石井 香KAORI ISHII

Last Updated :2024/09/02

所属・職名
大学院医系科学研究科（医）　助教
メールアドレス
ishiikhiroshima-u.ac.jp

基本情報

学位

  • 博士（医学）　(広島大学)
  • 理学修士　(九州大学)

教育活動

授業担当

  1. 2024年, 学部専門, 集中, 臨床実習I

研究活動

学術論文（★は代表的な論文）

  1. Impedance-Based Living Cell Analysis for Clinical Diagnosis of Type I Allergy., Sensors (Basel, Switzerland), 17巻, 11号, 2017
  2. Histamine and Toll-like receptor ligands synergistically induce endothelial cell gap formation by the extrinsic coagulating pathway., The Journal of allergy and clinical immunology, 141巻, 3号, 2018
  3. Different hypersensitivities against homologous proteins of MGL_1304 in patients with atopic dermatitis., Allergology international : official journal of the Japanese Society of Allergology, 67巻, 1号, 2018
  4. Sweat allergy: Extrinsic or intrinsic?, Journal of dermatological science, 87巻, 1号, 2017
  5. Angioedema associated with excessive sweating and sweat allergy., The Journal of dermatology, 44巻, 4号, 2017
  6. The role of adenosine for IgE receptor-dependent degranulation of human peripheral basophils and skin mast cells., Allergology international : official journal of the Japanese Society of Allergology, 67巻, 4号, 2018
  7. A human monoclonal IgE antibody that binds to MGL_1304, a major allergen in human sweat, without activation of mast cells and basophils., Biochemical and biophysical research communications, 468巻, 1-2号
  8. Evaluation of recombinant MGL_1304 produced by Pichia pastoris for clinical application to sweat allergy., Allergology international : official journal of the Japanese Society of Allergology, 64巻, 3号, 2015
  9. Surface plasmon resonance for cell-based clinical diagnosis., Sensors (Basel, Switzerland), 14巻, 3号, 2014
  10. Elevated serum IgE against MGL_1304 in patients with atopic dermatitis and cholinergic urticaria., Allergology international : official journal of the Japanese Society of Allergology, 63巻, 1号, 2014
  11. Remission rate of patients with wheat allergy sensitized to hydrolyzed wheat protein in facial soap., Allergology international : official journal of the Japanese Society of Allergology, 65巻, 1号, 2016
  12. Neuromedin U directly induces degranulation of skin mast cells, presumably via MRGPRX2., Allergy, 73巻, 11号, 2018
  13. Case of anaphylaxis to lansoprazole confirmed by histamine release test and oral provocation test., The Journal of dermatology, 46巻, 4号, 2019
  14. Activation of Human Peripheral Basophils in Response to High IgE Antibody Concentrations without Antigens., International journal of molecular sciences, 20巻, 1号, 2018
  15. Decreased intracellular histamine concentration and basophil activation in anaphylaxis., Allergology international : official journal of the Japanese Society of Allergology, 69巻, 1号, 2020
  16. High histamine concentrations in human sweat in association with type I allergy to the semi-purified sweat antigen., Allergology international : official journal of the Japanese Society of Allergology, 69巻, 2号, 2020
  17. Clinical utility of the basophil activation test in the diagnosis of sweat allergy., Allergology international : official journal of the Japanese Society of Allergology, 69巻, 2号, 2020
  18. Type-I-hypersensitivity to 15 kDa, 28 kDa and 54 kDa proteins in vitellogenin specific to Gadus chalcogrammus roe., Allergology international : official journal of the Japanese Society of Allergology, 69巻, 2号, 2020
  19. A case of millet allergy that developed into wheat-induced anaphylaxis by cross-reaction between millet and wheat antigens., Allergology international : official journal of the Japanese Society of Allergology, 69巻, 3号, 2020
  20. Case of anaphylaxis to maltose solution., The Journal of dermatology, 47巻, 4号, 2020
  21. Temporary wheat allergy in the postpartum period., Allergology international : official journal of the Japanese Society of Allergology, 70巻, 1号, 2021
  22. Histamine- or vascular endothelial growth factor-induced tissue factor expression and gap formation between vascular endothelial cells are synergistically enhanced by lipopolysaccharide, tumor necrosis factor-α, interleukin (IL)-33 or IL-1β., The Journal of dermatology, 47巻, 11号, 2020
  23. Coagulation factors induce human skin mast cell and basophil degranulation via activation of complement 5 and the C5a receptor., The Journal of allergy and clinical immunology, 147巻, 3号, 2021
  24. A novel detection method for cross-linking of IgE-receptors by autoantibodies in chronic spontaneous urticaria., Allergology international : official journal of the Japanese Society of Allergology, 71巻, 1号, 2022
  25. Minocycline-induced anaphylaxis mediated by antigen-specific immunoglobulin E., The Journal of dermatology, 49巻, 2号, 2022
  26. Clinical and histological characterization of transient dermal pain triggered by sweating stimuli., Allergology international : official journal of the Japanese Society of Allergology, 71巻, 3号, 2022
  27. Anaphylaxis due to thiamine disulfide phosphate, a derivative of vitamin B1; a case report and literature review., Allergology international : official journal of the Japanese Society of Allergology, 71巻, 3号, 2022
  28. Immunological Changes of Basophil Hyperreactivity to Sweat in Patients With Well-Controlled Atopic Dermatitis., Frontiers in immunology, 13巻, 2022
  29. Basophils activation of patients with chronic spontaneous urticaria in response to C5a despite failure to respond to IgE-mediated stimuli., Frontiers in immunology, 13巻, 2022
  30. Elevated serum IgE against MGL_1304 in patients with atopic dermatitis and cholinergic urticaria., Allergology international : official journal of the Japanese Society of Allergology, 63巻, 1号, 2014
  31. [Cholinergic urticaria successfully treated by immunotherapy with partially purified sweat antigen]., Arerugi = [Allergy], 56巻, 1号, 2007
  32. Applying surface plasmon resonance to monitor the IgE-mediated activation of human basophils., Allergology international : official journal of the Japanese Society of Allergology, 57巻, 4号, 2008
  33. Peritoneal injection of fucoidan suppresses the increase of plasma IgE induced by OVA-sensitization., Biochemical and biophysical research communications, 387巻, 3号, 2009
  34. [Efficacy of sweat-antigen-inactivating skin care products on itching of patients with atopic dermatitis]., Arerugi = [Allergy], 60巻, 1号, 2011
  35. Evaluation of peripheral blood basophil activation by means of surface plasmon resonance imaging., Biosensors & bioelectronics, 32巻, 1号, 2012
  36. [The sensitivity and clinical course of patients with wheat-dependent exercise-induced anaphylaxis sensitized to hydrolyzed wheat protein in facial soap]., Arerugi = [Allergy], 60巻, 12号, 2011
  37. Histamine release-neutralization assay for sera of patients with atopic dermatitis and/or cholinergic urticaria is useful to screen type I hypersensitivity against sweat antigens., Archives of dermatological research, 304巻, 8号, 2012
  38. Application of SPR imaging sensor for detection of individual living cell reactions and clinical diagnosis of type I allergy., Allergology international : official journal of the Japanese Society of Allergology, 62巻, 2号, 2013
  39. Fungal protein MGL_1304 in sweat is an allergen for atopic dermatitis patients., The Journal of allergy and clinical immunology, 132巻, 3号, 2013
  40. The sensitivity and clinical course of patients with wheat-dependent exercise-induced anaphylaxis sensitized to hydrolyzed wheat protein in facial soap - secondary publication., Allergology international : official journal of the Japanese Society of Allergology, 62巻, 3号, 2013
  41. Characterization of causative allergens for wheat-dependent exercise-induced anaphylaxis sensitized with hydrolyzed wheat proteins in facial soap., Allergology international : official journal of the Japanese Society of Allergology, 62巻, 4号, 2013
  42. Aspirin augments IgE-mediated histamine release from human peripheral basophils via Syk kinase activation., Allergology international : official journal of the Japanese Society of Allergology, 62巻, 4号, 2013
  43. Time Course of Priming Effect of TF Inducers on Synergistic TF Expression and Intra-Cellular Gap Formation of Human Vascular Endothelial Cells via the Extrinsic Coagulation Cascade, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24巻, 15号, 202308
    DOIを用いた論文検索結果へのリンク
  44. Clinical and histological characterization of transient dermal pain triggered by sweating stimuli, ALLERGOLOGY INTERNATIONAL, 71巻, 3号, pp. 362-372, 202207
    DOIを用いた論文検索結果へのリンク
  45. A novel detection method for cross-linking of IgE-receptors by autoantibodies in chronic spontaneous urticaria, ALLERGOLOGY INTERNATIONAL, 71巻, 1号, pp. 94-102, 202201
    DOIを用いた論文検索結果へのリンク
  46. Basophils activation of patients with chronic spontaneous urticaria in response to C5a despite failure to respond to IgE-mediated stimuli, FRONTIERS IN IMMUNOLOGY, 13巻, 20220928
    DOIを用いた論文検索結果へのリンク
  47. Immunological Changes of Basophil Hyperreactivity to Sweat in Patients With Well-Controlled Atopic Dermatitis, FRONTIERS IN IMMUNOLOGY, 13巻, 20220629
    DOIを用いた論文検索結果へのリンク
  48. Coagulation factors induce human skin mast cell and basophil degranula-tion via activation of complement 5 and the C5a receptor, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147巻, 3号, pp. 1101-+, 202103
    DOIを用いた論文検索結果へのリンク
  49. ★, A human monoclonal IgE antibody that binds to MGL_1304, a major allergen in human sweat, without activation of mast cells and basophils, Biochemical and Biophysical Research Communications, 468巻, pp. 99-104, 2015
  50. Fungal protein MGL_1304 in sweat is an allergen for atopic dermatitis patients, J Allergy Clinical Immunology, 132巻, 3号, pp. 608-615, 2013
  51. Elevated Serum IgE against MGL_1304 in Patients with Atopic Dermatitis and Cholinergic Urticaria, Allergology International, 63巻, pp. 83-93, 2014
  52. Histamine release-neutralization assay for sera of patients with atopic dermatitis and/or cholinergic urticaria is useful to screen type I hypersensitivity against sweat antigens, Arch Dermatol Res, 304巻, 8号, pp. 647-654, 2012
  53. Remission of wheat-dependent exercise-induced anaphylaxis after the cessation of hydrolyses wheat-containing soap usage, Acta Derm Venereol, 92巻, 5号, pp. 490-491, 2012
  54. The sensitivity and clinical course of patients with wheat-dependent exercise-induced anaphylaxis sensitized to hydrolyzed wheat protein in facial soap, Allergol International, 62巻, 3号, pp. 351-358, 2013
  55. Temporary wheat allergy in the postpartum period, Allergol International, 70巻, 1号, pp. 159-160, 2021
  56. Type-I-hypersensitivity to 15 KDa, 28 KDa and 54 KDa proteins in vitellogenin specific to Gadus chalcogrammus roe, Allergol International, 69巻, 2号, pp. 253-260, 2020
  57. High histamine concentrations in human sweat in association with type I allergy to the semi-purified sweat antigen, Allegol International, 69巻, 2号, pp. 307-309, 2020
  58. Case of anaphylaxis to maltose solution, J Dermatol, 47巻, 4号, pp. e107-e108, 2020
  59. Sweat allergy: Extrinsic or intrinsic ?, J Dermatol Science, 87巻, 1号, pp. 3-9, 2017

招待講演、口頭・ポスター発表等

  1. 汗刺激によるヒト真皮線維芽細胞応答の解析, 石井　香, 高萩　俊輔 秀　道広 田中　暁生, 第72回日本アレルギー学会学術大会, 2023年10月20日, 通常, 日本語, 日本アレルギー学会, 東京国際フォーラム

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業（基盤C）, 真皮内汗漏出による線維芽細胞応答を介した汗アレルギーの解明とその抑制因子の探索, 2024年, 2027年
  2. 科学研究費助成事業(若手研究), 汗アレルギーにおける抗原感作経路と汗抗原感作における汗のアジュバント効果の解明, 2022年, 2023年
  3. 科学研究費助成事業(若手研究), 汗アレルギーにおける抗原感作経路とIgE産生機序の解明, 2020年, 2021年