中佐 智幸TOMOYUKI NAKASA

Last Updated :2025/04/03

所属・職名
大学院医系科学研究科（医）　寄附講座准教授
メールアドレス
tn618hiroshima-u.ac.jp

基本情報

学位

  • 博士（医学）　(広島大学)

研究分野

  • 医歯薬学 / 外科系臨床医学 / 整形外科学

教育活動

授業担当

  1. 2025年, 学部専門, 通年, 器官・システム病態制御学II
  2. 2025年, 学部専門, 集中, 臨床実習I
  3. 2025年, 修士課程・博士課程前期, セメスター（後期）, 臨床医歯学総論

研究活動

学術論文（★は代表的な論文）

  1. Responses of microRNAs 124a and 223 following spinal cord injury in mice., Spinal Cord, 48巻, 3号, pp. 192-6, 20100301
  2. Inhibitory effect of microRNA-146 expression on bone destruction in collagen-induced arthritis., Arthritis Rheum, 20110601
  3. A mini-review:microRNA in arthritis., Physiol Genomics, 20110501
  4. Expression of MicroRNA-146 in rheumatoid arthritis synovial tissue, ARTHRITIS AND RHEUMATISM, 58巻, 5号, pp. 1284-1292, 200805
    DOIを用いた論文検索結果へのリンク
  5. Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro, RHEUMATOLOGY, 49巻, 11号, pp. 2054-2060, 201011
    DOIを用いた論文検索結果へのリンク
  6. The effect of microRNA-21 on proliferation and matrix synthesis of chondrocytes embedded in atelocollagen gel, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 18巻, 12号, pp. 1679-1684, 201012
    DOIを用いた論文検索結果へのリンク
  7. MicroRNA-223 expression in neutrophils in the early phase of secondary damage after spinal cord injury, NEUROSCIENCE LETTERS, 492巻, 2号, pp. 114-118, 20110401
    DOIを用いた論文検索結果へのリンク
  8. A mini-review: microRNA in arthritis, PHYSIOLOGICAL GENOMICS, 43巻, 10号, pp. 566-570, 201105
    DOIを用いた論文検索結果へのリンク
  9. The Transverse Ligament as a Landmark for Tibial Sagittal Insertions of the Anterior Cruciate Ligament: A Cadaveric Study, ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 27巻, 10号, pp. 1395-1399, 201110
    DOIを用いた論文検索結果へのリンク
  10. The Inhibitory Effect of MicroRNA-146a Expression on Bone Destruction in Collagen-Induced Arthritis, ARTHRITIS AND RHEUMATISM, 63巻, 6号, pp. 1582-1590, 201106
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  11. Effects of knee immobilization on morphological changes in the semitendinosus muscle-tendon complex after hamstring harvesting for anterior cruciate ligament reconstruction: evaluation using three-dimensional computed tomography, JOURNAL OF ORTHOPAEDIC SCIENCE, 17巻, 1号, pp. 39-45, 201201
    DOIを用いた論文検索結果へのリンク
  12. Characteristic shape of the lateral femoral condyle in patients with osteochondritis dissecans accompanied by a discoid lateral meniscus, JOURNAL OF ORTHOPAEDIC SCIENCE, 17巻, 2号, pp. 124-128, 201203
    DOIを用いた論文検索結果へのリンク
  13. The relationship of anterior and rotatory laxity between surgical navigation and clinical outcome after ACL reconstruction, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 20巻, 4号, pp. 778-784, 201204
    DOIを用いた論文検索結果へのリンク
  14. Clinical Comparisons Between the Transtibial Technique and the Far Anteromedial Portal Technique for Posterolateral Femoral Tunnel Drilling in Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction, ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 28巻, 5号, pp. 658-666, 201205
    DOIを用いた論文検索結果へのリンク
  15. Changes in microRNA expression in peripheral mononuclear cells according to the progression of osteoarthritis, MODERN RHEUMATOLOGY, 22巻, 3号, pp. 446-457, 201206
    DOIを用いた論文検索結果へのリンク
  16. Angiogenic microRNA-210 is present in cells surrounding osteonecrosis, JOURNAL OF ORTHOPAEDIC RESEARCH, 30巻, 8号, pp. 1263-1270, 201208
    DOIを用いた論文検索結果へのリンク
  17. The Effect of Intra-articular Injection of MicroRNA-210 on Ligament Healing in a Rat Model, AMERICAN JOURNAL OF SPORTS MEDICINE, 40巻, 11号, pp. 2470-2478, 201211
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  18. Evaluation of Joint Position Sense Measured by Inversion Angle Replication Error in Patients with an Osteochondral Lesion of the Talus, JOURNAL OF FOOT & ANKLE SURGERY, 52巻, 3号, pp. 331-334, 2013
    DOIを用いた論文検索結果へのリンク
  19. A new distraction arthroplasty device using magnetic force; a cadaveric study, CLINICAL BIOMECHANICS, 28巻, 4号, pp. 423-428, 201304
    DOIを用いた論文検索結果へのリンク
  20. Treatment of cartilage defects by subchondral drilling combined with covering with atelocollagen membrane induces osteogenesis in a rat model, JOURNAL OF ORTHOPAEDIC SCIENCE, 18巻, 4号, pp. 627-635, 201307
    DOIを用いた論文検索結果へのリンク
  21. Overexpression of microRNA-223 in rheumatoid arthritis synovium controls osteoclast differentiation, MODERN RHEUMATOLOGY, 23巻, 4号, pp. 674-685, 201307
    DOIを用いた論文検索結果へのリンク
  22. Strong adhesiveness of a new biodegradable hydrogel glue, LYDEX, for use on articular cartilage, JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS, 11巻, 3号, pp. 180-186, 2013
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  23. Enhancement of muscle repair using human mesenchymal stem cells with a magnetic targeting system in a subchronic muscle injury model, JOURNAL OF ORTHOPAEDIC SCIENCE, 19巻, 3号, pp. 478-488, 201405
    DOIを用いた論文検索結果へのリンク
  24. Regenerative medicine in orthopedics using cells, scaffold, and microRNA, JOURNAL OF ORTHOPAEDIC SCIENCE, 19巻, 4号, pp. 521-528, 201407
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  25. Administration of MicroRNA-210 Promotes Spinal Cord Regeneration in Mice, SPINE, 39巻, 14号, pp. 1099-1107, 20140615
    DOIを用いた論文検索結果へのリンク
  26. Unique patellofemoral alignment in a patient with a symptomatic bipartite patella, KNEE, 23巻, 1号, pp. 127-132, 201601
    DOIを用いた論文検索結果へのリンク
  27. MicroRNAs and Bone Regeneration, Curr Genomics, 16巻, 6号, pp. 441-452
  28. Attenuation of cartilage degeneration by calcitonin gene-related peptide receptor antagonist via inhibition of subchondral bone sclerosis in osteoarthritis mice, J Orthop Res, 2015
  29. Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1, Arthritis Res Ther, 17巻, pp. 285
  30. Combination therapy with intra-articular injection of mesenchymal stem cells and articulated joint distraction for repair of a chronic osteochondral defect in the rabbit, J Orthop Res, 33巻, 10号, pp. 1466-1473
  31. Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration., FEBS Lett, 589巻, 11号, pp. 1257-1265, 2015
  32. The effect of administration of double stranded microRNA-210 on acceleration of Achilles tendon healing in rat model, J Orthop Science, 20巻, 3号, pp. 538-546, 2015
  33. Distraction Arthroplasty With Arthroscopic Microfracture in a Patient With Rheumatoid Arthritis of the Ankle Joint, J Foot Ankle Surg, 54巻, 2号, pp. 280-284, 2015
  34. Conservative treatment of severe clubfoot using a novel functional dynamic splint
  35. Unique Anatomic Feature of the Posterior Cruciate Ligament in Knees Associated With Osteochondritis Dissecans, ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE, 4巻, 5号, 201605
    DOIを用いた論文検索結果へのリンク
  36. Attenuation of cartilage degeneration by calcitonin gene-related paptide receptor antagonist via inhibition of subchondral bone sclerosis in osteoarthritis mice, JOURNAL OF ORTHOPAEDIC RESEARCH, 34巻, 7号, pp. 1177-1184, 201607
    DOIを用いた論文検索結果へのリンク
  37. Differences in joint morphology between the knee and ankle affect the repair of osteochondral defects in a rabbit model., J Orthop Surg Res, 11巻, 1号, pp. 110
  38. Autologous bone grafts with MSCs or FGF-2 accelerate bone union in large bone defects., J Orthop Surg Res, 11巻, 1号, pp. 105
  39. Inhibition of microRNA-222 expression accelerates bone healing with enhancement of osteogenesis, chondrogenesis, and angiogenesis in a rat refractory fracture model., JOURNAL OF ORTHOPAEDIC SCIENCE, 21巻, 6号, pp. 852-858, 201611
  40. Comparison of fibrin clots derived from peripheral blood and bone marrow., Connect Tissue Res
  41. Unique Anatomic Feature of the Posterior Cruciate Ligament in Knees Associated With Osteochondritis Dissecans., Orthop J Sports Med, 4巻, 5号, pp. 2325967116648138
  42. Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model, Arthritis Res Ther, 16巻, 6号, pp. 488
  43. Exosomes from IL-1beta stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes, Arthritis Res Ther, 16巻, 4号, pp. R163
  44. Appearance of Subchondral Bone in Computed Tomography Is Related to Cartilage Damage in Osteochondral Lesions of the Talar Dome, Foot Ankle Int, 35巻, 6号, pp. 600-606
  45. High flexion knee arthroplasty: the relationship between rotational angles and flexion angle after total knee arthroplasty, Curr Rev Musculoskelet Med, 7巻, 2号, pp. 103-107
  46. Far anteromedial portal technique for posterolateral femoral tunnel drilling in anatomic double-bundle anterior cruciate ligament reconstruction: a cadaveric study., Knee Surg Sports Traumatol Arthrosc, 22巻, 1号, pp. 181-187
  47. Biomechanical function of anterior cruciate ligament remnants: how long do they contribute to knee stability after injury in patients with complete tears?, Arthroscopy, 26巻, 12号, pp. 1577-1585
  48. MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients, BMC Musculoskelet Disord, 11巻, pp. 209
  49. MicroRNA-140 plays dual roles in both cartilage development and homeostasis, Genes Dev, 24巻, 11号, pp. 1173-1185
  50. The effect of an external magnetic force on cell adhesion and proliferation of magnetically labeled mesenchymal stem cells, Sports Med Arthrosc Rehabil Ther Technol, 2巻, 1号, pp. 5
  51. Acceleration of muscle regeneration by local injection of muscle-specific microRNAs in rat skeletal muscle injury model, J Cell Mol Med, 14巻, 10号, pp. 2495-2505
  52. ★, Induction of apoptosis in the synovium of autoantibody-mediated arthritis in mice by the intra-articular injection of double-stranded microRNA-15a, Arthritis Rheum, 60巻, 9号, pp. 2677-2683
  53. MicroRNA-140 is expressed in differentiated humanarticular chondrocytes and modulates IL-1 responses, Arthritis Rheum, 60巻, 9号, pp. 2723-2730
  54. Morphologic variations of the fibular malleolar groove with recurrent dislocation of the peroneal tendons, Foot Ankle Int, 30巻, 6号, pp. 540-544
  55. Acceleration of skeletal muscle regeneration in rat skeletal muscle injury model by local injection of human peripheral blood derived CD133-positive cells, Stem cells, 27巻, 4号, pp. 949-960
  56. Expression of microRNA-146 in osteoarthritis cartilage., Arthritis Rheum, 60巻, 4号, pp. 1035-1041
  57. Feasibility of prefabricated vascularized bone graft using the combination of FGF-2 and vascular bundle implantation within hydroxyapatite for osteointegration, J Biomed Mater Res A, 85巻, 4号, pp. 1090-1095
  58. Molecular network of cartilage homeostasis and osteoarthritis, Med Res Rev, 28巻, 3号, pp. 464-481
  59. The deficit of joint position sense in the chronic unstable ankle as measured by inversion angle replication error., Arch Orthop Trauma Surg, 128巻, 5号, pp. 445-449
  60. New parameter of flexion after posterior stabilized total knee arthroplasty: posterior condylar offset ratio on X-ray photographs, Arch Orthop Trauma Surg, 127巻, 3号, pp. 167-170
  61. Painful os intermetatarseum in athletes: report of four cases and review of the literature, Arch Orthop Trauma Surg, 127巻, 4号, pp. 261-264
  62. A prospective study of 3-day versus 2-week immobilization period after anterior cruciate ligament reconstruction, Knee, 14巻, 1号, pp. 34-38
  63. Superior retinaculoplasty for recurrent dislocation of peroneal tendons, Foot Ankle Int., 27巻, 12号, pp. 1074-1078
  64. Evaluation of anterior talofibular ligament lesion using 3-dimensional computed tomography, J Comput Assist Tomogr, 30巻, 3号, pp. 543-547
  65. Prefabrication of vascularized bone graft using a combination of fibroblast growth factor-2 and vascular bundle implantation into a novel interconnected porous calcium hydroxyapatite ceramic, J Biomed Mater Res A, 75巻, 2号, pp. 350-352
  66. Autologous bone grafts with MSCs or FGF-2 accelerate bone union in large bone defects, JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, 11巻, 20160926
    DOIを用いた論文検索結果へのリンク
  67. Differences in joint morphology between the knee and ankle affect the repair of osteochondral defects in a rabbit model, JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, 11巻, 20161004
    DOIを用いた論文検索結果へのリンク
  68. Comparison of fibrin clots derived from peripheral blood and bone marrow, CONNECTIVE TISSUE RESEARCH, 58巻, 2号, pp. 208-214, 201704
    DOIを用いた論文検索結果へのリンク
  69. Postoperative Repeat Dislocation of the Posterior Tibial Tendon: A Case Report, JOURNAL OF FOOT & ANKLE SURGERY, 56巻, 3号, pp. 687-691, 2017
    DOIを用いた論文検索結果へのリンク
  70. Evaluation of autologous skeletal muscle-derived factors for regenerative medicine applications, BONE & JOINT RESEARCH, 6巻, 5号, pp. 277-283, 201705
    DOIを用いた論文検索結果へのリンク
  71. Role of mesenchymal stem cells densities when injected as suspension in joints with osteochondral defects., Cartilage, May 1巻, pp. 1947603517708333
  72. In-vivo imaging of the sentinel vein using the near-infrared vascular imaging system in hallux valgus patients., journal of orthopaedic science
  73. In-vivo imaging of the sentinel vein using the near-infrared vascular imaging system in hallux valgus patients, JOURNAL OF ORTHOPAEDIC SCIENCE, 22巻, 6号, pp. 1066-1070, 201711
    DOIを用いた論文検索結果へのリンク
  74. Added Value of Preoperative Computed Tomography for Determining Cartilage Degeneration in Patients With Osteochondral Lesions of the Talar Dome, AMERICAN JOURNAL OF SPORTS MEDICINE, 46巻, 1号, pp. 208-216, 201801
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  75. A Technique for the Reduction of Complications Associated With Anterior Portal Placement During Ankle Arthroscopy Using a Peripheral Vein Illumination Device, ARTHROSCOPY TECHNIQUES, 7巻, 2号, pp. E125-E129, 201802
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  76. Risk factors for progression of articular cartilage damage after anatomical anterior cruciate ligament reconstruction A SECOND-LOOK ARTHROSCOPIC EVALUATION, BONE & JOINT JOURNAL, 100B巻, 3号, pp. 285-293, 201803
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  77. Anatomic feature of deltoid ligament attachment in posteromedial osteochondral lesion of talar dome, JOURNAL OF ORTHOPAEDIC SCIENCE, 23巻, 2号, pp. 377-382, 201803
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  78. Relationship Between Bone Marrow Lesions on MRI and Cartilage Degeneration in Osteochondral Lesions of the Talar Dome, FOOT & ANKLE INTERNATIONAL, 39巻, 8号, pp. 908-915, 201808
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  79. Evaluation of Articular Cartilage Injury Using Computed Tomography With Axial Traction in the Ankle Joint, FOOT & ANKLE INTERNATIONAL, 39巻, 9号, pp. 1120-1127, 201809
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  80. Histological Evaluation of Early-Phase Changes in the Osteochondral Unit After Microfracture in a Full-Thickness Cartilage Defect Rat Model, AMERICAN JOURNAL OF SPORTS MEDICINE, 46巻, 12号, pp. 3032-3039, 201810
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  81. Characteristic morphology of the proximal tibiofibular joint in patients with discoid lateral meniscus, KNEE, 25巻, 6号, pp. 1027-1032, 201812
    DOIを用いた論文検索結果へのリンク
  82. Lipoma arborescens in bilateral knee joints accompany gouty tophi: A case-based review of the literature, JOURNAL OF ORTHOPAEDIC SCIENCE, 24巻, 1号, pp. 184-188, 201901
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  83. Role of Mesenchymal Stem Cells Densities When Injected as Suspension in Joints with Osteochondral Defects, CARTILAGE, 10巻, 1号, pp. 61-69, 201901
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  84. Outcome of autologous bone grafting with preservation of articular cartilage to treat osteochondral lesions of the talus with large associated subchondral cysts, BONE & JOINT JOURNAL, 100B巻, 5号, pp. 590-595, 201805
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  85. MRI Tracking of the Effect of Bioabsorbable Pins on Bone Marrow Edema After Fixation of the Osteochondral Fragment in the Talus, FOOT & ANKLE INTERNATIONAL, 40巻, 3号, pp. 323-329, 201903
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  86. Application of a peripheral vein illumination device to reduce saphenous structure injury caused by screw insertion during arthroscopic ankle arthrodesis, JOURNAL OF ORTHOPAEDIC SCIENCE, 24巻, 4号, pp. 697-701, 201907
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  87. Repair of an Osteochondral Defect With Minced Cartilage Embedded in Atelocollagen Gel: A Rabbit Model, AMERICAN JOURNAL OF SPORTS MEDICINE, 47巻, 9号, pp. 2216-2224, 201907
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  88. Clinical Results of Bioabsorbable Pin Fixation Relative to the Bone Condition for Osteochondral Lesion of the Talus, FOOT & ANKLE INTERNATIONAL, 40巻, 12号, pp. 1388-1396, 201912
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  89. Relationship of T2 Value of High-signal Line on MRI to the Fragment in Osteochondral Lesion of the Talus, FOOT & ANKLE INTERNATIONAL, 41巻, 6号, pp. 698-704, 202006
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  90. New standardization method of tibial tubercle-posterior cruciate ligament distance according to patient size in patients with patellofemoral instability, KNEE, 27巻, 3号, pp. 695-700, 202006
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  91. Histological scoring system for subchondral bone changes in murine models of joint aging and osteoarthritis, SCIENTIFIC REPORTS, 10巻, 1号, 20200622
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  92. Increase in medial meniscal extrusion in the weight-bearing position observed on ultrasonography correlates with lateral thrust in earlystage knee osteoarthritis, JOURNAL OF ORTHOPAEDIC SCIENCE, 25巻, 4号, pp. 640-646, 202007
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  93. Role of vasoactive intestinal peptide in the progression of osteoarthritis through bone sclerosis and angiogenesis in subchondral bone, JOURNAL OF ORTHOPAEDIC SCIENCE, 25巻, 5号, pp. 897-906, 202009
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