見前 隆洋TAKAHIRO MIMAE

Last Updated :2024/12/02

所属・職名
原爆放射線医科学研究所　助教
メールアドレス
tmimae＠hiroshima-u.ac.jp

基本情報

主な職歴

  • 2012年04月01日, 2012年08月31日, 広島大学, 病院, 医科診療医
  • 2012年09月01日, 2015年03月31日, 広島大学, 原爆放射線医科学研究所放射線災害医療研究センター, 助教
  • 2015年04月, 2018年03月, Memorial Sloan Kettering Cancer Center, Research Fellow
  • 2018年04月01日, 2022年03月31日, 広島大学, 病院, 助教

学歴

  • 広島大学, 大学院医歯薬学総合研究科, 創生医科学専攻, 日本, 2008年04月, 2012年03月
  • 広島大学, 医学部, 医学科, 日本, 1997年04月, 2003年03月

学位

  • 博士（医学）　(広島大学)

担当主専攻プログラム

  • 医学プログラム

研究分野

  • 医歯薬学 / 外科系臨床医学 / 呼吸器外科学

教育活動

授業担当

  1. 2024年, 学部専門, 集中, 臨床実習入門プログラム
  2. 2024年, 学部専門, 集中, 臨床実習I
  3. 2024年, 学部専門, 集中, 臨床実習II
  4. 2024年, 学部専門, セメスター（前期）, 外科学I

研究活動

学術論文（★は代表的な論文）

  1. Prediction of Unexpected N2 Disease Associated With Clinical T1-2N0-1M0 Non-Small-Cell Lung Cancer., Clinical lung cancer, 22巻, 2号, 2021
  2. ASO Author Reflections: Is Wedge Resection Optimal for Octogenarians with Early-Stage Non-Small-Cell Lung Cancer Compared with Lobectomy/Segmentectomy?, Annals of surgical oncology, 28巻, 12号, 2021
  3. Survival of Octogenarians with Early-Stage Non-small Cell Lung Cancer is Comparable Between Wedge Resection and Lobectomy/Segmentectomy: JACS1303., Annals of surgical oncology, 28巻, 12号, 2021
  4. Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients., Scientific reports, 11巻, 1号, 2021
  5. Prognostic role of interstitial pneumonia with or without emphysema in patients with clinical stage I lung cancer., Japanese journal of clinical oncology, 51巻, 7号, 2021
  6. Complex Segmentectomy for Hypermetabolic Clinical Stage IA Non-Small Cell Lung Cancer., The Annals of thoracic surgery, 113巻, 4号, 2022
  7. Serum S100 calcium-binding protein A4 as a novel predictive marker of acute exacerbation of interstitial pneumonia after surgery for lung cancer., BMC pulmonary medicine, 21巻, 1号, 2021
  8. The impact of pathological lymph node metastasis with lymphatic invasion on the survival of patients with clinically node-negative non-small cell lung cancer: A multicenter study., Lung cancer (Amsterdam, Netherlands), 158巻, 2021
  9. Role of Soluble Receptor for Advanced Glycation End Products in Postoperative Fibrotic Lung Injury., The Annals of thoracic surgery, 113巻, 5号, 2022
  10. Systematic Versus Lobe-Specific Mediastinal Lymphadenectomy for Hypermetabolic Lung Cancer., Annals of surgical oncology, 28巻, 12号, 2021
  11. Postoperative Pulmonary Function After Complex Segmentectomy., Annals of surgical oncology, 28巻, 13号, 2021
  12. Utility of Newly Proposed Grading System From International Association for the Study of Lung Cancer for Invasive Lung Adenocarcinoma., JTO clinical and research reports, 2巻, 2号, 2021
  13. Segmentectomy versus lobectomy for solid predominant cN0 lung cancer: analysis using visual evaluation of positron emission tomography., European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 61巻, 2号, 2022
  14. Segmentectomy versus wedge resection for radiological solid predominant and low metabolic non-small cell lung cancer., Interactive cardiovascular and thoracic surgery, 34巻, 5号, 2022
  15. Interstitial pneumonia and advanced age negatively influence postoperative pulmonary function., Interactive cardiovascular and thoracic surgery, 34巻, 5号, 2022
  16. Oncological outcome of segmentectomy for early-stage non-small-cell lung cancer with invasive characteristics: a multicentre study., European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 62巻, 2号, 2022
  17. The prognostic impact of the ground-glass opacity component in nearly pure-solid stage IA non-small-cell lung cancer., European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2022
  18. Commentary: Segmentectomy as a standard surgery, a new era in small sized, peripheral, non-small cell lung cancer., JTCVS techniques, 12巻, 2022
  19. A Multicenter Study of Complex Segmentectomy Versus Wedge Resection in Clinical Stage 0-IA Non-Small Cell Lung Cancer., Clinical lung cancer, 23巻, 5号, 2022
  20. Psychological states regarding adjuvant chemotherapy in patients with non-small cell lung cancer., Cancer treatment and research communications, 32巻, 2022
  21. Complications and Survival After Lung Cancer Resection in Interstitial Lung Disease., The Annals of thoracic surgery, 2022
  22. Possible Therapeutic Utility of anti-Cell Adhesion Molecule 1 Antibodies for Malignant Pleural Mesothelioma., Frontiers in cell and developmental biology, 10巻, 2022
  23. Complex Segmentectomy for Hypermetabolic Clinical Stage IA Non-Small Cell Lung Cancer, ANNALS OF THORACIC SURGERY, 113巻, 4号, pp. 1317-1324, 202204
    DOIを用いた論文検索結果へのリンク
  24. ASO Author Reflections: Is Wedge Resection Optimal for Octogenarians with Early-Stage Non-Small-Cell Lung Cancer Compared with Lobectomy/Segmentectomy?, ANNALS OF SURGICAL ONCOLOGY, 28巻, 12号, pp. 7228-7229, 202111
    DOIを用いた論文検索結果へのリンク
  25. Role of Soluble Receptor for Advanced Glycation End Products in Postoperative Fibrotic Lung Injury, ANNALS OF THORACIC SURGERY, 113巻, 5号, pp. 1617-1623, 202205
    DOIを用いた論文検索結果へのリンク
  26. Interstitial pneumonia and advanced age negatively influence postoperative pulmonary function, INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 34巻, 5号, pp. 753-759, 20220502
    DOIを用いた論文検索結果へのリンク
  27. Segmentectomy versus wedge resection for radiological solid predominant and low metabolic non-small cell lung cancer, INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 34巻, 5号, pp. 814-821, 20220502
    DOIを用いた論文検索結果へのリンク
  28. Segmentectomy versus lobectomy for solid predominant cN0 lung cancer: analysis using visual evaluation of positron emission tomography, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 61巻, 2号, pp. 279-286, 20220124
    DOIを用いた論文検索結果へのリンク
  29. Upregulation of Notch2 and Six1 Is Associated with Progression of Early- Stage Lung Adenocarcinoma and a More Aggressive Phenotype at Advanced Stages, CLINICAL CANCER RESEARCH, 18巻, 4号, pp. 945-955, 20120215
    DOIを用いた論文検索結果へのリンク
  30. Novel application for pseudopodia proteomics using excimer laser ablation and two-dimensional difference gel electrophoresis, LABORATORY INVESTIGATION, 92巻, 9号, pp. 1374-1385, 201209
    DOIを用いた論文検索結果へのリンク
  31. Cathepsin D as a potential prognostic marker for lung adenocarcinoma, PATHOLOGY RESEARCH AND PRACTICE, 208巻, 9号, pp. 534-540, 2012
    DOIを用いた論文検索結果へのリンク
  32. Protein expression and gene copy number changes of receptor tyrosine kinase in thymomas and thymic carcinomas, ANNALS OF ONCOLOGY, 23巻, 12号, pp. 3129-3137, 201212
    DOIを用いた論文検索結果へのリンク
  33. The prognostic role of pathologic invasive component size, excluding lepidic growth, in stage I lung adenocarcinoma, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 146巻, 3号, pp. 580-585, 201309
    DOIを用いた論文検索結果へのリンク
  34. Increased ectodomain shedding of lung epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema, THORAX, 69巻, 3号, pp. 223-231, 201403
    DOIを用いた論文検索結果へのリンク
  35. alpha-Parvin, a pseudopodial constituent, promotes cell motility and is associated with lymph node metastasis of lobular breast carcinoma, BREAST CANCER RESEARCH AND TREATMENT, 144巻, 1号, pp. 59-69, 201402
    DOIを用いた論文検索結果へのリンク
  36. Role of lymphatic invasion in the prognosis of patients with clinical node-negative and pathologic node-positive lung adenocarcinoma, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 147巻, 6号, pp. 1820-1826, 201406
    DOIを用いた論文検索結果へのリンク
  37. Prediction for prognosis of resected pT1a-lbN0M0 adenocarcinoma based on tumor size and histological status: Relationship of TNM and IASLC/ATS/ERS classifications, LUNG CANCER, 85巻, 2号, pp. 270-275, 201408
    DOIを用いた論文検索結果へのリンク
  38. Role of Positron Emission Tomography/Computed Tomography Findings for Adjuvant Chemotherapy Indications in Stage T1b-2aN0M0 Lung Adenocarcinoma, ANNALS OF THORACIC SURGERY, 98巻, 2号, pp. 417-423, 201408
    DOIを用いた論文検索結果へのリンク
  39. Prognosis of Lung Cancer Patients with a Past History of Colorectal Cancer, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 44巻, 11号, pp. 1088-1095, 201411
    DOIを用いた論文検索結果へのリンク
  40. Paclitaxel followed by FEC 療法による乳癌術前化学療法の臨床病理学的評価, 日本臨床外科学会雑誌 = The journal of the Japan Surgical Association, 66巻, 5号, pp. 990-994, 20050525
  41. 胃静脈瘤出血を契機に発見された膵神経内分泌癌の1例, 日本臨床外科学会雑誌 = The journal of the Japan Surgical Association, 69巻, 8号, pp. 2108-2113, 20080825
  42. 膵癌根治手術における術中放射線照射の効果(肝・胆・膵37, 第60回日本消化器外科学会総会), 日本消化器外科学会雑誌, 38巻, 7号, 20050701
  43. 43.当院における大細胞神経内分泌癌症例(第46回日本肺癌学会中国・四国支部会), 肺癌, 47巻, 4号, 20070820
  44. 74.同時性両側肺がんの2手術例(第46回日本肺癌学会中国・四国支部会), 肺癌, 47巻, 4号, 20070820
  45. 幽門側胃切除術後Roux stasis syndromeの検討, 日本消化器外科学会雑誌, 41巻, 8号, pp. 1551-1556, 20080801
  46. 切除された術前未確診例の検討 : CT検診の臨床診断への影響, 日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery, 22巻, 7号, pp. 992-996, 20081115
  47. YT-12-3(YRA) 臨床病期1A期肺腺癌におけるリンパ管浸潤の意義(YT Young Researcher Award & Traveler's Grant,第113回日本外科学会定期学術集会), 日本外科学会雑誌, 114巻, 2号, 20130305
  48. YT-12-5(YRA) 病理病期I期の肺腺癌症例においては浸潤径がT因子を反映する(YT Young Researcher Award & Traveler's Grant,第113回日本外科学会定期学術集会), 日本外科学会雑誌, 114巻, 2号, 20130305
  49. PS-023-3 臨床病期stageIA肺腺癌における術前補助療法適用の可能性 : 術後遠隔転移再発リスク因子の検討(PS ポスターセッション,第113回日本外科学会定期学術集会), 日本外科学会雑誌, 114巻, 2号, 20130305
  50. PS-023-5 より安全な縮小手術のために : リンパ節転移予測因子としての画像的浸潤径とSUVmaxの有用性(PS ポスターセッション,第113回日本外科学会定期学術集会), 日本外科学会雑誌, 114巻, 2号, 20130305
  51. VSY-6-1 原発性肺癌に対するロボット手術の初期経験(VSY-6 ビデオシンポジウム(6)Robotic Surgeryによる呼吸器外科施術,第114回日本外科学会定期学術集会), 日本外科学会雑誌, 115巻, 2号, 20140305
  52. PS-029-8 肺気腫発症の新規機序 : Cell adhesion molecule 1のshedding亢進による細胞内ドメインの産生(PS-029 肺 基礎-1,ポスターセッション,第114回日本外科学会定期学術集会), 日本外科学会雑誌, 115巻, 2号, 20140305
  53. PS-106-8 シスプラチン誘発性の食思不振とQOL低下に対する六君子湯投与の意義(PS-106 肺 合併症-2・その他,ポスターセッション,第114回日本外科学会定期学術集会), 日本外科学会雑誌, 115巻, 2号, 20140305
  54. Ｐａｃｌｉｔａｘｅｌ　ｆｏｌｌｏｗｅｄ　ｂｙ　ＦＥＣ療法による乳癌術前化学療法の臨床病理学的評価, 日本臨床外科学会雑誌, 66巻, 5号, pp. 990-994, 2005
  55. 幽門側胃切除術後Ｒｏｕｘ　ｓｔａｓｉｓ　ｓｙｎｄｒｏｍｅの検討, 日本消化器外科学会雑誌, 41巻, 8号, pp. 1551-1556, 2008
  56. 胃静脈瘤出血を契機に発見された膵神経内分泌癌の１例, 日本臨床外科学会雑誌, 69巻, 8号, pp. 2108-2113, 2008
  57. [A clinical study of endoscopic local coagulation therapy for hepatocellular carcinoma (HCC)]., Gan to kagaku ryoho. Cancer & chemotherapy, 32巻, 11号, 2005
  58. [A case of recurrent gastric cancer with improvement of obstructive symptoms caused by carcinomatous peritonitis and prolonged survival by chemotherapy with combined use of Paclitaxel and 5-FU]., Gan to kagaku ryoho. Cancer & chemotherapy, 33巻, 2号, 2006
  59. Esophagectomy via left thoracotomy for esophageal cancer with situs inversus totalis: report of a case., Surgery today, 38巻, 11号, 2008
  60. Advantage of absorbable suture material for pulmonary artery ligation., General thoracic and cardiovascular surgery, 58巻, 10号, 2010
  61. Upregulation of notch2 and six1 is associated with progression of early-stage lung adenocarcinoma and a more aggressive phenotype at advanced stages., Clinical cancer research : an official journal of the American Association for Cancer Research, 18巻, 4号, 2012
  62. c-MET/phospho-MET protein expression and MET gene copy number in non-small cell lung carcinomas., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 7巻, 2号, 2012
  63. Novel application for pseudopodia proteomics using excimer laser ablation and two-dimensional difference gel electrophoresis., Laboratory investigation; a journal of technical methods and pathology, 92巻, 9号, 2012
  64. Cathepsin D as a potential prognostic marker for lung adenocarcinoma., Pathology, research and practice, 208巻, 9号, 2012
  65. Increased ectodomain shedding of lung epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema., Thorax, 69巻, 3号, 2014
  66. α-Parvin, a pseudopodial constituent, promotes cell motility and is associated with lymph node metastasis of lobular breast carcinoma., Breast cancer research and treatment, 144巻, 1号, 2014
  67. Role of lymphatic invasion in the prognosis of patients with clinical node-negative and pathologic node-positive lung adenocarcinoma., The Journal of thoracic and cardiovascular surgery, 147巻, 6号, 2014
  68. Segmentectomy versus lobectomy for clinical stage IA lung adenocarcinoma., Annals of cardiothoracic surgery, 3巻, 2号, 2014
  69. Role of positron emission tomography/computed tomography findings for adjuvant chemotherapy indications in stage T1b-2aN0M0 lung adenocarcinoma., The Annals of thoracic surgery, 98巻, 2号, 2014
  70. Prediction for prognosis of resected pT1a-1bN0M0 adenocarcinoma based on tumor size and histological status: relationship of TNM and IASLC/ATS/ERS classifications., Lung cancer (Amsterdam, Netherlands), 85巻, 2号, 2014
  71. Surgical outcomes of non-small-cell lung carcinoma in patients previously treated for gastric cancer., European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47巻, 4号, 2015
  72. Prognosis of lung cancer patients with a past history of colorectal cancer., Japanese journal of clinical oncology, 44巻, 11号, 2014
  73. Reply to the editor., The Journal of thoracic and cardiovascular surgery, 148巻, 4号, 2014
  74. A novel approach to pseudopodia proteomics: excimer laser etching, two-dimensional difference gel electrophoresis, and confocal imaging., Protocol exchange, 2014巻, 2014
  75. New challenges in pseudopodial proteomics by a laser-assisted cell etching technique., Biochimica et biophysica acta, 1854巻, 6号, 2015
  76. Comparison of malignant grade between pure and partially invasive types of early lung adenocarcinoma., The Annals of thoracic surgery, 99巻, 3号, 2015
  77. What are the radiologic findings predictive of indolent lung adenocarcinoma?, Japanese journal of clinical oncology, 45巻, 4号, 2015
  78. Histologic changes associated with the use of fibrinogen- and thrombin-impregnated collagen in the prevention of pulmonary air leakage., The Journal of thoracic and cardiovascular surgery, 149巻, 4号, 2015
  79. Negative prognostic influence of micropapillary pattern in stage IA lung adenocarcinoma., European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 49巻, 1号, 2016
  80. Surgical Outcomes of Lung Cancer in Patients with Combined Pulmonary Fibrosis and Emphysema., Annals of surgical oncology, 22 Suppl 3巻, 2015
  81. Radiologic findings to predict low-grade malignant tumour among clinical T1bN0 lung adenocarcinomas: lessons from histological subtypes., Japanese journal of clinical oncology, 45巻, 8号, 2015
  82. Increased ectodomain shedding of cell adhesion molecule 1 as a cause of type II alveolar epithelial cell apoptosis in patients with idiopathic interstitial pneumonia., Respiratory research, 16巻, 2015
  83. The intracellular domain of cell adhesion molecule 1 is present in emphysematous lungs and induces lung epithelial cell apoptosis., Journal of biomedical science, 22巻, 2015
  84. The Difference in Maximum Standardized Uptake Value among Lung Adenocarcinomas Located at the Upper and Lower Zone on PET/CT., Respiration; international review of thoracic diseases, 90巻, 4号, 2015
  85. Impact of Lepidic Component Occupancy on Effects of Adjuvant Chemotherapy for Lung Adenocarcinoma., The Annals of thoracic surgery, 100巻, 6号, 2015
  86. Prognostic value of the new IASLC/ATS/ERS classification of clinical stage IA lung adenocarcinoma., Lung cancer (Amsterdam, Netherlands), 90巻, 2号, 2015
  87. Association between [18F]-fluoro-2-deoxyglucose uptake and expressions of hypoxia-induced factor 1α and glucose transporter 1 in non-small cell lung cancer., Japanese journal of clinical oncology, 45巻, 12号, 2015
  88. Application of Lepidic Component Predominance to Adjuvant Chemotherapy with Oral Fluoropyrimidines for Stage I Lung Adenocarcinoma., Clinical lung cancer, 17巻, 5号, 2016
  89. Prognostic Role of Subtype Classification in Small-Sized Pathologic N0 Invasive Lung Adenocarcinoma., The Annals of thoracic surgery, 102巻, 5号, 2016
  90. Severity of lung fibrosis affects early surgical outcomes of lung cancer among patients with combined pulmonary fibrosis and emphysema., Medicine, 95巻, 29号, 2016
  91. Feasibility and efficacy of salvage lung resection after definitive chemoradiation therapy for Stage III non-small-cell lung cancer., Interactive cardiovascular and thoracic surgery, 23巻, 6号, 2016
  92. Prognostic significance of vascular invasion in intermediate-grade subtype of lung adenocarcinoma., Japanese journal of clinical oncology, 2016
  93. Integrin-α10 Dependency Identifies RAC and RICTOR as Therapeutic Targets in High-Grade Myxofibrosarcoma., Cancer discovery, 6巻, 10号, 2016
  94. Is cancer history really an exclusion criterion for clinical trial of lung cancer? Influence of gastrointestinal tract cancer history on the outcomes of lung cancer surgery., Japanese journal of clinical oncology, 47巻, 2号, 2017
  95. Is cancer history really an exclusion criterion for clinical trial of lung cancer? Influence of gastrointestinal tract cancer history on the outcomes of lung cancer surgery., Japanese journal of clinical oncology, 47巻, 2号, 2017
  96. 今月の臨床 肺大細胞神経内分泌癌の手術例, 胸部外科, 62巻, 6号, pp. 442-445, 200906
  97. 2年間経過観察後に切除した膵併存腫瘍の1例, 胆と膵, 27巻, pp. 601-605, 2006
  98. [Correlations between hormonal receptor and HER2 status or nuclear grades and response rate in breast cancer treated with neoadjuvant chemotherapy of docetaxel alone]., Gan to kagaku ryoho. Cancer & chemotherapy, 36巻, 4号, 2009
  99. Steroid receptor expression in thymomas and thymic carcinomas., Cancer, 117巻, 19号, 2011
  100. Insulin-like growth factor-1 receptor protein expression and gene copy number alterations in non-small cell lung carcinomas., Human pathology, 44巻, 6号, 2013
  101. The prognostic role of pathologic invasive component size, excluding lepidic growth, in stage I lung adenocarcinoma., The Journal of thoracic and cardiovascular surgery, 146巻, 3号, 2013

受賞

  1. 2018年05月18日, 日本呼吸器外科学会学会賞, 特定非営利活動法人　日本呼吸器外科学会
  2. 2011年, 日本胸部外科学会優秀論文賞, 特定非営利活動法人　日本胸部外科学会

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業, 肺腺癌のATP関連がん代謝型Glycolysis/OXPHOS評価と薬物耐性克服, 2018年
  2. 広島大学 サタケ基金 平成30年度研究助成金, 2018年