村上 英介EISUKE MURAKAMI

Last Updated :2026/07/07

所属・職名
大学院医系科学研究科(医) 寄附講座准教授
メールアドレス
emusukehiroshima-u.ac.jp

基本情報

主な職歴

  • 2015年04月01日, 2017年03月31日, 広島市立安佐市民病院, 副部長
  • 2017年04月01日, 2024年03月31日, 広島大学, 病院, 助教
  • 2024年04月01日, 2026年06月31日, 広島大学, 病院, 講師

学歴

  • 広島大学, 大学院医歯薬学総合研究科, 博士課程創生医科学専攻, 日本, 2010年04月, 2014年09月
  • 広島大学, 医学部, 医学科, 日本, 1998年04月, 2004年03月

学位

  • 博士(医学) (広島大学)

教育担当

  • 【学士課程】 医学部 : 医学科 : 医学プログラム
  • 【学士課程】 歯学部 : 歯学科 : 歯学プログラム
  • 【博士課程】 医系科学研究科 : 医歯薬学専攻 : 医学専門プログラム

研究分野

  • 医歯薬学 / 内科系臨床医学 / 消化器内科学

所属学会

  • 日本肝臓学会
  • 日本消化器病学会
  • 日本消化器内視鏡学会
  • 日本内科学会

教育活動

授業担当

  1. 2026年, 学部専門, 通年, 器官・システム病態制御学I
  2. 2026年, 学部専門, 集中, 臨床実習入門プログラム
  3. 2026年, 学部専門, 集中, 臨床実習I
  4. 2026年, 学部専門, 集中, 臨床実習II
  5. 2026年, 学部専門, セメスター(前期), 内科学I
  6. 2026年, 博士課程・博士課程後期, セメスター(前期), 消化器内科学特別演習
  7. 2026年, 博士課程・博士課程後期, セメスター(後期), 消化器内科学特別演習
  8. 2026年, 博士課程・博士課程後期, セメスター(前期), 消化器内科学特別研究
  9. 2026年, 博士課程・博士課程後期, セメスター(後期), 消化器内科学特別研究

研究活動

学術論文(★は代表的な論文)

  1. The Efficacy and Safety of Atezolizumab Plus Bevacizumab after Durvalumab Plus Tremelimumab for the Treatment of Hepatocellular Carcinoma, INTERNAL MEDICINE, 65巻, 8号, pp. 1083-1089, 2026
  2. A Study on the Association Between Treatment Response to Atezolizumab Plus Bevacizumab Combination Therapy for Advanced Hepatocellular Carcinoma and Gut Microbiota, MICROORGANISMS, 14巻, 4号, 20260412
  3. Machine Learning Approach Enables Highly Accurate Identification of At-Risk Metabolic Dysfunction-Associated Steatohepatitis, HEPATOLOGY RESEARCH, 56巻, 5号, pp. 753-761, 202605
  4. Efficacy and Safety of Second-Line Lenvatinib After First-Line Durvalumab Plus Tremelimumab in Unresectable Hepatocellular Carcinoma, HEPATOLOGY RESEARCH, 56巻, 5号, pp. 861-866, 202605
  5. Association between diabetes mellitus and impaired single-leg stance in patients with chronic liver disease: A cross-sectional study, PLOS ONE, 21巻, 3号, 20260324
  6. AI-based phenotyping of hepatic fiber morphology to inform molecular alterations in metabolic dysfunction-associated steatotic liver disease, HEPATOLOGY, 83巻, 3号, pp. 575-590, 202603
  7. Utility of Serum HBV RNA Measurement During Nucleoside/Nucleotide Analog Therapy in Chronic Hepatitis B Patients, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 26巻, 20号, 20251018
  8. First-Line Durvalumab plus Tremelimumab Treatment for Unresectable Hepatocellular Carcinoma in Real-World Clinical Practice, ONCOLOGY, 103巻, 8号, pp. 742-747, 202508
  9. Metabolic dysfunction-associated steatotic liver disease affects the development of hepatocellular carcinoma after sustained virologic response in chronic hepatitis C patients, JOURNAL OF GASTROENTEROLOGY, 60巻, 8号, pp. 1014-1025, 202508
  10. Pharmacist intervention through protocol-based pharmacotherapy management is effective to ensure safety in invasive procedures for chronic liver disease, JOURNAL OF PHARMACEUTICAL HEALTH CARE AND SCIENCES, 11巻, 1号, 20250814
  11. Comparison of Differentially Expressed Genes in Human Versus in Chimeric Mouse Livers Following HBV Infection, LIVERS, 5巻, 2号, 20250414
  12. Clinical Significance of Small-Bowel Mucosal Changes in Liver Cirrhosis Patients With Suspected Small-Bowel Bleeding: A Capsule Endoscopy Study, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 40巻, 7号, pp. 1736-1744, 202507
  13. Analysis of the treatment outcome of duodenal varices: A retrospective case series of 15 patients from a single institution, DEN Open, 5巻, 1号, pp. e70119, 20250416
  14. Analysis of the treatment outcome of duodenal varices: A retrospective case series of 15 patients from a single institution, DEN OPEN, 5巻, 1号, 202504
  15. Usefulness of serum HBV RNA levels for predicting antiviral response to entecavir treatment in patients with chronic hepatitis B, JOURNAL OF GASTROENTEROLOGY, 60巻, 4号, pp. 469-478, 202504
  16. Serum IL-6 concentration is a useful biomarker to predict the efficacy of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma, JOURNAL OF GASTROENTEROLOGY, 60巻, 3号, pp. 328-339, 202503
  17. Deep learning and digital pathology powers prediction of HCC development in steatotic liver disease, HEPATOLOGY, 81巻, 3号, pp. 976-989, 202503
  18. Multiomics Analysis of Liver Molecular Dysregulation Leading to Nonviral-Related Hepatocellular Carcinoma Development, JOURNAL OF PROTEOME RESEARCH, 24巻, 3号, pp. 1102-1117, 20250221
  19. Impact of viral eradication by direct-acting antivirals on clinical outcomes after curative treatment for hepatitis C virus-associated hepatocellular carcinoma, THERAPEUTIC ADVANCES IN GASTROENTEROLOGY, 18巻, 2025
  20. A case of complete response to radiotherapy combined with durvalumab and tremelimumab in a patient with unknown primary hepatocellular carcinoma arising in the lumbar spine, CLINICAL JOURNAL OF GASTROENTEROLOGY, 18巻, 1号, pp. 107-113, 202502
  21. Prediction of Hepatocellular Carcinoma After Hepatitis C Virus Sustained Virologic Response Using a Random Survival Forest Model, JCO CLINICAL CANCER INFORMATICS, 8巻, 202412
  22. Significance of changes in tumor markers in patients treated with durvalumab plus tremelimumab combination therapy as a surrogate marker for tumor response to unresectable hepatocellular carcinoma, HEPATOLOGY RESEARCH, 55巻, 1号, pp. 149-154, 202501
  23. Alteration of Gene Expression After Entecavir and Pegylated Interferon Therapy in HBV-Infected Chimeric Mouse Liver, VIRUSES-BASEL, 16巻, 11号, 202411
  24. Value of autotaxin for hepatocellular carcinoma risk assessment in chronic hepatitis B patients treated with nucleos(t)ide analogs, HEPATOLOGY RESEARCH, 54巻, 11号, pp. 981-992, 202411
  25. The Hepatitis B Virus PreS1/HBsAg Ratio Is a Predictive Marker for the Occurrence of Hepatocellular Carcinoma, LIVERS, 4巻, 3号, pp. 364-376, 202409
  26. Useful Predictor for Exacerbation of Esophagogastric Varices after Hepatitis C Virus Eradication by Direct-Acting Antivirals, LIVERS, 4巻, 3号, pp. 352-363, 202409
  27. Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease, SCIENTIFIC REPORTS, 14巻, 1号, 20240321
  28. Predictive factors of portal hypertensive enteropathy exacerbations based on long-term outcomes, BMC GASTROENTEROLOGY, 24巻, 1号, 20240826
  29. Real-world efficacy and safety of durvalumab-tremelimumab as second-line systemic therapy after atezolizumab-bevacizumab in unresectable hepatocellular carcinoma, MEDICINE, 103巻, 34号, 20240823
  30. Integrator complex subunit 6 promotes hepatocellular steatosis via (3-catenin-PPARγ axis, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1869巻, 7号, 202410
  31. Impact of MAFLD criteria on postoperative recurrence of non-B, non-C HCC, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 36巻, 4号, pp. 430-437, 202404
  32. Peripheral T Cell Subpopulations as a Potential Surrogate Biomarker during Atezolizumab plus Bevacizumab Treatment for Hepatocellular Carcinoma, CANCERS, 16巻, 7号, 202404
  33. The Analysis of Muscle Volume Measured by Bioelectrical Impedance in Patients with Hepatocellular Carcinoma Treated with First-Line Atezolizumab plus Bevacizumab Combination Therapy or First-Line Lenvatinib, ONCOLOGY, 101巻, 8号, pp. 491-501, 202308
  34. Efficacy and safety of atezolizumab plus bevacizumab in patients with portal hypertension for unresectable hepatocellular carcinoma, CANCER MEDICINE, 13巻, 5号, 202403
  35. Clinical Outcomes of Switching from Zoledronic Acid to Denosumab for the Management of Severe Bone Metastasis from Hepatocellular Carcinoma: A Single-Center, Open-Label, Prospective Intervention Trial, YONAGO ACTA MEDICA, 66巻, 4号, pp. 422-431, 202311
  36. Therapeutic Efficacy and Safety of Lenvatinib after Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma, CANCERS, 15巻, 22号, 202311
  37. Lenvatinib activates anti-tumor immunity by suppressing immunoinhibitory infiltrates in the tumor microenvironment of advanced hepatocellular carcinoma, COMMUNICATIONS MEDICINE, 3巻, 1号, 20231025
  38. Risk factors for Early onset of Proteinuria in Patients Receiving Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma., LIVER CANCER, 12巻, 3号, pp. 251-261, 202308
  39. Serum interleukin-6 level predicts the prognosis for patients with alcohol-related acute-on-chronic liver failure, HEPATOLOGY INTERNATIONAL, 17巻, 5号, pp. 1225-1232, 202310
  40. Correlation between serum pro-inflammatory cytokine levels and the prognosis of the patients with acute liver failure, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 38巻, 9号, pp. 1637-1646, 202309
  41. Association of Hepatobiliary Phase of Gadoxetic-Acid-Enhanced MRI Imaging with Immune Microenvironment and Response to Atezolizumab Plus Bevacizumab Treatment, CANCERS, 15巻, 17号, 202309
  42. Sodium-glucose cotransporter-2 inhibitors improve FibroScan-aspartate aminotransferase scores in patients with nonalcoholic fatty liver disease complicated by type 2 diabetes, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 35巻, 9号, pp. 989-996, 202309
  43. Successful Lenvatinib Re-challenge following Atezolizumab Plus Bevacizumab Combination Therapy Failure for Unresectable Hepatocellular Carcinoma, INTERNAL MEDICINE, 62巻, 12号, pp. 1771-1774, 2023
  44. Impact and usefulness of the transition to the new MAFLD classification for non-B, non-C HCC: a retrospective cohort study, BMC GASTROENTEROLOGY, 23巻, 1号, 20230628
  45. Evaluation of Response to Atezolizumab Plus Bevacizumab in Patients with Advanced Hepatocellular Carcinoma Using the Combination of Response Evaluation Criteria in Solid Tumors and Alpha-Fetoprotein, CANCERS, 15巻, 8号, 202304
  46. Hepatitis B Virus (HBV) Upregulates TRAIL-R3 Expression in Hepatocytes Resulting in Escape From Both Cell Apoptosis and Suppression of HBV Replication by TRAIL, JOURNAL OF INFECTIOUS DISEASES, 227巻, 5号, pp. 686-695, 20230301
  47. Acute liver injury in a non-alcoholic fatty liver disease patient with chloroform exposure: a case report, CLINICAL JOURNAL OF GASTROENTEROLOGY, 16巻, 2号, pp. 250-253, 202304
  48. Effectiveness of Repeated Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma-Consideration of the Locations of Target Lesions, CANCERS, 15巻, 3号, 202302
  49. Evaluation of atezolizumab plus bevacizumab combination therapy for hepatocellular carcinoma using contrast-enhanced ultrasonography, JOURNAL OF MEDICAL ULTRASONICS, 50巻, 1号, pp. 57-62, 202301
  50. Hepatic venous pressure gradient after balloon-occluded retrograde transvenous obliteration and liver stiffness measurement predict the prognosis of patients with gastric varices, BMC GASTROENTEROLOGY, 22巻, 1号, 20221222
  51. The presence of vessels encapsulating tumor clusters is associated with an immunosuppressive tumor microenvironment in hepatocellular carcinoma, INTERNATIONAL JOURNAL OF CANCER, 151巻, 12号, pp. 2278-2290, 20221215
  52. Molecular Signature Predictive of Long-Term Liver Fibrosis Progression to Inform Antifibrotic Drug Development, GASTROENTEROLOGY, 162巻, 4号, pp. 1210-1225, 202204
  53. The effect of the skin-liver capsule distance on the accuracy of ultrasound diagnosis for liver steatosis and fibrosis, JOURNAL OF MEDICAL ULTRASONICS, 49巻, 3号, pp. 443-450, 202207
  54. Calcium channel blockers improve the prognosis of patients with intrahepatic cholangiocarcinoma after resection, JOURNAL OF GASTROENTEROLOGY, 57巻, 9号, pp. 676-683, 202209
  55. The importance of body composition assessment for patients with advanced hepatocellular carcinoma by bioelectrical impedance analysis in lenvatinib treatment, PLOS ONE, 17巻, 1号, 20220118
  56. Efficacy and safety of chemoradiation therapy using one-shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion: a single-arm retrospective cohort study, BMC GASTROENTEROLOGY, 22巻, 1号, 20220602
  57. Construction of an anti-hepatitis B virus preS1 antibody and usefulness of preS1 measurement for chronic hepatitis B patients Anti-HBV PreS1 antibody, JOURNAL OF INFECTION, 84巻, 3号, pp. 391-399, 202203
  58. Benign Recurrent Intrahepatic Cholestasis Type 1 with Novel Nonsense Mutations in the ATP8B1 Gene, CASE REPORTS IN GASTROENTEROLOGY, 16巻, 1号, pp. 110-115, 2022
  59. Underestimation of impaired glucose tolerance and usefulness of a continuous glucose monitoring system in chronic liver disease, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 37巻, 3号, pp. 592-599, 202203
  60. Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin., Antimicrobial Agents and Chemotherapy, 58巻, 4号, pp. 2105-2112, 20140127
  61. ★, Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones., Journal of infection, 72巻, 1号, pp. 91-102, 20151026
  62. Hepatic arterial infusion chemotherapy using 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma in combination with or without three-dimensional conformal radiotherapy to venous tumor thrombosis in hepatic vein or inferior vena cava., Hepatology Research, 42巻, 5号, pp. 442-453, 20111116
  63. Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS, SCIENTIFIC REPORTS, 7巻, 20170831
  64. Clinical outcomes of stereotactic body radiotherapy for elderly patients with hepatocellular carcinoma, HEPATOLOGY RESEARCH, 48巻, 2号, pp. 193-204, 201802
  65. Comparison of Outcome of Hepatic Arterial Infusion Chemotherapy Combined with Radiotherapy and Sorafenib for Advanced Hepatocellular Carcinoma Patients with Major Portal Vein Tumor Thrombosis, ONCOLOGY, 94巻, 4号, pp. 215-222, 2018
  66. Hepatic arterial infusion chemotherapy followed by sorafenib in patients with advanced hepatocellular carcinoma (HICS 55): an open label, non-comparative, phase II trial, BMC CANCER, 18巻, 20180604
  67. Clinical outcomes of sorafenib treatment failure for advanced hepatocellular carcinoma and candidates for regorafenib treatment in real-world practice, HEPATOLOGY RESEARCH, 48巻, 10号, pp. 814-820, 201809
  68. Comparison of clinical outcome of hepatic arterial infusion chemotherapy and sorafenib for advanced hepatocellular carcinoma according to macrovascular invasion and transcatheter arterial chemoembolization refractory status, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33巻, 10号, pp. 1780-1786, 201810
  69. Advanced liver fibrosis effects on the response to sofosbuvir-based antiviral therapies for chronic hepatitis C, JOURNAL OF MEDICAL VIROLOGY, 90巻, 12号, pp. 1834-1840, 201812
  70. Early experience of seven hepatocellular carcinoma cases treated with regorafenib, CLINICAL CASE REPORTS, 6巻, 11号, pp. 2217-2223, 201811
  71. CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients, JOURNAL OF VIRAL HEPATITIS, 25巻, 12号, pp. 1555-1564, 201812
  72. Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes, VIROLOGY, 525巻, pp. 48-61, 201812
  73. Comparison of hepatic arterial infusion chemotherapy between 5-fluorouracil-based continuous infusion chemotherapy and low-dose cisplatin monotherapy for advanced hepatocellular carcinoma, HEPATOLOGY RESEARCH, 48巻, 13号, pp. 1118-1130, 201812
  74. The association between serum cytokine and chemokine levels and antiviral response by entecavir treatment in chronic hepatitis B patients, ANTIVIRAL THERAPY, 23巻, 3号, pp. 239-248, 2018
  75. Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures, JOURNAL OF GASTROENTEROLOGY, 54巻, 3号, pp. 291-296, 201903
  76. Levocarnitine Use Is Associated With Improvement in Sarcopenia in Patients With Liver Cirrhosis, HEPATOLOGY COMMUNICATIONS, 3巻, 3号, pp. 348-355, 201903
  77. Reduction of hepatitis B surface antigen in sequential versus add-on pegylated interferon to nucleoside/nucleotide analogue therapy in HBe-antigen-negative chronic hepatitis B patients: a pilot study, ANTIVIRAL THERAPY, 23巻, 8号, pp. 639-646, 2018
  78. Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice, JOURNAL OF GASTROENTEROLOGY, 54巻, 7号, pp. 650-659, 201907
  79. Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice, JOURNAL OF GENERAL VIROLOGY, 100巻, 7号, pp. 1123-1131, 201907
  80. Percutaneous transvenous shunt occlusion for portosystemic encephalopathy due to lenvatinib administration to a patient with hepatocellular carcinoma and portosystemic shunt, CLINICAL JOURNAL OF GASTROENTEROLOGY, 12巻, 4号, pp. 341-346, 201908
  81. Correlation between Early Tumor Marker Response and Imaging Response in Patients with Advanced Hepatocellular Carcinoma Treated with Lenvatinib, ONCOLOGY, 97巻, 2号, pp. 75-81, 2019
  82. Early changes in ammonia levels and liver function in patients with advanced hepatocellular carcinoma treated by lenvatinib therapy, SCIENTIFIC REPORTS, 9巻, 20190820
  83. Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis, BMC GASTROENTEROLOGY, 19巻, 1号, 20191024
  84. Management of refractory ascites attenuates muscle mass reduction and improves survival in patients with decompensated cirrhosis, JOURNAL OF GASTROENTEROLOGY, 55巻, 2号, pp. 217-226, 202002
  85. Preoperative PET-CT is useful for predicting recurrent extrahepatic metastasis of hepatocellular carcinoma after resection, EUROPEAN JOURNAL OF RADIOLOGY, 124巻, 202003
  86. Successful retreatment with 12 weeks of glecaprevir and pibrentasvir for a genotype 2a HCV-infected hemodialysis patient who failed to respond to 8 weeks of prior glecaprevir and pibrentasvir therapy, CLINICAL JOURNAL OF GASTROENTEROLOGY, 13巻, 2号, pp. 267-270, 202004
  87. Three Children Treated with Direct-acting Antivirals for Chronic Hepatitis C Virus Genotype 1b Infection, INTERNAL MEDICINE, 59巻, 7号, pp. 941-944, 2020
  88. Skeletal Muscle Loss during Tyrosine Kinase Inhibitor Treatment for Advanced Hepatocellular Carcinoma Patients, LIVER CANCER, 9巻, 2号, pp. 148-155, 202004
  89. Isolated cardiac metastases of hepatocellular carcinoma after resection: a case report, CLINICAL JOURNAL OF GASTROENTEROLOGY, 13巻, 3号, pp. 421-427, 202006
  90. Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receiving lenvatinib, THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 12巻, 202005
  91. Incidence of microsatellite instability-high hepatocellular carcinoma among Japanese patients and response to pembrolizumab, HEPATOLOGY RESEARCH, 50巻, 7号, pp. 885-888, 202007
  92. Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma, CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, 11巻, 202005
  93. Risk factors for histological progression of non-alcoholic steatohepatitis analyzed from repeated biopsy cases, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 35巻, 8号, pp. 1412-1419, 202008
  94. Treatment outcomes after splenectomy with gastric devascularization or balloon-occluded retrograde transvenous obliteration for gastric varices: a propensity score-weighted analysis from a single institution, JOURNAL OF GASTROENTEROLOGY, 55巻, 9号, pp. 877-887, 202009
  95. A case of advanced HCC treated with lenvatinib after hepatic arterial infusion chemotherapy combined with radiation therapy treatment for portal vein tumor thrombosis in the main trunk, CLINICAL JOURNAL OF GASTROENTEROLOGY, 13巻, 5号, pp. 839-843, 202010
  96. Complete response to pembrolizumab in advanced hepatocellular carcinoma with microsatellite instability, CLINICAL JOURNAL OF GASTROENTEROLOGY, 13巻, 5号, pp. 867-872, 202010
  97. Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C infection, BMC GASTROENTEROLOGY, 20巻, 1号, 20200925
  98. Trends in Hepatic Functional Reserve of Patients with Hepatocellular Carcinoma Treated with Tyrosine Kinase Inhibitors, ONCOLOGY, 98巻, 10号, pp. 727-733, 202010
  99. Analysis of Post-Progression Survival in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib, ONCOLOGY, 98巻, 11号, pp. 787-797, 202011
  100. Impact of viral eradication by direct-acting antivirals on the risk of hepatocellular carcinoma development, prognosis, and portal hypertension in hepatitis C virus-related compensated cirrhosis patients, HEPATOLOGY RESEARCH, 50巻, 11号, pp. 1222-1233, 202011
  101. Real-world efficacy of sofosbuvir plus velpatasvir therapy for patients with hepatitis C virus-related decompensated cirrhosis, HEPATOLOGY RESEARCH, 50巻, 11号, pp. 1234-1243, 202011
  102. Abatacept treatment for patients with severe acute hepatitis caused by hepatitis B virus infection-Pilot study, JOURNAL OF VIRAL HEPATITIS, 28巻, 2号, pp. 400-409, 202102
  103. Signal Activation of Hepatitis B Virus-Related Hepatocarcinogenesis by Up-regulation of SUV39h1, JOURNAL OF INFECTIOUS DISEASES, 222巻, 12号, pp. 2061-2070, 20201215
  104. A case with life-threatening secondary sclerosing cholangitis caused by nivolumab, CLINICAL JOURNAL OF GASTROENTEROLOGY, 14巻, 1号, pp. 283-287, 202102
  105. Hepatic Arterial Infusion Chemotherapy Combined with Radiation Therapy for Advanced Hepatocellular Carcinoma with Tumor Thrombosis of the Main Trunk or Bilobar of the Portal Vein, LIVER CANCER, 10巻, 2号, pp. 151-160, 202104
  106. A case of acute liver failure with echovirus infection diagnosed by a multi-virus real-time PCR system, IDCASES, 23巻, 2021
  107. Comparison of the Clinical Outcome of Ramucirumab for Unresectable Hepatocellular Carcinoma with That of Prior Tyrosine Kinase Inhibitor Therapy, ONCOLOGY, 99巻, 5号, pp. 327-335, 202104
  108. yRibavirin induces hepatitis C virus genome mutations in chronic hepatitis patients who failed to respond to prior daclatasvir plus asunaprevir therapy, JOURNAL OF MEDICAL VIROLOGY, 92巻, 2号, pp. 210-218, 202002
  109. Novel drug resistance-associated substitutions against pibrentasvir emerged in genotype 1b hepatitis C virus-infected human hepatocyte transplanted mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 559巻, pp. 78-83, 20210625
  110. In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism, MOLECULAR MEDICINE REPORTS, 23巻, 1号, 202101
  111. Extracellular water to total body water ratio obtained by bioelectrical impedance analysis determines the dose intensity of lenvatinib for the treatment of patients with advanced hepatocellular carcinoma, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 36巻, 6号, pp. 1685-1693, 202106
  112. Identification and monitoring of mutations in circulating cell-free tumor DNA in hepatocellular carcinoma treated with lenvatinib, JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 40巻, 1号, 20210626
  113. Therapeutic effects of sleeve gastrectomy for non-alcoholic steatohepatitis estimated by paired liver biopsy in morbidly obese Japanese patients, MEDICINE, 100巻, 26号, 20210702
  114. Complete Response for Advanced Hepatocellular Carcinoma by Conversion Surgery Therapy Following a Good Response of Regorafenib Despite Rapid Progressive Disease with Sorafenib, INTERNAL MEDICINE, 60巻, 13号, pp. 2047-2053, 2021
  115. Efficacy and Safety of Lenvatinib-Transcatheter Arterial Chemoembolization Sequential Therapy for Patients with Intermediate-Stage Hepatocellular Carcinoma, ONCOLOGY, 99巻, 8号, pp. 507-517, 202107
  116. Clinical Outcomes of 2nd-and 3rd-Line Regorafenib for Advanced Hepatocellular Carcinoma, ONCOLOGY, 99巻, 8号, pp. 491-498, 202107
  117. Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: single-institution 20-year study, BMC GASTROENTEROLOGY, 21巻, 1号, 20210731
  118. Serum PreS1 and HBsAg ratio reflects liver fibrosis and predicts the development of hepatocellular carcinoma in chronic hepatitis B patients, JOURNAL OF VIRAL HEPATITIS, 28巻, 9号, pp. 1304-1311, 202109
  119. In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism., Mol Med Rep ., 23巻, 1号, pp. 16, 2021
  120. Therapeutic effects of sleeve gastrectomy for non-alcoholic steatohepatitis estimated by paired liver biopsy in morbidly obese Japanese patients., Medicine (Baltimore), 100巻, 26号, 2021
  121. Early Tumor Response and Safety of Atezolizumab Plus Bevacizumab for Patients with Unresectable Hepatocellular Carcinoma in Real-World Practice, CANCERS, 13巻, 16号, 202108
  122. Advanced hepatocellular carcinoma with response to lenvatinib after atezolizumab plus bevacizumab, MEDICINE, 100巻, 42号, 20211022
  123. Analysis of Survival and Response to Lenvatinib in Unresectable Hepatocellular Carcinoma, CANCERS, 14巻, 2号, 202201

招待講演、口頭・ポスター発表等

  1. 非代償性肝硬変症の長期観察例の予後因子の解析, 第46回日本肝臓学会西部会, 2025年12月04日, 通常, 日本語
  2. ELFスコアと代謝機能障害関連脂肪肝炎の肝関連合併症に関する解析, 第32回日本門脈圧亢進症学会総会, 2025年09月11日, 通常, 日本語
  3. 非B非C型非代償性肝硬変症例の予後解析, 第60回日本肝臓学会総会, 2024年06月13日, 通常, 日本語
  4. 非代償性肝硬変症の予後因子としての門脈圧亢進症治療, 第110回日本消化器病学会総会, 2024年05月09日, 通常, 日本語
  5. 門脈圧亢進症に対する治療介入を行った 肝硬変症例における筋肉量評価, 第29回日本門脈圧亢進症学会総会, 2022年09月09日, 通常, 日本語
  6. 脳症ないしは腹水を合併した非代償性肝硬変症に対する内服治療と予後の解析, 第59回日本肝臓学会総会, 2023年06月16日, 通常, 日本語
  7. 非代償性肝硬変症に対する栄養学的評価と内服介入の予後解析, 第58回日本肝臓学会総会, 2022年06月03日, 通常, 日本語
  8. 門脈圧亢進症を合併した 非ウイルス性慢性肝疾患 110 例の解析, 第28回日本門脈圧亢進症学会総会, 2021年09月16日, 通常, 日本語
  9. 非代償性肝硬変症に対する内服治療と予後の解析, 第44回日本肝臓学会西部会, 2021年12月09日, 通常, 日本語
  10. 非アルコール性脂肪肝炎に対するトコフェロール製剤の治療効果の解析, JDDW2021, 2021年12月05日, 通常, 英語
  11. Transmembrane 6 superfamily 2 の一塩基多型に影響される肝星細胞活性化の基礎的解析, 第107回日本消化器病学会総会, 2021年04月15日, 通常, 日本語
  12. 食道胃静脈瘤治療を行った非B非C型慢性肝疾患の臨床的特徴, 第27回日本門脈圧亢進症学会総会, 2020年09月11日, 通常, 日本語
  13. 胃食道静脈瘤を伴う非アルコール性脂肪肝炎21例の解析, JDDW, 2020年11月04日, 通常, 日本語
  14. 2型糖尿病合併非アルコール性脂肪肝炎に対する治療前後の血清中micro RNA 122の解析, 第106回日本消化器病学会総会, 2020年08月11日, 通常, 日本語
  15. 食道胃静脈瘤治療を行った 非B非C型慢性肝疾患の臨床的特徴, 第27回日本門脈圧亢進症学会総会, 2020年09月11日, 通常, 日本語
  16. 門脈圧亢進症を伴う非アルコール性脂肪性肝炎の臨床的特徴の解析, 第26回日本門脈圧亢進症学会総会, 2019年09月12日, 通常, 日本語
  17. 治療介入を要する門脈圧亢進症を伴った非アルコール性脂肪性肝炎の臨床的特徴, 第55回日本肝臓学会総会, 2019年05月30日, 通常, 日本語
  18. 推定内臓脂肪重量を用いた非アルコール性脂肪性肝炎の病態評価, 第105回日本消化器病学会総会, 2019年05月11日, 通常, 日本語
  19. 2型糖尿病を合併する非B非C肝癌の臨床的特徴の解析, 第26回日本消化器関連学会週間, 2018年11月01日, 通常, 日本語
  20. 2型糖尿病合併非アルコール性脂肪肝炎に対するSGLT2阻害薬の治療効果に関連する因子の解析, 第5回肝臓と糖尿病・代謝研究会, 2018年07月21日, 通常, 日本語
  21. 2型糖尿病合併非アルコール性脂肪肝炎に対するGLP-1受容体作動薬の治療効果の解析, 2018年06月14日, 通常, 日本語
  22. 非B非C型慢性肝疾患患者の アルコール摂取量で群別化した比較検討, 第104 回日本消化器病学会総会, 2018年04月19日, 通常, 日本語
  23. 糖尿病合併非アルコール性脂肪肝炎に対する SGLT2阻害薬の治療効果の解析, 第42 回日本肝臓学会 西部会, 2017年11月30日, 通常, 日本語

受賞

  1. 平成25年度 日本肝臓学会 研究奨励賞, 日本肝臓学会
  2. 平成27年度 日本肝臓学会 機関誌 High Citation賞, 日本肝臓学会

外部資金

競争的資金等の採択状況

  1. 肝炎等克服実用化研究事業 肝炎等克服緊急対策研究事業, 代謝関連脂肪性肝疾患および肝がんの病態解明に関する研究, 2024年/4月/1日, 2025年/3月/3日
  2. ギリアド・サイエンシズ株式会社肝疾患領域の研究助成プログラム, 2018年04月01日
  3. 科学研究費助成事業(若手研究), ヒト培養肝細胞を用いた非アルコール性脂肪肝炎のin vitroモデルの作成, 2018年, 2020年

社会活動

その他社会貢献活動(広大・部局主催含)

  1. 職域における肝炎対策セミナー, 肝疾患早く見つけてちゃんと治療へ, 2024年/07月/26日, 講師, 講演会, 社会人・一般
  2. 広島県肝疾患診療連携拠点病院研修会, 脂肪肝診療における多職種連携, 2026年/03月/07日, 講師, 講演会, 社会人・一般
  3. 市民公開講座, 令和4年市民公開講座, 2021年/06月/03日, 講師, 講演会, 社会人・一般
  4. 市民公開講座, 平成30年度市民公開講座, 2018年/06月/23日, 講師, 講演会, 社会人・一般
  5. ひろしま肝疾患コーディネーター養成講座, 肝疾患コーディネーター継続研修, 広島県, 2021年/10月/16日, 講師, 資格認定講習, 社会人・一般
  6. ひろしま肝疾患コーディネーター養成講座, 肝疾患コーディネーター継続研修, 広島県, 2019年/09月/14日, 講師, 資格認定講習, 社会人・一般
  7. ひろしま肝疾患コーディネーター養成講座, 肝疾患コーディネーター継続研修, 広島県, 2017年/09月/10日, 講師, 資格認定講習, 社会人・一般
  8. ひろしま肝疾患コーディネーター養成講座, 肝疾患コーディネーター継続研修, 広島県, 2025年/10月/17日, 講師, 資格認定講習, 社会人・一般
  9. 広島県肝疾患診療連携拠点病院研修会, 脂肪肝について, 2028年/03月/24日, 講師, 講演会, 社会人・一般
  10. ひろしま肝疾患コーディネーター養成講座, 肝疾患コーディネーター継続研修, 広島県, 2018年/09月/24日, 講師, 資格認定講習, 社会人・一般
  11. 職域における肝炎対策セミナー, 肝疾患における治療と仕事の両立支援, 2025年/07月/30日, 講師, 講演会, 社会人・一般
  12. 広島県肝疾患診療連携拠点病院研修会, 脂肪肝について, 2018年/03月/24日, 講師, 講演会, 社会人・一般