浜井 洋一YOICHI HAMAI

Last Updated :2019/11/12

所属・職名
病院(医)消化器診療科講師
メールアドレス
yyhamaihiroshima-u.ac.jp

基本情報

主な職歴

  • 1997年05月16日, 1998年03月30日, 広島大学, 医学部附属病院, 医員(研修医)
  • 1998年04月01日, 2000年03月31日, 広島市立市民病院, 非常勤嘱託研修医
  • 2000年04月01日, 2002年03月31日, 独立行政法人国立病院機構四国がんセンター, レジデント
  • 2004年04月01日, 2005年09月30日, 広島大学, 病院, 医員
  • 2005年10月01日, 2007年03月31日, 広島大学, 病院, 助手
  • 2007年04月01日, 2012年12月31日, 広島大学, 病院助教
  • 2013年01月01日, 2016年03月31日, 広島大学, 原爆放射線医科学研究所放射線災害医療研究センター, 助教
  • 2016年04月01日, 広島大学, 病院, 講師

学歴

  • 広島大学, 大学院医歯薬学総合研究科, 日本, 2002年04月, 2005年03月

学位

  • 博士(医学)(広島大学)

教育担当

  • 【学士課程】 医学部 : 医学科

担当主専攻プログラム

  • 医学プログラム

研究分野

  • 医歯薬学 / 外科系臨床医学 / 消化器外科学

教育活動

授業担当

  1. 2019年, 学部専門, 集中, 器官・システム病態制御学I
  2. 2019年, 学部専門, 集中, 症候診断治療学
  3. 2019年, 学部専門, 集中, 臨床実習入門プログラム

研究活動

学術論文(★は代表的な論文)

  1. Successful management of multiple esophagorespiratory fistulas using two types of stent: Report of a case, SURGERY TODAY, 41巻, 4号, pp. 560-562, 201104
  2. Esophageal reconstruction using the terminal ileum and right colon in esophageal cancer surgery, SURGERY TODAY, 42巻, 4号, pp. 342-350, 201204
  3. Airway Stenting for Malignant Respiratory Complications in Esophageal Cancer, ANTICANCER RESEARCH, 32巻, 5号, pp. 1785-1790, 201205
  4. Neoadjuvant chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil for esophageal cancer, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 69巻, 6号, pp. 1499-1505, 201206
  5. Advanced esophageal cancer with an esophago-bronchial fistula successfully treated by chemoradiotherapy following esophageal bypass surgery: report of a case, SURGERY TODAY, 42巻, 11号, pp. 1088-1090, 201211
  6. Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report, BMC GASTROENTEROLOGY, 12巻, 20120731
  7. Airway Stenting for Tracheal Obstruction Due to Lymph Node Metastasis of Hepatocellular Carcinoma, ANTICANCER RESEARCH, 33巻, 4号, pp. 1761-1764, 201304
  8. Involvement of ribonucleotide reductase-M1 in 5-fluorouracil-induced DNA damage in esophageal cancer cell lines, INTERNATIONAL JOURNAL OF ONCOLOGY, 42巻, 6号, pp. 1951-1960, 201306
  9. Treatment Outcomes and Prognostic Factors for Thoracic Esophageal Cancer with Clinical Evidence of Adjacent Organ Invasion, ANTICANCER RESEARCH, 33巻, 8号, pp. 3495-3502, 201308
  10. Esophageal Bypass Operation Prior to Definitive Chemoradiotherapy in Advanced Esophageal Cancer With Tracheobronchial Invasion, ANNALS OF THORACIC SURGERY, 97巻, 1号, pp. 290-295, 201401
  11. Involvement of homologous recombination in the synergism between cisplatin and poly (ADP-ribose) polymerase inhibition, CANCER SCIENCE, 104巻, 12号, pp. 1593-1599, 201312
  12. ヒストンアセチル化とがん, 血液・腫瘍科, 48巻, 2号, pp. 221-227, 20040401
  13. A single nucleotide polymorphism in the 5’ untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer., Pathobiology, 72巻, pp. 133-138, 20050401
  14. Melanoma-associated antigen-A1 expression predicts resistance to decetaxel and paclitaxel in advanced and recurrent gastric cancer, Oncol Rep, 18巻, pp. 329-336, 20070101
  15. Melanoma-associated antigen-A1 expression predicts resistance to decetaxel and paclitaxel in advanced and recurrent gastric cancer., Oncol Rep, 18巻, 2号, pp. 329-336, 20070601
  16. Emergency escape surgery for a gastro-bronchial fistula with respiratory failure that developed after esophagectomy, Surgery Today, 45巻, 3号, pp. 369-373, 201503
  17. Effects of neoadjuvant chemoradiotherapy on postoperative morbidity and mortality associated with esophageal cancer, DISEASES OF THE ESOPHAGUS, 28巻, 4号, pp. 358-364, 2015
  18. Lung Abscess Presenting as Tension Pyopneumothorax in a Gastrointestinal Cancer Patient, ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, 20巻, pp. 478-481, 2014
  19. Advanced esophageal cancer with situs inversus totalis successfully treated with chemoradiotherapy followed by esophagectomy: case report, Hiroshima J Med Sci, 60巻, 1号, pp. 21-4, 20110601
  20. 再発形式と予後因子からみた食道癌に対する外科治療戦略, 癌の臨床, 56巻, 3号, pp. 213-218, 20100301
  21. 高度進行胃癌に対するAdjuvant Surgeryの有用性に関する検討, 癌と化学療法, 37巻, 2号, pp. 263-266, 20100201
  22. Skin tube reconstruction for esophageal defect due to postoperative complication, Ann Thorac Surg, 87巻, 5号, pp. 1605-7, 20090501
  23. Docetaxelと5-FUを用いた術前化学放射線療法の治療成績, 癌の臨床, 53巻, 1号, pp. 49-55, 20080101
  24. 食道癌切除術後6ヵ月目に再建胃管壊死を来した1症例, 日本消化器外科学会雑誌, 40巻, 9号, pp. 1565-1569, 20070901
  25. イマチニブの術前投与により縮小手術が可能になった十二指腸GISTの1例, 日本臨床外科学会雑誌, 68巻, 9号, pp. 2248-52, 20070901
  26. Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines, Oncol Rep, 17巻, 1号, pp. 161-7, 20070101
  27. Phase I study of docetaxel (TXT) and 5-fluorouracil (5-FU) with concurrent radiotherapy in patients with advanced esophageal cancer, Anticancer Research, 27巻, 4C号, pp. 2597-603, 20070701
  28. DNA methylation of CHFR is not a predictor of the response to docetaxel and paclitaxel in advanced and recurrent gastric cancer, ANTICANCER RESEARCH, 26巻, 1A号, pp. 49-54, 2006
  29. Postoperative immunosuppression cascade and immunotherapy using lymphokine-activated killer cells for patients with esophageal cancer: Possible application for compensatory anti-inflammatory response syndrome, ONCOLOGY REPORTS, 15巻, 4号, pp. 895-901, 200604
  30. Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines, ONCOLOGY REPORTS, 17巻, 1号, pp. 161-167, 200701
  31. Melanoma-associated antigen-A1 expression predicts resistance to docetaxel and paclitaxel in advanced and recurrent gastric cancer, ONCOLOGY REPORTS, 18巻, 2号, pp. 329-336, 200708
  32. Phase I study of docetaxel (TXT) and 5-fluorouracil (5-FU) with concurrent radiotherapy in patients with advanced esophageal cancer, ANTICANCER RESEARCH, 27巻, 4C号, pp. 2597-2603, 2007
  33. Laparoscopic Thoracic Duct Clipping for Persistent Chylothorax After Extrapleural Pneumonectomy, ANNALS OF THORACIC SURGERY, 93巻, 5号, pp. E131-E132, 201205
  34. Hemoglobin Level Influences Tumor Response and Survival After Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Carcinoma, WORLD JOURNAL OF SURGERY, 38巻, 8号, pp. 2046-2051, 201408
  35. Results of Neoadjuvant Chemoradiotherapy With Docetaxel and 5-Fluorouracil Followed by Esophagectomy to Treat Locally Advanced Esophageal Cancer, ANNALS OF THORACIC SURGERY, 99巻, 6号, pp. 1887-1893, 201506
  36. DNA hypermethylation and histone hypoacetylation of the HLTF gene are associated with reduced expression in gastric carcinoma, Cancer science, 94巻, 8号, pp. 692-698, 20030831
  37. Clinical Significance of FDG-PET to Predict Pathologic Tumor Invasion and Lymph Node Metastasis of Superficial Esophageal Squamous Cell Carcinoma, ANNALS OF SURGICAL ONCOLOGY, 23巻, 12号, pp. 4086-4092, 201611
  38. Ability of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography to Predict Outcomes of Neoadjuvant Chemoradiotherapy Followed by Surgical Treatment for Esophageal Squamous Cell Carcinoma, ANNALS OF THORACIC SURGERY, 102巻, 4号, pp. 1132-1140, 201610
  39. Role of definitive chemoradiotherapy using docetaxel and 5-fluorouracil in patients with unresectable locally advanced esophageal squamous cell carcinoma: a phase II study, DISEASES OF THE ESOPHAGUS, 29巻, 8号, pp. 1115-1120, 2016
  40. Role of Postoperative C-Reactive Protein Levels in Predicting Prognosis After Surgical Treatment of Esophageal Cancer, WORLD JOURNAL OF SURGERY, 41巻, 6号, pp. 1558-1565, 201706
  41. Role of Postoperative C-Reactive Protein Levels in Predicting Prognosis After Surgical Treatment of Esophageal Cancer., World J Surg, 41巻, 6号, pp. 1558-1565
  42. Surgical Resection of Thoracic Esophageal Cancer with Interstitial Lung Disease: A Case Report., Hiroshima J Med Sci., 65巻, 1号, pp. 19-23, 2017
  43. Effects of Neoadjuvant Chemoradiotherapy on Pathological TNM Stage and Their Prognostic Significance for Surgically-treated Esophageal Squamous Cell Carcinoma, ANTICANCER RESEARCH, 37巻, 10号, pp. 5639-5646, 201710
  44. Clinicopathologic Features of Submucosal Esophageal Squamous Cell Carcinoma, ANNALS OF THORACIC SURGERY, 104巻, 6号, pp. 1858-1864, 201712
  45. Evaluation of Prognostic Factors for Esophageal Squamous Cell Carcinoma Treated with Neoadjuvant Chemoradiotherapy Followed by Surgery, WORLD JOURNAL OF SURGERY, 42巻, 5号, pp. 1496-1505, 201805
  46. Treatment Outcomes and Prognostic Factors After Recurrence of Esophageal Squamous Cell carcinoma, WORLD JOURNAL OF SURGERY, 42巻, 7号, pp. 2190-2198, 201807
  47. Preoperative prediction of a pathologic complete response of esophageal squamous cell carcinoma to neoadjuvant chemoradiotherapy, SURGERY, 164巻, 1号, pp. 40-48, 201807
  48. Long-term results of neoadjuvant chemoradiotherapy using cisplatin and 5-fluorouracil followed by esophagectomy for resectable, locally advanced esophageal squamous cell carcinoma., J Radiat Res.
  49. Impact of Interval Between Neoadjuvant Chemoradiation and Surgery Upon Morbidity and Survival of Patients with Squamous Cell Carcinoma of Thoracic Esophagus.
  50. Impact of Interval Between Neoadjuvant Chemoradiation and Surgery Upon Morbidity and Survival of Patients with Squamous Cell Carcinoma of Thoracic Esophagus, ANTICANCER RESEARCH, 38巻, 9号, pp. 5239-5245, 201809

招待講演、口頭・ポスター発表等

  1. 2015, 2015年, 通常, 日本語
  2. 進行食道癌におけるFDG-PETを用いた術前化学放射線療法の効果予測, 2015, 浜井洋一, 第115回日本外科学会定期学術集会, 通常, 日本語
  3. 食道癌術前化学放射線療法症例におけるFDG-PETによるリンパ節転移診断と予後予測, 浜井洋一, 檜原 淳,古川高意,山北伊知子,岡田守人, 第70回日本消化器外科学会総会, 2015年, 通常, 日本語
  4. 食道癌の術前化学放射線療法におけるTNM stageの変化と予後の検討, 浜井洋一, 檜原 淳,古川高意,山北伊知子,岡田守人, 第69回日本食道学会学術集会, 2015年, 通常, 日本語

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業(基盤研究(C)), SAGE法による新たな消化器癌幹細胞特異的遺伝子の同定とその機能解析, 2012年, 2014年
  2. 科学研究費助成事業(若手研究(B)), 新たな分子標的薬の開発 : SELEX法を用いたEGFに対するRNAアプタマーの創製, 2010年, 2011年
  3. 科学研究費助成事業(基盤研究(C)), DNA修復阻害による合成致死性を応用した新たな食道癌化学放射線療法の開発, 2015年, 2017年
  4. 内視鏡医学研究振興財団, 胸腔鏡下食道切除術における神経刺激モニタリングを利用した反回神経麻痺の術中評価と麻痺防止のための郭清手技の開発