田中 茂SHIGERU TANAKA
Last Updated :2024/12/11
- 所属・職名
- 大学院医系科学研究科(医) 准教授
- ホームページ
- メールアドレス
- tanakamdhiroshima-u.ac.jp
- 自己紹介
- 恒常的活性化型受容体GPR3に関する基礎研究と脳梗塞・緑内障・多発性硬化症など病態との関連を研究しています。
基本情報
学位
教育担当
- 【学士課程】 医学部 : 医学科 : 医学プログラム
- 【博士課程前期】 医系科学研究科 : 総合健康科学専攻 : 生命医療科学プログラム
- 【博士課程後期】 医系科学研究科 : 総合健康科学専攻 : 生命医療科学プログラム
- 【博士課程】 医系科学研究科 : 医歯薬学専攻 : 医学専門プログラム
研究分野
- 医歯薬学 / 基礎医学 / 薬理学一般
- 医歯薬学 / 内科系臨床医学 / 神経内科学
研究キーワード
- 脳梗塞
- G蛋白共役型受容体
- 神経細胞保護
- オートファジー
所属学会
- 日本薬理学会
- 日本神経科学学会
- 米国神経科学学会
- 日本神経化学学会
- 日本脳卒中学会
- 日本脳循環代謝学会
- 日本内科学会
- 日本神経学会
- 日本脳神経超音波学会
- 日本分子生物学学会
教育活動
授業担当
- 2024年, 学部専門, 通年, 生体反応学
研究活動
学術論文(★は代表的な論文)
- Protein kinase C (PKC) inhibitor Calphostin C activates PKC in a light-dependent manner at high concentrations via the production of singlet oxygen, EUROPEAN JOURNAL OF PHARMACOLOGY, 984巻, 20241205
- S-Palmitoylation of the serotonin transporter promotes its cell surface expression and serotonin uptake, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 662巻, pp. 58-65, 20230625
- Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells, FRONTIERS IN PHARMACOLOGY, 14巻, 20231107
- Identification of protein kinase C domains involved in its translocation induced by propofol, EUROPEAN JOURNAL OF PHARMACOLOGY, 955巻, 20230915
- P2Y2 receptor mediates dying cell removal via inflammatory activated microglia, JOURNAL OF PHARMACOLOGICAL SCIENCES, 153巻, 1号, pp. 55-67, 202309
- GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice, NEUROBIOLOGY OF DISEASE, 172巻, 20221001
- ★, Potential role of inducible GPR3 expression under stimulated T cell conditions, JOURNAL OF PHARMACOLOGICAL SCIENCES, 148巻, 3号, pp. 307-314, 202203
- ★, GPR3 accelerates neurite outgrowth and neuronal polarity formation via PI3 kinase-mediating signaling pathway in cultured primary neurons, MOLECULAR AND CELLULAR NEUROSCIENCE, 118巻, 20220101
- ★, Detailed neuronal distribution of GPR3 and its co-expression with EF-hand calcium-binding proteins in the mouse central nervous system, BRAIN RESEARCH, 1750巻, 20210101
- Evaluation of the Effectiveness of Post-Stroke Metformin Treatment Using Permanent Middle Cerebral Artery Occlusion in Rats, PHARMACEUTICALS, 14巻, 4号, 202104
- ★, Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli, NEUROBIOLOGY OF DISEASE, 68巻, pp. 215-227, 2014
- ★, The Gs-Linked Receptor GPR3 Inhibits the Proliferation of Cerebellar Granule Cells during Postnatal Development, PLOS ONE, 4巻, 6号, 2009
- Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant, JOURNAL OF PHARMACOLOGICAL SCIENCES, 148巻, 1号, pp. 187-195, 202201
- Role of the E3 ubiquitin ligase HRD1 in the regulation of serotonin transporter function, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 534巻, pp. 583-589, 20210101
- Syntaxin 3 interacts with serotonin transporter and regulates its function, JOURNAL OF PHARMACOLOGICAL SCIENCES, 145巻, 4号, pp. 297-307, 202104
- Component of nicotine-induced intracellular calcium elevation mediated through alpha 3-and alpha 5-containing nicotinic acetylcholine receptors are regulated by cyclic AMP in SH-SY 5Y cells, PLOS ONE, 15巻, 11号, 20201130
- Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria, EUROPEAN JOURNAL OF PHARMACOLOGY, 884巻, 20201005
- Histone deacetylase 10 knockout activates chaperone-mediated autophagy and accelerates the decomposition of its substrate, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 523巻, 1号, pp. 246-252, 20200226
- SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism, JOURNAL OF PHARMACOLOGICAL SCIENCES, 139巻, 1号, pp. 29-36, 2019
- Spinocerebellar ataxia type 14 caused by a nonsense mutation in the PRKCG gene, MOLECULAR AND CELLULAR NEUROSCIENCE, 98巻, pp. 46-53, 2019
- The Role of Cysteine String Protein alpha Phosphorylation at Serine 10 and 34 by Protein Kinase C gamma for Presynaptic Maintenance, JOURNAL OF NEUROSCIENCE, 38巻, 2号, pp. 278-290, 2018
- Propofol induced diverse and subtype-specific translocation of PKC families, JOURNAL OF PHARMACOLOGICAL SCIENCES, 137巻, 1号, pp. 20-29, 2018
- Modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in Alzheimer's disease - Hyperphosphorylation and cleavage of 4-and 3-repeat tau, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 37巻, 7号, pp. 2441-2457, 2017
- The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling, NEUROCHEMISTRY INTERNATIONAL, 93巻, pp. 82-94, 2016
- Discovery and characterization of GPR6 inverse agonists, FASEB JOURNAL, 28巻, 1号, 2014
- A Brain-specific Grb2-associated Regulator of Extracellular Signal-regulated Kinase (Erk)/Mitogen-activated Protein Kinase (MAPK) (GAREM) Subtype, GAREM2, Contributes to Neurite Outgrowth of Neuroblastoma Cells by Regulating Erk Signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 288巻, 41号, pp. 29934-29942, 2013
著書等出版物
- 2014年, 最新臨床脳卒中学, 虚血による神経障害の分子メカニズム オートファジー, 脳梗塞
オートファジー, 日本臨床, 2014年, 7, その他, 共著, 田中茂、土肥栄祐、酒井規雄, 735, 106-110
- 2012年, 分子脳血管病, オートファジー制御と脳梗塞再生療法, 脳梗塞
オートファジー, 先端医学社, 2012年, その他, 共著
- 2018年, 脳卒中病態学のススメ, 単行本(学術書), 共著