin Treatment Against Recurrent Stroke), STROKE, 49(1), 107-+, 201801
- Desirable Low-Density Lipoprotein Cholesterol Levels for Preventing Stroke Recurrence A Post Hoc Analysis of the J-STARS Study (Japan Statin Treatment Against Recurrent Stroke), STROKE, 49(4), 865-+, 201804
- Antithrombotic Therapy Strategy for Cancer-Associated Ischemic Stroke: A Case Series of 26 Patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 27(9), E206-E211, 201809
- Screening for Fabry Disease in Japanese Patients with Young-Onset Stroke by Measuring alpha-Galactosidase A and Globotriaosylsphingosine, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 27(12), 3563-3569, 201812
- Steroid-responsive Nivolumab-induced Involuntary Movement with Anti-thyroid Antibodies, INTERNAL MEDICINE, 58(24), 3577-3581, 2019
- Baseline Carotid Intima-Media Thickness and Stroke Recurrence During Secondary Prevention With Pravastatin, STROKE, 50(6), 1586-1589, 201906
- Warm Front Passage on the Previous Day Increased Ischemic Stroke Events, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 28(7), 1873-1878, 201907
- Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke A Randomized Clinical Trial and Meta-analysis, JAMA NEUROLOGY, 76(11), 1309-1318, 201911
- Different Influences of Statin Treat en in Preventing At-Risk Stroke Subtypes A Post Hoc Analysis of J-STARS, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 27(5), 449-460, 2020
- Effect of Statin on Stroke Recurrence Prevention at Different Infarction Locations: A Post Hoc Analysis of The J-STARS Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 27(6), 524-533, 2020
- Effect of tooth loss and nutritional status on outcomes after ischemic stroke, NUTRITION, 71, 202003
- Increased blood pressure variability during the subacute phase in patients with ischemic stroke presenting with a low ankle-brachial index, GERIATRICS & GERONTOLOGY INTERNATIONAL, 20(5), 448-454, 202005
- Serum immunoglobulin G antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 200(3), 302-309, 202006
- Conus Medullaris Infarction Involving the Paraspinal Muscles and Nerve Roots, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 29(8), 202008
- Effects of vascular compression on the rostral ventrolateral medulla for blood pressure variability in stroke patients, JOURNAL OF HYPERTENSION, 38(12), 2443-2450, 202012
- Increased blood pressure variability during the subacute phase of ischemic stroke is associated with poor functional outcomes at 3 months, SCIENTIFIC REPORTS, 10(1), 20200121
- Serum IgG titers to periodontal pathogens predict 3-month outcome in ischemic stroke patients, PLOS ONE, 15(8), 20200806
- Prognostic role of the controlling nutritional status score in acute ischemic stroke among stroke subtypes, JOURNAL OF THE NEUROLOGICAL SCIENCES, 416, 20200915
- Association between periodontal disease due to Campylobacter rectus and cerebral microbleeds in acute stroke patients, PLOS ONE, 15(10), 20201008
- Serum IgG titers against periodontal pathogens are associated with cerebral hemorrhage growth and 3-month outcome, PLOS ONE, 15(10), 20201028
- Rapid ping-pong eye deviation following a recovery from carbon dioxide narcosis, BMJ CASE REPORTS, 14(3), 202103
- Socio-economic impact on epilepsy outside of the nation-wide COVID-19 pandemic area, EPILEPSY & BEHAVIOR, 117, 202104
- Giant Cell Arteritis with Internal Carotid Artery Occlusion in the Absence of Typical Clinical Features, INTERNAL MEDICINE, 60(8), 1293-1297, 202104
- cnm-Positive Streptococcus mutans and diffusion-weighted imaging hyperintensities in acute intracerebral hemorrhage, EUROPEAN JOURNAL OF NEUROLOGY, 28(5), 1581-1589, 202105
- Utility of Magnetic Resonance Spectroscopy for the Progression of Neurological Symptoms in Lenticulostriate Artery Territory Infarction, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 30(6), 202106
- Short-term or long-term outcomes for stroke patients with cancer according to biological markers, JOURNAL OF THE NEUROLOGICAL SCIENCES, 436, 20220515
- Diffusion-Weighted Imaging Hyperintensities in Acute and
Subacute-Phase Intracerebral Hemorrhage, Journal of Stroke and Cerebrovascular Diseases, 31(8), 202205
- Seizure Deterioration with Increased Levetiracetam Blood Concentration during the Postpartum Period in Refractory Temporal Lobe Epilepsy, INTERNAL MEDICINE, 61(8), 1237-1240, 2022
- Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle- Brachial Index, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 29(5), 719-730, 2022
- Predictors of Stroke Outcome Extracted from Multivariate Linear Discriminant Analysis or Neural Network Analysis, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 29(1), 99-110, 2022
- Assessment of Serum IgG Titers to Various Periodontal Pathogens Associated with Atrial Fibrillation in Acute Stroke Patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 31(3), 202203
- Clinical characteristics and tumor markers in ischemic stroke patients with active cancer, INTERNAL AND EMERGENCY MEDICINE, 17(3), 735-741, 202204
- Various effects of nutritional status on clinical outcomes after intracerebral hemorrhage, INTERNAL AND EMERGENCY MEDICINE, 17(4), 1043-1052, 202206
- Effect of region-wide use of prehospital stroke triage scale on management of patients with acute stroke, JOURNAL OF NEUROINTERVENTIONAL SURGERY, 14(7), 677-682, 202207
- The association between nutritional intake one week after admission and outcome in acute ischemic stroke patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 31(11), 202211
- A longitudinal seizure outcome following the COVID-19 pandemic in 2020 and 2021: Transient exacerbation or sustainable mitigation, JOURNAL OF THE NEUROLOGICAL SCIENCES, 434, 20220315
- Density spectrum array and difficult to diagnose seizure activity, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 116(11), 947-948, 202311
- Peak expiratory flow, but not tongue pressure, can predict pneumonia development in older adults, EUROPEAN GERIATRIC MEDICINE, 14(1), 211-217, 202302
- 'Raisin bread sign' feature of pontine autosomal dominant microangiopathy and leukoencephalopathy, BRAIN COMMUNICATIONS, 5(6), 20231101
- Association between Carotid Wall Shear Stress-Based Vascular Vector Flow Mapping and Cerebral Small Vessel Disease, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 30(9), 1165-1175, 2023
- Case report: Mitochondrial trifunctional protein deficiency caused by HADHB gene mutation (c.1175C>T) characterized by higher brain dysfunction followed by neuropathy, presented gadolinium enhancement on brain imaging in an adult patient, FRONTIERS IN NEUROLOGY, 14, 20230613
- Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching, PARKINSONISM & RELATED DISORDERS, 106, 202301
- Immediate and 6-month seizure outcomes following first and second SARS-CoV2 mRNA vaccinations: A multicenter study with a nationwide survey, EPILEPSY & BEHAVIOR, 139, 202302
- Encephalopathy after COVID-19 vaccination during treatment with nivolumab: A case report, CLINICAL NEUROLOGY AND NEUROSURGERY, 226, 202303
- On-scene time delays for epileptic seizures in emergencies during a social pandemic: A population-based study, EPILEPSY & BEHAVIOR, 142, 202305
- Paradoxical effects of levetiracetam in people with epilepsy with rhythmic epileptiform discharges, EPILEPSY & BEHAVIOR, 143, 202306
- A case of ischemic stroke associated with protein-losing gastroenteropathy and protein S deficiency, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 32(7), 202307
- Oral condition at admission predicts functional outcomes and hospital-acquired pneumonia development among acute ischemic stroke patients, CLINICAL ORAL INVESTIGATIONS, 28(8), 20240719
- Interictal head-turning sign in patients with idiopathic generalized epilepsy during initial medical interview: A matched multicenter study, EPILEPSY & BEHAVIOR, 160, 202411
- Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging, JOURNAL OF NEUROVIROLOGY, 30(2), 197-201, 202404
- Vagus nerve size determined via ultrasonography is associated with white matter lesions in patients with vascular risk factors, JOURNAL OF ULTRASOUND, 27(3), 723-732, 202409
- Clinical manifestations and outcomes associated with a high 2HELPS2B score in patients with acute impaired consciousness, JOURNAL OF THE NEUROLOGICAL SCIENCES, 465, 20241015
- Emergency medical service response for cases of stroke-suspected seizure: A population-based study, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 33(6), 202406
- An Early Neurological Indicator of Immune Effector Cell-Associated Neurotoxicity Syndrome, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(3), 20240330
- On-scene time delays for epileptic seizures in developed community-based integrated care system regions, EPILEPSY & BEHAVIOR, 151, 202402
- Liver fibrosis index is associated with functional outcome among acute ischemic stroke patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 33(2), 202402
- Fusobacterium nucleatum in the oral cavity is associated with cerebral small vessel disease in patients with ischemic stroke, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 34(1), 202501
- Long-term changes in carotid intima-media thickness according to baseline blood pressure level: J-STARS Echo study, JOURNAL OF THE NEUROLOGICAL SCIENCES, 468, 20250115
Invited Lecture, Oral Presentation, Poster Presentation
- A Comparable Study of Favorable and Unfavorable Warfarin Controlled Groups for Cerebral Infarction, Aoki S, Takamatsu K, Goto K, Fukushima T, Ohta K, 3rd Japanese-Korean Joint Stroke Conference, 2006/11/15, Without Invitation, English
- Effect of Arterial Compression onto Rostral Ventrolateral Medulla on Blood Pressure Variation in Acute Infratentorial Ischemic Stroke, Aoki S, Ohtsuki T, Nomura E, Sueda Y, Kono T, Kohriyama T, Matsumoto M, 6th World Stroke Congress, 2008/09/20, Without Invitation, English, Vienna
- Relationship between Blood Pressure Variability and Prognosis in Acute Ischemic Stroke Patients with Vascular Compression on the Rostral Ventrolateral Medulla (RVLM), Aoki S, Ohtsuki T, Hosomi N, Sueda Y, Kono T, Yamawaki T, Matsumoto M, 20th European Stroke Conference, 2011/05/25, Without Invitation, English, Hamburg
- The consideration of the patients with TIA mimics in our hospital, Aoki S, Hosomi N, Nezu T, Kubo S, Ohtsuki T, Maruyama H, Matsumoto M, International TIA/ACVS Conference, 2013/11/20, Without Invitation, English, Tokyo
- The multidisciplinary participatory swallowing team approach significantly decreased the rate of pneumonia in acute stroke patients, Shiro Aoki, Naohisa Hosomi, Junko Hirayama, Masahiro Nakamori, Tomohisa Nezu, Satoshi Kubo, Kazuhide Ochi, Hiromi Yamamoto, Hirohumi Maruyama, Masayasu Matsumoto, World stroke congress 2015, 2014/10/22, Without Invitation, English, World stroke organization, Istanbul
- Characteristics and patterns of acute ischemic lesions in intracerebral hemorrhage, Shiro Aoki, Naohisa Hosomi, Tomohisa Nezu, Mutsuko Araki, Hayato Matsushima, Ryo Shimomura, Naoto Kinoshita, Hirofumi Maruyama, World Congress of Neurology 2017, 2017/09/17, Without Invitation, English, Kyoto
- Utility of MR spectroscopy for progression of neurological symptoms in penetrating artery territory infarction, ESO-WSO 2020 Conference, 2020/11/07, Without Invitation, English
Social Activities
History as Peer Reviews of Academic Papers
- 2017, Stroke, Others, 1
- 2018, Stroke, Others, 2
- 2019, Stroke, Others, 1
- 2019, Neurology, Others, 1
- 2020, International Journal of Stroke, Others, 1
- 2021, BMC Neurology, Others, 2