HAYES CLAIR NELSONCLAIR NELSON HAYES

Last Updated :2017/09/07

所属・職名
大学院医歯薬保健学研究科(医) 医学講座 准教授
自己紹介
I am a bioinformatician and Java programmer using a data science approach to investigate viral hepatitis as a member of the Chayama Laboratory. I use a supercomputer to analyze next generation sequencing data and analyze experimental data using statistics and machine learning. I also develop relational and NoSQL database approaches for data management and build web applications using Java and Angular. Recently I have begun to focus on deep learning and graph analytics to identify host factors implicated in hepatitis B and C infection and explore potential medical applications of the Raspberry Pi and Arduino in the Internet of Things. In 2003, I received a PhD in biology from the Pennsylvania State University, where I studied evolutionary ecology of mating systems. In 2005, I became a postdoctoral fellow in the Kanehisa Laboratory in the Bioinformatics Center at Kyoto University, where I developed the varDB antigenic variation database to examine mechanisms of immune escape in Plasmodium falciparum and other human pathogens.

基本情報

主な職歴

  • 2003年09月01日, 2004年12月31日, ペンシルバニア州立大学, 生物学科, マルチメディアサポートアシスタント
  • 2005年01月01日, 2005年10月15日, ペンシルバニア州立大学, 生物学科, 専任講師
  • 2005年10月16日, 2009年09月30日, 京都大学, 化学研究所ンター バイオインフォマティクスセ, 特定研究員、日本学術振興会研究員を含む
  • 2009年10月01日, 2010年05月31日, 広島大学, 病院, 研究員
  • 2010年06月01日, 2012年03月31日, 広島大学, 大学院医歯薬学総合研究科, 特任助教
  • 2012年04月01日, 2013年03月31日, 広島大学, 大学院医歯薬保健学研究院, 特任助教
  • 2013年04月01日, 2014年03月31日, 広島大学, 大学院医歯薬保健学研究院, 特任講師
  • 2014年04月01日, 2014年12月31日, 広島大学, 大学院医歯薬保健学研究院, 特任准教授
  • 2015年01月01日, 広島大学, 大学院医歯薬保健学研究院, 准教授

学歴

  • ペンシルバニア州立大学, 生物学科, 生物学, アメリカ合衆国, 1996年08月, 2003年12月
  • ワシントン・ジェファーソン大学, 生物学科, 生物学, アメリカ合衆国, 1992年08月, 1996年06月

学位

  • 博士(生物学) (ペンシルバニア州立大学)

研究分野

  • 医歯薬学 / 基礎医学 / ウイルス学
  • 医歯薬学 / 基礎医学 / 人類遺伝学
  • 総合生物 / ゲノム科学 / ゲノム医科学
  • 情報学 / 計算基盤 / ソフトウェア
  • 情報学 / 計算基盤 / 高性能計算
  • 生物学 / 基礎生物学 / 進化生物学
  • 生物学 / 基礎生物学 / 生態・環境

研究キーワード

  • 肝炎
  • ウイルス学
  • 肝臓
  • ジャヴァ
  • 次世代シーケンシング
  • スーパーコンピュータ
  • データベース

研究活動

学術論文(★は代表的な論文)

  1. Identification of novel HCV deletion mutants in chronic hepatitis C patients, ANTIVIRAL THERAPY, 17巻, 8号, pp.1551-pp.1561, 2012
  2. Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients, JOURNAL OF HEPATOLOGY, 53巻, 3号, pp.439-pp.443, SEP 2010
  3. Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice, JOURNAL OF HEPATOLOGY, 54巻, 5号, pp.872-pp.878, MAY 2011
  4. Rapid Emergence of Telaprevir Resistant Hepatitis C Virus Strain from Wildtype Clone In Vivo, HEPATOLOGY, 54巻, 3号, pp.781-pp.788, SEP 2011
  5. Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b, JOURNAL OF HEPATOLOGY, 54巻, 3号, pp.408-pp.414, MAR 2011
  6. Prediction of Response to Peginterferon-Alfa-2b Plus Ribavirin Therapy in Japanese Patients Infected With Hepatitis C Virus Genotype 1b, JOURNAL OF MEDICAL VIROLOGY, 83巻, 6号, pp.981-pp.988, JUN 2011
  7. Common Genetic Polymorphism of ITPA Gene Affects Ribavirin-Induced Anemia and Effect of Peg-Interferon Plus Ribavirin Therapy, JOURNAL OF MEDICAL VIROLOGY, 83巻, 6号, pp.1048-pp.1057, JUN 2011
  8. IL-28B predicts response to chronic hepatitis C therapy - fine-mapping and replication study in Asian populations, JOURNAL OF GENERAL VIROLOGY, 92巻, pp.1071-pp.1081, MAY 2011
  9. IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy, JOURNAL OF HEPATOLOGY, 54巻, 6号, pp.1094-pp.1101, JUN 2011
  10. ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo, JOURNAL OF HEPATOLOGY, 55巻, 1号, pp.11-pp.18, JUL 2011
  11. IL28B But Not ITPA Polymorphism Is Predictive of Response to Pegylated Interferon, Ribavirin, and Telaprevir Triple Therapy in Patients With Genotype 1 Hepatitis C, JOURNAL OF INFECTIOUS DISEASES, 204巻, 1号, pp.84-pp.93, JUL 1 2011
  12. Effects of Hepatitis B Virus Infection on the Interferon Response in Immunodeficient Human Hepatocyte Chimeric Mice, JOURNAL OF INFECTIOUS DISEASES, 204巻, 2号, pp.224-pp.228, JUL 15 2011
  13. Inverse Association of IL28B Genotype and Liver mRNA Expression of Genes Promoting or Suppressing Antiviral State, JOURNAL OF MEDICAL VIROLOGY, 83巻, 9号, pp.1597-pp.1607, SEP 2011
  14. Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers, NATURE GENETICS, 43巻, 8号, pp.797-pp.U108, AUG 2011
  15. Hepatitis C Virus Infection Suppresses the Interferon Response in the Liver of the Human Hepatocyte Chimeric Mouse, PLOS ONE, 6巻, 8号, AUG 23 2011
  16. Impact of Viral Amino Acid Substitutions and Host Interleukin-28B Polymorphism on Replication and Susceptibility to Interferon of Hepatitis C Virus, HEPATOLOGY, 54巻, 3号, pp.764-pp.771, SEP 2011
  17. Serum PAI-1 is a novel predictor for response to pegylated interferon-a-2b plus ribavirin therapy in chronic hepatitis C virus infection, JOURNAL OF VIRAL HEPATITIS, 19巻, 2号, pp.E126-pp.E133, FEB 2012
  18. Hepatocellular carcinoma: Towards personalized medicine, CANCER SCIENCE, 103巻, 5号, pp.846-pp.850, MAY 2012
  19. Toward the Establishment of a Prediction System for the Personalized Treatment of Chronic Hepatitis C, JOURNAL OF INFECTIOUS DISEASES, 205巻, 2号, pp.204-pp.210, JAN 15 2012
  20. Genetics of IL28B and HCV-response to infection and treatment, NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 9巻, 7号, pp.406-pp.417, JUL 2012
  21. Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse, HEPATOLOGY, 56巻, 2号, pp.555-pp.566, AUG 2012
  22. Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication, HEPATOLOGY RESEARCH, 42巻, 9号, pp.841-pp.853, SEP 2012
  23. IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients, JOURNAL OF GASTROENTEROLOGY, 47巻, 7号, pp.834-pp.844, JUL 2012
  24. Hepatitis B Virus-Specific miRNAs and Argonaute2 Play a Role in the Viral Life Cycle, PLOS ONE, 7巻, 10号, OCT 16 2012
  25. Treatment of chronic hepatitis C virus infection in Japan: update on therapy and guidelines, JOURNAL OF GASTROENTEROLOGY, 48巻, 1号, pp.1-pp.12, JAN 2013
  26. Interleukin-28B polymorphisms and hepatitis C virus clearance, GENOME MEDICINE, 5巻, JAN 29 2013
  27. Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B, JOURNAL OF MEDICAL VIROLOGY, 85巻, 5号, pp.789-pp.798, MAY 2013
  28. HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study, PLOS ONE, 8巻, 12号, DEC 20 2013
  29. A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation, PLOS GENETICS, 9巻, 4号, APR 2013
  30. Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice, GUT, 62巻, 7号, pp.1055-pp.1061, JUL 2013
  31. A Translational Study of Resistance Emergence Using Sequential Direct-Acting Antiviral Agents for Hepatitis C Using Ultra-Deep Sequencing, AMERICAN JOURNAL OF GASTROENTEROLOGY, 108巻, 9号, pp.1464-pp.1472, SEP 2013
  32. Serum HBV RNA and HBeAg are useful markers for the safe discontinuation of nucleotide analogue treatments in chronic hepatitis B patients, JOURNAL OF GASTROENTEROLOGY, 48巻, 10号, pp.1188-pp.1204, OCT 2013
  33. Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice, JOURNAL OF GASTROENTEROLOGY, 48巻, 11号, pp.1259-pp.1270, NOV 2013
  34. A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441巻, 1号, pp.230-pp.235, NOV 8 2013
  35. Ultradeep Sequencing Study of Chronic Hepatitis C Virus Genotype 1 Infection in Patients Treated with Daclatasvir, Peginterferon, and Ribavirin, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58巻, 4号, pp.2105-pp.2112, APR 2014
  36. Effect of vitamin D supplementation on pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b: a randomized controlled trial, JOURNAL OF VIRAL HEPATITIS, 21巻, 5号, pp.348-pp.356, MAY 2014
  37. Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA, JOURNAL OF VIRAL HEPATITIS, 21巻, 9号, pp.E89-pp.E97, SEP 2014
  38. IFNL4/IL-28B haplotype structure and its impact on susceptibility to hepatitis C virus and treatment response in the Japanese population, JOURNAL OF GENERAL VIROLOGY, 95巻, pp.1297-pp.1306, JUN 2014
  39. New Insight Into the Enhanced Effect of Pegylated Interferon-alpha, HEPATOLOGY, 60巻, 4号, pp.1435-pp.1437, OCT 2014
  40. Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1, JOURNAL OF VIRAL HEPATITIS, 22巻, 2号, pp.158-pp.165, FEB 2015
  41. Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C, JOURNAL OF GASTROENTEROLOGY, 49巻, 12号, pp.1548-pp.1556, DEC 2014
  42. Emerging treatments for chronic hepatitis C, JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 114巻, 3号, pp.204-pp.215, MAR 2015
  43. Differences in serum microRNA profiles in hepatitis B and C virus infection, JOURNAL OF INFECTION, 70巻, 3号, pp.273-pp.287, MAR 2015
  44. Interferon lambda 4 polymorphism affects on outcome of telaprevir, pegylated interferon and ribavirin combination therapy for chronic hepatitis C, HEPATOLOGY RESEARCH, 44巻, 14号, pp.E447-pp.E454, DEC 2014
  45. Effect of prolonged administration of pegylated interferon/ribavirin therapy in genotypes 2a and 2b: Propensity score-matched analysis, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 30巻, 2号, pp.337-pp.344, FEB 2015
  46. Ribavirin dose reduction during telaprevir/ribavirin/peg-interferon therapy overcomes the effect of the ITPA gene polymorphism, JOURNAL OF VIRAL HEPATITIS, 22巻, 2号, pp.166-pp.174, FEB 2015
  47. Optimizing triple therapy and IFN/RBV-free regimens for hepatitis C virus infection, EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 9巻, 1号, pp.21-pp.30, JAN 2015
  48. Hepatitis C Virus (HCV) Reactivation Caused by Steroid Therapy for Dermatomyositis, INTERNAL MEDICINE, 53巻, 23号, pp.2689-pp.2693, 2014
  49. Two Patients Treated With Simeprevir Plus Pegylated-Interferon and Ribavirin Triple Therapy for Recurrent Hepatitis C After Living Donor Liver Transplantation: Case Report, TRANSPLANTATION PROCEEDINGS, 47巻, 3号, pp.809-pp.814, APR 2015
  50. Novel Robust in Vitro Hepatitis B Virus Infection Model Using Fresh Human Hepatocytes Isolated from Humanized Mice, AMERICAN JOURNAL OF PATHOLOGY, 185巻, 5号, pp.1275-pp.1285, MAY 2015
  51. Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay, PLOS ONE, 10巻, 6号, JUN 17 2015
  52. Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A, JOURNAL OF HEPATOLOGY, 63巻, 3号, pp.554-pp.563, SEP 2015
  53. Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice, JOURNAL OF VIROLOGY, 89巻, 19号, pp.10087-pp.10096, OCT 2015
  54. Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy, JOURNAL OF MEDICAL VIROLOGY, 87巻, 11号, pp.1913-pp.1920, NOV 2015

招待講演、口頭・ポスター発表等

  1. A comparison of male and female responses to inbreeding in Cucurbita texana. Poster., Hayes, C.N.,, Winsor, J.A., Stephenson, A.G., Symposium: Frontiers in Sexual Plant Reproduction in Honor of Prof. Joseph Mascarenhas, 2001年01月, 通常, 英語
  2. Inbreeding depression in male and female functions in Cucurbita texana., Hayes, C.N., Winsor, J.A., Stephenson, A.G., 16th Annual Penn State Symposium in Plant Physiology: Plant Reproduction 2002: From evolutionary and physiological analyses to molecular genetic studies., 2002年05月01日, 通常, 英語
  3. Male vs. female inbreeding depression in Cucurbita texana, Hayes, C.N., Winsor, J.A., Stephenson, A.G., Ecological Society of America Annual Meeting, 2002年08月01日, 通常, 英語
  4. Assessing undergraduate learning in web-based biology instruction, Cyr, R., Harris, S., Hayes, C.N. Woodward, D, National Association for Research in Science Teaching, 2002年10月01日, 通常, 英語
  5. Inbreeding depression in male and female functions in Cucurbita texana., Hayes, C.N., Winsor, J.A., Stephenson, A.G., Royal Society Discussion Meeting on Mechanisms Regulating Gene Flow in Flowering Plants. London, UK., 2002年12月15日, 通常, 英語
  6. varDB: a sequence database of protein families involved in antigenic variation in pathogens., Hayes, C.N., Diez, D., Kanehisa, M., Wahlgren, M., Wheelock, C., Goto, S., Genome Informatics Workshop 2007. Singapore, SINGAPORE., 2007年12月10日, 通常, 英語
  7. Tools for investigating mechanisms of antigenic variation: new extensions to varDB, Hayes CN, Diez D, Joannin N, Kanehisa M, Wahlgren M, Wheelock CE, Goto S, Genome Informatics Workshop 2009, Yokohama, Japan, 2009年12月06日, 通常, 英語
  8. Serum miRNAs and the hepatitis B virus life cycle, C. Nelson Hayes, Sakura Akamatsu, Masataka Tsuge, Daiki Miki, Nobuhiko Hiraga, Michio Imamura, Shoichi Takahashi, Hidenori Ochi, Kazuaki Chayama, AASLD, 2012年11月05日, 通常, 英語
  9. Early and late changes in gene expression profiles following infection with hepatitis B or C virus in human hepatocyte chimeric mice, Hayes, C. Nelson, Sakura Akamatsu, Masataka Tsuge, Daiki Miki, Nobuhiko Hiraga, Hiromi Abe, Michio Imamura1, Shoichi Takahashi, Hidenori Ochi, Kazuaki Chayama, AALSD 2013, 2013年11月04日, 通常, 英語
  10. Challenges in somatic mutation calling in virus-induced hepatocellular carcinoma, C. Nelson Hayes, Atsushi Ono, Sakura Akamatsu, Eisuke Murakami, Hiroshi Aikata, Michio Imamura, Daiki Miki, Hidenori Ochi, and Kazuaki Chayama, JCUP V, 2014年06月14日, 招待, 英語
  11. Hepatitis B virus infection leads to activation of interferon-stimulated genes in primary cultured human hepatocytes, but infection efficiency decreases monotonically with decreasing cell density, C. Nelson Hayes, Hiromi Abe, Sakura Akamatsu, Nobuhiko Hiraga, Michio Imamura, Masataka Tsuge, Daiki Miki, Hiroshi Aikata, , Hidenori Ochi, Yuji Ishida, Chise Tateno, and Kazuaki Chayama, HBV Single topic conference 2014, 2014年11月18日, 通常, 英語
  12. Hepatitis B virus infection efficiency and immune response decreases with cell density in primary cultured hepatocytes, C. Nelson Hayes, Hiromi Abe, Sakura Akamatsu, Nobuhiko Hiraga, Michio Imamura, Masataka Tsuge, Daiki Miki, Hiroshi Aikata, , Hidenori Ochi, Yuji Ishida, Chise Tateno, and Kazuaki Chayama, AASLD, 2014年11月14日, 通常, 英語

受賞

  1. 1992年09月01日, Presidential Scholarship, Washington and Jefferson College
  2. 1999年08月01日, J. Ben and Helen D. Hill graduate student award, Pennsylvania State University
  3. 1999年07月15日, Eberly College of Science Braddock Fellowship, Pennsylvania State University
  4. 2002年05月15日, Graduate Assistant Outstanding Teaching Award, Pennsylvania State University
  5. 2006年04月01日, 日本学術振興会研究員, 日本学術振興会
  6. 2009年12月16日, Best paper award, Genome Informatics Workshop