藤村 孝志TAKASHI FUJIMURA

Last Updated :2021/03/02

所属・職名
大学院統合生命科学研究科 特任助教
メールアドレス
fmuratkshiroshima-u.ac.jp

研究活動

学術論文(★は代表的な論文)

  1. Intravenous immunoglobulin (IVIg) acts directly on conventional T cells to suppress T cell receptor signaling, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 522巻, 3号, pp. 792-798, 20200212
  2. Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-kappa B, and STAT3, PHARMACOLOGICAL REPORTS, 71巻, 2号, pp. 289-298, 201904
  3. Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy, FRONTIERS IN IMMUNOLOGY, 10巻, 20190823
  4. Prominent IgE-binding and cytokine-inducing capacities of a newly cloned N-terminal region of Der f 14, an apolipophorin-like house dust mite allergen, JOURNAL OF BIOCHEMISTRY, 163巻, 1号, pp. 51-60, 201801
  5. A methoxyflavanone derivative from the Asian medicinal herb (Perilla frutescens) induces p53-mediated G(2)/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma, CYTOTECHNOLOGY, 70巻, 3号, pp. 899-912, 201806
  6. Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma, CYTOTECHNOLOGY, 70巻, 3号, pp. 913-919, 201806
  7. Anti-inflammatory intravenous immunoglobulin (IVIg) suppresses homeostatic proliferation of B cells, CYTOTECHNOLOGY, 70巻, 3号, pp. 921-927, 201806
  8. Prominent IgE-binding and cytokine-inducing capacities of a newly cloned N-terminal region of Der f 14, an apolipophorin-like house dust mite allergen, JOURNAL OF BIOCHEMISTRY, 163巻, 1号, pp. 51-60, 2018
  9. A methoxyflavanone derivative from the Asian medicinal herb (Perilla frutescens) induces p53-mediated G(2)/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma, CYTOTECHNOLOGY, 70巻, 3号, pp. 899-912, 2018
  10. Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma, CYTOTECHNOLOGY, 70巻, 3号, pp. 913-919, 2018
  11. Anti-inflammatory intravenous immunoglobulin (IVIg) suppresses homeostatic proliferation of B cells, CYTOTECHNOLOGY, 70巻, 3号, pp. 921-927, 2018
  12. Der f 35: An MD-2-like house dust mite allergen that cross-reacts with Der f 2 and Pso o 2, ALLERGY, 72巻, 11号, pp. 1728-1736, 201711
  13. A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 483巻, 1号, pp. 674-679, 2017
  14. Plasma Cluster Ions Reduce the IgE-Binding Capacity of House Dust Mite Allergens under a Simulated Indoor Environmental Condition, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 173巻, 4号, pp. 199-203, 2017
  15. Der f 35: An MD-2-like house dust mite allergen that cross-reacts with Der f 2 and Pso o 2, ALLERGY, 72巻, 11号, pp. 1728-1736, 2017
  16. Impact of Histone H1 on the Progression of Allergic Rhinitis and Its Suppression by Neutralizing Antibody in Mice, PLOS ONE, 11巻, 4号, 2016
  17. A novel methoxyflavanone from a Chinese medicinal herb (Perilla frutescens) induces G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma cells, CANCER RESEARCH, 76巻, 2016
  18. Exposure to positively- and negatively-charged plasma cluster ions impairs IgE-binding capacity of indoor cat and fungal allergens, WORLD ALLERGY ORGANIZATION JOURNAL, 9巻, 2016
  19. Der f 34, a Novel Major House Dust Mite Allergen Belonging to a Highly Conserved Rid/YjgF/YER057c/UK114 Family of Imine Deaminases, JOURNAL OF BIOLOGICAL CHEMISTRY, 291巻, 41号, pp. 21607-21615, 2016
  20. Recombinant Fusion Allergens, Cry j 1 and Cry j 2 from Japanese Cedar Pollen, Conjugated with Polyethylene Glycol Potentiate the Attenuation of Cry j 1-Specific IgE Production in Cry j 1-Sensitized Mice and Japanese Cedar Pollen Allergen-Sensitized Monkeys, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 168巻, 1号, pp. 32-43, 2015
  21. Immunological parameters associated with the development of allergic rhinitis: A preliminary prospective study, AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 26巻, 2号, pp. 92-96, 2012
  22. IgE reactivity to a Cry j 3, an allergen of Japanese cedar (Cryptomeria japonica) pollen in dogs with canine atopic dermatitis, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 149巻, 1-2号, pp. 132-135, 2012
  23. Increase of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis, CLINICAL IMMUNOLOGY, 139巻, 1号, pp. 65-74, 2011
  24. Approaches to immunotherapies for Japanese cedar pollinosis, AURIS NASUS LARYNX, 38巻, 4号, pp. 431-438, 2011
  25. Induction of Th1 immune responses to Japanese cedar pollen allergen (Cry j 1) in mice immunized with Cry j 1 conjugated with CpG oligodeoxynucleotide, COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 34巻, 2号, pp. 157-161, 2011
  26. The Induced Regulatory T Cell Level, Defined as the Proportion of IL-10(+)Foxp3(+) Cells among CD25(+)CD4(+) Leukocytes, Is a Potential Therapeutic Biomarker for Sublingual Immunotherapy: A Preliminary Report, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 153巻, 4号, pp. 378-387, 2010
  27. A randomized controlled trial of sublingual immunotherapy for Japanese cedar pollinosis, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 146巻, 1号, pp. 76-84, 2008

外部資金

競争的資金等の採択状況

  1. 基盤研究C, IgEを介したアレルギーマーチ発症機序の解明 (16719674), 2016年, 2018年
  2. 平成29年度研究助成事業 個人研究助成, うるち米デンプンとアレルゲンの共摂食による経口免疫寛容誘導の検討, 2017年, 2017年