JIA TONY ZTONY Z JIA

Last Updated :2025/06/13

所属・職名
広島大学

基本情報

主な職歴

  • 2022年04月, Blue Marble Space Institute of Science, Research Investigator
  • 2019年05月, 2022年04月, Blue Marble Space Institute of Science, Affiliated Researcher
  • 2025年06月, Hiroshima University, Office of Research and Academia-Government-Community Collaboration, Professor, HIRAKU-Global Program Manager
  • 2022年07月, 2025年05月, Earth-Life Science Institute, Institute of Science Tokyo, Specially Appointed Associate Professor, A-PI
  • 2022年04月, 2022年06月, Earth-Life Science Institute, Tokyo Institute of Technology, Specially Appointed Assistant Professor, A-PI
  • 2019年06月, 2022年03月, Earth-Life Science Institute, Tokyo Institute of Technology, Specially Appointed Assistant Professor, Lab Manager
  • 2017年01月, 2019年05月, Earth-Life Science Institute, Tokyo Institute of Technology, Research Scientist

学歴

  • Harvard University, Chemistry, PhD, 2010年08月, 2016年11月
  • Harvard University, Chemistry, Master of Arts, 2010年08月, 2012年05月
  • California Institute of Technology, Chemistry and Business, Economics, and Management, Bachelor’s of Science, 2006年09月, 2010年06月

研究分野

  • 生物学 / 生物科学 / 生物物理学
  • 数物系科学 / 地球惑星科学 / 地球宇宙化学
  • 数物系科学 / 物理学 / 生物物理・化学物理・ソフトマターの物理
  • 化学 / 材料化学 / 高分子・繊維材料
  • 化学 / 複合化学 / 分析化学
  • 化学 / 複合化学 / 高分子化学
  • 複合領域 / 生体分子科学 / 生物分子化学
  • 化学 / 基礎化学 / 物理化学

研究キーワード

  • Origins of Life
  • Astrobiology
  • Biophysics
  • Materials Science
  • Prebiotic Chemistry

所属学会

  • Biophysical Society of Japan Artificial Cell Models & Molecular Robotics Subgroup, 2021年
  • Network of Researchers on the Chemical Evolution of Life (NoRCEL), 2021年
  • Origin of Life Early Career Network, 2020年
  • Astrobiology Society of Asia-Pacific, 2020年
  • Blue Marble Space Institute of Science, 2019年
  • Japan Society for Cell Synthesis Research, 2018年
  • 日本生物物理学会, 2017年
  • The Japan Society for Analytical Chemistry, 2023年, 2025年
  • Japanese Society for Biological Sciences in Space, 2022年, 2025年
  • Molecular Biology Society of Japan, 2023年, 2024年
  • American Chemical Society, 2020年, 2023年
  • 日本化学会, 2019年, 2023年
  • International Society of Artificial Life, 2021年, 2022年
  • Japan Geophysical Union, 2020年, 2021年

研究活動

学術論文（★は代表的な論文）

  1. ★, Low-temperature green synthesis and assembly of poly(lactate-co-malate) gel-based microdroplets from plastic polylactate straw waste, ACS Applied Polymer Materials, 7巻, 7号, pp. 4218-4227, 2025
  2. An Amino Acid Self-Regenerating Cell-Free Protein Synthesis System that Feeds on PLA Plastics, CO2, Ammonium, and alpha-ketoglutarate, ACS Catalysis, 15巻, pp. 7696-7706, 2024
  3. Chapter 11: Astrobiology Education, Engagement, and Resources, Astrobiology, pp. S-216-S-227, 2024
  4. Microalgal polyphosphate drives one-pot complete enzymatic generation of FAD from adenosine and riboflavin, ACS Sustainable Chemistry, 12巻, 2号, pp. 680-686, 2024
  5. One-pot chemo-enzymatic synthesis and one-step recovery of length-variable long-chain polyphosphates from microalgal biomass, Green Chemistry, 25巻, pp. 9896-9907, 2023
  6. Upcycling soybean pulp for sustainable protein biomanufacturing via a one-pot thermophilic protease cascade, Chemical Engineering Journal, 474巻, pp. 145925, 2023
  7. A Compositional View Comparing Modern Biological Condensates and Primitive Phase-separated Compartments, Peptide Science, 115巻, 6号, pp. e24331, 2023
  8. Applying Novel Techniques from Physical and Biological Sciences to Life Detection, Space: Science & Technology, 3巻, pp. 40, 2023
  9. Sensitive and specific miRNA hybridization using partially neutralized antisense DNA probes, GEN Biotechnology, 1巻, 5号, pp. 447-455, 2022
  10. The Effects of Dehydration Temperature and Monomer Chirality on Primitive Polyester Synthesis and Microdroplet Assembly, Macromolecular Chemistry and Physics, 223巻, 23号, pp. 2200235, 2022
  11. AbGradCon 2021: Lessons in Digital Meetings, International Collaboration, and Interdisciplinarity in Astrobiology, International Journal of Astrobiology, 2022
  12. Tractable Adaptation in a Designed Complex Peptide System, Chem, 2022
  13. Liquid Crystal Peptide/DNA Coacervates in the Context of Prebiotic Molecular Evolution, Crystals, 2020
  14. ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit., Nature structural & molecular biology, 17巻, 6号, 2010
  15. Digital RNA sequencing minimizes sequence-dependent bias and amplification noise with optimized single-molecule barcodes., Proceedings of the National Academy of Sciences of the United States of America, 109巻, 4号, 2012
  16. Rapid RNA exchange in aqueous two-phase system and coacervate droplets., Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 44巻, 1号, 2014
  17. N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes., Journal of the American Chemical Society, 138巻, 51号, 2016
  18. Mineral Surface-Templated Self-Assembling Systems: Case Studies from Nanoscience and Surface Science towards Origins of Life Research., Life (Basel, Switzerland), 8巻, 2号, 2018
  19. ★, Membraneless polyester microdroplets as primordial compartments at the origins of life., Proceedings of the National Academy of Sciences of the United States of America, 116巻, 32号, 2019
  20. Deciphering Biosignatures in Planetary Contexts., Astrobiology, 19巻, 9号, 2019
  21. A general LC-MS-based RNA sequencing method for direct analysis of multiple-base modifications in RNA mixtures., Nucleic acids research, 47巻, 20号, 2019
  22. A Bifunctional Polyphosphate Kinase Driving the Regeneration of Nucleoside Triphosphate and Reconstituted Cell-Free Protein Synthesis., ACS synthetic biology, 9巻, 1号, 2020
  23. Polyesters as a Model System for Building Primitive Biologies from Non-Biological Prebiotic Chemistry., Life (Basel, Switzerland), 10巻, 1号, 2020
  24. Biological phase separation: cell biology meets biophysics., Biophysical reviews, 12巻, 2号, 2020
  25. Unbinding events of amino acids and peptides from water-pyrite interfaces: A case study of life's origin on mineral surfaces., Biophysical chemistry, 260巻, 2020
  26. Direct Sequencing of tRNA by 2D-HELS-AA MS Seq Reveals Its Different Isoforms and Dynamic Base Modifications., ACS chemical biology, 15巻, 6号, 2020
  27. Protoenzymes: The Case of Hyperbranched Polymer-Scaffolded ZnS Nanocrystals., Life (Basel, Switzerland), 10巻, 8号, 2020
  28. ★, Liquid Crystal Coacervates Composed of Short Double-Stranded DNA and Cationic Peptides., ACS nano, 14巻, 11号, 2020
  29. Prebiotic oligomerization and self-assembly of structurally diverse xenobiological monomers., Scientific reports, 10巻, 1号, 2020
  30. Incorporation of Basic α-Hydroxy Acid Residues into Primitive Polyester Microdroplets for RNA Segregation., Biomacromolecules, 22巻, 4号, 2021
  31. Origin of Species before Origin of Life: The Role of Speciation in Chemical Evolution., Life (Basel, Switzerland), 11巻, 2号, 2021
  32. A General LC-MS-Based Method for Direct and De Novo Sequencing of RNA Mixtures Containing both Canonical and Modified Nucleotides., Methods in molecular biology (Clifton, N.J.), 2298巻, 2021
  33. Connecting primitive phase separation to biotechnology, synthetic biology, and engineering., Journal of biosciences, 46巻, 3号, 2021
  34. Increasing complexity of primitive compartments., Biophysics and physicobiology, 18巻, 2021
  35. A material-based panspermia hypothesis: The potential of polymer gels and membraneless droplets., Biopolymers, 113巻, 5号, 2022
  36. Editorial: Biological Phase Separation., Frontiers in genetics, 13巻, 2022
  37. A Physicochemical Consideration of Prebiotic Microenvironments for Self-Assembly and Prebiotic Chemistry., Life (Basel, Switzerland), 12巻, 10号, 2022
  38. A liquid crystal world for the origins of life., Emerging topics in life sciences, 6巻, 6号, 2022
  39. Sequencing the origins of life., BBA advances, 2巻, 2022
  40. Alternating co-synthesis of glycol nucleic acid (GNA) monomers with dicarboxylic acids via drying., Chemical communications (Cambridge, England), 59巻, 45号, 2023
  41. ★, Spectroscopic and Biophysical Methods to Determine Differential Salt-Uptake by Primitive Membraneless Polyester Microdroplets., Small methods, 7巻, 12号, 2023
  42. Recent progress in primitive polyester synthesis and membraneless microdroplet assembly., Biophysics and physicobiology, 20巻, 1号, 2023
  43. Primitive membraneless compartments as a window into the earliest cells., Biophysical reviews, 15巻, 6号, 2023
  44. Chapter 1: The Astrobiology Primer 3.0., Astrobiology, 24巻, S1号, 2024
  45. Chapter 4: A Geological and Chemical Context for the Origins of Life on Early Earth., Astrobiology, 24巻, S1号, 2024
  46. ★, Reactions Driven by Primitive Nonbiological Polyesters., Accounts of chemical research, 57巻, 15号, 2024
  47. Alternative Pathways in Astrobiology: Reviewing and Synthesizing Contingency and Non-Biomolecular Origins of Terrestrial and Extraterrestrial Life., Life (Basel, Switzerland), 14巻, 9号, 2024
  48. Various Viewpoints to Investigate the Origins of Life Are Needed., Life (Basel, Switzerland), 14巻, 10号, 2024
  49. Recent Advances in Origins of Life Research by Biophysicists in Japan, Challenges, 10巻, 1号, pp. 28, 2019
  50. Prebiotic chemistry and protocells during the faint young sun event., Biophysical reviews, 16巻, 5号, 2024
  51. How biophysics shapes the origins of life: a 21st IUPAB/62nd BSJ joint congress symposium overview., Biophysical reviews, 16巻, 5号, 2024
  52. Probing the Limits of Reactant Concentration and Volume in Primitive Polyphenyllactate Synthesis and Microdroplet Assembly Processes., ACS bio & med chem Au, 5巻, 1号, 2025
  53. ★, Primitive homochiral polyester formation driven by tartaric acid and calcium availability., Proceedings of the National Academy of Sciences of the United States of America, 122巻, 12号, 2025
  54. A deeper dive into primitive polylactate polymerization and microdroplet assembly under restrictive early Earth conditions, Polymer Journal, pp. 10.1038/s41428-025-01048-2, 20250430

著書等出版物

  1. 2024年04月, Japanese Encyclopedia of Origin of Life, 分担執筆

取得

  1. 特許権, US11,866,781, 2024年01月09日
  2. 特許権, US11,834,712, 2023年12月05日
  3. 特許権, US11,629,379, 2023年04月18日
  4. 特許権, US11,608,527, 2023年03月21日
  5. 特許権, US11352669, 2022年06月07日
  6. 特許権, US11286523, 2022年03月29日
  7. 特許権, US11,078,533, 2021年08月03日
  8. 特許権, US11,035,001, 2021年06月15日
  9. 特許権, US10,584,382, 2020年03月10日
  10. 特許権, US10,287,630, 2019年05月14日, Single cell nucleic acid detection and analysis
  11. 特許権, US9260753, 2016年02月16日, Single cell nucleic acid detection and analysis

外部資金

競争的資金等の採択状況

  1. Mizuho Foundation for the Promotion of Science, Construction of a membrane-bound protocell using polyester droplets as templates, 2023年06月, 2025年06月
  2. Joint Use Collaborative Research Grant, Creation of a membraneless protocell with Earth-abudant transition-metal catalysts (CHEN CHEN), 2023年04月, 2025年03月
  3. World Research Hub Faculty Research Abroad Grant - UNSW Sydney, Digital Holographic Microscopy to Observe Polyester Protocell Motion, 2023年03月, 2024年12月
  4. Work-Life Balance Support Unit, Diversity Promotion Office, Assistant Staffing Program, 2023年11月, 2024年09月
  5. Grant-in-Aid for Early-Career Scientists (若手研究) 21K14746, Biomolecule compartmentalization by phase separated protocells, 2021年04月, 2023年03月
  6. Joint Use Collaborative Research Grant, Composition of “Extraterrestrial” Polyester Gel Microdroplets, 2019年04月, 2022年03月
  7. Grant-in-Aid for Early-Career Scientists (若手研究) 18K14354, in vitro RNA進化におけるコアセルベート液滴の機能的役割の検証, 2018年04月, 2022年03月
  8. Kakenhi Grant-in-aid for Scientific Research C (基盤C) 21K03735, Origin of Enzymes: Study of Hyperbranched Polymer Scaffolded Nanoparticles, 2021年04月, 2022年02月
  9. Gender Equality Section, Diversity Promotion Office, Assistant Staffing Program, 2021年04月, 2022年
  10. Yoshinori Ohsumi Fund for Fundamental Research, Origin of Primitive Membraneless Cells through Polyester Microdroplet Protocells, 2021年, 2022年
  11. JSPS-CAS (Chinese Academy of Science) Bilateral Seminar, Geoelectrochemical Drivers of Deep Sea Biochemical Processes, 2020年, 2022年
  12. Project Grant AB021008, Structure and Function of Extraterrestrial Polyester Protocells, 2020年, 2021年
  13. Project Grant AB311021, Structure and Function of Extraterrestrial and Exoplanetary Protocells, 2019年04月, 2020年03月
  14. Exploratory/Developmental R21 Grant 1R21HG009576, Development of LC/MS-Based Direct RNA Sequencing with Concomitant Basecalling and Modification Analysis Capability, 2018年, 2020年
  15. Programme Exploration France 2019, 2019年02月, 2019年09月
  16. Seed Grant “Tane” for Challenging Research (種1798), 複合的化学手法による自己集合ポリエステルゲル材料の新規探索, 2017年11月, 2018年10月

社会活動

その他社会貢献活動（広大・部局主催含）

  1. “Everyone is an Astrobiologist”, Ruia College In Mumbai, Maharashtra, India, as part of India National Science Day, 2019年, 2019年
  2. Science Education and Outreach Event Organizing Team, Tokyo Tech Festival (工大祭), 2018年, 2019年
  3. Science Careers Outreach Seminar, Hiroo Gakuen Junior and Senior High School, 2018年, 2018年
  4. High School Science Mentor and Station Leader for Science Education and Outreach Event, Massachusetts General Hospital Center for Community Health