藤井 創太郎SOTARO FUJII

Last Updated :2024/05/08

所属・職名
大学院統合生命科学研究科 助教
メールアドレス
sofujihiroshima-u.ac.jp

基本情報

学位

  • 修士(農学) (広島大学)
  • 博士(農学) (広島大学)

研究分野

  • 農学 / 農芸化学 / 応用微生物学

研究キーワード

  • 極限環境生物

教育活動

授業担当

  1. 2024年, 教養教育, 1ターム, SDGsに向けた生物生産学入門
  2. 2024年, 教養教育, 1ターム, 教養ゼミ
  3. 2024年, 学部専門, 1ターム, 生物生産学入門
  4. 2024年, 学部専門, 3ターム, 生物有機化学
  5. 2024年, 学部専門, セメスター(後期), 卒業論文I
  6. 2024年, 学部専門, セメスター(前期), 卒業論文II
  7. 2024年, 学部専門, セメスター(後期), 卒業論文III
  8. 2024年, 学部専門, 3ターム, ゲノム科学II
  9. 2024年, 学部専門, 集中, 分子農学生命科学実験I
  10. 2024年, 学部専門, 4ターム, 生命物質分析学
  11. 2024年, 学部専門, 3ターム, 分子農学生命科学外書講読
  12. 2024年, 修士課程・博士課程前期, 1ターム, 食品生命科学特別演習A
  13. 2024年, 修士課程・博士課程前期, 2ターム, 食品生命科学特別演習A

研究活動

学術論文(★は代表的な論文)

  1. Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi, IUCrJ, 10巻, 4号, 20230701
  2. A heme pocket aromatic quadrupole modulates gas binding to cytochrome c'-beta: Implications for NO sensors, Journal of Biological Chemistry, 299巻, 6号, pp. 104742, 20230424
  3. Lentilactobacillus hilgardii H-50 strongly inhibits lipopolysaccharide-induced inflammatory responses in mouse splenocytes via its specific surface layer proteins, JOURNAL OF APPLIED MICROBIOLOGY, 134巻, 3号, 20230301
  4. Heterologous expression and biochemical comparison of two homologous SoxX proteins of endosymbiotic Candidatus Vesicomyosocius okutanii and free-living Hydrogenovibrio crunogenus from deep-sea environments, PROTEIN EXPRESSION AND PURIFICATION, 200巻, 202212
  5. Crystal structure of thermally stable homodimeric cytochrome c '-beta from Thermus thermophilus, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 78巻, pp. 217-225, 20220527
  6. ★, High thermal stability and unique trimer formation of cytochrome c' from thermophilic Hydrogenophilus thermoluteolus., Biosci. Biotechnol. Biochem., 77巻, 8号, pp. 1677-1681, 2013
  7. Stabilization of mesophilic Allochromatium vinosum cytochrome c through specific mutations modeled by a thermophilic homologue, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 82巻, 2号, pp. 304-311, 2018
  8. Commonly stabilized cytochromes c from deep-sea Shewanella and Pseudomonas, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 82巻, 5号, pp. 792-799, 2018
  9. ★, High stability of apo-cytochrome c' from thermophilic Hydrogenophilus thermoluteolus, Bioscience, Biotechnology, and Biochemistry, 78巻, 7号, pp. 1191-1194, 2014
  10. Thermal stability of cytochrome c' from mesophilic Shewanella amazonensis., Biosci. Biotechnol. Biochem., 79巻, 7号, pp. 1125-1129, 20150310
  11. Comparative study on stabilization mechanism of monomeric cytochrome c5 from deep-sea piezophilic Shewanella violacea., Biosci. Biotechnol. Biochem., 80巻, 12号, pp. 2365-2370, 20160920
  12. Difference in NaCl tolerance of membrane-bound 5'-nucleotidases purified from deep-sea and brackish water Shewanella species., Extremophiles, 21巻, 2号, pp. 357-368, 20170321
  13. ★, Structural and functional insights into thermally stable cytochrome c' from a thermophile, Protein Sci., 26巻, pp. 737-748, 2017
  14. Pyrophosphate hydrolysis in the extremely halophilic archaeon Haloarcula japonica is catalyzed by a single enzyme with a broad ionic strength range., Extremophiles, 21巻, 3号, pp. 471-477, 20170217
  15. Pseudomonas aeruginosa cytochrome c551 denaturation by five systematic urea derivatives that differ in the alkyl chain length., Biosci. Biotechnol. Biochem., 81巻, 7号, pp. 1274-1278, 20170320
  16. Stability of cytochromes c' from psychrophilic and piezophilic Shewanella species: implications for complex multiple adaptation to low temperature and high hydrostatic pressure., Extrempphiles, 23巻, 2号, pp. 239-248, 20190128
  17. Conferment of CO-Controlled Dimer-Monomer Transition Property to Thermostable Cytochrome c ' by Mutation in the Subunit-Subunit Interface, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 92巻, 3号, pp. 702-709, 201903
  18. One fold, two functions: cytochrome P460 and cytochrome c '-beta from the methanotroph Methylococcus capsulatus (Bath), CHEMICAL SCIENCE, 10巻, 10号, pp. 3031-3041, 20190314
  19. Response of neutrophilic Shewanella violacea to acid stress: growth rate, organic acid production, and gene expression, EXTREMOPHILES, 23巻, 3号, pp. 319-326, 201905
  20. Differences in biochemical properties of two 5-nucleotidases from deep- and shallow-sea Shewanella species under various harsh conditions, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 83巻, 6号, pp. 1085-1093, 20190603
  21. Expression of two glutamate decarboxylase genes in Lactobacillus brevis during gamma-aminobutyric acid production with date residue extract, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 84巻, 5号, pp. 1069-1072, 20200503
  22. Fermented date residue extract mix containing gamma-aminobutyric acid augments the immune function of mouse splenocytes, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 85巻, 7号, pp. 1753-1758, 20210624
  23. Identification of six CPC-like genes and their differential expression in leaves of tea plant, Camellia sinensis, JOURNAL OF PLANT PHYSIOLOGY, 263巻, 202108
  24. ★, Transcriptome analysis of Chironomus sulfurosus larvae living in acidic environments: Insights into molecular mechanisms for acid tolerance, JOURNAL OF INSECT PHYSIOLOGY, 133巻, pp. 104288, 20210731
  25. ★, Thermal stability tuning without affecting gas-binding function of Thermochromatium tepidum cytochrome c', BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 85巻, 8号, pp. 1846-1852, 20210723
  26. Unexpectedly high thermostability of an NADP-dependent malic enzyme from a psychrophilic bacterium, Shewanella livingstonensis Ac10, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 21巻, pp. S1389-1723, 20210808

著書等出版物

  1. 2022年11月09日, つくると食べるをつなぐサイエンス: 最先端の生物生産学図鑑, 恒星社厚生閣, 2022年, 教科書, 共編著, J, 三本木至宏 監, 中村隼明 編, 松崎芽衣 編, 坂井陽一 編, 妹尾あいら 編, 平山真 編, 藤井創太郎 編, 山本祥也 編, 若林香織 編, 130, 5-2.酵母工場(船戸耕一・藤井創太郎)
  2. 2021年11月30日, SDGsに向けた生物生産学入門, 2021年, 教科書, 分担執筆, 日本語, 三本木 至宏 監修・ 上田 晃弘 編・ 杉野 利久 編・ 鈴木 卓弥 編・ 冨山 毅 編・ 船戸 耕一 編, 256, 1.5 代謝とエネルギー

外部資金

競争的資金等の採択状況

  1. 海外特別研究員, 極限環境生物由来シトクロムc‘のNO親和性と構造的特徴の解明, 2021年02月01日, 2023年01月31日