KUMRUNGSEE ThanutchapornThanutchaporn KUMRUNGSEE

Last Updated :2020/09/16

所属・職名
大学院統合生命科学研究科 准教授
ホームページ
メールアドレス
kumrunghiroshima-u.ac.jp
自己紹介

私の研究の興味は、生活習慣病を予防する食品因子を見出し、それらの作用メカニズムを明らかにすることです。

"Let Food be Your Medicine"

基本情報

主な職歴

  • 2019年06月04日, 2019年08月28日, McMaster University, Canada, Faculty of Health Sciences, Visiting Professor
  • 2016年04月01日, 2019年03月31日, 広島大学, 大学院生物圏科学研究科, 助教
  • 2015年10月01日, 2016年03月31日, 九州大学, Graduate School of Bioresource and Bioenvironmental Sciences, Postdoctoral researcher
  • 2019年04月01日, 2020年03月31日, 広島大学, 大学院統合生命科学研究科, 助教
  • 2020年04月01日, 広島大学, 大学院統合生命科学研究科, 准教授

学歴

  • Kyushu University, Graduate School of Bioresource and Bioenvironmental Sciences, Food Science and Biotechnology, 2012年10月, 2015年09月
  • Kyushu University, Graduate School of Bioresource and Bioenvironmental Sciences, Food Science and Biotechnology, 2010年10月, 2012年09月
  • Kasetsart University, Departmnet of Food Science and Technology, Food Science and Technology, Thailand, 2004年05月, 2009年03月

学位

  • 博士(農学) (九州大学)

教育担当

  • 【学士課程】 生物生産学部 : 生物生産学科
  • 【博士課程前期】 統合生命科学研究科 : 統合生命科学専攻 : 食品生命科学プログラム
  • 【博士課程後期】 統合生命科学研究科 : 統合生命科学専攻 : 食品生命科学プログラム

担当主専攻プログラム

  • 食品科学プログラム

研究分野

  • 農学 / 農芸化学 / 食品科学

研究キーワード


  • Skeletal muscle
    Muscle stem cells (satellite cells)
    Muscle regeneration
    functional foods
    bioactive compounds
    Carnosine/Homocarnosine
    vitamin B6

所属学会

  • American Society for Nutrition, 2020年02月
  • 公益社団法人 日本栄養・食糧学会, 2016年
  • 公益社団法人日本農芸化学会, 2017年
  • American Physiological Society, 2019年09月

教育活動

授業担当

  1. 2020年, 教養教育, 2ターム, 生命・食・環境のサイエンス
  2. 2020年, 教養教育, 3ターム, 食の安心・安全と健康科学
  3. 2020年, 学部専門, 2ターム, 外書講読
  4. 2020年, 学部専門, 2ターム, Introduction to Applied Biological Science I
  5. 2020年, 学部専門, 集中, 栄養生化学実験
  6. 2020年, 学部専門, 1ターム, 食品健康科学
  7. 2020年, 学部専門, 3ターム, Modern Food Science
  8. 2020年, 修士課程・博士課程前期, 4ターム, 食品栄養機能学Ⅱ
  9. 2020年, 修士課程・博士課程前期, 1ターム, 食品生命科学特別演習A
  10. 2020年, 修士課程・博士課程前期, 2ターム, 食品生命科学特別演習A
  11. 2020年, 修士課程・博士課程前期, 3ターム, 食品生命科学特別演習B
  12. 2020年, 修士課程・博士課程前期, 4ターム, 食品生命科学特別演習B
  13. 2020年, 修士課程・博士課程前期, 年度, 食品生命科学特別研究

研究活動

学術論文(★は代表的な論文)

  1. Mungbean seed coat water extract inhibits inflammation in LPS-induced acute liver injury mice and LPS-stimulated RAW 246.7 macrophages via the inhibition of TAK1/IκBα/NF-κB, Journal of Food Science and Technology, 57巻, 7号, pp. 2659-2668, 202007
  2. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles, AMINO ACIDS, 52巻, 5号, pp. 743-753, 202005
  3. The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment, SCIENTIFIC REPORTS, 9巻, 20191001
  4. Novel metabolic disturbances in marginal vitamin B-6-deficient rat heart, JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 65巻, pp. 26-34, 201903
  5. Feeding Aspergillus protease preparation combined with adequate protein diet to rats increases levels of cecum gut-protective amino acids, partially linked to Bifidobacterium and Lactobacillus, Bioscience, Biotechnology, and Biochemistry, 83巻, 10号, pp. 1901-1911, 2019, 06, 11
  6. Consumption of Low-Dose of Ethanol Suppresses Colon Tumorigenesis in 1,2-Dimethylhydrazine-Treated Rats, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 65巻, 5号, pp. 443-450, 2019
  7. High-dose D-glucosamine Consumption Increases Serum and Cecum Levels of Ammonia and Ethanol and Causes Bacterial Overgrowth in Rats, FOOD SCIENCE AND TECHNOLOGY RESEARCH, 25巻, 1号, pp. 107-113, 201901
  8. GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 316巻, 2号, pp. C162-C174, 201902
  9. Novel preventive mechanisms of vitamin B6 against inflammation, inflammasome, and chronic diseases, Molecular Nutrition: Vitamins, pp. 283-299, 201901
  10. Beneficial Effects of Dietary Tempeh Prepared with Rhizopus stolonifer on Liver Function in Rats Fed with a High-Fat Diet, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 64巻, 5号, pp. 379-383, 2018
  11. Increased intestinal ethanol following consumption of fructooligosaccharides in rats, BIOMEDICAL REPORTS, 9巻, 5号, pp. 427-432, 201811
  12. Feeding of the water extract from Ganoderma lingzhi to rats modulates secondary bile acids, intestinal microflora, mucins, and propionate important to colon cancer, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81巻, 9号, pp. 1796-1804, 2017
  13. The effects of tempe fermented with Rhizopus microsporus, Rhizopus oryzae, or Rhizopus stolonifer on the colonic luminal environment in rats, JOURNAL OF FUNCTIONAL FOODS, 49巻, pp. 162-167, 201810
  14. The effects of tempe fermented with Rhizopus microsporus, Rhizopus oryzae, or Rhizopus stolonifer on the colonic luminal environment in rats, Journal of Functional Foods, 49巻, pp. 162-167, 2018, October
  15. Production of Isoflavone Aglycone-enriched Tempeh with Rhizopus stolonifer, FOOD SCIENCE AND TECHNOLOGY RESEARCH, 24巻, 3号, pp. 493-499, MAR 2018
  16. Gender Difference and Dietary Supplemental Vitamin B-6: Impact on Colon Luminal Environment, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 64巻, 2号, pp. 116-128, 2018
  17. Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass, GENES TO CELLS, 23巻, 3号, pp. 136-145, MAR 2018
  18. Rice bran wax oleogel: A potential margarine replacement and its digestibility effect in rats fed a high-fat diet, JOURNAL OF FUNCTIONAL FOODS, 39巻, pp. 250-256, DEC 2017
  19. Consumption of an acid protease derived from Aspergillus oryzae causes bifidogenic effect in rats, NUTRITION RESEARCH, 44巻, pp. 60-66, 42948
  20. TALEN-mediated targeted editing of the GDE5 gene suppresses fibroblastic cell proliferation, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81巻, 11号, pp. 2164-2167, 2017
  21. Time-course microarrays reveal early activation of the immune transcriptome in a choline-deficient mouse model of liver injury, LIFE SCIENCES, 184巻, pp. 103-111, SEP 1 2017
  22. Identification of peptides in wheat germ hydrolysate that demonstrate calmodulin-dependent protein kinase II inhibitory activity, Food Chemistry, 213巻, pp. 329-335, 2016, December, 15
  23. Vasorelaxant effect of 5'-methylthioadenosine obtained from Candida utilis yeast extract through the suppression of intracellular Ca2+ concentration in rat isolated aorta, Journal of Agricultural and Food Chemistry, In Press巻, 2016
  24. Elution profile of di-peptides on a sulfonated ethylstyrene-divinylbenzene copolymer resin column by high-performance liquid chromatography, Analytical Sciences, 31巻, pp. 45-50, 20150110
  25. Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells, Food Chemistry, 152巻, pp. 218-224, 2014
  26. ★, Inhibition of calcium-calmodulin complex formation by vasorelaxant basic dipeptides demonstrated by in vitro and in silico analyses, Biochimica et Biophysica Acta- General Subjects, 1840巻, pp. 3073-3078, 2014

著書等出版物

  1. 2017年11月, Science within Food: Up-to-date Advances on Research and Educational Ideas, Vitamin B6: a heart-protective molecule through a novel mechanism of increasing histidine-related compounds, vitamin B6; histidine-related compounds; carnosine; histamine; heart; cardiovascular disease, Formatex Research Center, 2017年, November, 単行本(学術書), 単著, E, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Norihisa Kato, Noriyuki Yanaka and Hong C. Lai, 978-84-947512-1-9, 299
  2. 2018年01月30日, 酵母菌・麹菌・乳酸菌の産業応用展開, 麹菌由来プロテアーゼによる腸内善玉菌増加作用, 機能性食品 / 微生物 / 酵母菌 / 麹菌 / 乳酸菌 / 育種 / バイオリファイナリー / 物質生産 / 酵素 / 生理活性ペプチド / 化粧品原料 / バイオ医薬品 / 抗菌剤 / 生理活性物質 / プロバイオティクス / 細胞リプログラミング, シーエムシー, 2018年, January, 教科書, J, 加藤範久, 楊 永寿, Kumrungsee T, 978-4-7813-1317-7, 264

招待講演、口頭・ポスター発表等

  1. A new muscle atrophy model, GDE5 transgenic mice, for searching for food factors preventing sarcopenia, 小丸 拓海, 佐藤 可奈子, 矢中規之, Thanutchaporn Kumrungsee, 第53回 日本栄養·食糧学会 中国·四国支部大会(オンライン開催), 2020年10月, 通常, 日本語
  2. Muscle regeneration ability and satellite cell content in a new muscle atrophy model, GDE5 transgenic mice, 小丸 拓海, 佐藤 可奈子, 矢中規之, Thanutchaporn Kumrungsee, 日本農芸化学会2020年度 中四国支部大会(第57回講演会), 2020年09月, 通常, 日本語
  3. Vitamin B6 deficiency reduces satellite cell number in mouse skeletal muscle fibers, Thanutchaporn Kumrungsee, Kai Onishi, Takumi Komaru, Norihisa Kato, Noriyuki Yanaka, 第74回日本栄養・食糧学会大会, 2020年05月, 通常, 日本語, Tohoku University, Sendai International Center, Sendai
  4. The potential roles of vitamin B6 in satellite cell functions, Thanutchaporn Kumrungsee, Kai Onishi, Takumi Komaru, Noriyuki Yanaka, 日本農芸化学会大会2020年度大会, 2020年03月, 通常, 日本語, 九州大学福岡県
  5. We are in the age when banana, chocolate, and steak may disappear, 1. Thanutchaporn Kumrungsee, INU Student Seminar on Global Citizenship and Peace, 2018年08月10日, 招待, 英語, Hiroshima University, Hiroshima University
  6. Vitamin B6 deficiency impairs imidazole homeostasis and energy metabolism in rat heart, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, Norihisa Kato, Nutrition 2018, 2018年06月09日, 通常, 英語, American Society of Nutrition, Boston, MA, USA
  7. Agriculture and Food Innovation: Functional foods as value-added agricultural products for health promotion, Thanutchaporn Kumrungsee, Triple Helix International Seminar: Linking University-Industry-Government, 2018年03月07日, 招待, 英語, . University of Guanajuato, Guanajuato, Mexico
  8. Why is vitamin B6 important for your heart and skeletal muscle?, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, and Norihisa Kato, 2018年03月05日, 招待, 英語, Tianjin University of Science and Technology, Tianjin, China, Tianjin University of Science and Technology, Tianjin, China
  9. Vitamin B6: an underestimated compound regulating homeostasis of heart-protective peptides., Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, Norihisa Kato., The First International Conference of “Innovation of Functional Foods in Asia (IFFA), 2018年01月22日, 通常, 英語, Phayao, Thailand
  10. A possible novel mechanism underlying heart-protective effects of vitamin B6, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, and Norihisa Kato, 46th Annual Meeting of Food and Agriculture Panel United States-Japan Cooperative Program in Natural Resources (UJNR), 2017年11月11日, 招待, 英語, Hiroshima, Japan
  11. Decreased levels of putative heart protective metabolites in heart tissues of rats fed a vitamin B6 deficient diet: a metabolomics approach, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, and Norihisa Kato, 22nd International Conference of Functional Food Center, 2017年09月22日, 通常, 英語, Boston, MA, USA
  12. Challenging of finding a new type of calmodulin inhibitors, Thanutchaporn Kumrungsee, Noriyuki Yanaka, 22nd International Conference of Functional Food Center, 2017年09月22日, 通常, 英語, Boston, MA, USA
  13. Histidine-related compounds as possible key mediators underlying a heart-protective effect of vitamin B6, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Norihisa Kato, International Congress on Carnosine and Anserine, 2017年09月12日, 通常, 英語, Louisville, KY, USA
  14. Vitamin B6: A heart protective molecule through a novel mechanism, Thanutchaporn Kumrungsee, 2017 年度(第21回)生物機能研究会, 2017年06月17日, 招待, 英語, Hiroshima University, Higashi-shiroshima
  15. フラクトオリゴ糖摂取ラットの大腸内容物、及 び組織のエタノールの増加, Thanutchaporn Kumrungsee、山口 将大 、 Yongshou Yang、加藤 範久, The 71st Annual Meeting of the Japan Society of Nutrition and Food Science, 2017年05月19日, 通常, 日本語, The Japan Society of Nutrition and Food Science, Ginowann city, Okinawa
  16. Calmodulin-dependent protein kinase II inhibitory compounds derived from foodstuffs and their possible role in vascular protection, Thanutchaporn Kumrungsee, Tomomi Saiki, Masato Omae, Kazuhiro Hamasawa, Toshiro Matsui, Norihisa Kato, BIT 5th Annual World Congress of Food and Nutrition, 2016年11月18日, 通常, 英語, BIT Congress, Kaohsiung, Taiwan
  17. Bioactive compounds in yeast extract and their role in the regulation of blood vessel contraction, Thanutchaporn Kumrungsee, Tomomi Saiki, Masato Omae, Kazuhiro Hamasawa, Toshiro Matsui, Norihisa Kato, The Food Factor I Barcelona Conference, 2016年11月02日, 通常, 英語, Formatex Research Center, Barcelona, Spain
  18. Novel active peptides derived from wheat germ hydrolysate as putative nutraceuticals preventing calmodulin-dependent protein kinase II associated diseases, Thanutchaporn Kumrungsee, Toshiro Matsui, Norihisa Kato, 17th International Nutrition & Diagnostics Conference, 2016年10月03日, 通常, 英語, Institute of Nutrition and Diagnostics Pardubice, Prague, Czech Republic
  19. Novel food-derive compounds as potent nutraceuticals for preventing vascular-related diseases, Thanutchaporn KUMRUNGSEE, 2016年07月21日, 招待, 英語, aculty of Agro-Industry, Department of Food Science and Technology, Kasetsart University, Faculty of Agro-Industry, Department of Food Science and Technology, Kasetsart University
  20. A novel bioactive compound derived from yeast extract as a potent nutraceutical for preventing vascular-related diseases, Thanutchaporn Kumrungsee, Tomomi Saiki, Masato Omae, Kazuhiro Hamasawa, Toshiro Matsui, Norihisa Kato, 2nd International Conference on Nutraceuticals and Nutrition Supplements, 2016年07月18日, 通常, 英語, Conference Series LLC, Bangkok, Thailand
  21. Food factors for health promotion and disease prevention, Thanutchaporn KUMRUNGSEE, 生物圏科学研究科セミナー, 2016年07月11日, 招待, 英語, Graduate School of Biosphere Science, Hiroshima University, Graduate School of Biosphere Science, Hiroshima University

受賞

  1. 2019年11月04日, Young Investigator Award (to Kanako Sato, Master student), The 7th International Conference on Food Factors, γ-Aminobutyric acid induces biosynthesis of a novel imidazole peptide in skeletal muscle
  2. 2016年07月18日, Phenomenal and worthy oral presentation, 2nd International Conference on Nutraceuticals and Nutrition Supplements, A novel bioactive compound derived from yeast extract as a potent nutraceutical for preventing vascular-related diseases

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業(若手研究), ホモカルノシンを骨格筋において増加させる新規手法およびその生理機能の探索, 2018年, 2020年
  2. 平成30年度女性研究者国際共同研究助成金, 2018年11月01日, 2019年09月30日