杉本 太路TAKAMICHI SUGIMOTO

Last Updated :2026/06/14

所属・職名
大学院医系科学研究科(医) 助教
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自己紹介
神経免疫疾患(重症筋無力症[MG]、慢性炎症性脱髄性多発ニューロパチー[CIDP]、ギラン・バレー症候群[GBS]、多発性硬化症[MS]、視神経脊髄炎スペクトラム障害[NMOSD]、抗MOG抗体関連疾患[MOGAD]など)を専門に診療しています。神経免疫(初診)外来があります。 広島地域における神経免疫疾患診療の拠点として、これらに関連する鑑別疾患にも幅広く対応しています。これまで数多くの神経難病を診療しており、神経内科疾患全般の診療に携わっています。

基本情報

主な職歴

  • 2006年04月, 2008年03月, 昭和大学横浜市北部病院, 初期臨床研修医
  • 2008年04月01日, 2013年09月30日, 広島大学, 病院, 医科診療医
  • 2013年10月, 2017年03月, 中国労災病院, 医長
  • 2017年04月, 2021年03月, 広島市立広島市民病院, 副部長
  • 2021年04月01日, 2025年03月31日, 広島大学, 病院, 助教
  • 2025年04月01日, 広島大学, 大学院医系科学研究科, 助教

学位

  • 修士(工学) (広島大学)
  • 博士(医学) (広島大学)

教育活動

授業担当

  1. 2026年, 学部専門, 通年, 脳神経医学III
  2. 2026年, 学部専門, セメスター(前期), 内科学I

研究活動

学術論文(★は代表的な論文)

  1. Elucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma, NATURE COMMUNICATIONS, 17巻, 1号, 20260312
  2. A case of low-frequency myokymia visualized by simultaneous EMG-ultrasound recording, CLINICAL NEUROPHYSIOLOGY PRACTICE, 11巻, pp. 348-351, 2026
  3. Ultrasonographic Reference Values of the Brachial Plexus Cross-Sectional Area in Healthy Japanese Adults, MUSCLE & NERVE, 73巻, 2号, pp. 277-282, 202602
  4. Corticosteroid-induced Cushingoid Appearance in Myasthenia Gravis, INTERNAL MEDICINE, 64巻, 24号, pp. 3486-3492, 2025
  5. Association between Myasthenia Gravis and Smoking, INTERNAL MEDICINE, 64巻, 24号, pp. 3478-3485, 2025
  6. The periodontal pathogen Fusobacterium nucleatum is associated with disease severity in multiple sclerosis, SCIENTIFIC REPORTS, 15巻, 1号, 20251103
  7. Comparison of prednisolone monotherapy vs. tacrolimus combination in NMOSD: Efficacy, safety, and optimal therapeutic timing, JOURNAL OF NEUROIMMUNOLOGY, 408巻, 20251115
  8. Cutoffs on severity metrics for minimal manifestations or better status in patients with generalized myasthenia gravis, FRONTIERS IN IMMUNOLOGY, 15巻, 20241223
  9. Worsening of myasthenic symptoms associated with statins, JOURNAL OF THE NEUROLOGICAL SCIENCES, 464巻, 20240915
  10. Therapeutic Responses to Efgartigimod for Generalized Myasthenia Gravis in Japan, NEUROLOGY-CLINICAL PRACTICE, 14巻, 3号, 202406
  11. Detection of episodic nocturnal hypercapnia in patients with neurodegenerative disorders, SLEEP AND BREATHING, 28巻, 1号, pp. 393-399, 202403
  12. Taste disorders and alopecia in myasthenia gravis, BMC NEUROLOGY, 24巻, 1号, 20240425
  13. Real-world experience with eculizumab and switching to ravulizumab for generalized myasthenia gravis, ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 11巻, 5号, pp. 1338-1346, 202405
  14. Diagnostic value of lower extremity ultrasonographic nerve enlargement for differentiating demyelinating Charcot-Marie-Tooth disease from chronic inflammatory demyelinating polyneuropathy, JOURNAL OF THE NEUROLOGICAL SCIENCES, 460巻, 20240515
  15. Clinical features and outcomes of patients with muscle-specific kinase antibody-positive myasthenia gravis in Japan, JOURNAL OF NEUROIMMUNOLOGY, 385巻, 20231215
  16. Effectiveness of early cycles of fast-acting treatment in generalised myasthenia gravis, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 94巻, 6号, pp. 467-473, 202306
  17. Impact of Early Treatment with Intravenous High-Dose Methylprednisolone for Ocular Myasthenia Gravis, NEUROTHERAPEUTICS, 20巻, 2号, pp. 518-523, 202303
  18. Nerve Ultrasonography for the Diagnosis and Evaluation of Neuralgic Amyotrophy, INTERNAL MEDICINE, 62巻, 12号, pp. 1843-1847, 2023
  19. 発症5年以上の全身型重症筋無力症患者の重症筋無力症-日常生活動作スコアに関連する因子の検討:難治性の診断のために., 臨床神経, 62巻, pp. 915-921, 20221129
  20. Features of repetitive nerve stimulation and nerve conduction studies in patients with amyotrophic lateral sclerosis, NEUROLOGY AND CLINICAL NEUROSCIENCE, 11巻, 3号, pp. 134-139, 202305
  21. A case of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations: Long-term treatment with repeated courses of immunotherapy, NEUROLOGY AND CLINICAL NEUROSCIENCE, 10巻, 6号, pp. 321-324, 202211
  22. ★, Ultrasonographic reference sizes of the median and ulnar nerves and the cervical nerve roots in healthy Japanese adults, Ultrasound Med Biol, 39巻, pp. 1560-1570, 2013
  23. ★, Ultrasonographic nerve enlargement of the median and ulnar nerves and the cervical nerve roots in patients with demyelinating Charcot-Marie-Tooth disease: distinction from patients with chronic inflammatory demyelinating polyneuropathy, J Neurol, 260巻, pp. 2580-2587, 2013
  24. CD34+/CD144+ circulating endothelial cells as an indicator of carotid atherosclerosis, J Stroke Cerebrovasc Dis, 24巻, pp. 583-590, 2015
  25. A case of anti-MOG antibody-positive unilaterally dominant meningoencephalitis followed by longitudinally extensive transverse myelitis, Mult Scler Relat Diord, 25巻, pp. 128-130, 2018
  26. Ultrasonographic measurement of cross-sectional area of the median and ulnar nerves in healthy Japanese children, Neurosonology, 31巻, pp. 128-130, 2018
  27. 重症筋無力症における有害事象を考慮したステロイド(経口,ステロイドパルス)の使用, 神経治療, 38巻, pp. 590-593, 2021
  28. 腎細胞癌に対するイピリムマブとニボルマブ併用療法後に髄膜脳炎と多発神経根炎を発症した76歳男性例, 臨床神経, 61巻, pp. 658-662, 2021
  29. A 36-year-old man with repeated short-term hyperammonemia and impaired consciousness with a confirmed carbamoyl phosphate synthase 1 gene monoallelic mutation, Intern Med, 2021
  30. Double trouble: A case of spinal muscular atrophy type III founcd to be complicated by myasthenia gravis due to subacute dysphagia., Clin Exp Neuroimmunol, 2022
  31. Changes in the amplitude decremental response to repetitive nerve stimulation following fast-acting treatment in patients with myasthenia gravis during hospitalization, Clin Exp Neuroimmunol, 2022
  32. Characteristics of cause of death and triggers for crisis in patients with myasthenia gravis, Neurol Clin Neurosci, 10巻, 3号, pp. 147-154, 202205
  33. ★, Initial deterioration and intravenous methylprednisolone therapy in patients with myasthenia gravis., J Neurol Sci, 412巻, pp. 116740, 2020
  34. Impact of anatomical variations on ultrasonographic reference values of lower extremity peripheral nerves, Muscle Nerve, 63巻, 6号, pp. 890-896, 2021
  35. Leptomeningeal myelomatosis with hypertrophy of the cauda equina nerve roots: A case report., Neurol Clin Neurosci, 8巻, pp. 403-405, 2020
  36. MRI abnormality of the bilateral middle cerebellar peduncles and long-term follow up in hypoglycemic encephalopathy: A case report., Neurol Clin Neurosci, 9巻, pp. 130-133, 2021
  37. Brachial plexus neuropathy induced by methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis., Neurol Clin Neurosci, 9巻, pp. 233-236, 2021
  38. 前兆のある片頭痛との鑑別を要した瘢痕脳回に伴う後頭葉てんかん発作後頭痛の16歳男性例., 日本頭痛学会誌, 48巻, pp. 193-197, 2021
  39. Clinical comorbidities correlated with a response to the cerebrospinal fluid tap test in idiopathic normal-pressure hydrocephalus, J Neurol Sci, 430巻, 20211115