片柳 克夫Katsuo Katayanagi

Last Updated :2018/11/01

所属・職名
大学院理学研究科 生命理学講座 准教授
メールアドレス
kkatahiroshima-u.ac.jp

基本情報

主な職歴

  • 1994年01月01日, 1996年09月30日, 三菱化学
  • 1996年10月01日, 広島大学
  • 1986年04月01日, 1993年12月31日, 蛋白工学研究所

学位

  • 博士(薬学) (大阪大学)
  • 工学修士 (東京工業大学)

研究分野

  • 生物学 / 生物科学 / 生物物理学

研究キーワード

  • 構造機能相関
  • 蛋白質結晶学

教育活動

授業担当

  1. 2018年, 学部専門, セメスター(前期), 卒業研究
  2. 2018年, 学部専門, セメスター(後期), 卒業研究
  3. 2018年, 学部専門, 3ターム, 生物構造化学
  4. 2018年, 修士課程・博士課程前期, セメスター(前期), 放射光科学特論I
  5. 2018年, 修士課程・博士課程前期, セメスター(前期), 生命理学概論
  6. 2018年, 修士課程・博士課程前期, セメスター(前期), 数理分子生命理学セミナー
  7. 2018年, 修士課程・博士課程前期, セメスター(後期), 数理分子生命理学セミナー
  8. 2018年, 修士課程・博士課程前期, セメスター(前期), 数理分子生命理学特別研究
  9. 2018年, 修士課程・博士課程前期, セメスター(後期), 数理分子生命理学特別研究
  10. 2018年, 修士課程・博士課程前期, セメスター(前期), プロテオミクス
  11. 2018年, 修士課程・博士課程前期, セメスター(前期), 分子生物物理学セミナー
  12. 2018年, 修士課程・博士課程前期, セメスター(後期), 分子生物物理学セミナー
  13. 2018年, 修士課程・博士課程前期, セメスター(前期), プロテオミクス実験法・同実習

研究活動

学術論文(★は代表的な論文)

  1. Halophilic mechanism of the enzymatic function of a moderately halophilic dihydrofolate reductase from Haloarcula japonica strain TR-1, EXTREMOPHILES, 21巻, 3号, pp.591-pp.602, MAY 2017
  2. Vacuum-Ultraviolet Circular Dichroism Spectra of Escherichia coli Dihydrofolate Reductase and Its Mutants: Contributions of Phenylalanine and Tyrosine Side Chains and Exciton Coupling of Two Tryptophan Side Chains, JOURNAL OF PHYSICAL CHEMISTRY B, 119巻, 41号, pp.13002-pp.13008, OCT 15 2015
  3. Effects of salt on the structure, stability, and function of a halophilic dihydrofolate reductase from a hyperhalophilic archaeon, Haloarcula japonica strain TR-1, EXTREMOPHILES, 19巻, 2号, pp.479-pp.493, MAR 2015
  4. ★, Structure-function relationship of assimilatory nitrite reductases from the leaf and root of tobacco based on high-resolution structures, PROTEIN SCIENCE, 21巻, 3号, pp.383-pp.395, MAR 2012
  5. ★, The reductive reaction mechanism of tobacco nitrite reductase derived from a combination of crystal structures and ultraviolet-visible microspectroscopy, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 80巻, 8号, pp.2035-pp.2045, AUG 2012
  6. ★, X-Ray Crystal Structure of a Mutant Assimilatory Nitrite Reductase That Shows Sulfite Reductase-Like Activity, CHEMISTRY & BIODIVERSITY, 9巻, 9号, pp.1989-pp.1999, SEP 2012
  7. Structural implication for the impaired binding of W150A mutant LOX-1 to oxidized low density lipoprotein, OxLDL, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1824巻, 5号, pp.739-pp.749, MAY 2012
  8. The initial N-O bond cleavage mechanism of nitrite in assimilatory- nitrite-reductase from tabacum: effective utilization of X-ray structures and UV-Vis microspectroscopy., JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY SUPPLEMENT, 16巻, pp.S55, NOV 2011
  9. Fluorescent probes for the analysis of DNA strand scission in base excision repair, NUCLEIC ACIDS RESEARCH, 38巻, 7号, APR 2010
  10. Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of Actinobacillus actinomycetemcomitans, INFECTION AND IMMUNITY, 74巻, 12号, pp.7014-pp.7020, DEC 2006
  11. Evolutional design of a hyperactive cysteine- and methionine-free mutant of Escherichia coli dihydrofolate reductase, JOURNAL OF BIOLOGICAL CHEMISTRY, 281巻, 19号, pp.13234-pp.13246, MAY 12 2006
  12. Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase, NUCLEIC ACIDS RESEARCH, 32巻, 17号, pp.5291-pp.5302, 2004
  13. Effects of mutation and ligand binding on the compressibility of protein, PROGRESS IN BIOCHEMISTRY, 19巻, pp.63-pp.70, APR 2002
  14. Crystal structure analysis of new-type lectin from algae., Spring-8 User Experimental Report, 7(2001A)巻, pp.274, OCT 2001
  15. Single amino acid substitutions in flexible loops can induce large compressibility changes in dihydrofolate reductase, JOURNAL OF BIOCHEMISTRY, 128巻, 1号, pp.21-pp.27, JUL 01 2000
  16. The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome., JOURNAL OF BIOLOGICAL CHEMISTRY, 272巻, 17号, pp.11402-pp.11407, APR 25 1997
  17. Proposal of new roles for two invariant residues in Escherichia coli ribonuclease H., PROTEIN ENGINEERING, 9巻, 10号, pp.857-pp.867, OCT 1 1996
  18. ★, Architectures of class-defining and specific domains of glutamyl-tRNA synthetase., SCIENCE, 267巻, 5206号, pp.1958-pp.1965, MAY 1995
  19. Crystal structure of a pyrimidine dimer-specific excision repair enzyme from bacteriophage T4; refinement at 1.45 A and X-ray analysis of the three active site mutants., JOURNAL OF MOLECULAR BIOLOGY, 249巻, 2号, pp.360-pp.375, JUN 1995
  20. Crystallization and preliminary crystallographic data of the alpha-amylase inhibitors, Haim I and Paim I., JOURNAL OF BIOCHEMISTRY, 115巻, 1号, pp.168-pp.170, JAN 1994
  21. Crystal structure of T4 endonuclease V. An excision repair enzyme for a pyrimidine dimer., ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 726巻, pp.198-pp.207, APR 1994
  22. Crystal structure of ribonuclease H from Thermus thermophilus HB8 refined at 2.8 A resolution., JOURNAL OF MOLECULAR BIOLOGY, 230巻, 2号, pp.529-pp.542, MAR 1993
  23. The crystal structure of ribonuclease F1 of Fusarium moniliforme in its free form and in complex with 2’GMP., JOURNAL OF MOLECULAR BIOLOGY, 230巻, 2号, pp.979-pp.996, APR 1993
  24. ★, Crystal structures of ribonuclease HI active site mutants from Escherichia coli., JOURNAL OF BIOLOGICAL CHEMISTRY, 268巻, 29号, pp.22092-pp.22099, DEC 1993
  25. ★, Crystal structure of Escherichia coli RNase HI in complex with Mg2+ at 2.8 A resolution; Proof for a single Mg2+-binding site., PROTEINS; STRUCTURE, FUNCTIONS, AND GENETICS, 17巻, 4号, pp.337-pp.346, DEC 1993
  26. ★, Structural details of ribonuclease H from Escherichia coli as refined to an atomic resolution., JOURNAL OF MOLECULAR BIOLOGY, 223巻, 4号, pp.1029-pp.1052, FEB 1992
  27. ★, X-ray structure of T4 endonuclease V; An excision repair enzyme specific for a pyrimidine dimer., SCIENCE, 256巻, 5056号, pp.523-pp.526, APR 1992
  28. Effect of cavity-modulating mutations on the stability of Escherichia coli ribonuclease HI., EUROPEAN JOURNAL OF BIOCHEMISTRY, 206巻, 2号, pp.337-pp.343, JUN 1992
  29. Stabilization of Escherichia coli ribonuclease H by introduction of an artificial disulfide bond., JOURNAL OF BIOLOGICAL CHEMISTRY, 19巻, 8号, pp.6038-pp.6044, APR 1991
  30. Structural models of ribonuclease H domains in reverse transcriptases from retroviruses., NUCLEIC ACIDS RESEARCH, 19巻, 8号, pp.1817-pp.1823, APR 1991
  31. Effect of mutagenesis at each of five histidine residues on enzymic activity and stability of ribonuclease H from Escherichia coli, EUROPEAN JOURNAL OF BIOCHEMISTRY, 198巻, 2号, pp.437-pp.440, JUN 1991
  32. Atomic structure of a pyrimidine-dimer specific exision-repair enzyme from bacterio-phage T4., NUCLEIC ACIDS RESEARCH SYMPOSIUM, Series 24巻, pp.181-pp.184, SEP 1991
  33. Cocrystallization of Escherichia coli RNase H with synthetic DNA/RNA hybrid oligomers., NUCLEIC ACIDS RESEARCH SYMPOSIUM, Series 24巻, pp.253, SEP 1991
  34. How does RNase H recognize a DNA-RNA hybrid ?, PROCEEDINGS OF NATIONAL ACADEMY OF SCIENCE U.S.A., 88巻, 24号, pp.11535-pp.11539, DEC 1991
  35. ★, Three-dimensional structure of ribonuclease H from E. coli., NATURE, 347巻, 6290号, pp.306-pp.309, SEP 20 1990

著書等出版物

  1. RNase H; three-dimensional structure and function. , Bulletin of Institute Pasteur 90, 1992年, FEB, 単行本(学術書), 森川 耿右, 片柳 克夫, pp.71-82
  2. タンパク質工学とX線解析-RNase H の構造機能相関を例として-. , 細胞工学12, 秀潤社, 1993年01月, 単行本(学術書), 片柳克夫, 森川耿右, 11-20
  3. 新生化学実験講座 第7章 X線, 東京化学同人, 1993年, 単行本(学術書), 片柳 克夫 森川耿右 , pp.131-168
  4. RNase H; crystallographic approach to function, in Molecular Biology (Life Science Advances) 13, 1993年, 単行本(学術書), 片柳克夫, 森川耿右, pp.193-202
  5. Crystal structures of ribonuclease H of prokaryotes. , in "Ribonuclease H" (ed. R.J. Crouch), Inserm, 1998年, 単行本(学術書), 森川 耿右, 片柳克夫, pp.181-193

招待講演、口頭・ポスター発表等

  1. Structure and function of assimilatory nitrite reductases from tobacco leaf and root., Katsuo Katayanagi, Shogo Nakano, WGC-2015, 2015年11月13日, 招待, 英語, Qingtao (PRC)