藤本 仰一KOICHI FUJIMOTO

Last Updated :2024/02/01

所属・職名
広島大学 教授
ホームページ
メールアドレス
kfjmthiroshima-u.ac.jp
自己紹介
動植物や微生物の発生・進化・共存の数理、複雑系科学。 数理モデリングと実験データ数理解析を連携して、生命や社会現象を駆動する数理を探究します。主な対象は、細胞-多細胞-器官-個体-社会の多階層にわたる動植物・微生物の動的な振舞い(形づくり、動き、遺伝子発現)とその多様性です。数学・生物・物理・化学を駆使して、現象の背後で働く階層間の相互作用や遺伝子のネットワーク等を介した複雑な因果を明らかにします。複雑なシステムを理解し予測する科学を発展させます。

基本情報

学位

  • 修士(学術) (東京大学)
  • 博士(学術) (東京大学)
  • 学術博士 (東京大学総合文化研究科広域科学専攻)
  • 学士 (東京大学工学部物理工学科)

研究キーワード

  • 対称性
  • 反応拡散
  • 細胞間コミュニケーション
  • 形づくり
  • トポロジー
  • 増殖
  • 統計物理
  • ネットワーク
  • 進化
  • 生命の物理
  • 揺らぎ
  • ゆらぎ
  • 形態形成
  • メカノバイオロジー

教育活動

授業担当

  1. 2023年, 教養教育, 3ターム, 線形代数学II[1理物,1理化,1理地]
  2. 2023年, 学部専門, セメスター(前期), 数学情報課題研究
  3. 2023年, 学部専門, セメスター(後期), 数学情報課題研究
  4. 2023年, 修士課程・博士課程前期, 3ターム, 数理生物学

研究活動

学術論文(★は代表的な論文)

  1. Patterned proliferation orients tissue-wide stress to control root vascular symmetry in Arabidopsis, Current Biology, 33巻, 5号, pp. 886-898.e8, 202303
  2. GRAS transcription factors regulate cell division planes in moss overriding the default rule., Proceedings of the National Academy of Sciences of the United States of America, 120巻, 4号, pp. e2210632120, 20230124
  3. Neural mechanism of experience-dependent sensory gain control in C. elegans, Neuroscience Research, 202301
  4. Collective Cell Movement under Cell-Scale Tension Gradient at Tissue Interface, Journal of the Physical Society of Japan, 91巻, 5号, 20220515
  5. Traveling wave of inflammatory response to regulate the expansion or shrinkage of skin erythema., PloS one, 17巻, 2号, pp. e0263049, 2022
  6. Polymorphism in the symmetries of gastric pouch arrangements in the sea anemone D. lineata., Zoological letters, 7巻, 1号, pp. 12-12, 20210906
  7. Polarity Fluctuation Inhibition by Memory in Collective Cell Motion, JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 90巻, 5号, 202105
  8. Rotation angle of stem cell division plane controls spiral phyllotaxis in mosses., Journal of plant research, 134巻, 3号, pp. 457-473, 202105
  9. Tissue growth constrains root organ outlines into an isometrically scalable shape., Development (Cambridge, England), 148巻, 4号, 20210226
  10. A Mechanical Instability in Planar Epithelial Monolayers Leads to Cell Extrusion., Biophysical journal, 118巻, 10号, pp. 2549-2560, 20200519
  11. Perianth Phyllotaxis Is Polymorphic in the Basal Eudicot Anemone and Eranthis Species, Frontiers in Ecology and Evolution, 8巻, 20200327
  12. A design principle for floral organ number and arrangement in flowers with bilateral symmetry., Development (Cambridge, England), 147巻, 3号, 20200204
  13. Crowding-Boosting Polarity and Motion Order of Cells (込み合いによる細胞の極性と運動の秩序促進), Proceedings of the Symposium on Simulation of Traffic Flow, 25巻, pp. 21-24, 201912
  14. Optimal Scaling of Critical Size for Metamorphosis in the Genus Drosophila., iScience, 20巻, pp. 348-358, 20191025
  15. Cell Motion Alignment as a Polarity Memory Effect, Journal of the Physical Society of Japan, 88巻, 10号, pp. 103801-103801, 20191015
  16. Curved surface geometry-induced topological change of an excitable planar wavefront., Chaos (Woodbury, N.Y.), 29巻, 9号, pp. 093120-093120, 201909
  17. Lateral Inhibition by a Peptide Hormone-Receptor Cascade during Arabidopsis Lateral Root Founder Cell Formation., Developmental cell, 48巻, 1号, pp. 64-75, 20190107
  18. Cell Migration driven by Receptor Density Polarity of Cell-Matrix Adhesion (細胞基質間接着の受容体密度極性による細胞運動), Proseeding of the Symposium on Simulation of Traffic Flow, 24巻, pp. 5-8, 201812
  19. Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology., Current biology : CB, 28巻, 13号, pp. 2115-2128, 20180709
  20. A quantitative study of the diversity of stripe-forming processes in an arthropod cell-based field undergoing axis formation and growth., Developmental biology, 437巻, 2号, pp. 84-104, 20180515
  21. Spiral phyllotaxis underlies constrained variation in Anemone (Ranunculaceae) tepal arrangement., Journal of plant research, 131巻, 3号, pp. 459-468, 201805
  22. Plant-inspired pipettes., Journal of the Royal Society, Interface, 15巻, 140号, 201803
  23. Mouse spermatozoa with higher fertilization rates have thinner nuclei., PeerJ, 5巻, pp. e3913, 2017
  24. Inference of Cell Mechanics in Heterogeneous Epithelial Tissue Based on Multivariate Clone Shape Quantification., Frontiers in cell and developmental biology, 5巻, pp. 68-68, 2017
  25. Stochastic occurrence of trimery from pentamery in floral phyllotaxis of Anemone (Ranunculaceae), Acta Societatis Botanicorum Poloniae, 85巻, 4号, 201612
  26. Relationship between the species-representative phenotype and intraspecific variation in Ranunculaceae floral organ and Asteraceae flower numbers., Annals of botany, 117巻, 5号, pp. 925-35, 201604
  27. Neural field dynamics for growing brains, Nonlinear Theory and Its Applications, IEICE, 7巻, 2号, pp. 226-233, 2016
  28. A dynamical phyllotaxis model to determine floral organ number., PLoS computational biology, 11巻, 5号, pp. e1004145, 201505
  29. A developmental basis for stochasticity in floral organ numbers., Frontiers in plant science, 5巻, pp. 545-545, 2014
  30. Robustness of self-organizing chemoattractant field arising from precise pulse induction of its breakdown enzyme: a single-cell level analysis of PDE expression in Dictyostelium., Biophysical journal, 104巻, 5号, pp. 1191-202, 20130305
  31. A design principle of group-level decision making in cell populations., PLoS computational biology, 9巻, 6号, pp. e1003110, 2013
  32. COLLECTIVE DECISION-MAKING AND OSCILLATORY BEHAVIORS IN CELL POPULATIONS, ENGINEERING OF CHEMICAL COMPLEXITY, 11巻, pp. 279-297, 2013
  33. Collective oscillations in developing cells: insights from simple systems., Development, growth & differentiation, 53巻, 4号, pp. 503-17, 201105
  34. Inter-origin cooperativity of geminin action establishes an all-or-none switch for replication origin licensing., Genes to cells : devoted to molecular & cellular mechanisms, 16巻, 4号, pp. 380-96, 201104
  35. The onset of collective behavior in social amoebae., Science (New York, N.Y.), 328巻, 5981号, pp. 1021-5, 20100521
  36. Network evolution of body plans., PloS one, 3巻, 7号, pp. e2772, 20080723
  37. Emergence of multi-time scales in coupled oscillators with plastic frequencies, Europhysics Letters (EPL), 78巻, 2号, pp. 20004, 200704
  38. Relation between Adaptation and Irreversible Circulation in Bacteria Chemotaxis, Progress of Theoretical Physics Supplement, 161巻, 161号, pp. 251-254, 2006
  39. Cross talking of network motifs in gene regulation that generates temporal pulses and spatial stripes., Genes to cells : devoted to molecular & cellular mechanisms, 10巻, 11号, pp. 1025-1038, 200511
  40. Noisy signal amplification in ultrasensitive signal transduction., Proceedings of the National Academy of Sciences of the United States of America, 102巻, 2号, pp. 331-336, 20050101
  41. Convective instability with time scale translation of the transmitted fluctuation, Physica D: Nonlinear Phenomena, 196巻, 1-2号, pp. 67-89, 200409
  42. Bifurcation cascade as chaotic itinerancy with multiple time scales., Chaos (Woodbury, N.Y.), 13巻, 3号, pp. 1041-1056, 200309
  43. How fast elements can affect slow dynamics, Physica D: Nonlinear Phenomena, 180巻, 1-2号, pp. 1-16, 200306
  44. Sensitive boundary condition dependence of noise-sustained structure., Physical Review E, 63巻, 3 Pt 2号, pp. 036218, 200103
  45. Noise-induced input dependence in a convectively unstable dynamical system, Physica D: Nonlinear Phenomena, 129巻, 3-4号, pp. 203-222, 199905