河本 正次Seiji Kawamoto

Last Updated :2019/11/01

所属・職名
大学院統合生命科学研究科先端・分子生命化学(先端支援室)教授
ホームページ
メールアドレス
skawahiroshima-u.ac.jp
その他連絡先
〒739-8530 東広島市鏡山1-3-1 先端科学総合研究棟707W
TEL:082-424-7753 FAX:082-424-7867

基本情報

主な職歴

  • 2014年09月01日, 2019年03月31日, 広島大学, 大学院先端物質科学研究科, 教授
  • 2008年06月01日, 2014年08月31日, 広島大学, 大学院先端物質科学研究科, 准教授
  • 2002年07月01日, 2004年06月30日, ハーバード大学医学部, リサーチフェロー(日本学術振興会海外特別研究員)
  • 1999年04月01日, 広島大学, 大学院先端物質科学研究科, 助手
  • 1997年04月01日, 1999年03月31日, 広島大学, 工学部, 助手
  • 1996年04月01日, 1997年03月31日, 日本学術振興会, 特別研究員PD
  • 1996年01月01日, 1996年03月31日, 日本学術振興会, 特別研究員DC2

学歴

  • 愛媛県立今治西高等学校, 1987年
  • 九州大学, 農学部, 食糧化学工学科, 日本, 1987年04月, 1991年03月
  • 九州大学, 大学院農学研究科遺伝子資源工学専攻, 日本, 1991年04月, 1996年03月

学位

  • 博士(農学)(九州大学)
  • 修士(農学)(九州大学)

担当主専攻プログラム

  • 生物工学プログラム

研究分野

  • 農学 / 境界農学 / 応用分子細胞生物学
  • 農学 / 農芸化学 / 応用生物化学
  • 農学 / 農芸化学 / 食品科学
  • 複合領域 / 生活科学 / 食生活学

研究キーワード

  • 免疫制御による加齢病の克服
  • アレルギーの次世代診断・治療技術の開発
  • 食による炎症性難病の予防

所属学会

  • 日本免疫学会
  • 日本農芸化学会
  • 日本生物工学会
  • 日本動物細胞工学会
  • 日本食品免疫学会
  • 癌・炎症と抗酸化研究会

教育活動

授業担当

  1. 2019年, 教養教育, 1ターム, 教養ゼミ
  2. 2019年, 学部専門, 2ターム, 基礎工業概論
  3. 2019年, 学部専門, 3ターム, 生物化学II
  4. 2019年, 学部専門, 4ターム, 糖鎖・免疫工学
  5. 2019年, 学部専門, 通年, 卒業論文
  6. 2019年, 修士課程・博士課程前期, 1ターム, 生命科学概論
  7. 2019年, 修士課程・博士課程前期, セメスター(前期), 分子生命機能科学セミナー
  8. 2019年, 修士課程・博士課程前期, セメスター(後期), 分子生命機能科学セミナー
  9. 2019年, 修士課程・博士課程前期, 1ターム, 統合生命科学特別講義
  10. 2019年, 博士課程・博士課程後期, 3ターム, 生命科学キャリアデザイン開発
  11. 2019年, 修士課程・博士課程前期, 4ターム, 細胞機能科学B
  12. 2019年, 修士課程・博士課程前期, 1ターム, 生命科学概論
  13. 2019年, 修士課程・博士課程前期, 年度, 生物工学演習
  14. 2019年, 修士課程・博士課程前期, 年度, 生物工学演習
  15. 2019年, 修士課程・博士課程前期, 1ターム, 生物工学特別演習A
  16. 2019年, 修士課程・博士課程前期, 2ターム, 生物工学特別演習A
  17. 2019年, 修士課程・博士課程前期, 3ターム, 生物工学特別演習B
  18. 2019年, 修士課程・博士課程前期, 4ターム, 生物工学特別演習B
  19. 2019年, 修士課程・博士課程前期, 年度, 生物工学特別研究
  20. 2019年, 博士課程・博士課程後期, 年度, 統合生命科学特別研究
  21. 2019年, 博士課程・博士課程後期, 年度, 統合生命科学特別研究

研究活動

学術論文(★は代表的な論文)

  1. Der f 35: an MD-2−like house dust mite allergen that cross-reacts with Der f 2 and Pso o 2, Allergy
  2. A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 483巻, 1号, pp. 674-679, JAN 29 2017
  3. Der f 34, a novel major house dust mite allergen belonging to a highly conserved Rid/YjgF/YER057c/UK114 family of imine deaminases, JOURNAL OF BIOLOGICAL CHEMISTRY, Aug 18, 2016
  4. Impact of histone H1 on the progression of allergic rhinitis and its suppression by neutralizing antibody in mice, PLoS ONE, 11巻, pp. e0153630, APR 18, 2016
  5. Exposure to positively- and negatively-charged plasma cluster ions impairs IgE-binding capacity of indoor cat and fungal allergens, WORLD ALLERGY ORGANIZATION JOURNAL, 9巻, pp. 27, SEP 6, 2016
  6. Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases, JOURNAL OF LIPID RESEARCH, 57巻, 1号, pp. 89-99, JAN 2016
  7. A Novel Anti-Histone H1 Monoclonal Antibody, SSV Monoclonal Antibody, Improves Lung Injury and Survival in a Mouse Model of Lipopolysaccharide-Induced Sepsis-Like Syndrome, Biomed Research International, 2015
  8. Spectrum of allergens for Japanese cedar pollinosis and impact of component-resolved diagnosis on allergen-specific immunotherapy, ALLERGOLOGY INTERNATIONAL, 64巻, 4号, pp. 312-320, OCT 2015
  9. Regulation of Polyunsaturated Fatty Acid Biosynthesis by Seaweed Fucoxanthin and Its Metabolite in Cultured Hepatocytes, LIPIDS, 49巻, 2号, pp. 133-141, FEB 2014
  10. Glyceraldehyde-3-phosphate dehydrogenase ( GAPDH) prevents lipopolysaccharide (LPS)-induced, sepsis-related severe acute lung injury in mice, SCIENTIFIC REPORTS, 4巻, JUN 6 2014
  11. Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 78巻, 4号, pp. 655-661, APR 2014
  12. Unexpected T cell regulatory activity of anti-histone H1 autoantibody: Its mode of action in regulatory T cell-dependent and -independent manners, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 431巻, 2号, pp. 246-252, FEB 8 2013
  13. Competitive advantage and tolerance of selected shochu yeast in barley shochu mash, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 116巻, 1号, pp. 79-84, JUL 2013
  14. Utilization of Waste Syrup for Production of Polyunsaturated Fatty Acids and Xanthophylls by Aurantiochytrium, JOURNAL OF OLEO SCIENCE, 62巻, 9号, pp. 729-736, SEP 2013
  15. Bifidobacterium longum Alleviates Dextran Sulfate Sodium-Induced Colitis by Suppressing IL-17A Response: Involvement of Intestinal Epithelial Costimulatory Molecules, PLOS ONE, 8巻, 11号, NOV 8 2013
  16. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109巻, 13号, pp. 4992-4997, MAR 27 2012
  17. Prophylactic effect of Lactobacillus oral vaccine expressing a Japanese cedar pollen allergen, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 113巻, 4号, pp. 536-541, APR 2012
  18. Immunological and Regenerative Aspects of Hepatic Mast Cells in Liver Allograft Rejection and Tolerance, PLOS ONE, 7巻, 5号, MAY 15 2012
  19. Sake Less Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation, Bioscience, biotechnology, and biochemistry, 75巻, 1号, pp. 140-144, 20110123
  20. Metabolism and synthesis of lipids in the polyunsaturated fatty acid-producing fungus Mortierella alliacea., J. Oleo Sci., 60巻, 1号, pp. 11-17, 20110101
  21. Autoimmunity and liver transplantation immunology, Curr. Trends Immunol., 12巻, pp. 41285, 20111101
  22. アレルゲンによる上皮細胞からのTSLP産生誘導, 臨床免疫・アレルギー科, 56巻, 5号, pp. 473-477, 20111101
  23. 微粉砕コンニャクグルコマンナンの抗炎症作用, 生物機能研究, 15巻, pp. 44-47, 20111101
  24. Sake Lees Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 75巻, 1号, pp. 140-144, JAN 2011
  25. Metabolism and Synthesis of Lipids in the Polyunsaturated Fatty Acid-Producing Fungus Mortierella alliacea, JOURNAL OF OLEO SCIENCE, 60巻, 1号, pp. 11-17, JAN 2011
  26. Purification and characterization of intracellular lipase from the polyunsaturated fatty acid-producing fungus Mortierella alliacea, NEW BIOTECHNOLOGY, 28巻, 2号, pp. 158-164, FEB 28 2011
  27. Selective Detection of Antigen-Antibody Reaction Using Si Ring Optical Resonators, JAPANESE JOURNAL OF APPLIED PHYSICS, 49巻, 4号, 2010
  28. アレルギーワクチンの創製, 化学と生物, 48巻, 7号, pp. 453-455, 20100701
  29. アレルギーワクチンの創製, 化学と生物, 48巻, 7号, pp. 453-455, 20100701
  30. Molecular cloning and immunochemical characterization of a new Japanese cedar pollen allergen homologous to plant subtilisin-like serine protease., World Allergy Organization J., 3巻, 11号, pp. 262-265, 20101101
  31. Immunological aspects and therapeutic significance of an auto-Ab against histone H1 in a rat model of Con A-induced hepatitis., Immunology, 129巻, 4号, pp. 547-555, 20100401
  32. Molecular cloning and immunochemical characterization of a novel major Japanese cedar pollen allergen belonging to the aspartic protease family., Int. Arch. Allergy Immunol., 152巻, 3号, pp. 207-218, 20100601
  33. メタボも免疫病?, 生物工学会誌, 88巻, 8号, pp. 412, 20100801
  34. A new lipid transfer protein homologue identified as a cross-reactive allergen from Japanese cedar pollen., Biosci. Biotechnol. Biochem., 74巻, 3号, pp. 504-509, 20100301
  35. Molecular cloning and immunochemical characterization of a novel major Japanese cedar pollen allergen belonging to the aspartic protease family., Int. Arch. Allergy Immunol., 152巻, 3号, pp. 207-218, 20100201
  36. A New Lipid Transfer Protein Homolog Identified as an IgE-Binding Antigen from Japanese Cedar Pollen, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74巻, 3号, pp. 504-509, MAR 2010
  37. Molecular Cloning and Immunochemical Characterization of a Novel Major Japanese Cedar Pollen Allergen Belonging to the Aspartic Protease Family, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 152巻, 3号, pp. 207-218, 2010
  38. Immunological aspects and therapeutic significance of an autoantibody against histone H1 in a rat model of concanavalin A-induced hepatitis, IMMUNOLOGY, 129巻, 4号, pp. 547-555, APR 2010
  39. A novel peptide mimotope identified as a potential immunosuppressive vaccine for organ transplantation., J. Immunol., 182巻, pp. 4282-8, 20090401
  40. A Novel Peptide Mimotope Identified As a Potential Immunosuppressive Vaccine for Organ Transplantation, JOURNAL OF IMMUNOLOGY, 182巻, 7号, pp. 4282-4288, APR 1 2009
  41. Development of autoantibody responses in NC/Nga mice: its prevention by pulverized konjac glucomannan feeding, ARCHIVES OF DERMATOLOGICAL RESEARCH, 300巻, 2号, pp. 95-99, FEB 2008
  42. Development of a two-step chromatography procedure that allows the purification of a high-purity anti-histone H1 monoclonal immunoglobulin M antibody with immunosuppressant activity, BIOMEDICAL CHROMATOGRAPHY, 22巻, 1号, pp. 13-19, JAN 2008
  43. アレルギーワクチンの開発に向けて, バイオインダストリー, 25巻, 9号, pp. 69-77, 20080901
  44. Involvement of autoimmunity against nuclear histone H1 in liver transplantation tolerance, TRANSPLANT IMMUNOLOGY, 19巻, 2号, pp. 87-92, MAY 2008
  45. 喘息における好酸球の役割, The 14th Symposium of Asthma in Tokyo, 33-36号, 20070401
  46. Nutritional enrichment in larval fish feed with thraustochytrid producing polyunsaturated fatty acids and xanthophylls., Journal of Bioscience and Bioengineering, 104巻, pp. 200-206, 20070901
  47. Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in mice., Biosci. Biotechnol. Biochem., 71巻, pp. 2551-2556, 20071007
  48. Dietary pulverized konjac glucomannan suppresses scratching behavior and skin inflammatory immune responses in NC/Nga mice., Int. Arch. Allergy Immunol., 144巻, pp. 95-104, 20070524
  49. Experimental and clinical significance of antinuclear antibodies in liver transplantation., Transplantation, 83巻, 1122-1125号, 20070427
  50. Impact of vaccine therapy using nuclear histone H1 on allograft survival in experimental organ transplantation., Transplant Immunology, 17巻, 147-152号, 20070401
  51. The immunological role of lipid transfer/metabolic proteins in liver transplantation tolerance., Transplant Immunology, 17巻, 130-136号, 20070201
  52. The immunological role of lipid transfer/metabolic proteins in liver transplantation tolerance, TRANSPLANT IMMUNOLOGY, 17巻, 2号, pp. 130-136, FEB 2007
  53. Impact of vaccine therapy using nuclear histone H1 on allograft survival in experimental organ transplantation, TRANSPLANT IMMUNOLOGY, 17巻, 3号, pp. 147-152, APR 2007
  54. Experimental and clinical significance of antinuclear antibodies in liver transplantation, TRANSPLANTATION, 83巻, 8号, pp. 1122-1125, APR 27 2007
  55. Dietary pulverized konjac glucomannan suppresses scratching behavior and skin inflammatory immune responses in NC/Nga mice, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 144巻, 2号, pp. 95-104, 2007
  56. Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in mice, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71巻, 10号, pp. 2551-2556, OCT 2007
  57. Nutritional enrichment of larval fish feed with thraustochytrid producing polyunsaturated fatty acids and xanthophylls, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 104巻, 3号, pp. 200-206, SEP 2007
  58. TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45., International Immunology, 18巻, pp. 101-111, 20060401
  59. 肝移植により誘導される自然免疫寛容の成立機構解明, 上原記念生命科学財団研究報告集, 20巻, pp. 286-288, 20060401
  60. Utilization of shochu distillery wastewater for production of polyunsaturated fatty acids and xanthophylls by thraustochytrid., Journal of Bioscience and Bioengineering, 102巻, pp. 323-327, 20061001
  61. プロテオーム解析によるスギ花粉・ダニアレルゲンの全容解明, アレルギー・免疫, 13巻, pp. 340-344, 20060301
  62. Decrease in the allergenicity of Japanese cedar pollen allergen by treatment with positive and negative cluster ions., International Archives of Allergy and Immunology, 141巻, 313-321号, 20060801
  63. Oral administration of pulverized Konjac glucomannan prevents the increase of plasma immunoglobulin E and immunoglobulin G levels induced by the injection of syngeneic keratinocyte extracts in BALB/c mice., Clinical and Experimental Allergy, 36巻, 102-110号, 20060401
  64. Role of antinuclear antibodies in experimental and clinical liver transplantation., Transplantation Proceedings, 38巻, 3605-3606号, 20061201
  65. Histone H1 vaccine therapy for overcoming acute rejection in experimental organ transplantation., Transplantation Proceedings, 38巻, 3247-3248号, 20061201
  66. Anti-histone H1 autoantibody: an inducible immunosuppressive factor in liver transplantation., Animal Cell Technology: Basic & Applied Aspects, 15巻, IN PRESS号, 20060925
  67. Anti-histone H1 autoantibody directly acts on T cells to exert its immunosuppressive activity., Animal Cell Technology: Basic & Applied Aspects, 15巻, IN PRESS号, 20060925
  68. Oral administration of pulverized Konjac glucomannan prevents the increase of plasma immunoglobulin E and immunoglobulin G levels induced by the injection of syngeneic keratinocyte extracts in BALB/c mice, CLINICAL AND EXPERIMENTAL ALLERGY, 36巻, 1号, pp. 102-110, JAN 2006
  69. TRAF1 regulates T(h)2 differentiation, allergic inflammation and nuclear localization of the T(h)2 transcription factor, NIP45, INTERNATIONAL IMMUNOLOGY, 18巻, 1号, pp. 101-111, JAN 2006
  70. Decrease in the allergenicity of Japanese cedar pollen allergen by treatment with positive and negative cluster ions, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 141巻, 4号, pp. 313-321, 2006
  71. Utilization of shochu distillery wastewater for production of polyunsaturated fatty acids and xanthophylls using thraustochytrid, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 102巻, 4号, pp. 323-327, OCT 2006
  72. COX-2 inhibition enhances the Th2 immune response to epicutaneous sensitization., Journal of Allergy and Clinical Immunology, 116巻, pp. 390-396, 20050401
  73. TRAF1 controls the Th2 differentiation of T cells by limiting NIP45 nuclear translocation, FASEB Journal, 19巻, pp. A1448, 20050401
  74. イオン処理によるダニアレルゲンのアレルゲン性の低減化, アレルギーの臨床, 25巻, pp. 818-822, 20051001
  75. ダニアレルゲン-分子種構成、分子多型、ならびに特異的免疫治療-, アレルギー科, 19巻, pp. 549-556, 20050601
  76. Characterization of immunosuppressive factors expressed in serum by rat tolerogenic liver transplantation., Transplantation Proceedings, 37巻, pp. 80-81, 20050401
  77. The effects of anti-histone H1 antibody on immune cells responsible for rejection reaction., Molecular Immunology, 42巻, 1155-1164号, 20050601
  78. Molecular cloning of a class IV chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen and competitive inhibition of its immunoglobulin E-binding capacity by latex C-serum., Clinical and Experimental Allergy, 35巻, 234-243号, 20050201
  79. A new immunomodulatory function of low-viscous konjac glucomannan with a small particle size: its oral intake suppresses spontaneously occurring dermatitis in NC/Nga mice., International Archives of Allergy and Immunology, 136巻, 258-265号, 20050301
  80. Molecular cloning of a class IV chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen and competitive inhibition of its immunoglobulin E-binding capacity by latex C-serum, CLINICAL AND EXPERIMENTAL ALLERGY, 35巻, 2号, pp. 234-243, FEB 2005
  81. A new immunomodulatory function of low-viscous konjac glucomannan with a small particle size: Its oral intake suppresses spontaneously occurring dermatitis in NC/Nga mice, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 136巻, 3号, pp. 258-265, 2005
  82. Characterization of immunosuppressive factors expressed in serum by rat tolerogenic liver transplantation, TRANSPLANTATION PROCEEDINGS, 37巻, 1号, pp. 80-81, JAN-FEB 2005
  83. The effects of anti-histone H1 antibody on immune cells responsible for rejection reaction, MOLECULAR IMMUNOLOGY, 42巻, 10号, pp. 1155-1164, JUN 2005
  84. Two-dimensional IgE-binding spectrum of Japanese cedar (Cryptomeria japonica) pollen allergens., Int. Arch. Allergy Immunol., 133巻, pp. 125-135, 20040201
  85. ★, The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen., Journal of Clinical Investigation, 114巻, pp. 399-407, 20040801
  86. Liver transplantation-induced anti-histone H1 autoantibodies suppress mixed lymphocyte reaction., Transplant, 77巻, pp. 1595-1603, 20040401
  87. The ability of konjac-glucomannan to suppress spontaneously occurring dermatitis in NC/Nga mice depends upon the particle size., BioFactors, 21巻, 163-166号, 20041230
  88. Two-dimensional IgE-binding spectrum of Japanese cedar (Cryptomeria japonica) pollen allergens, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 133巻, 2号, pp. 125-135, 2004
  89. Liver transplantation-induced antihistone H1 autoantibodies suppress mixed lymphocyte reaction, TRANSPLANTATION, 77巻, 10号, pp. 1595-1603, MAY 27 2004
  90. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen, JOURNAL OF CLINICAL INVESTIGATION, 114巻, 3号, pp. 399-407, AUG 2004
  91. The ability of konjac-glucomannan to suppress spontaneously occurring dermatitis in NC/Nga mice depends upon the particle size, BIOFACTORS, 21巻, 1-4号, pp. 163-166, 2004
  92. Differential response to low temperature of two D6 fatty acid desaturases from Mucor circinelloides., Appl. Microbiol. Biotechnol., 62巻, pp. 362-368, 20030401
  93. Grouping newly isolated docosahexaenoic acid-producing thraustochytrids based on their polyunsaturated fatty acid profiles and comparative analysis of 18S rRNA genes., Marine Biotechnol., 5巻, pp. 450-457, 20030401
  94. Thraustochytrid as a potential source of carotenoids., J. Am. Oil Chem. Soc., 80巻, 8号, pp. 789-794, 20030401
  95. Extracellular secretion of free fatty acids by disruption of fatty acyl-CoA synthetase gene in Saccharomyces cerevisiae., J. Biosci. Bioeng., 95巻, 5号, pp. 435-440, 20030401
  96. cDNA cloning and functional expression of α-glucosidase from Mortierella alliacea., Appl. Microbiol. Biotechnol., 62巻, pp. 202-209, 20030401
  97. Evidence of isozymes for Δ6 fatty acid desaturase in rat hepatocytes., Biosci. Biotechnol. Biochem., 67巻, pp. 451-454, 20030401
  98. Induction of inducible nitric oxide synthase mRNA expression and nitric oxide production from macrophages stimulated with high-molecular size mite antigen HM1., Allergol. Int., 52巻, pp. 97-103, 20030401
  99. Epicutaneous sensitization with superantigen induces allergic skin inflammation., Journal of Allergy and Clinical Immunology, 112巻, pp. 981-987, 20031101
  100. Extracellular secretion of free fatty acids by disruption of a fatty acyl-CoA synthetase gene in Saccharomyces cerevisiae, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 95巻, 5号, pp. 435-440, MAY 2003
  101. Evidence of isozymes for Delta 6 fatty acid desaturase in rat hepatocytes, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 67巻, 2号, pp. 451-454, FEB 2003
  102. Thraustochytrid as a potential source of carotenoids, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 80巻, 8号, pp. 789-794, AUG 2003
  103. cDNA cloning and functional expression of alpha-glucosidase from Mortierella alliacea, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 62巻, 2-3号, pp. 202-209, AUG 2003
  104. Differential response to low temperature of two Delta 6 fatty acid desaturases from Mucor circinelloides, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 62巻, 4号, pp. 362-368, SEP 2003
  105. Grouping newly isolated docosahexaenoic acid-producing thraustochytrids based on their polyunsaturated fatty acid profiles and comparative analysis of 18S rRNA genes, MARINE BIOTECHNOLOGY, 5巻, 5号, pp. 450-457, SEP-OCT 2003
  106. Identification and expression of a rat fatty acid elongase involved in the biosynthesis of C18 fatty acids., Biosci. Biotech. Biochem., 66巻, 3号, pp. 613-621, 20020301
  107. Analysis of immunosuppressive factors expressed in serum of liver transplanted rats., Animal Cell Technology: Basic & Applied Aspects, 12巻, pp. 257-261, 20020401
  108. Identification of differentially expressed genes in atopic dermatitis-prone NC/Nga mouse., Animal Cell Technology: Basic & Applied Aspects, 12巻, pp. 379-383, 20020401
  109. Gamma-linolenic acid suppresses IgE production in vitro as well as in vivo., Animal Cell Technology: Basic & Applied Aspects, 12巻, pp. 461-465, 20020401
  110. Purification and characterization of a novel fungal α-glucosidase from Mortierella alliacea with high starch-hydrolytic activity., Biosci. Biotechnol. Biochem., 66巻, 11号, pp. 2415-2423, 20021101
  111. A high-molecular-size mite antigen (HM1) fraction aggravated airway hyperresponsiveness of allergic mice in house dusts and whole mite cultures., Int. Arch. Allergy Immunol., 129巻, pp. 204-211, 20020401
  112. Toward elucidating the full spectrum of mite allergen ---state of the art., J. Biosci. Bioeng., 94巻, pp. 285-298, 20020401
  113. Molecular cloning and characterization of a new Japanese cedar pollen allergen homologous to plant isoflavone reductase family., Clin. Exp. Allergy, 32巻, pp. 1064-1070, 20020401
  114. Enzyme preparation of glycerides rich in docosahexaenoic acid from Thraustochytrid single cell oils by Candida rugosa Lipase., J. Oleo Sci., 51巻, pp. 447-455, 20020401
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  142. Properties of ras-amplified recombinant BHK-21 cells in protein-free culture., Cytotechnology, 33巻, pp. 21-26, 20000401
  143. Purification and characterization of sea squirt alpha-N-acetylgalactosaminidase, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 89巻, 1号, pp. 84-86, JAN 2000
  144. T-cell epitope analysis of Mag 3, an important allergen from the house dust mite, Dermatophagoides farinae, IMMUNOLOGY LETTERS, 72巻, 1号, pp. 53-60, APR 3 2000
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  148. Molecular cloning and functional characterization of rat Delta-6 fatty acid desaturase., Biochem. Biophys. Res. Commun., 255巻, 3号, pp. 575-579, 19990201
  149. Purification and characterization of M-177, a 177 kD allergen, from the house dust mite, Dermatophagoides farinae., Allergol. Int., 48巻, pp. 43-51, 19990101
  150. Effectiveness of vitamin A acetate for enhancing the production of lung cancer specific monoclonal antibodies., Cytotechnology, 31巻, pp. 77-883, 19990401
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  152. A newly identified allergen p29, the C-terminal fragment of Cry j 1, induces potently conjunctival congestion of patients with cedar pollenosis., The 9th Tohwa University International Symposium, pp. 271-274, 19990401
  153. Altered antigenicity of M-177, a 177-KDa allergen from the house dust mite, Dermatophagoides farinae, in stored extract., Clin. Exp. Allergy, 28巻, pp. 1549-58, 19980401
  154. Altered expression of the Cip/Kip family CDK inhibitors in tumor phenotype-suppressed human lung cancer cells., Animal Cell Technology: Basic & Applied Aspects, 10巻, pp. 347-351, 19981201
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  157. Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma., 生化的生物物理学的研究報告集, 237巻, pp. 313-317, 19970801
  158. Cytokeratin 8 and 19 as antigens recognized by adenocarcinoma-reactive human monoclonal antibody AE6F4., Human Antibodies, 8巻, pp. 195-202, 19970401
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  164. Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system., Journal of Fermentation and Bioengineering, 81巻, pp. 466-469, 19960401
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