檜井 孝夫TAKAO HINOI

Last Updated :2024/05/07

所属・職名
病院（医）　教授
メールアドレス
thinoihiroshima-u.ac.jp
その他連絡先
広島市南区霞1-2-3 臨床研究棟2階共用室2
TEL:082-257-2019
自己紹介
　平成元年に広島大学を卒業し、広島大学第二外科に入局後、5年間の外科研修を行い、広島大学第一生化学の菊池章教授（現、大阪大学分子病態生化学教授）の指導の下、低分子量GTP結合蛋白質のRASのシグナル伝達機構に関する研究を行い博士課程を修了しました。その後、米国ミシガン大学内科学Division of Molecular Medicine and GeneticsのEric R. Fearon教授の指導の下、Post-doctoral fellowとして8年間、大腸癌関連遺伝子ならびに大腸癌疾患モデルマウスの研究に従事しました。平成18年に帰国後、広島大学病院や呉医療センターに外科医として勤務するとともに、大腸癌関連遺伝子の研究を継続しつつ遺伝性大腸癌症候群の診療と研究を行いました。 　平成31年4月、広島大学病院遺伝子診療部特任教授に着任後、がんゲノム医療の院内体制整備を行い、令和元年９月に広島大学病院が「がんゲノム医療拠点病院」に指定されました。令和２年１月より遺伝子診療科特任教授として、広島大学病院でエキスパートパネルを開始しました。 　令和３年４月１日付にて広島大学病院遺伝子診療科教授を拝命致しました。ゲノム情報に基づいた医療は急速に拡大傾向ですが、同時に遺伝子診療リテラシーの醸成は急務であり、令和３年度より「認定遺伝カウンセラー養成課程（博士課程前期）」を設置し人材育成に着手しています。

基本情報

主な職歴

  • 1989年06月01日, 1990年03月30日, 広島大学, 医学部附属病院, 医員（研修医）
  • 1990年04月01日, 1993年05月31日, 県立広島病院, 医師
  • 1993年06月01日, 1993年09月30日, 広島大学, 病院, 医員
  • 1993年10月01日, 1994年03月31日, 国立療養所柳井病院, 外科医師
  • 1998年06月01日, 2006年07月31日, ミシガン大学, 医学部, リサーチ・フェロー
  • 2006年08月01日, 2006年09月30日, 広島大学, 病院, 医員
  • 2006年10月01日, 2007年03月31日, 広島大学, 病院, 助手
  • 2007年04月01日, 2010年09月30日, 広島大学, 大学院医歯薬学総合研究科, 寄附講座講師
  • 2010年10月01日, 2015年09月30日, 広島大学, 病院, 講師

学歴

  • 広島大学, 大学院医学系研究科, 博士課程外科学専攻, 日本, 1994年04月, 1998年03月
  • 広島大学, 医学部, 医学科, 日本, 1983年04月, 1989年03月

学位

  • 博士（医学）　(広島大学)

担当主専攻プログラム

  • 医学プログラム

研究分野

  • 医歯薬学 / 基礎医学 / 人類遺伝学
  • 医歯薬学 / 外科系臨床医学 / 消化器外科学

研究キーワード

  • がんゲノム医療
  • 遺伝性腫瘍、遺伝カウンセリング
  • がん薬物療法
  • 腫瘍外科学
  • 大腸癌
  • 低侵襲外科

所属学会

  • 日本外科学会
  • 日本癌学会
  • 日本臨床腫瘍学会
  • 日本癌治療学会
  • 日本遺伝性腫瘍学会
  • 日本遺伝カウンセリング学会
  • 日本遺伝子診療学会
  • 日本消化器外科学会
  • 日本消化器病学会
  • 大腸癌研究会
  • 日本消化器癌発生学会
  • 日本大腸肛門病学会
  • 日本ストーマ排泄リハビリテーション研究会
  • 日本乳癌学会
  • 日本透析医学会
  • 日本緩和医療学会

教育活動

授業担当

  1. 2024年, 修士課程・博士課程前期, ３ターム, 医療情報リテラシー
  2. 2024年, 博士課程・博士課程後期, ３ターム, 医療情報リテラシー活用[オンデマンド]
  3. 2024年, 学部専門, セメスター（前期）, 人類遺伝学
  4. 2024年, 学部専門, ２ターム, がんの生物学
  5. 2024年, 修士課程・博士課程前期, セメスター（前期）, 特別演習
  6. 2024年, 修士課程・博士課程前期, セメスター（後期）, 特別演習
  7. 2024年, 修士課程・博士課程前期, セメスター（前期）, 特別研究
  8. 2024年, 修士課程・博士課程前期, セメスター（後期）, 特別研究
  9. 2024年, 修士課程・博士課程前期, １ターム, 生命・医療倫理学A
  10. 2024年, 博士課程・博士課程後期, ３ターム, 生命・医療倫理学B
  11. 2024年, 修士課程・博士課程前期, セメスター（前期）, 基礎人類遺伝学演習
  12. 2024年, 修士課程・博士課程前期, セメスター（後期）, 臨床遺伝学特論
  13. 2024年, 修士課程・博士課程前期, セメスター（前期）, 遺伝医療と生命倫理学特論
  14. 2024年, 修士課程・博士課程前期, セメスター（後期）, 遺伝カウンセリング演習Ⅰ
  15. 2024年, 修士課程・博士課程前期, セメスター（前期）, 遺伝カウンセリング演習Ⅱ
  16. 2024年, 修士課程・博士課程前期, セメスター（前期）, 遺伝カウンセリング実習
  17. 2024年, 修士課程・博士課程前期, セメスター（後期）, 遺伝カウンセリング実習
  18. 2024年, 修士課程・博士課程前期, セメスター（前期）, 遺伝カウンセリング研究
  19. 2024年, 修士課程・博士課程前期, セメスター（後期）, 遺伝カウンセリング研究

研究活動

学術論文（★は代表的な論文）

  1. Preservation of peritoneal fibrinolysis owing to decreased transcription of plasminogen activator inhibitor-1 in peritoneal mesothelial cells suppresses postoperative adhesion formation in laparoscopic surgery, SURGERY, 153巻, 3号, pp. 344-356, 201303
    DOIを用いた論文検索結果へのリンク
  2. ラザロイドU74389Gエンドトキシン誘発肝障害抑制作用について, G.I Research, 17巻, pp. 326, 19990401
  3. Malignant mesothelioma originating in the hepatic falciform ligament : Report of a case, Surgery Today, 28巻, pp. 929-931, 19980401
  4. A case of abdominal aortic aneurysm associated with systemic lupus erythematosus, Hiroshima J. Med. Sci., 47巻, pp. 85-87, 19980401
  5. 腎移植患者の悪性腫瘍症例、特に肝癌症例の検討, 中国腎不全研究会誌, 6巻, pp. 289-291, 19970401
  6. 腸上皮特異的ホメオボックス転写因子CDX2はセルロプラスミン関連蛋白質Hephaestinの発現の制御を介して腸上皮細胞内の鉄濃度を調節する, G.I Research, 13巻, 4号, pp. 328-329, 20050801
  7. 下部直腸カルチノイドに対し腹腔鏡下内肛門括約筋切除（LAP-ISR)を施行した１例, 日本大腸肛門病学会雑誌, 60巻, 5号, pp. 281-185, 20070501
  8. S状結腸･直腸に対する腹腔鏡補助下IMA温存リンパ節郭清, 手術, 61巻, 8号, pp. 1133-1138, 20070701
  9. PREVENTION OF ACUTE EXACERBATION OF INTERSTITIAL PNEUMONIA AFTER VATS LUNG BIOPSY BY A SELECTIVE BRONCHIAL BLOCKADE, 15th International Congress of the European Association for Endoscopic Surgery(EAES), 20070705
  10. Recording the Senior Surgeon's Advice on an Operation Video Is an Efficient Way to Make Progress on Surgical Techniques, American College of Surgeons 93rd Annual (Clinical Congress ), 20071007
  11. A Laparoscopic Assisted Low Anterior Resection with Conventional Double Stapling Technique through the Minimum Incision, 16th Asian Congress of Surgery & Chinese Surgical Week 2007, 20071021
  12. S状結腸･直腸進行癌に対する腹腔鏡下手術の手技のポイント, 日本内視鏡外科外科学会雑誌, 13巻, 1号, pp. 83-88, 20080201
  13. 下部直腸カルチノイドに対し腹腔鏡下内肛門括約筋切除(LAP-ISR)を施行した1例, 日本大腸肛門病学会雑誌, 60巻, 5号, pp. 281-285, 20070501
  14. 胃がん・大腸がん医療連携推進特別委員会(平成24年度)　胃がん・大腸がんの医療連携体制の構築に向けて, 広島医学, 66巻, 12号, pp. 840-845, 20131201
  15. Inhibition of Wnt signaling pathway by a novel axin-binding protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 275巻, 47号, pp. 37030-37037, 20001124
    DOIを用いた論文検索結果へのリンク
  16. Generating somatic mosaicism with a Cre recombinase - microsatellite sequence transgene, NATURE METHODS, 5巻, 3号, pp. 231-233, 200803
    DOIを用いた論文検索結果へのリンク
  17. Gastrointestinal stromal tumors of the small intestine in pediatric populations: a case report and literature review, PEDIATRIC SURGERY INTERNATIONAL, 26巻, 6号, pp. 649-654, 201006
    DOIを用いた論文検索結果へのリンク
  18. Search for transmembrane protein in gastric cancer by the Escherichia coli ampicillin secretion trap: expression of DSC2 in gastric cancer with intestinal phenotype, JOURNAL OF PATHOLOGY, 221巻, 3号, pp. 275-284, 201007
    DOIを用いた論文検索結果へのリンク
  19. Immunohistochemical analysis of colorectal cancer with gastric phenotype: Claudin-18 is associated with poor prognosis, PATHOLOGY INTERNATIONAL, 60巻, 10号, pp. 673-680, 201010
    DOIを用いた論文検索結果へのリンク
  20. CDX2 Regulates Multidrug Resistance 1 Gene Expression in Malignant Intestinal Epithelium, CANCER RESEARCH, 70巻, 17号, pp. 6767-6778, 20100901
    DOIを用いた論文検索結果へのリンク
  21. Olfactomedin 4 (GW112, hGC-1) is an independent prognostic marker for survival in patients with colorectal cancer, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 1巻, 1号, pp. 73-78, 2010
    DOIを用いた論文検索結果へのリンク
  22. Malignant peripheral nerve sheath tumor arising from the greater omentum: Case report, WORLD JOURNAL OF SURGICAL ONCOLOGY, 9巻, 20110321
    DOIを用いた論文検索結果へのリンク
  23. External Validation of Two Nomograms for Predicting Patient Survival After Hepatic Resection for Metastatic Colorectal Cancer, WORLD JOURNAL OF SURGERY, 35巻, 10号, pp. 2275-2282, 201110
    DOIを用いた論文検索結果へのリンク
  24. Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer, SURGERY TODAY, 41巻, 10号, pp. 1370-1379, 201110
    DOIを用いた論文検索結果へのリンク
  25. SINGLE-INCISION LAPAROSCOPIC COLECTOMY USING THE GELPORT SYSTEM FOR EARLY COLON CANCER, SCANDINAVIAN JOURNAL OF SURGERY, 101巻, 1号, pp. 16-20, 2012
    DOIを用いた論文検索結果へのリンク
  26. Identification of patients likely to benefit from metastasectomy in stage IV colorectal cancer, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 27巻, 10号, pp. 1339-1346, 201210
    DOIを用いた論文検索結果へのリンク
  27. Single-port laparoscopic colectomy versus conventional laparoscopic colectomy for colon cancer: a comparison of surgical results, WORLD JOURNAL OF SURGICAL ONCOLOGY, 10巻, 20120424
    DOIを用いた論文検索結果へのリンク
  28. Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer, CANCER SCIENCE, 103巻, 9号, pp. 1744-1750, 201209
    DOIを用いた論文検索結果へのリンク
  29. Primary lung cancer presenting with metastasis to the colon: a case report, WORLD JOURNAL OF SURGICAL ONCOLOGY, 10巻, 20120628
    DOIを用いた論文検索結果へのリンク
  30. Reg IV Is a Direct Target of Intestinal Transcriptional Factor CDX2 in Gastric Cancer, PLOS ONE, 7巻, 11号, 20121102
    DOIを用いた論文検索結果へのリンク
  31. Procalcitonin as a predictive marker for surgical site infection in elective colorectal cancer surgery, LANGENBECKS ARCHIVES OF SURGERY, 398巻, 6号, pp. 833-839, 201308
    DOIを用いた論文検索結果へのリンク
  32. Surgical treatment for isolated inguinal lymph node metastasis in lower rectal adenocarcinoma patients improves outcome, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 28巻, 12号, pp. 1675-1680, 201312
    DOIを用いた論文検索結果へのリンク
  33. Effect of Left Colonic Artery Preservation on Anastomotic Leakage in Laparoscopic Anterior Resection for Middle and Low Rectal Cancer, WORLD JOURNAL OF SURGERY, 37巻, 12号, pp. 2935-2943, 201312
    DOIを用いた論文検索結果へのリンク
  34. Overexpression of Hypoxia Inducible Factor-1 Alpha is an Independent Risk Factor for Recurrence After Curative Resection of Colorectal Liver Metastases, ANNALS OF SURGICAL ONCOLOGY, 20巻, pp. S527-S536, 201312
    DOIを用いた論文検索結果へのリンク
  35. High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer, INTERNATIONAL JOURNAL OF CANCER, 134巻, 8号, pp. 1926-1934, 20140415
    DOIを用いた論文検索結果へのリンク
  36. Colonoscopy as a tool for evaluating colorectal tumor development in a mouse model, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 29巻, 2号, pp. 217-223, 201402
    DOIを用いた論文検索結果へのリンク
  37. Avoiding restorative proctocolectomy for colorectal cancer in patients with ulcerative colitis based on preoperative diagnosis involving p53 immunostaining: report of a case, WORLD JOURNAL OF SURGICAL ONCOLOGY, 13巻, 20150326
    DOIを用いた論文検索結果へのリンク
  38. Up-front systemic chemotherapy is a feasible option compared to primary tumor resection followed by chemotherapy for colorectal cancer with unresectable synchronous metastases, WORLD JOURNAL OF SURGICAL ONCOLOGY, 13巻, 20150424
    DOIを用いた論文検索結果へのリンク
  39. Laparoscopic Versus Open Surgery for Colorectal Cancer in Elderly Patients: A Multicenter Matched Case-Control Study, ANNALS OF SURGICAL ONCOLOGY, 22巻, 6号, pp. 2040-2050, 201506
    DOIを用いた論文検索結果へのリンク
  40. Chlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient Mice, PLOS ONE, 10巻, 7号, 20150717
    DOIを用いた論文検索結果へのリンク
  41. Oxaliplatin and molecular-targeted drug therapies improved the overall survival in colorectal cancer patients with synchronous peritoneal carcinomatosis undergoing incomplete cytoreductive surgery, SURGERY TODAY, 45巻, 8号, pp. 986-992, 201508
    DOIを用いた論文検索結果へのリンク
  42. A case of Turcot's syndrome type 1 with loss of immunoexpression of MSH6 in colon cancer and liver metastasis due to secondary somatic mutation in coding mononucleotide (C)8 tract: a case report, BMC MEDICAL GENETICS, 21巻, 1号, 20200701
    DOIを用いた論文検索結果へのリンク
  43. Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral, JOURNAL OF BIOLOGICAL CHEMISTRY, 273巻, 2号, pp. 814-821, 1998
  44. Malignant mesothelioma originating in the hepatic falciform ligament: Report of a case, SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 28巻, 9号, pp. 929-931, 1998
  45. Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis, ONCOGENE, 18巻, 43号, pp. 5915-5922, 1999
  46. Complex formation of adenomatous polyposis coli gene product and Axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin, JOURNAL OF BIOLOGICAL CHEMISTRY, 275巻, 44号, pp. 34399-34406, 2000
  47. Inhibition of Wnt signaling pathway by a novel axin-binding protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 275巻, 47号, pp. 37030-37037, 2000
  48. Reduced CDX2 expression and high-frequency microsatellite instability in anaplastic carcinomas of the colon., MODERN PATHOLOGY, 14巻, 1号, pp. 96A-96A, 2001
  49. Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A, JOURNAL OF BIOLOGICAL CHEMISTRY, 276巻, 29号, pp. 26875-26882, 2001
  50. Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon, AMERICAN JOURNAL OF PATHOLOGY, 159巻, 6号, pp. 2239-2248, 2001
  51. L1-cadherin, a key transcriptional target of the CDX2 homeobox protein, GASTROENTEROLOGY, 122巻, 4号, pp. A105-A105, 2002
  52. Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system, GUT, 51巻, 2号, pp. 184-190, 2002
  53. CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia, GASTROENTEROLOGY, 123巻, 5号, pp. 1565-1577, 2002
  54. Impact of insulin resistance and hyperinsulin response on arterial stiffness, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 41巻, 6号, pp. 309A-309A, 2003
  55. Silencing of CDX2 expression in colon cancer via a dominant repression pathway, JOURNAL OF BIOLOGICAL CHEMISTRY, 278巻, 45号, pp. 44608-44616, 2003
  56. Intravascular ultrasound-guided coronary artery stenting for spontaneous coronary artery dissection in a case of acute myocardial infarction associated with vasospasm in a non-culprit coronary artery during the hospitalization, INTERNAL MEDICINE, 45巻, 12号, pp. 763-767, 2006
  57. Chlorinated drinking water alters carcinogenesis in a mice model of colon cancer, CANCER RESEARCH, 72巻, 2012
  58. CDX2 regulates expression of ceruloplasmin-related protein hephaestin in intestinal and colonic epithelium, GASTROENTEROLOGY, 126巻, 4号, pp. A132-A132, 2004
  59. cis elements of the human CDX2 gene regulate expression of transgenes in mouse colonic epithelial cells, GASTROENTEROLOGY, 126巻, 4号, pp. A133-A133, 2004
  60. Paradoxical peripheral embolism coincident with acute pulmonary thromboembolism, INTERNAL MEDICINE, 44巻, 3号, pp. 243-245, 2005
  61. CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium, GASTROENTEROLOGY, 128巻, 4号, pp. 946-961, 2005
  62. CDX2 and sonic hedgehog expression in intestinal metaplasia: the implication for gastric carcinogenesis, GASTROENTEROLOGY, 128巻, 4号, pp. A351-A351, 2005
  63. Acute effect of atorvastatin on coronary circulation measured by transthoracic Doppler echocardiography in patients without coronary artery disease by angiography, AMERICAN JOURNAL OF CARDIOLOGY, 96巻, 1号, pp. 89-91, 2005
  64. Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer exhibits sonic hedgehog loss and aberrant CDX2 expression, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 24巻, pp. 71-80, 2006
  65. Drosophila split ends homologue SHARP functions as a positive regulator of wnt/beta-catenin/T-cell factor signaling in neoplastic transformation, CANCER RESEARCH, 67巻, 2号, pp. 482-491, 2007
  66. Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation, CANCER RESEARCH, 67巻, 20号, pp. 9721-9730, 2007
  67. Feasibility of a rapid protocol of 1-day single-isotope rest/adenosine stress Tc-99m sestamibi ECG-gated myocardial perfusion imaging, JOURNAL OF NUCLEAR CARDIOLOGY, 15巻, 1号, pp. 35-41, 2008
  68. Generating somatic mosaicism with a Cre recombinase - microsatellite sequence transgene, NATURE METHODS, 5巻, 3号, pp. 231-233, 2008
  69. Telmisartan, an angiotensin II type I receptor blocker, improves coronary microcirculation and insulin resistance among essential hypertensive patients without left ventricular hypertrophy, HYPERTENSION RESEARCH, 31巻, 4号, pp. 615-622, 2008
  70. Abscess in the inguinal hernial sac after peritonitis surgery: A case report, WORLD JOURNAL OF GASTROENTEROLOGY, 15巻, 8号, pp. 1007-1009, 2009
  71. Coronary flow reserve: a new target for treating hypertension Response, HYPERTENSION RESEARCH, 32巻, 4号, pp. 317-317, 2009
  72. Retroperitoneal abscess complicated with necrotizing fasciitis of the thigh in a patient with sigmoid colon cancer, WORLD JOURNAL OF SURGICAL ONCOLOGY, 7巻, 2009
  73. Hybrid Hand-Assisted Colectomy for Transverse Colon Cancer: A Useful Technique for Non-Expert Laparoscopic Surgeons, WORLD JOURNAL OF SURGERY, 33巻, 12号, pp. 2683-2687, 2009
  74. Gastrointestinal stromal tumors of the small intestine in pediatric populations: a case report and literature review, PEDIATRIC SURGERY INTERNATIONAL, 26巻, 6号, pp. 649-654, 2010
  75. Malignant peripheral nerve sheath tumor arising from the greater omentum: Case report, WORLD JOURNAL OF SURGICAL ONCOLOGY, 9巻, 2011
  76. External Validation of Two Nomograms for Predicting Patient Survival After Hepatic Resection for Metastatic Colorectal Cancer, WORLD JOURNAL OF SURGERY, 35巻, 10号, pp. 2275-2282, 2011
  77. Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer, SURGERY TODAY, 41巻, 10号, pp. 1370-1379, 2011
  78. SINGLE-INCISION LAPAROSCOPIC COLECTOMY USING THE GELPORT SYSTEM FOR EARLY COLON CANCER, SCANDINAVIAN JOURNAL OF SURGERY, 101巻, 1号, pp. 16-20, 2012
  79. Single-port laparoscopic colectomy versus conventional laparoscopic colectomy for colon cancer: a comparison of surgical results, WORLD JOURNAL OF SURGICAL ONCOLOGY, 10巻, 2012
  80. Primary lung cancer presenting with metastasis to the colon: a case report, WORLD JOURNAL OF SURGICAL ONCOLOGY, 10巻, 2012
  81. Identification of patients likely to benefit from metastasectomy in stage IV colorectal cancer, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 27巻, 10号, pp. 1339-1346, 2012
  82. Preservation of peritoneal fibrinolysis owing to decreased transcription of plasminogen activator inhibitor-1 in peritoneal mesothelial cells suppresses postoperative adhesion formation in laparoscopic surgery, SURGERY, 153巻, 3号, pp. 344-356, 2013
  83. Multicenter matched case-control study comparing laparoscopic surgery with open surgery for elderly colon and rectal cancer patients, JOURNAL OF CLINICAL ONCOLOGY, 30巻, 15号, 2012
  84. Procalcitonin as a predictive marker for surgical site infection in elective colorectal cancer surgery, LANGENBECKS ARCHIVES OF SURGERY, 398巻, 6号, pp. 833-839, 2013
  85. Surgical treatment for isolated inguinal lymph node metastasis in lower rectal adenocarcinoma patients improves outcome, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 28巻, 12号, pp. 1675-1680, 2013
  86. Effect of Left Colonic Artery Preservation on Anastomotic Leakage in Laparoscopic Anterior Resection for Middle and Low Rectal Cancer, WORLD JOURNAL OF SURGERY, 37巻, 12号, pp. 2935-2943, 2013
  87. Overexpression of Hypoxia Inducible Factor-1 Alpha is an Independent Risk Factor for Recurrence After Curative Resection of Colorectal Liver Metastases, ANNALS OF SURGICAL ONCOLOGY, 20巻, pp. S527-S536, 2013
  88. Colonoscopy as a tool for evaluating colorectal tumor development in a mouse model, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 29巻, 2号, pp. 217-223, 2014
  89. Avoiding restorative proctocolectomy for colorectal cancer in patients with ulcerative colitis based on preoperative diagnosis involving p53 immunostaining: report of a case, WORLD JOURNAL OF SURGICAL ONCOLOGY, 13巻, 2015
  90. IMPACT OF INTRAOPERATIVE BLOOD LOSS ON MORBIDITY AND SURVIVAL AFTER RADICAL SURGERY FOR COLORECTAL CANCER PATIENTS AGED 80 YEARS OR OLDER., DISEASES OF THE COLON & RECTUM, 58巻, 5号, pp. E366-E366, 2015
  91. Up-front systemic chemotherapy is a feasible option compared to primary tumor resection followed by chemotherapy for colorectal cancer with unresectable synchronous metastases, WORLD JOURNAL OF SURGICAL ONCOLOGY, 13巻, 2015
  92. Laparoscopic Versus Open Surgery for Colorectal Cancer in Elderly Patients: A Multicenter Matched Case-Control Study, ANNALS OF SURGICAL ONCOLOGY, 22巻, 6号, pp. 2040-2050, 2015
  93. A multi-institutional feasibility study of S-1/oxaliplatin (SOX) plus bevacizumab in patients with advanced/metastatic colorectal cancer: HiSCO-02 prospective phase II study., JOURNAL OF CLINICAL ONCOLOGY, 33巻, 3号, 2015
  94. Chlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient Mice, PLOS ONE, 10巻, 7号, 2015
  95. Oxaliplatin and molecular-targeted drug therapies improved the overall survival in colorectal cancer patients with synchronous peritoneal carcinomatosis undergoing incomplete cytoreductive surgery, SURGERY TODAY, 45巻, 8号, pp. 986-992, 2015
  96. Predictive factor for toxicities and treatment termination in adjuvant capecitabine therapy for stage III colorectal cancer; based on the data of a randomized trial, JCOG0910, EUROPEAN JOURNAL OF CANCER, 51巻, pp. S375-S375, 2015
  97. Significance of miR-148a in Colorectal Neoplasia: Downregulation of miR-148a Contributes to the Carcinogenesis and Cell Invasion of Colorectal Cancer, PATHOBIOLOGY, 82巻, 5号, pp. 233-241, 2015
  98. Impact of intraoperative blood loss on morbidity and survival after radical surgery for colorectal cancer patients aged 80 years or older, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 31巻, 2号, pp. 327-334, 2016
  99. Upper gastrointestinal tumours in Japanese familial adenomatous polyposis patients, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 46巻, 4号, pp. 310-315, 2016
  100. Causes of Cancer Death Among First-Degree Relatives in Japanese Families with Lynch Syndrome, ANTICANCER RESEARCH, 36巻, 4号, pp. 1985-1989, 2016
  101. Chemotherapeutic outcomes for metastatic colorectal cancer in elderly patients aged >= 75 years: A single-institutional retrospective analysis, ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 12巻, 2号, pp. 151-158, 2016
  102. Prevalence of laparoscopic surgical treatment and its clinical outcomes in patients with familial adenomatous polyposis in Japan, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 21巻, 4号, pp. 713-722, 2016
  103. Lower body mass index predicts worse cancer-specific prognosis in octogenarians with colorectal cancer, JOURNAL OF GASTROENTEROLOGY, 51巻, 8号, pp. 779-787, 2016
  104. KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer, ONCOGENESIS, 5巻, 2016
  105. Feasibility of laparoscopic total proctocolectomy with ileal pouch-anal anastomosis and total colectomy with ileorectal anastomosis for familial adenomatous polyposis: results of a nationwide multicenter study, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 21巻, 5号, pp. 953-961, 2016
  106. Therapeutic approaches for patients with coexisting familial adenomatous polyposis and colorectal cancer, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 46巻, 9号, pp. 819-824, 2016
  107. Childbirth after surgery for familial adenomatous polyposis in Japan, SURGERY TODAY, 47巻, 2号, pp. 233-237, 2017
  108. Choline Deficiency Causes Colonic Type II Natural Killer T (NKT) Cell Loss and Alleviates Murine Colitis under Type I NKT Cell Deficiency, PLOS ONE, 12巻, 1号, 2017
  109. Association between the age and the development of colorectal cancer in patients with familial adenomatous polyposis: a multi-institutional study, SURGERY TODAY, 47巻, 4号, pp. 470-475, 2017
  110. Current status of prophylactic surgical treatment for familial adenomatous polyposis in Japan, SURGERY TODAY, 47巻, 6号, pp. 690-696, 2017
  111. Influence of previous abdominal surgery on surgical outcomes between laparoscopic and open surgery in elderly patients with colorectal cancer: subanalysis of a large multicenter study in Japan, JOURNAL OF GASTROENTEROLOGY, 52巻, 6号, pp. 695-704, 2017
  112. The treatment of desmoid tumors associated with familial adenomatous polyposis: the results of a Japanese multicenter observational study, SURGERY TODAY, 47巻, 10号, pp. 1259-1267, 2017
  113. Prognostic impact of hospital volume on familial adenomatous polyposis: a nationwide multicenter study, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 32巻, 10号, pp. 1489-1498, 2017
  114. Multicenter phase II study of biweekly XELIRI plus bevacizumab as a second-line therapy in patients with metastatic colorectal cancer (JSWOG-C3 study), ANNALS OF ONCOLOGY, 28巻, 2017
  115. PREOPERATIVE SERUM OXIDATIVE STRESS LEVELS ARE ASSOCIATED WITH ABERRANT PCDH10 METHYLATION IN SERUM AND POOR CLINICAL OUTCOMES IN CURATIVELY RESECTED NODE-NEGATIVE NON-SMALL CELL LUNG, RESPIROLOGY, 22巻, pp. 112-113, 2017
  116. Pten haploinsufficiency enhances carcinogenesis in mouse colon epithelium with Apc deficiency, CANCER SCIENCE, 109巻, pp. 174-174, 2018
  117. Clinicopathological significance of RCAN-2 expression in gastric carcinoma, CANCER SCIENCE, 109巻, pp. 1086-1086, 2018
  118. SURVIVAL BENEFIT OF LYMPH NODE DISSECTION IN SURGERY FOR COLON CNACER IN ELDERLY PATIENTS: A MULTICENTER POPEN-SITYY SCORE-MATCHED CASE-CONTROL STUDY IN JAPAN., DISEASES OF THE COLON & RECTUM, 61巻, 5号, pp. E146-E146, 2018
  119. RIGHT-SIDED VS LEFT-SIDED COLORECTAL CNCER AFTER CURATIVE RESECTION IN PATIENTS OVER 80 YEARS OF AGE: AN ANALYSIS OF A LARGE MULTICENTER STUDY IN JAPAN, DISEASES OF THE COLON & RECTUM, 61巻, 5号, pp. E227-E228, 2018
  120. Risk factors for postoperative pneumonia in elderly patients with colorectal cancer: a sub-analysis of a large, multicenter, case-control study in Japan, SURGERY TODAY, 48巻, 8号, pp. 756-764, 2018
  121. Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum, SURGERY TODAY, 48巻, 8号, pp. 810-814, 2018
  122. A colorectal cancer organoid library provides a promising screening tool for assessment of chemosensitivity, CANCER RESEARCH, 77巻, 2017
  123. Construction of Integrated Database of Clinical and Genetic Information for Lynch syndrome in Japan, CANCER SCIENCE, 109巻, pp. 779-779, 2018
  124. Identification of pathways associated with tumor invasion in mouse model for colon cancer with Pten haploinsufficiency, CANCER SCIENCE, 109巻, pp. 1236-1236, 2018
  125. Clinicopathological significance of ADAM28 expression in colorectal cancer, CANCER SCIENCE, 109巻, pp. 1346-1346, 2018
  126. Prevalence of and risk factors for thyroid carcinoma in patients with familial adenomatous polyposis: results of a multicenter study in Japan and a systematic review, SURGERY TODAY, 49巻, 1号, pp. 72-81, 2019
  127. Spontaneous regression of transverse colon cancer with high-frequency microsatellite instability: a case report and literature review, WORLD JOURNAL OF SURGICAL ONCOLOGY, 17巻, 2019
  128. Clinicopathological significance of RCAN2 production in gastric carcinoma, HISTOPATHOLOGY, 74巻, 3号, pp. 430-442, 2019
  129. BRAF(V600E) mutation and loss of CDX2 synergize in serrated colorectal tumorigenesis, CANCER RESEARCH, 78巻, 13号, 2018
  130. Expression analysis of transcribed-ultraconserved regions in cancer stem cell population using colorectal cancer organoids, CANCER RESEARCH, 78巻, 13号, 2018
  131. Pten haploinsufficiency promotes tumor invasion and carcinogenesis in mouse colon epithelium with Apc deficiency, CANCER RESEARCH, 78巻, 13号, 2018
  132. Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model, PLOS ONE, 14巻, 6号, 2019
  133. CLINICOPATHOLOGICAL CHARACTERISTICS OF UPPER TRACT UROTHELIAL CANCER WITH LOSS OF IMMUNOHISTOCHEMICAL EXPRESSION OF MISMATCH REPAIR PROTEINS IN UNIVERSAL SCREENING, JOURNAL OF UROLOGY, 203巻, pp. E1246-E1246, 2020
  134. A case of Turcot's syndrome type 1 with loss of immunoexpression of MSH6 in colon cancer and liver metastasis due to secondary somatic mutation in coding mononucleotide (C)8 tract: a case report, BMC MEDICAL GENETICS, 21巻, 1号, 2020
  135. Oncogenic mutation in RAS-RAF axis leads to increased expression ofGREB1, resulting in tumor proliferation in colorectal cancer, CANCER SCIENCE, 2020
  136. Antithrombin attenuates the progression of hepatocellular carcinoma by regulating neutrophil/interleukin-8 signaling, HEPATOLOGY RESEARCH, 2020
  137. BACTERIOLOGICAL INVESTIGATION OF BILE IN PATIENTS WITH CHOLELITHIASIS, SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 23巻, 5号, pp. 390-395, 1993
  138. Ras-interacting domain of Ral GDP dissociation stimulator like (RGL) reverses v-Ras-induced transformation and Raf-1 activation in NIH3T3 cells, CANCER RESEARCH, 56巻, 10号, pp. 2387-2392, 1996
  139. Post-translational modifications of Ras and Ral are important for the action of Ral GDP dissociation stimulator, JOURNAL OF BIOLOGICAL CHEMISTRY, 271巻, 33号, pp. 19710-19716, 1996
  140. Effect of pretreatment with coenzyme Q(10) and monoclonal antibodies to adhesion molecules on ischemic small intestine preservation, TRANSPLANTATION PROCEEDINGS, 28巻, 5号, pp. 2600-2601, 1996
  141. Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator, ONCOGENE, 14巻, 5号, pp. 515-521, 1997
  142. Protective effect of monoclonal antibodies to adhesion molecules on rat liver ischemia-reperfusion injury, SURGERY, 122巻, 1号, pp. 45-52, 1997
  143. The post-translational modifications of Ral and Rac1 are important for the action of Ral-binding protein 1, a putative effector protein of Ral, FEBS LETTERS, 410巻, 2-3号, pp. 169-174, 1997

招待講演、口頭・ポスター発表等

  1. がんの本質に迫る 「がんゲノム医療」の現状と課題, 檜井孝夫, がんゲノム医療について, 2020年02月16日, 通常, 日本語, 広島県医学検査学会, 広島
  2. がんの本質に迫る「がんゲノム医療」の現状と課題, 檜井孝夫, 第37回広島県医学検査学会, 2020年02月16日, 通常, 日本語, 一般社団法人広島県臨床検査技師会, 広島
  3. がんゲノム医療について, 檜井孝夫, 広島県国民健康保険診療報酬審査委員会, 2020年01月23日, 通常, 日本語, 広島県国民健康保険団体連合会, 広島
  4. がんゲノム医療の現状と今後の展開, 檜井孝夫, 広島県がん診療連携拠点病院薬剤師研修会, 2020年01月22日, 通常, 日本語, 広島大学病院(都道府県がん診療連携拠点病院)薬剤部, 広島
  5. がんゲノムの現状と今後の展開, 檜井孝夫, がんゲノム医療, 2019年11月01日, 通常, 日本語, 広島県厚生農業協同組合連合, 広島
  6. がんゲノム医療を考える, 檜井孝夫, みんなで学ぶがん治療～再診話題に迫る「がんゲノム医療って何？」～, 2019年10月19日, 通常, 日本語, 中外製薬株式会社/広島ホームテレビ, 広島
  7. がんゲノム医療, 檜井孝夫, 最新話題に迫る「がんゲノム医療って何？」, 2019年10月19日, 通常, 日本語, 認定NPO法人乳がん患者会の会きらら, 広島
  8. がんゲノム医療について, 檜井孝夫, がんサロン(がんゲノム医療について), 2019年08月09日, 通常, 日本語, 独立行政法人国立病院機構　呉医療センター・中国がんセンター, 広島
  9. 広島大学病院におけるがんゲノム医療体制の構築と今後の展望, 檜井孝夫, 第14回広島臨床遺伝セミナー, 2019年07月13日, 通常, 日本語, 広島臨床遺伝研究会事務局, 広島
  10. これから始まるがん治療革命～令和元年6月「がんゲノム医療」がついに保険診療に！～, 檜井孝夫, 広島大学病院がん医療従事者研修会, 2019年07月19日, 通常, 日本語, 広島大学病院/中国・四国広域がんプロ養成コンソーシアム/広島大学がんプロフェッショナル養成基盤推進プラン, 広島
  11. がんゲノム医療について, 檜井孝夫, HiSCO周術期管理講習会, 2019年06月29日, 通常, 日本語, HiSCO事務局, 広島
  12. 「がんゲノム医療の基礎知識と問題点」〜外科領域における運用の実際について〜, 檜井孝夫, 第5回外科周術期管理講習会, 2019年06月29日, 通常, 日本語, 広島臨床腫瘍外科研究グループ, 広島

受賞

  1. 2012年, 広島大学大学院医歯薬学総合研究科教員顕彰, 広島大学

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業(基盤研究(C)), 大腸癌のサブクラス分類に対応するマウスモデルとオルガノイドの確立とその臨床応用, 2018年04月01日, 2021年03月31日
  2. 科学研究費助成事業(基盤研究(B)), 遺伝子不安定性の異なるサブクラス分類に有用な新規マウス大腸癌疾患モデルの確立, 2013年, 2016年
    関連URL
  3. 科学研究費助成事業(基盤研究(B)), 新規大腸癌転移マウスモデル実験系の構築と臓器特異的転移関連バイオマーカーの同定, 2010年, 2013年
    関連URL
  4. 科学研究費助成事業(挑戦的萌芽研究), 人工多能性幹細胞由来の腸上皮細胞株の確立と大腸癌幹細胞モデルの構築, 2010年, 2011年
    関連URL
  5. 科学研究費助成事業(基盤研究(C)), 大腸浸潤癌マウスモデルの作製, 2007年, 2008年
    関連URL

社会活動

委員会等委員歴

  1. 代議員, 2014年04月, 2016年02月, （社）日本外科学会
  2. 遺伝カウンセリング委員会委員, 日本遺伝カウンセリング学会
  3. 遺伝学的検査委員会委員, 日本遺伝カウンセリング学会
  4. 国際委員会委員, 日本遺伝性腫瘍学会

学術雑誌論文査読歴

  1. 2020年, Frontier Oncology, 1
  2. International J Cancer, 1
  3. Surgical Case Reports, 3
  4. 2020年, Japanese Journal of Clinical Oncology, 2
  5. 2020年, Surgery Today, 1
  6. 2020年, Asia-Pacific Journal of Clinical Oncology, 1
  7. 2019年, Surgical Case Reports, 1
  8. 2019年, Japanese Journal of Clinical Oncology, 1
  9. 2019年, Journal of Cellular and Molecular Medicine, 1
  10. 2019年, Cancer Science, 1
  11. 2019年, Cancer Medicine, 1
  12. 2019年, Asian Journal of Endoscopic Surgery, 1