Last Updated :2023/02/02

Affiliations, Positions
Hiroshima University Hospital(Medical), Associate Professor or Lecturer
I am engaged in treatment and prevention of stroke.

Basic Information

Major Professional Backgrounds

  • 2003/05/16, 2003/09/30, Hiroshima University, Medical Hospital, Clinical Resident
  • 2003/10/01, 2003/12/31, Hiroshima University, Hospital, Clinical Resident
  • 2004/01/01, 2004/03/31, Kajikawa Hospital, Doctor
  • 2004/04/01, 2005/03/31, Hiroshima University, Hospital, Clinical Resident
  • 2005/04/01, 2007/03/31, Brain Attack Center Ota Memorial Hospital, Doctor
  • 2007/04/01, 2012/06/30, Hiroshima University Hospital, Advanced Emergency and Critical Care Center, Clinical Fellow
  • 2012/07/01, 2013/06/30, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor (Special Appointment)
  • 2013/07/01, 2022/03/31, Hiroshima University, Hospital, Assistant Professor
  • 2022/04/01, Hiroshima University, Hospital, Lecturer

Educational Backgrounds

  • Hiroshima University, Japan, 1997/04, 2003/03
  • Hiroshima university graduate school, clinical neuroscience and therapeutics, Japan, 2007/04, 2011/03

Academic Degrees

  • Hiroshima University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Neurology

Research Keywords

  • stroke/cerebral circulation/neurology

Affiliated Academic Societies

  • Japanese Society of Interanl Medicine
  • Japanese Society of Neurology
  • Japan Stroke Society

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Intensive, Introduction to clinical clerkship
  2. 2022, Undergraduate Education, Year, Medical Neuroscience III
  3. 2022, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2022, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2022, Undergraduate Education, First Semester, Internal Medicine I

Research Activities

Academic Papers

  1. Positional Relationship between Recurrent Intracerebral Hemorrhage/Lacunar Infarction and Previously Detected Microbleeds, AMERICAN JOURNAL OF NEURORADIOLOGY, 31(8), 1498-1503, 201009
  2. Blood pressure variability and prognosis in acute ischemic stroke with vascular compression on the rostral ventrolateral medulla (RVLM), HYPERTENSION RESEARCH, 34(5), 617-622, 201105
  3. Association of Serum Anti-Periodontal Pathogen Antibody with Ischemic Stroke, CEREBROVASCULAR DISEASES, 34(5-6), 385-392, 2012
  4. Cancer-associated ischemic stroke is associated with elevated d-dimer and fibrin degradation product levels in acute ischemic stroke with advanced cancer, GERIATRICS & GERONTOLOGY INTERNATIONAL, 12(3), 468-474, 201207
  5. Alpha2-macroglobulin as a promising biomarker for cerebral small vessel disease in acute ischemic stroke patients, JOURNAL OF NEUROLOGY, 260(10), 2642-2649, 201310
  6. The Association between Hyperintense Vessel Sign and Final Ischemic Lesion Differ in Its Location, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 23(6), 1337-1343, 201407
  7. Safety Evaluation of Substituting Clopidogrel for Ticlopidine in Japanese Patients with Ischemic Stroke-Hiroshima Ticlopidine, Clopidogrel Safe Exchange Trial, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 23(6), 1485-1490, 201407
  8. Changes over Time in Intracranial Air in Patients with Cerebral Air Embolism: Radiological Study in Two Cases, CASE REPORTS IN NEUROLOGICAL MEDICINE, 2015
  9. CD34+/CD144+Circulating Endothelial Cells as an Indicator of Carotid Atherosclerosis, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(3), 583-590, 201503
  10. Endothelial dysfunction is associated with the severity of cerebral small vessel disease, HYPERTENSION RESEARCH, 38(4), 291-297, 201504
  11. Effects of Meteorological Conditions on the Risk of Ischemic Stroke Events in Patients Treated with Alteplase-HEWS-tPA, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(7), 1500-1505, 201507
  12. Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study, EBIOMEDICINE, 2(8), 960-967, 201508
  13. The Japan Statin Treatment Against Recurrent Stroke (J-STARS): A Multicenter, Randomized, Open-label, Parallel-group Study, EBIOMEDICINE, 2(9), 1071-1078, 201509
  14. A Case of Recurrent Ischemic Stroke Involving Subacute, Progressive Intracranial Cerebral Arterial Sclerosis Prior to Diagnosis with JAK2-mutated Polycythemia Vera, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(12), E4-E6, 201512
  15. Multicenter Study of Intravenous Recombinant Tissue Plasminogen Activator Infusion around Hiroshima, Japan: The Hiroshima Acute Stroke Retrospective and Prospective Registry Study, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(12), 2747-2753, 201512
  16. Greater Severity of Neurological Defects in Women Admitted With Atrial Fibrillation-Related Stroke, CIRCULATION JOURNAL, 80(1), 250-+, 201512
  17. Carotid Intima-Media Thickness for Atherosclerosis, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 23(1), 18-31, 2016
  18. Temporal Trends in Stroke Severity and Prior Antithrombotic Use Among Acute Ischemic Stroke Patients in Japan, CIRCULATION JOURNAL, 80(9), 2033-2036, 201609
  19. Warfarin-Resistant Deep Vein Thrombosis during the Treatment of Acute Ischemic Stroke in Lung Adenocarcinoma, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 25(9), E141-E145, 201609
  20. The Multidisciplinary Swallowing Team Approach Decreases Pneumonia Onset in Acute Stroke Patients, PLOS ONE, 11(5), 20160503
  21. Blood pressure control with cilnidipine treatment in Japanese post-stroke hypertensive patients: The CA-ATTEND study, CLINICAL AND EXPERIMENTAL HYPERTENSION, 39(3), 225-234, 2017
  22. Various meteorological conditions exhibit both immediate and delayed influences on the risk of stroke events: The HEWS-stroke study, PLOS ONE, 12(5), 20170602
  23. Pravastatin Reduces the Risk of Atherothrombotic Stroke when Administered within Six Months of an Initial Stroke Event, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(3), 262-268, 2018
  24. Blood Pressure Variability in Acute Ischemic Stroke: Influence of Infarct Location in the Insular Cortex, EUROPEAN NEUROLOGY, 79(1-2), 90-99, 2018
  25. Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(4), 350-358, 2018
  26. Factors Associated with Intima-Media Complex Thickness of the Common Carotid Artery in Japanese Noncardioembolic Stroke Patients with Hyperlipidemia: The J-STARS Echo Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(4), 359-373, 2018
  27. Effects of Cilnidipine, an L/N-Type Calcium Channel Blocker, on Carotid Atherosclerosis in Japanese Post-Stroke Hypertensive Patients: Results from the CA-ATTEND Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(6), 490-504, 2018
  28. Controlling nutritional status score for predicting 3-mo functional outcome in acute ischemic stroke, NUTRITION, 55-56, 1-6, 2018
  29. Long-Term Effect of Pravastatin on Carotid Intima-Media Complex Thickness The J-STARS Echo Study (Japan Statin Treatment Against Recurrent Stroke), STROKE, 49(1), 107-+, 201801
  30. Desirable Low-Density Lipoprotein Cholesterol Levels for Preventing Stroke Recurrence A Post Hoc Analysis of the J-STARS Study (Japan Statin Treatment Against Recurrent Stroke), STROKE, 49(4), 865-+, 201804
  31. Antithrombotic Therapy Strategy for Cancer-Associated Ischemic Stroke: A Case Series of 26 Patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 27(9), E206-E211, 201809
  32. Screening for Fabry Disease in Japanese Patients with Young-Onset Stroke by Measuring alpha-Galactosidase A and Globotriaosylsphingosine, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 27(12), 3563-3569, 201812
  33. Steroid-responsive Nivolumab-induced Involuntary Movement with Anti-thyroid Antibodies, INTERNAL MEDICINE, 58(24), 3577-3581, 2019
  34. Baseline Carotid Intima-Media Thickness and Stroke Recurrence During Secondary Prevention With Pravastatin, STROKE, 50(6), 1586-1589, 201906
  35. Warm Front Passage on the Previous Day Increased Ischemic Stroke Events, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 28(7), 1873-1878, 201907
  36. Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke A Randomized Clinical Trial and Meta-analysis, JAMA NEUROLOGY, 76(11), 1309-1318, 201911
  37. Different Influences of Statin Treat en in Preventing At-Risk Stroke Subtypes A Post Hoc Analysis of J-STARS, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 27(5), 449-460, 2020
  38. Effect of Statin on Stroke Recurrence Prevention at Different Infarction Locations: A Post Hoc Analysis of The J-STARS Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 27(6), 524-533, 2020
  39. Effect of tooth loss and nutritional status on outcomes after ischemic stroke, NUTRITION, 71, 202003
  40. Increased blood pressure variability during the subacute phase in patients with ischemic stroke presenting with a low ankle-brachial index, GERIATRICS & GERONTOLOGY INTERNATIONAL, 20(5), 448-454, 202005
  41. Serum immunoglobulin G antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 200(3), 302-309, 202006
  42. Conus Medullaris Infarction Involving the Paraspinal Muscles and Nerve Roots, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 29(8), 202008
  43. Effects of vascular compression on the rostral ventrolateral medulla for blood pressure variability in stroke patients, JOURNAL OF HYPERTENSION, 38(12), 2443-2450, 202012
  44. Increased blood pressure variability during the subacute phase of ischemic stroke is associated with poor functional outcomes at 3 months, SCIENTIFIC REPORTS, 10(1), 20200121
  45. Serum IgG titers to periodontal pathogens predict 3-month outcome in ischemic stroke patients, PLOS ONE, 15(8), 20200806
  46. Prognostic role of the controlling nutritional status score in acute ischemic stroke among stroke subtypes, JOURNAL OF THE NEUROLOGICAL SCIENCES, 416, 20200915
  47. Association between periodontal disease due to Campylobacter rectus and cerebral microbleeds in acute stroke patients, PLOS ONE, 15(10), 20201008
  48. Serum IgG titers against periodontal pathogens are associated with cerebral hemorrhage growth and 3-month outcome, PLOS ONE, 15(10), 20201028
  49. Rapid ping-pong eye deviation following a recovery from carbon dioxide narcosis, BMJ CASE REPORTS, 14(3), 202103
  50. Socio-economic impact on epilepsy outside of the nation-wide COVID-19 pandemic area, EPILEPSY & BEHAVIOR, 117, 202104
  51. Giant Cell Arteritis with Internal Carotid Artery Occlusion in the Absence of Typical Clinical Features, INTERNAL MEDICINE, 60(8), 1293-1297, 202104
  52. cnm-Positive Streptococcus mutans and diffusion-weighted imaging hyperintensities in acute intracerebral hemorrhage, EUROPEAN JOURNAL OF NEUROLOGY, 28(5), 1581-1589, 202105
  53. Utility of Magnetic Resonance Spectroscopy for the Progression of Neurological Symptoms in Lenticulostriate Artery Territory Infarction, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 30(6), 202106
  54. Effect of region-wide use of prehospital stroke triage scale on management of patients with acute stroke, JOURNAL OF NEUROINTERVENTIONAL SURGERY, 14(7), 677-682, 202207
  55. Various effects of nutritional status on clinical outcomes after intracerebral hemorrhage, INTERNAL AND EMERGENCY MEDICINE, 17(4), 1043-1052, 202206
  56. Assessment of Serum IgG Titers to Various Periodontal Pathogens Associated with Atrial Fibrillation in Acute Stroke Patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 31(3), 202203
  57. Seizure Deterioration with Increased Levetiracetam Blood Concentration during the Postpartum Period in Refractory Temporal Lobe Epilepsy, INTERNAL MEDICINE, 61(8), 1237-1240, 2022
  58. Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle- Brachial Index, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 29(5), 719-730, 2022
  59. Predictors of Stroke Outcome Extracted from Multivariate Linear Discriminant Analysis or Neural Network Analysis, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 29(1), 99-110, 2022
  60. Clinical characteristics and tumor markers in ischemic stroke patients with active cancer, INTERNAL AND EMERGENCY MEDICINE, 17(3), 735-741, 202204
  61. A longitudinal seizure outcome following the COVID-19 pandemic in 2020 and 2021: Transient exacerbation or sustainable mitigation, JOURNAL OF THE NEUROLOGICAL SCIENCES, 434, 20220315

Invited Lecture, Oral Presentation, Poster Presentation

  1. A Comparable Study of Favorable and Unfavorable Warfarin Controlled Groups for Cerebral Infarction, Aoki S, Takamatsu K, Goto K, Fukushima T, Ohta K, 3rd Japanese-Korean Joint Stroke Conference, 2006/11/15, Without Invitation, English
  2. Effect of Arterial Compression onto Rostral Ventrolateral Medulla on Blood Pressure Variation in Acute Infratentorial Ischemic Stroke, Aoki S, Ohtsuki T, Nomura E, Sueda Y, Kono T, Kohriyama T, Matsumoto M, 6th World Stroke Congress, 2008/09/20, Without Invitation, English, Vienna
  3. Relationship between Blood Pressure Variability and Prognosis in Acute Ischemic Stroke Patients with Vascular Compression on the Rostral Ventrolateral Medulla (RVLM), Aoki S, Ohtsuki T, Hosomi N, Sueda Y, Kono T, Yamawaki T, Matsumoto M, 20th European Stroke Conference, 2011/05/25, Without Invitation, English, Hamburg
  4. The consideration of the patients with TIA mimics in our hospital, Aoki S, Hosomi N, Nezu T, Kubo S, Ohtsuki T, Maruyama H, Matsumoto M, International TIA/ACVS Conference, 2013/11/20, Without Invitation, English, Tokyo
  5. The multidisciplinary participatory swallowing team approach significantly decreased the rate of pneumonia in acute stroke patients, Shiro Aoki, Naohisa Hosomi, Junko Hirayama, Masahiro Nakamori, Tomohisa Nezu, Satoshi Kubo, Kazuhide Ochi, Hiromi Yamamoto, Hirohumi Maruyama, Masayasu Matsumoto, World stroke congress 2015, 2014/10/22, Without Invitation, English, World stroke organization, Istanbul
  6. Characteristics and patterns of acute ischemic lesions in intracerebral hemorrhage, Shiro Aoki, Naohisa Hosomi, Tomohisa Nezu, Mutsuko Araki, Hayato Matsushima, Ryo Shimomura, Naoto Kinoshita, Hirofumi Maruyama, World Congress of Neurology 2017, 2017/09/17, Without Invitation, English, Kyoto
  7. Utility of MR spectroscopy for progression of neurological symptoms in penetrating artery territory infarction, ESO-WSO 2020 Conference, 2020/11/07, Without Invitation, English

Social Activities

History as Peer Reviews of Academic Papers

  1. 2017, Stroke, Others, 1
  2. 2018, Stroke, Others, 2
  3. 2019, Stroke, Others, 1
  4. 2019, Neurology, Others, 1
  5. 2020, International Journal of Stroke, Others, 1
  6. 2021, BMC Neurology, Others, 2