島田 昌之Masayuki Shimada

Last Updated :2018/11/05

所属・職名
大学院生物圏科学研究科 陸域動物生産学講座 教授
メールアドレス
mashimadhiroshima-u.ac.jp

基本情報

学位

  • 博士(獣医学) (山口大学)
  • 修士(農学) (広島大学)

研究分野

  • 農学 / 動物生命科学 / 動物生産科学

研究キーワード

  • 卵子|排卵
  • 受精/ 体外受精
  • 体外成熟
  • 卵巣
  • 生殖補助技術(医療)
  • 精子形成
  • 精巣
  • 精子保存

教育活動

授業担当

  1. 2018年, 教養教育, 4ターム, 生物生産と自然との関わり
  2. 2018年, 教養教育, セメスター(前期), 食文化論
  3. 2018年, 学部専門, 集中, 基礎生物学実験I
  4. 2018年, 学部専門, 集中, 基礎生物学実験II
  5. 2018年, 学部専門, 2ターム, 動物生産サイエンス入門
  6. 2018年, 学部専門, 3ターム, 動物生殖学
  7. 2018年, 学部専門, 集中, 動物生殖学実験実習
  8. 2018年, 学部専門, 年度, 卒業論文
  9. 2018年, 学部専門, セメスター(前期), 発生工学
  10. 2018年, 学部専門, セメスター(後期), 実験動物学
  11. 2018年, 学部専門, 集中, 海外生物生産学演習I
  12. 2018年, 学部専門, 集中, 海外生物生産学演習II
  13. 2018年, 学部専門, 集中, 海外生物生産学演習III
  14. 2018年, 学部専門, 集中, 国際課題研究
  15. 2018年, 修士課程・博士課程前期, 1ターム, 分子内分泌学
  16. 2018年, 修士課程・博士課程前期, 3ターム, 動物生殖細胞学
  17. 2018年, 修士課程・博士課程前期, セメスター(前期), 家畜生殖細胞利用学実験実習
  18. 2018年, 修士課程・博士課程前期, セメスター(前期), 陸域動物生産学演習(A)
  19. 2018年, 修士課程・博士課程前期, セメスター(後期), 陸域動物生産学演習(A)
  20. 2018年, 博士課程・博士課程後期, セメスター(前期), 陸域動物生産学演習(B)
  21. 2018年, 博士課程・博士課程後期, セメスター(後期), 陸域動物生産学演習(B)
  22. 2018年, 修士課程・博士課程前期, セメスター(前期), 陸域動物生産学実験実習

研究活動

学術論文(★は代表的な論文)

  1. Induction of immune-related gene expression by seminal exosomes in the porcine endometrium, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 495巻, 1号, pp.1094-pp.1101, JAN 1 2018
  2. Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice, PLOS ONE, 13巻, 2号, FEB 8 2018
  3. Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass, GENES TO CELLS, 23巻, 3号, pp.136-pp.145, MAR 2018
  4. A proinflammatory response of bovine endometrial epithelial cells to active sperm in vitro, MOLECULAR REPRODUCTION AND DEVELOPMENT, 85巻, 3号, pp.215-pp.226, MAR 2018
  5. Oviduct epithelium induces interferon-tau in bovine Day-4 embryos, which generates an anti-inflammatory response in immune cells, SCIENTIFIC REPORTS, 8巻, MAY 18 2018
  6. Evidence that interferon-tau secreted from Day-7 embryo in vivo generates anti-inflammatory immune response in the bovine uterus, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 500巻, 4号, pp.879-pp.884, JUN 12 2018
  7. The Cell Type-Specific Expression of Lhcgr in Mouse Ovarian Cells: Evidence for a DNA-Demethylation-Dependent Mechanism, ENDOCRINOLOGY, 159巻, 5号, pp.2062-pp.2074, MAY 2018
  8. Creatine enhances the duration of sperm capacitation: a novel factor for improving in vitro fertilization with small numbers of sperm, HUMAN REPRODUCTION, 33巻, 6号, pp.1117-pp.1129, JUN 2018
  9. Bovine embryo induces an anti-inflammatory response in uterine epithelial cells and immune cells in vitro: possible involvement of interferon tau as an intermediator, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 63巻, 4号, pp.425-pp.434, 42948
  10. The acceleration of reproductive aging in Nrg1(flox/flox);Cyp19-Cre female mice, AGING CELL, 16巻, 6号, pp.1288-pp.1299, DEC 2017
  11. De Novo-Synthesized Retinoic Acid in Ovarian Antral Follicles Enhances FSH-Mediated Ovarian Follicular Cell Differentiation and Female Fertility, ENDOCRINOLOGY, 157巻, 5号, pp.2160-pp.2172, 42491
  12. The Novel Pig In Vitro Maturation System to Improve Developmental Competence of Oocytes Derived from Atretic Nonvascularized Follicles, BIOLOGY OF REPRODUCTION, 95巻, 4号, OCT 1 2016
  13. Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice, ENDOCRINOLOGY, 157巻, 12号, pp.4899-pp.4913, 42705
  14. Protein Kinase C (PKC) Increases TACE/ADAM17 Enzyme Activity in Porcine Ovarian Somatic Cells, Which Is Essential for Granulosa Cell Luteinization and Oocyte Maturation, ENDOCRINOLOGY, 155巻, 3号, pp.1080-pp.1090, 42808
  15. The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice, DEVELOPMENT, 141巻, 23号, pp.4618-pp.4627, 43083
  16. Targeted Disruption of Nrg1 in Granulosa Cells Alters the Temporal Progression of Oocyte Maturation, MOLECULAR ENDOCRINOLOGY, 28巻, 5号, pp.706-pp.721, 2014
  17. Anti-Bacterial Factors Secreted From Cumulus Cells of Ovulated COCs Enhance Sperm Capacitation During In Vitro Fertilization, AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 69巻, 2号, pp.168-pp.179, 42779
  18. Androgen/androgen receptor pathway regulates expression of the genes for cyclooxygenase-2 and amphiregulin in periovulatory granulosa cells, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 369巻, 42737号, pp.42-pp.51, APR 30 2013
  19. 卵の成熟におけるEGF受容体の活性化と活性化因子, 生体の科学, 64巻, pp.462-463, 201308
  20. New strategies of boar sperm cryopreservation: Development of novel freezing and thawing methods with a focus on the roles of seminal plasma, ANIMAL SCIENCE JOURNAL, 83巻, 9号, pp.623-pp.629, 2012
  21. Artificial Insemination With Seminal Plasma Improves the Reproductive Performance of Frozen-Thawed Boar Epididymal Spermatozoa, JOURNAL OF ANDROLOGY, 33巻, 5号, pp.990-pp.998, SEP-OCT 2012
  22. Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human, FERTILITY AND STERILITY, 98巻, 2号, pp.471-pp.+, 42959
  23. The Release of EGF Domain from EGF-like Factors by a Specific Cleavage Enzyme Activates the EGFR-MAPK3/1 Pathway in Both Granulosa Cells and Cumulus Cells During the Ovulation Process, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 58巻, 5号, pp.510-pp.514, 2012
  24. Endogenous acetaldehyde toxicity during antral follicular development in the mouse ovary, REPRODUCTIVE TOXICOLOGY, 33巻, 3号, pp.322-pp.330, 2012
  25. EGF-Like Factors Induce Expansion of the Cumulus Cell-Oocyte Complexes by Activating Calpain-Mediated Cell Movement, ENDOCRINOLOGY, 153巻, 8号, pp.3949-pp.3959, 2012
  26. The addition of calcium ion chelator, EGTA to thawing solution improves fertilizing ability in frozen-thawed boar sperm, ANIMAL SCIENCE JOURNAL, 82巻, 3号, pp.412-pp.419, 2011
  27. Toll-like receptors (TLR) 2 and 4 on human sperm recognize bacterial endotoxins and mediate apoptosis, HUMAN REPRODUCTION, 26巻, 10号, pp.2799-pp.2806, 43019
  28. Positive Feedback Loop Between Prostaglandin E2 and EGF-Like Factors Is Essential for Sustainable Activation of MAPK3/1 in Cumulus Cells During In Vitro Maturation of Porcine Cumulus Oocyte Complexes, BIOLOGY OF REPRODUCTION, 85巻, 5号, pp.1073-pp.1082, 43050
  29. Cumulus Cell-Oocyte Complex Expansion Is Regulated by Ca2+ Induced m-Calpain Activity Leading to Cumulus Cell Motility and Migration, BIOLOGY OF REPRODUCTION, 85巻, 2011
  30. LH-Induced Neuregulin 1 (NRG1) Type III Transcripts Control Granulosa Cell Differentiation and Oocyte Maturation, MOLECULAR ENDOCRINOLOGY, 25巻, 1号, pp.104-pp.116, 2011
  31. Positive Feedback Loop Between Prostaglandin E2 and EGF-Like Factors Is Essential for Sustainable Activation of MAPK3/1 in Cumulus Cells During In Vitro Maturation of Porcine Cumulus Oocyte Complexes, BIOLOGY OF REPRODUCTION, 85巻, 5号, pp.1073-pp.1082, 2011
  32. The Expression of Acetaldehyde Dehydrogenase (ALDH) Type I Family Members Is Required to Decrease of Endogenous Acetaldehyde Toxicity During Ovarian Follicular Development in Mouse and Human, BIOLOGY OF REPRODUCTION, 85巻, 2011
  33. Possible involvement of phosphatidylinositol 3-kinase in the maintenance of metaphase II attest in porcine oocytes matured in vitro, ANIMAL SCIENCE JOURNAL, 81巻, 1号, pp.42-pp.47, 2010
  34. beta-Catenin (CTNNB1) Promotes Preovulatory Follicular Development but Represses LH-Mediated Ovulation and Luteinization, MOLECULAR ENDOCRINOLOGY, 24巻, 8号, pp.1529-pp.1542, 42957
  35. Polymyxin B neutralizes bacteria-released endotoxin and improves the quality of boar sperm during liquid storage and cryopreservation, THERIOGENOLOGY, 74巻, 9号, pp.1691-pp.1700, 43079
  36. Progesterone is Essential for Maintenance of Tace/Adam17 mRNA Expression, But not EGF-like Factor, in Cumulus Cells, Which Enhances the EGF Receptor Signaling Pathway During In Vitro Maturation of Porcine COCs, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 56巻, 3号, pp.315-pp.323, 2010
  37. Polymyxin B neutralizes bacteria-released endotoxin and improves the quality of boar sperm during liquid storage and cryopreservation, THERIOGENOLOGY, 74巻, 9号, pp.1691-pp.1700, 2010
  38. Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ADAM17 gene expression during in vitro maturation of porcine COCs, JOURNAL OF OVARIAN RESEARCH, 2巻, 1号, 2009
  39. MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility, SCIENCE, 324巻, 5929号, pp.938-pp.941, MAY 15 2009
  40. Interleukin-6: An Autocrine Regulator of the Mouse Cumulus Cell-Oocyte Complex Expansion Process, ENDOCRINOLOGY, 150巻, 7号, pp.3360-pp.3368, 42925
  41. Neuregulin 1 Is a Novel Oocyte Maturation Regulatory Factor Expressed in Granulosa Cells During the Ovulation Process in Mice., BIOLOGY OF REPRODUCTION, pp.59-pp.59, 2009
  42. ERK1/2 in Ovarian Granulosa Cells Are Essential for Female Fertility., BIOLOGY OF REPRODUCTION, pp.82-pp.82, 2009
  43. MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility, SCIENCE, 324巻, 5929号, pp.938-pp.941, 2009
  44. Interleukin-6: An Autocrine Regulator of the Mouse Cumulus Cell-Oocyte Complex Expansion Process, ENDOCRINOLOGY, 150巻, 7号, pp.3360-pp.3368, 2009
  45. Selective expression of Kras(G12D) in granulosa cells of the mouse ovary causes defects in follicle development and ovulation, DEVELOPMENT, 135巻, 12号, pp.2127-pp.2137, JUN 15 2008
  46. Hyaluronan fragments generated by sperm-secreted hyaluronidase stimulate cytokine/chemokine production via the TLR2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilization, DEVELOPMENT, 135巻, 11号, pp.2001-pp.2011, JUN 1 2008
  47. Sequential exposure of porcine cumulus cells to FSH and/or LH is critical for appropriate expression of steroidogenic and ovulation-related genes that impact oocyte maturation in vivo and in vitro, REPRODUCTION, 136巻, 1号, pp.9-pp.21, 42924
  48. Immune-like mechanisms in ovulation, TRENDS IN ENDOCRINOLOGY AND METABOLISM, 19巻, 6号, pp.191-pp.196, 42955
  49. Sequential exposure of porcine cumulus cells to FSH and LH is critical for appropriate expression of steroidogenic and ovulation-related genes that impact oocyte maturation in vivo and in vitro, BIOLOGY OF REPRODUCTION, pp.150-pp.150, 2008
  50. PGE2 and progesterone enhance EGFR activation in porcine cumulus cells via the induction of TACE/ADAM17 expression but not EGF like factors expression during oocyte maturation in vivo and in vitro, BIOLOGY OF REPRODUCTION, pp.150-pp.150, 2008
  51. Hyaluronan fragments generated by sperm-secreted hyaluronidase stimulate cytokine/chemokine production via the TLR2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilization, DEVELOPMENT, 135巻, 11号, pp.2001-pp.2011, 2008
  52. The involvement of the Toll-like receptor family in ovulation, JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 25巻, 6号, pp.223-pp.228, 2008
  53. Sequential exposure of porcine cumulus cells to FSH and/or LH is critical for appropriate expression of steroidogenic and ovulation-related genes that impact oocyte maturation in vivo and in vitro, REPRODUCTION, 136巻, 1号, pp.9-pp.21, 2008
  54. Selective expression of constitutively active KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation, BIOLOGY OF REPRODUCTION, pp.127-pp.127, 2008
  55. Assessment of human oocyte quality by cumulus cell morphology and circulating hormone profile, Reproductive BioMedicine Online, 14巻, 1号, 20070101
  56. Synaptosomal associated protein 25 (Snap25) gene expression is hormonally regulated during ovulation and is involved in cytokine/chemokine exocytosis from granulosa cells., Molecular Endocrinology, 21巻, 10号, pp.2487-pp.2502, 20071001
  57. Involvment of Ca2+-dependent proteasome in the degradation of both cyclin B1 and Mos during spontaneous activation of matured rat oocytes., Theriogenology, 67巻, 3号, pp.475-pp.485, 20070301
  58. Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/a disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor receptor, ENDOCRINOLOGY, 148巻, 12号, pp.6164-pp.6175, 2007
  59. Gene expression profiles of cumulus cell oocyte complexes during ovulation reveal that cumulus cells exhibit a diverse array of neuronal and immune-like functional activities: Are these cells multi-potential?, Molecular Endocrinology, 20巻, 6号, pp.in press, 20060601
  60. Paracrine and autocrine regulation of EGF-like factors in cumulus oocyte complexes (COCs) and granulosa cells: key roles for prostanglandin synthase 2 (Ptgs2) and progesterone receptor (Pgr), Molecular Endocrinology, 20巻, 6号, pp.in press, 20060601
  61. Induced expression of pattern recognition receptors (PRRs) in cumulus oocyte complexes (COCs): Novel evidence for immune-like functions during ovulation., Molecular Endocrinology, 20巻, 6号, pp.3228-pp.3239, 20060601
  62. Gonadotropin-induced delta 14-reductase and delta 7-reductase gene expression in cumulus cells during meiotic resumption of porcine oocytes, Endocrinology, 146巻, pp.186-pp.194, 20050101
  63. The timing of MAP kinase inactivation effects on emission of polar body in porcine oocytes activated by Ca2+ ionophore, Molecular Reproduction and Development, 70巻, pp.64-pp.69, 20050201
  64. Enzyme immunoassay of progesterone in the feces from beef cattle to monitor the ovarian cycle., Animal Reproduction Science, 87巻, pp.1-pp.10, 20050601
  65. Contribution of high p34cdc2 kinase activity to premature chromosome condensation of injected somatic cell nuclei in rat oocytes., Reproduction, 129巻, pp.172-pp.180, 20050401
  66. Transcripts encoding the enzymes that convert acetyl-CoA to cholesterol are induced in cumulus cells and are essential for progesterone biosynthesis and meiotic resumption of porcine oocytes., Japanese Journal of Reproductive Endocrinology, 10巻, pp.15-pp.20, 20051101
  67. TAF4b, a TBP Associated Factor is Required for Multiple Aspects of Oocyte Development., 発生生物学, 208巻, 6号, pp.405-pp.409, 20050615
  68. Mice null for Frizzled4 (Fzd4-/-) are infertile and exhibit impaired corpus lutea formation and function: a critical for vascularization., Biology of Reproduction, 73巻, 7号, pp.1135-pp.1146, 20050729
  69. Mitogen-Activated Protein Kinase Kinase Inhibitor Suppresses Cyclin B1 Synthesis and Reactivation of p34cdc2 Kinase, Which Improves Pronuclear Formation Rate in Matured Porcine Oocytes Activated by Ca2+ Ionophore, Biology of Reproduction, 70巻, pp.797-pp.804, 20040301
  70. Dramatic changese in motility and penetration competence of miniture pig spermatozoa frozen after exposure to seminal plasma, Theriogenology, 61巻, 42769号, pp.351-pp.364, 20040101
  71. Expression of two progesterone receptor isoforms in cumulus cells and their roles during meiotic resumption of porcine oocytes, Journal of Molecular Endocrinology, pp.in press, 20040401
  72. The role of Calcium/Calmodulin-dependent protein kinase II (CaMKII) on inactivation of MAP kinase and p34cdc2 kinase during fertilization and activation in pig oocytes, Reproduction, 128巻, pp.409-pp.415, 20040401
  73. Down-regulated expression of ADAMTS-1 by progesterone receptor antagonist is associated with impaired expansion of porcine cumulus-oocyte complexes, Endocrinology, 145巻, pp.4603-pp.4614, 20040401
  74. Effects of adding LH to FSH-containing medium on progesterone-induced differentiation of cumulus cells during meiotic resumption of porcine oocytes, Animal Science Journal, pp.in press, 20040401
  75. FSH-induced activation of PI 3-kinase-PKB pathway is essential for LH receptor formation in cumulus cells during meiotic resumption of porcine oocytes., Japanese Journal of Reproductive Endocrinology, pp.in press, 20040401
  76. Effects of adding luteinizing hormone to a medium containing follicle stimulating hormone on progesterone-induced differentiation of cumulus cells during meiotic resumption of porcine oocytes, Animal Science Journal, 75巻, pp.515-pp.523, 20040401
  77. The production of progesterone from de novo-synthesized cholesterol in cumulus cells, and its physiological role during meiotic resumption of porcine oocytes, Biology of Reproduction, 68巻, 4号, pp.1193-pp.1198, 20030401
  78. Effects of estrone sulfate injection on reproductive functions in male Japanese quail., Journal of Poultry Science, 40巻, pp.243-pp.247, 20031001
  79. PI 3-kinase in cumulus cells is responsible for both suppression of spontaneous maturation and induction of gonadotropin-stimulated maturation of porcine oocytes., Journal of Endocrinology, 179巻, pp.25-pp.34, 20031001
  80. Effect of Protein kinase C activator on mitogen-activated protein kinase and p34cdc2 kinase activity during parthenogenetic activation of porcine oocytes by calcium ionophore., Biology of Reproduction, 69巻, pp.1675-pp.1682, 20031101
  81. LH receptor formation in cumulus cells surrounding porcine oocytes, and its role during meiotic maturation of porcine oocytes., Biology of Reproduction, 68巻, 4号, pp.1142-pp.1149, 20030401
  82. Time dependent changes in progesterone receptor expression in cumulus cells during meiotic resumption of porcine oocytes, Journal of Mammalian Ova Research, 20巻, pp.113-pp.117, 20031001
  83. Time dependent changes in progesterone receptor expression in cumulus cells during meiotic resumption of porcine oocytes, Journal of Mammalian Ova Research, 20巻, pp.113-pp.117, 20030401
  84. LH reduces proliferative activity of cumulus cells and accelerates GVBD of porcine oocytes, Molecular and Cellular Endocrinology, 209巻, pp.43-pp.50, 20030401
  85. Roles of cAMP in Regulation of both MAP kinase and p34cdc2 kinase activity during Meiotic Progression,especially beyond the MI stage., Molecular Reproduction and Development, 62巻, 1号, pp.124-pp.131, 20020501
  86. ★, FSH and LH induce progesterone production and progesterone receptor synthesis in cumulus cells: a requirement for meiotic resumption in porcine oocytes., Molecular Human Reproduction, 8巻, pp.621-pp.628, 20020701
  87. Delay of nuclear maturation and reduction in developmental competence of pig oocytes after mineral oil overlay of in vitro maturation media., Reproduction, 124巻, pp.557-pp.564, 20021001
  88. Both Ca2+-PKC pathway and cAMP-PKA pathway require for progesterone production in FSH- and LH-stimulated cumulus cells during in vitro maturation of porcine oocytes., J Mamm Ova Res, 19巻, 3号, pp.81-pp.88, 20021001
  89. Dynamic changes of connexin-43, gap junctional protein, in outer layers of cumulus cells are regulated by PKC and PI 3-kinase during meiotic resumption in porcine oocytes, Biology of Reproduction, 64巻, 4号, pp.1255-pp.1263, 20010401
  90. PI 3-kinase in cumulus cells and oocytes is responsible for activation of oocyte MAP kinase during meiotic progression beyond the MI stage in pigs, Biology of Reproduction, 64巻, 4号, pp.1106-pp.1114, 20010401
  91. The drop of cAMP level due to the closure of gap junctional communication between cumulus cells and oocyte is essential for meiotic progression beyond the MI stage in porcine oocytes, J Mamm Ova Res, 18巻, 3号, pp.99-pp.105, 20010401
  92. Progression of nuclear maturation and p34cdc2 kinase activity in porcine oocytes during in vitro culture in different medium, J Mamm Ova Res, 18巻, 1号, pp.39-pp.43, 20010401
  93. Survival of Boar Spermatozoa Frozen in Diluents of Varying Osmolality., Theriogenology, 56巻, 8号, pp.447-pp.458, 20010401
  94. ★, Inhibition of PI 3-kinase or MEK Leads to Suppression of p34cdc2 kinase Activity and Meiotic Progression beyond the MI stage in Porcine Oocyte Surrounded with Cumulus Cells., Biology of Reproduction, 65巻, 2号, pp.442-pp.448, 20010401
  95. Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, blocks in vitro fertilization and embryonic development of bovine oocytes matured in vitro with epidermal growth factor., J Mamm Ova Res, 17巻, 3号, pp.109-pp.114, 20000401
  96. Meiotic Maturation of Bovine Oocytes Cultured In vitro with EGF and Wortmannin., J Mamm Ova Res, 17巻, 3号, pp.103-pp.108, 20000401
  97. Activation by stimuli of sperm penetration in bovine oocytes treated with high concentration of BAPTA/AM., J Mamm Ova Res, 17巻, 3号, pp.96-pp.102, 20000401
  98. Effects of wortmannin on the kinetics of GVBD and the activities of the maturation-promoting factor and mitogen-activated protein kinase during bovine oocyte maturation in vitro, Theriogenology, 53巻, 5号, pp.1797-pp.1806, 20000401
  99. Phosphorylation of Connexin-43, Gap Junctional Protein, in Cumulus Cells Are Regulated by Mitogen Activated Protein Kinase and Phosphatidylinositol 3-Kinase during In Vitro Meiotic Resumption in Porcine Follicular Oocytes., J Mamm Ova Res, 16巻, 3号, pp.37-pp.42, 19990401
  100. A Role for PI 3-Kinase in bovine oocytes nuclear maturation., Theriogenology, 50巻, 7号, pp.347-pp.356, 19980401
  101. Phosphatidylinositol 3-Kinase in Cumulus Cells is Responsible for Meiotic Progression from MⅠ to MⅡ Stage in Porcine Follicular Oocytes., J Mamm Ova Res, 15巻, 3号, pp.68-pp.76, 19980401
  102. ★, Effects of Phosphatidylinositol 3-Kinase Inhibitors, Wortmannin and LY294002 on Germinal Vesicle Breakdown (GVBD) in Porcine Oocytes., J Reprod Dev, 44巻, 5号, pp.281-pp.288, 19980401
  103. Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ADAM17 gene expression during in vitro maturation of porcine COCs, JOURNAL OF OVARIAN RESEARCH, 2巻, 1号, 2009
  104. Fecal progestagen and estrone during pregnancy in a giraffe: A case report, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 53巻, 1号, pp.159-pp.164, 2007
  105. MAP kinase およびPl 3-kinaseが卵丘細胞間ギャップ結合の構成因子Connexin-43のリン酸化をブタ卵胞卵子の減数分裂再開時に制御する, Journal of mammalian ova research = 日本哺乳動物卵子学会誌, 16巻, 1号, pp.37-pp.42, 19990401
  106. ERK1^<-/-> ; ERK2^ ; Cyp19A1Cre mice を用いた卵胞内エストロジェン濃度低下と排卵機構の解析, Journal of mammalian ova research = 日本哺乳動物卵子学会誌, 26巻, 2号, 20090401
  107. ラット排卵卵子の減数分裂停止に関わるMos/MEK/MAPK系と p34^ kinase の相補的な機能, Journal of mammalian ova research = 日本哺乳動物卵子学会誌, 22巻, 2号, 20050401
  108. 卵丘細胞のPI 3-kinase とMI以降のブタ卵子のp34^ kinase との関係, Journal of mammalian ova research = 日本哺乳動物卵子学会誌, 16巻, 2号, 19990401
  109. 異なる成熟培地で培養したブタ卵子のp34cdc2 kinase活性の変化と核相の進行, Journal of mammalian ova research = 日本哺乳動物卵子学会誌, 18巻, 1号, pp.39-pp.43, 20010401

招待講演、口頭・ポスター発表等

  1. 採卵された(てしまった)未成熟卵を如何に培養するか?, 島田昌之, 日本受精着床学会, 2016年91月, 招待, 日本語, 長野県