中野 亮介RYOSUKE NAKANO

Last Updated :2025/02/04

所属・職名
病院（医）　助教
メールアドレス
rynkhiroshima-u.ac.jp
その他連絡先
広島市南区霞1-2-3  臨床研究棟707
TEL:0822575222
自己紹介
肝移植免疫寛容、細胞療法

基本情報

主な職歴

  • 2021年08月01日, 広島大学, 病院, 医科診療医
  • 2023年04月01日, 広島大学, 病院, 助教

学歴

  • 広島大学, 医学部, 医学科, 日本, 2001年04月, 2007年03月
  • 広島大学, 大学院医歯薬保健学研究科, 医歯薬学専攻, 日本, 2015年04月, 2019年03月

学位

  • 博士（医学）　(広島大学)

研究分野

  • 医歯薬学 / 外科系臨床医学 / 消化器外科学

研究キーワード

  • 肝移植後免疫寛容
  • 移植免疫学

教育活動

授業担当

  1. 2024年, 学部専門, 集中, 臨床実習入門プログラム
  2. 2024年, 博士課程・博士課程後期, セメスター（前期）, 消化器・移植外科学特別演習
  3. 2024年, 博士課程・博士課程後期, セメスター（後期）, 消化器・移植外科学特別演習
  4. 2024年, 博士課程・博士課程後期, セメスター（前期）, 消化器・移植外科学特別研究
  5. 2024年, 博士課程・博士課程後期, セメスター（後期）, 消化器・移植外科学特別研究

研究活動

学術論文（★は代表的な論文）

  1. Protection From Second Warm Ischemic Injury Using a Thermal Barrier Bag in Kidney Transplantation, Transplant Direct, 202302
  2. Correction: Surgery‑related disseminated intravascular coagulation predicts postoperative complications, BMC Surg, 202306
  3. Protocol to evaluate the efficacy and safety of tolvaptan in patients with refractory ascites after liver resection: an open-label, single-arm phase I/II, INTERNATIONAL JOURNAL OF SURGERY PROTOCOLS, 28巻, 1号, pp. 1-5, 2024
    DOIを用いた論文検索結果へのリンク
  4. Efficacy and safety of lenvatinib-transcatheter arterial chemoembolisation sequential therapy followed by surgical resection for intermediate-stage hepatocellular carcinoma beyond Up-to-7 criteria: a study protocol for a multicentre, single-arm, prospective study, BMJ OPEN, 13巻, 10号, 202310
    DOIを用いた論文検索結果へのリンク
  5. Effect of Abdominal Aortic Calcification on Recurrence Following Initial Hepatectomy for Colorectal Liver Metastases, ANTICANCER RESEARCH, 44巻, 2号, pp. 649-658, 202402
    DOIを用いた論文検索結果へのリンク
  6. Impact of KIR-HLA Genotype on Natural-Killer-Cell-Based Immunotherapy for Preventing Hepatocellular Carcinoma after Living-Donor Liver Transplantation, CANCERS, 16巻, 3号, 202402
    DOIを用いた論文検索結果へのリンク
  7. CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis, Oncoimmunology, 20231020
  8. IL-22BP controls the progression of liver metastasis in colorectal cancer, Front Oncol, 20230531
  9. The aryl hydrocarbon receptor maintains antitumor activity of liver resident natural killer cells after partial hepatectomy in C57BL/6J mice, CANCER MEDICINE, 12巻, 19号, pp. 19821-19837, 202310
    DOIを用いた論文検索結果へのリンク
  10. Preoperative percutaneous or transvascular marking for curative resection of small liver tumours with potential for missing during hepatectomy: a study protocol for an open-label, single-arm phase II study, BMJ OPEN, 13巻, 10号, 202310
    DOIを用いた論文検索結果へのリンク
  11. Impact of a new liver immune status index among patients with hepatocellular carcinoma after initial hepatectomy, ANNALS OF GASTROENTEROLOGICAL SURGERY, 7巻, 6号, pp. 987-996, 202311
    DOIを用いた論文検索結果へのリンク
  12. Effectiveness of Thermal Barrier Bag for Prolonged Vascular Anastomosis in Kidney Transplantation, TRANSPLANTATION PROCEEDINGS, 55巻, 4号, pp. 752-755, 202305
    DOIを用いた論文検索結果へのリンク
  13. Genetic Polymorphisms in Follicular Helper T Cell-Related Molecules Predispose Patients to De Novo Donor-Specific Antibody Formation After Kidney Transplantation, TRANSPLANTATION PROCEEDINGS, 55巻, 4号, pp. 1048-1054, 202305
    DOIを用いた論文検索結果へのリンク
  14. Arteriosclerosis Decreases Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Expression on Liver Natural Killer Cells in Living Donor Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 55巻, 4号, pp. 906-912, 202305
    DOIを用いた論文検索結果へのリンク
  15. Surgery-related disseminated intravascular coagulation predicts postoperative complications, BMC SURGERY, 23巻, 1号, 20230411
    DOIを用いた論文検索結果へのリンク
  16. Adoptive immunotherapy overcomes genetic susceptibility to bloodstream infections due to fc-gamma receptor polymorphisms after liver transplantation., Am J Transplant, 22巻, pp. 2392-2400, 2022
  17. Adoptive immunotherapy with natural killer cells from peripheral blood CD34(+) stem cells to prevent hepatocellular carcinoma recurrence after curative hepatectomy: a study protocol for an open-label, single-arm phase I study., BMJ Open, 12巻, pp. e064526, 2022
  18. Acute portal hypertension using portal vein ligation abrogates TRAIL expression of liver-resident NK cells, Hepatol Commun, 6巻, pp. 2551-2564, 2022
  19. Impact of Abdominal Aortic Calcification After Major Hepatobiliary Pancreatic Surgery: A Retrospective Cohort Study., Anticancer Res, 42巻, pp. 5983-5989, 2022
  20. Dendritic Cell-Mediated Regulation of Liver Ischemia-Reperfusion Injury and Liver Transplant Rejection., Front Immunol, 12巻, pp. eCollection 2021, 2021
  21. Donor plasmacytoid dendritic cells modulate effector and regulatory T cell responses in mouse spontaneous liver transplant tolerance. Donor plasmacytoid dendritic cells modulate effector and regulatory T cell responses in mouse spontaneous liver transplant tolerance., Am J Transplant, 21巻, pp. 2040-2055, 2021
  22. Management of Refractory Ascites for Liver Transplant Candidates: A Novel Cell-free and Concentrated Ascites Reinfusion Therapy., Transplant Proc, 51巻, pp. 2740-2744, 2019
  23. DNAX Activating Protein of 12 kDa/Triggering Receptor Expressed on Myeloid Cells 2 Expression by Mouse and Human Liver Dendritic Cells: Functional Implications and Regulation of Liver Ischemia-Reperfusion Injury., Hepatology, 70巻, pp. 696-710, 2019
  24. mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells., Front Immunol, 10巻, pp. eCollection 2019, 2019
  25. Reply: Hepatectomy versus stereotactic body radiotherapy for primary early hepatocellular carcinoma: A propensity -matched analysis in a single institution., Surgery, 165巻, pp. 1054-1057, 2019
  26. Impact of Abdominal Aortic Calcification Among Liver Transplantation Recipients., Liver Transpl, 25巻, pp. 79-87, 2019
  27. Polymorphisms in TRAIL predict long-term survival and extrahepatic recurrence following initial hepatectomy for hepatocellular carcinoma., J Hepatobiliary Pancreat Sci, 25巻, pp. 370-376, 2018
  28. Independent risk factors that predict bile leakage after hepatectomy for hepatocellular carcinoma: Cohort study., Int J Surg, 57巻, pp. 1-7, 2018
  29. ★, Hepatic irradiation persistently eliminates liver resident NK cells., PLoS One, 13巻, pp. e0198904, 2018
  30. Hepatectomy versus stereotactic body radiotherapy for primary early hepatocellular carcinoma: A propensity-matched analysis in a single institution., Surgery, 164巻, pp. 219-226, 2018
  31. Hepatectomy leads to loss of TRAIL-expressing liver NK cells via downregulation of the CXCL9-CXCR3 axis in mice., PLoS One, 12巻, pp. e01869972017, 2017
  32. Acute Graft Rejection and Formation of De Novo Donor-Specific Antibodies Triggered by Low Cyclosporine Levels and Interferon Therapy for Recurrent Hepatitis C Infection After Liver Transplantation: A Case Report., Transplant Proc, 2017
  33. Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report., Int J Surg Case Rep, 9巻, pp. 119-122, 2015
  34. Treatment of hepatic amyloid light-chain amyloidosis with bortezomib and dexamethasone in a liver transplant patient., Hepatol Res, 45巻, pp. E150-155, 2015

招待講演、口頭・ポスター発表等

  1. Management Strategies for Marginal Donors in Liver Transplantation at Hiroshima University Hospital, The 36th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery, 2024年06月28日, 通常, 英語
  2. The role of NK cells during liver transplantation. Basic research and clinical appliance of liver NK cells, The 36th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery, 2024年06月29日, 招待, 英語
  3. Atherosclerosis Deteriorate Liver Ischemia/Reperfusion Injury via IRF-1 over expression in a Murine Model, 08282023, the Asian Transplantation Society 2023, 2023年08月, 通常, 英語
  4. Donor plasmacytoid dendritic cells modulate effector and regulatory T cell responses in mouse spontaneous liver transplant tolerance, Transplantation Science Symposium Asian Regional Meeting 2022, 2022年11月, 通常, 英語
  5. Donor liver plasmacytoid dendritic cells promote effector T cell exhaustion and augment Treg responses in mouse spontaneous liver transplant tolerance, The Transplantation Society 2020, 2020年09月, 通常, 英語
  6. Liver plasmacytoid dendritic cells express high levels of DAP12, TREM2 and PD-L1 and promote effector T cell exhaustion and augmented Treg responses in spontaneous liver transplant tolerance, American Transplant Congress 2020, 2020年05月, 通常, 英語
  7. Negative influence of liver irradiation on liver resident NK cells, The Transplantation Society 2016, 2016年08月, 通常, 英語

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業, RANKLを介したTRAIL陽性肝内在性NK細胞脆弱化メカニズムの解明と制御, 2022年, 2025年