ヘイズ ネルソンNelson Hayes

Last Updated :2022/05/09

所属・職名
大学院医系科学研究科(医) 准教授
自己紹介
I am a bioinformatician and Java programmer using a data science approach to investigate viral hepatitis as a member of the Chayama Laboratory. I use a supercomputer to analyze next generation sequencing data and analyze experimental data using statistics and machine learning. I also develop relational and NoSQL database approaches for data management and build web applications using Java and Angular. Recently I have begun to focus on deep learning and graph analytics to identify host factors implicated in hepatitis B and C infection and explore potential medical applications of the Raspberry Pi and Arduino in the Internet of Things. In 2003, I received a PhD in biology from the Pennsylvania State University, where I studied evolutionary ecology of mating systems. In 2005, I became a postdoctoral fellow in the Kanehisa Laboratory in the Bioinformatics Center at Kyoto University, where I developed the varDB antigenic variation database to examine mechanisms of immune escape in Plasmodium falciparum and other human pathogens.

基本情報

主な職歴

  • 2009年10月01日, 2010年05月31日, 広島大学, 病院, 研究員
  • 2010年06月01日, 2012年03月31日, 広島大学, 大学院医歯薬学総合研究科, 特任助教
  • 2012年04月01日, 2013年03月31日, 広島大学, 大学院医歯薬保健学研究院, 特任助教
  • 2013年04月01日, 2014年03月31日, 広島大学, 大学院医歯薬保健学研究院, 特任講師
  • 2014年04月01日, 2014年12月31日, 広島大学, 大学院医歯薬保健学研究院, 特任准教授
  • 2015年01月01日, 2019年03月31日, 広島大学, 大学院医歯薬保健学研究院, 准教授
  • 2003年09月01日, 2004年12月31日, ペンシルバニア州立大学, 生物学科, マルチメディアサポートアシスタント
  • 2005年01月01日, 2005年10月15日, ペンシルバニア州立大学, 生物学科, 専任講師
  • 2005年10月16日, 2009年09月30日, 京都大学, 化学研究所ンター バイオインフォマティクスセ, 特定研究員、日本学術振興会研究員を含む

学歴

  • ペンシルバニア州立大学, 生物学科, 生物学, アメリカ合衆国, 1996年08月, 2003年12月
  • ワシントン・ジェファーソン大学, 生物学科, 生物学, アメリカ合衆国, 1992年08月, 1996年06月

学位

  • 博士(生物学) (ペンシルバニア州立大学)

研究分野

  • 医歯薬学 / 基礎医学 / ウイルス学
  • 医歯薬学 / 基礎医学 / 人類遺伝学
  • 総合生物 / ゲノム科学 / ゲノム医科学
  • 情報学 / 計算基盤 / ソフトウェア
  • 情報学 / 計算基盤 / 高性能計算
  • 生物学 / 基礎生物学 / 進化生物学
  • 生物学 / 基礎生物学 / 生態・環境

研究キーワード

  • 肝炎
  • ウイルス学
  • 肝臓
  • ジャヴァ
  • 次世代シーケンシング
  • スーパーコンピュータ
  • データベース

教育活動

授業担当

  1. 2022年, 博士課程・博士課程後期, セメスター(前期), English Presentation
  2. 2022年, 博士課程・博士課程後期, セメスター(前期), English Presentation

研究活動

学術論文(★は代表的な論文)

  1. IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy, JOURNAL OF HEPATOLOGY, 54巻, 6号, pp. 1094-1101, 201106
  2. Reduction of hepatitis B surface antigen in sequential versus add-on pegylated interferon to nucleoside/nucleotide analogue therapy in HBe-antigen-negative chronic hepatitis B patients: a pilot study, ANTIVIRAL THERAPY, 23巻, 8号, pp. 639-646, 2018
  3. Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy, CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 1巻, 5号, pp. 516-534, 201509
  4. Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP, SCIENTIFIC REPORTS, 9巻, 20190611
  5. Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice, JOURNAL OF GASTROENTEROLOGY, 54巻, 7号, pp. 650-659, 201907
  6. Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice, JOURNAL OF GENERAL VIROLOGY, 100巻, 7号, pp. 1123-1131, 201907
  7. Management of HCV patients in cases of direct-acting antiviral failure, EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 13巻, 9号, pp. 839-848, 20190902
  8. Genomic landscape of epithelium with low-grade atypia on gastric cancer after Helicobacter pylori eradiation therapy, JOURNAL OF GASTROENTEROLOGY, 54巻, 10号, pp. 907-915, 201910
  9. Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis, BMC GASTROENTEROLOGY, 19巻, 1号, 20191024
  10. Regression of Idiopathic Thrombocytopenic Purpura in a Patient With Eradication of Hepatitis C Virus by Direct-Acting Antivirals, HEPATOLOGY, 71巻, 1号, pp. 389-391, 202001
  11. Successful retreatment with 12 weeks of glecaprevir and pibrentasvir for a genotype 2a HCV-infected hemodialysis patient who failed to respond to 8 weeks of prior glecaprevir and pibrentasvir therapy, CLINICAL JOURNAL OF GASTROENTEROLOGY, 13巻, 2号, pp. 267-270, 202004
  12. ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo, JOURNAL OF HEPATOLOGY, 55巻, 1号, pp. 11-18, 201107
  13. Genomic Characterization of Non-Invasive Differentiated-Type Gastric Cancer in the Japanese Population, CANCERS, 12巻, 2号, 202002
  14. Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receiving lenvatinib, THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 12巻, 202005
  15. Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma, CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, 11巻, 202005
  16. Risk factors for histological progression of non-alcoholic steatohepatitis analyzed from repeated biopsy cases, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 35巻, 8号, pp. 1412-1419, 202008
  17. Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C infection, BMC GASTROENTEROLOGY, 20巻, 1号, 20200925
  18. Impact of viral eradication by direct-acting antivirals on the risk of hepatocellular carcinoma development, prognosis, and portal hypertension in hepatitis C virus-related compensated cirrhosis patients, HEPATOLOGY RESEARCH, 50巻, 11号, pp. 1222-1233, 202011
  19. Real-word efficacy of sofosbuvir, velpatasvir plus ribavirin therapy for chronic hepatitis patients who failed to prior DAA therapy with NS5A-P32 deletion mutated HCV infection, CLINICAL JOURNAL OF GASTROENTEROLOGY, 13巻, 6号, pp. 1233-1238, 202012
  20. Real-world efficacy of sofosbuvir plus velpatasvir therapy for patients with hepatitis C virus-related decompensated cirrhosis, HEPATOLOGY RESEARCH, 50巻, 11号, pp. 1234-1243, 202011
  21. PNPLA3andHLA-DQB1polymorphisms are associated with hepatocellular carcinoma after hepatitis C virus eradication, JOURNAL OF GASTROENTEROLOGY, 55巻, 12号, pp. 1162-1170, 202012
  22. Abatacept treatment for patients with severe acute hepatitis caused by hepatitis B virus infection-Pilot study, JOURNAL OF VIRAL HEPATITIS, 28巻, 2号, pp. 400-409, 202102
  23. IL28B But Not ITPA Polymorphism Is Predictive of Response to Pegylated Interferon, Ribavirin, and Telaprevir Triple Therapy in Patients With Genotype 1 Hepatitis C, JOURNAL OF INFECTIOUS DISEASES, 204巻, 1号, pp. 84-93, 2011
  24. Signal Activation of Hepatitis B Virus-Related Hepatocarcinogenesis by Up-regulation of SUV39h1, JOURNAL OF INFECTIOUS DISEASES, 222巻, 12号, pp. 2061-2070, 20201215
  25. A case with life-threatening secondary sclerosing cholangitis caused by nivolumab, CLINICAL JOURNAL OF GASTROENTEROLOGY, 14巻, 1号, pp. 283-287, 202102
  26. Clinical Usefulness of Serum Autotaxin for Early Prediction of Relapse in Male Patients with Type 1 Autoimmune Pancreatitis, DIGESTIVE DISEASES AND SCIENCES, 66巻, 4号, pp. 1268-1275, 202104
  27. Efficacy of Lusutrombopag for Thrombocytopenia in Patients with Chronic Liver Disease Scheduled to Undergo Invasive Procedures, INTERNAL MEDICINE, 60巻, 6号, pp. 829-837, 2021
  28. A case of acute liver failure with echovirus infection diagnosed by a multi-virus real-time PCR system, IDCASES, 23巻, 2021
  29. yRibavirin induces hepatitis C virus genome mutations in chronic hepatitis patients who failed to respond to prior daclatasvir plus asunaprevir therapy, JOURNAL OF MEDICAL VIROLOGY, 92巻, 2号, pp. 210-218, 202002
  30. Novel drug resistance-associated substitutions against pibrentasvir emerged in genotype 1b hepatitis C virus-infected human hepatocyte transplanted mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 559巻, pp. 78-83, 20210625
  31. Identification and monitoring of mutations in circulating cell-free tumor DNA in hepatocellular carcinoma treated with lenvatinib, JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 40巻, 1号, 20210626
  32. Serum PreS1 and HBsAg ratio reflects liver fibrosis and predicts the development of hepatocellular carcinoma in chronic hepatitis B patients, JOURNAL OF VIRAL HEPATITIS, 28巻, 9号, pp. 1304-1311, 202109
  33. Effects of Hepatitis B Virus Infection on the Interferon Response in Immunodeficient Human Hepatocyte Chimeric Mice, JOURNAL OF INFECTIOUS DISEASES, 204巻, 2号, pp. 224-228, 2011
  34. Inverse Association of IL28B Genotype and Liver mRNA Expression of Genes Promoting or Suppressing Antiviral State, JOURNAL OF MEDICAL VIROLOGY, 83巻, 9号, pp. 1597-1607, 201109
  35. Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers, NATURE GENETICS, 43巻, 8号, pp. 797-U108, 201108
  36. Hepatitis C Virus Infection Suppresses the Interferon Response in the Liver of the Human Hepatocyte Chimeric Mouse, PLOS ONE, 6巻, 8号, 2011
  37. Impact of Viral Amino Acid Substitutions and Host Interleukin-28B Polymorphism on Replication and Susceptibility to Interferon of Hepatitis C Virus, HEPATOLOGY, 54巻, 3号, pp. 764-771, 201109
  38. Serum PAI-1 is a novel predictor for response to pegylated interferon-a-2b plus ribavirin therapy in chronic hepatitis C virus infection, JOURNAL OF VIRAL HEPATITIS, 19巻, 2号, pp. E126-E133, 201202
  39. Hepatocellular carcinoma: Towards personalized medicine, CANCER SCIENCE, 103巻, 5号, pp. 846-850, 201205
  40. Identification of novel HCV deletion mutants in chronic hepatitis C patients, ANTIVIRAL THERAPY, 17巻, 8号, pp. 1551-1561, 2012
  41. Toward the Establishment of a Prediction System for the Personalized Treatment of Chronic Hepatitis C, JOURNAL OF INFECTIOUS DISEASES, 205巻, 2号, pp. 204-210, 2012
  42. Genetics of IL28B and HCV-response to infection and treatment, NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 9巻, 7号, pp. 406-417, 201207
  43. Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse, HEPATOLOGY, 56巻, 2号, pp. 555-566, 201208
  44. Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication, HEPATOLOGY RESEARCH, 42巻, 9号, pp. 841-853, 201209
  45. IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients, JOURNAL OF GASTROENTEROLOGY, 47巻, 7号, pp. 834-844, 201207
  46. Hepatitis B Virus-Specific miRNAs and Argonaute2 Play a Role in the Viral Life Cycle, PLOS ONE, 7巻, 10号, 2012
  47. Treatment of chronic hepatitis C virus infection in Japan: update on therapy and guidelines, JOURNAL OF GASTROENTEROLOGY, 48巻, 1号, pp. 1-12, 201301
  48. Interleukin-28B polymorphisms and hepatitis C virus clearance, GENOME MEDICINE, 5巻, 2013
  49. Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B, JOURNAL OF MEDICAL VIROLOGY, 85巻, 5号, pp. 789-798, 201305
  50. HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study, PLOS ONE, 8巻, 12号, 2013
  51. Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients, JOURNAL OF HEPATOLOGY, 53巻, 3号, pp. 439-443, 201009
  52. A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation, PLOS GENETICS, 9巻, 4号, 201304
  53. Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice, GUT, 62巻, 7号, pp. 1055-1061, 201307
  54. A Translational Study of Resistance Emergence Using Sequential Direct-Acting Antiviral Agents for Hepatitis C Using Ultra-Deep Sequencing, AMERICAN JOURNAL OF GASTROENTEROLOGY, 108巻, 9号, pp. 1464-1472, 201309
  55. Serum HBV RNA and HBeAg are useful markers for the safe discontinuation of nucleotide analogue treatments in chronic hepatitis B patients, JOURNAL OF GASTROENTEROLOGY, 48巻, 10号, pp. 1188-1204, 201310
  56. Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice, JOURNAL OF GASTROENTEROLOGY, 48巻, 11号, pp. 1259-1270, 201311
  57. A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441巻, 1号, pp. 230-235, 2013
  58. Ultradeep Sequencing Study of Chronic Hepatitis C Virus Genotype 1 Infection in Patients Treated with Daclatasvir, Peginterferon, and Ribavirin, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58巻, 4号, pp. 2105-2112, 201404
  59. Effect of vitamin D supplementation on pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b: a randomized controlled trial, JOURNAL OF VIRAL HEPATITIS, 21巻, 5号, pp. 348-356, 201405
  60. Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA, JOURNAL OF VIRAL HEPATITIS, 21巻, 9号, pp. E89-E97, 201409
  61. IFNL4/IL-28B haplotype structure and its impact on susceptibility to hepatitis C virus and treatment response in the Japanese population, JOURNAL OF GENERAL VIROLOGY, 95巻, pp. 1297-1306, 201406
  62. Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice, JOURNAL OF HEPATOLOGY, 54巻, 5号, pp. 872-878, 201105
  63. New Insight Into the Enhanced Effect of Pegylated Interferon-alpha, HEPATOLOGY, 60巻, 4号, pp. 1435-1437, 201410
  64. Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1, JOURNAL OF VIRAL HEPATITIS, 22巻, 2号, pp. 158-165, 201502
  65. Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C, JOURNAL OF GASTROENTEROLOGY, 49巻, 12号, pp. 1548-1556, 201412
  66. Emerging treatments for chronic hepatitis C, JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 114巻, 3号, pp. 204-215, 201503
  67. Differences in serum microRNA profiles in hepatitis B and C virus infection, JOURNAL OF INFECTION, 70巻, 3号, pp. 273-287, 201503
  68. Interferon lambda 4 polymorphism affects on outcome of telaprevir, pegylated interferon and ribavirin combination therapy for chronic hepatitis C, HEPATOLOGY RESEARCH, 44巻, 14号, pp. E447-E454, 201412
  69. Effect of prolonged administration of pegylated interferon/ribavirin therapy in genotypes 2a and 2b: Propensity score-matched analysis, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 30巻, 2号, pp. 337-344, 201502
  70. Ribavirin dose reduction during telaprevir/ribavirin/peg-interferon therapy overcomes the effect of the ITPA gene polymorphism, JOURNAL OF VIRAL HEPATITIS, 22巻, 2号, pp. 166-174, 201502
  71. Optimizing triple therapy and IFN/RBV-free regimens for hepatitis C virus infection, EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 9巻, 1号, pp. 21-30, 201501
  72. Hepatitis C Virus (HCV) Reactivation Caused by Steroid Therapy for Dermatomyositis, INTERNAL MEDICINE, 53巻, 23号, pp. 2689-2693, 2014
  73. Rapid Emergence of Telaprevir Resistant Hepatitis C Virus Strain from Wildtype Clone In Vivo, HEPATOLOGY, 54巻, 3号, pp. 781-788, 201109
  74. Two Patients Treated With Simeprevir Plus Pegylated-Interferon and Ribavirin Triple Therapy for Recurrent Hepatitis C After Living Donor Liver Transplantation: Case Report, TRANSPLANTATION PROCEEDINGS, 47巻, 3号, pp. 809-814, 201504
  75. Novel Robust in Vitro Hepatitis B Virus Infection Model Using Fresh Human Hepatocytes Isolated from Humanized Mice, AMERICAN JOURNAL OF PATHOLOGY, 185巻, 5号, pp. 1275-1285, 201505
  76. Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay, PLOS ONE, 10巻, 6号, 2015
  77. Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A, JOURNAL OF HEPATOLOGY, 63巻, 3号, pp. 554-563, 201509
  78. Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice, JOURNAL OF VIROLOGY, 89巻, 19号, pp. 10087-10096, 201510
  79. Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy, JOURNAL OF MEDICAL VIROLOGY, 87巻, 11号, pp. 1913-1920, 201511
  80. HCV Drug Resistance Challenges in Japan: The Role of Pre-Existing Variants and Emerging Resistant Strains in Direct Acting Antiviral Therapy, VIRUSES-BASEL, 7巻, 10号, pp. 5328-5342, 201510
  81. Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones, JOURNAL OF INFECTION, 72巻, 1号, pp. 91-102, 201601
  82. Early events in hepatitis B virus infection: From the cell surface to the nucleus, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 31巻, 2号, pp. 302-309, 201602
  83. Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir and BMS-788329 combination therapy in human hepatocyte chimeric mice, VIRUS RESEARCH, 213巻, pp. 62-68, 2016
  84. Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b, JOURNAL OF HEPATOLOGY, 54巻, 3号, pp. 408-414, 201103
  85. MicroRNAs as Biomarkers for Liver Disease and Hepatocellular Carcinoma, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17巻, 3号, 201603
  86. HBV culture and infectious systems, HEPATOLOGY INTERNATIONAL, 10巻, 4号, pp. 559-566, 201607
  87. Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy, JOURNAL OF VIRAL HEPATITIS, 23巻, 9号, pp. 708-717, 201609
  88. Daclatasvir and asunaprevir treatment improves liver function parameters and reduces liver fibrosis markers in chronic hepatitis C patients, HEPATOLOGY RESEARCH, 46巻, 8号, pp. 758-764, 201607
  89. Improvement of renal dysfunction in a patient with hepatitis C virus-related liver cirrhosis by daclatasvir and asunaprevir combination therapy: A case report, HEPATOLOGY RESEARCH, 46巻, 9号, pp. 944-948, 201608
  90. Three patients treated with daclatasvir and asunaprevir for recurrent hepatitis C after liver transplantation: Case report, HEPATOLOGY RESEARCH, 46巻, 7号, pp. 707-712, 201606
  91. Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection, JOURNAL OF GASTROENTEROLOGY, 51巻, 11号, pp. 1073-1080, 201611
  92. Effects of ITPA polymorphism on decrease of hemoglobin during simeprevir, peg-interferon, and ribavirin combination treatment for chronic hepatitis C, HEPATOLOGY RESEARCH, 46巻, 12号, pp. 1256-1263, 201611
  93. Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice, ANTIVIRAL THERAPY, 21巻, 4号, pp. 307-315, 2016
  94. Hepatitis C virus treatment update - A new era of all-oral HCV treatment, ADVANCES IN DIGESTIVE MEDICINE, 3巻, 4号, pp. 153-160, 201602
  95. Prediction of Response to Peginterferon-Alfa-2b Plus Ribavirin Therapy in Japanese Patients Infected With Hepatitis C Virus Genotype 1b, JOURNAL OF MEDICAL VIROLOGY, 83巻, 6号, pp. 981-988, 201106
  96. Protease Inhibitor Resistance Remains Even After Mutant Strains Become Undetectable by Deep Sequencing, JOURNAL OF INFECTIOUS DISEASES, 214巻, 11号, pp. 1687-1694, 2016
  97. The practical management of chronic hepatitis C infection in Japan - dual therapy of daclatasvir plus asunaprevir, EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 11巻, 2号, pp. 103-113, 201702
  98. Interferon Stimulated Genes and Innate Immune Activation Following Infection With Hepatitis B and C Viruses, JOURNAL OF MEDICAL VIROLOGY, 89巻, 3号, pp. 388-396, 201703
  99. Efficacy and Safety of Daclatasvir Plus Asunaprevir Therapy for Chronic Hepatitis C Patients With Renal Dysfunction, JOURNAL OF MEDICAL VIROLOGY, 89巻, 4号, pp. 665-671, 201704
  100. Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus, PLOS ONE, 12巻, 3号, 2017
  101. The relationship between HBcrAg and HBV reinfection in HBV related post-liver transplantation patients, JOURNAL OF GASTROENTEROLOGY, 52巻, 3号, pp. 366-375, 201705
  102. Real-world efficacy and safety of daclatasvir and asunaprevir therapy for hepatitis C virus-infected cirrhosis patients, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 32巻, 3号, pp. 645-650, 201705
  103. IFNL4 polymorphism effects on outcome of simeprevir, peginterferon, and ribavirin therapy for older patients with genotype 1 chronic hepatitis C, HEPATOLOGY RESEARCH, 47巻, 3号, pp. E5-E13, 201705
  104. Safety and efficacy of dual therapy with daclatasvir and asunaprevir for older patients with chronic hepatitis C, JOURNAL OF GASTROENTEROLOGY, 52巻, 4号, pp. 504-511, 201704
  105. Why highly effective drugs are not enough: the need for an affordable solution to eliminating HCV, EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 10巻, 6号, pp. 583-594, 2017
  106. Common Genetic Polymorphism of ITPA Gene Affects Ribavirin-Induced Anemia and Effect of Peg-Interferon Plus Ribavirin Therapy, JOURNAL OF MEDICAL VIROLOGY, 83巻, 6号, pp. 1048-1057, 201106
  107. ITPA polymorphism effects on decrease of hemoglobin during sofosbuvir and ribavirin combination treatment for chronic hepatitis C, JOURNAL OF GASTROENTEROLOGY, 52巻, 6号, pp. 746-753, 201706
  108. Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61巻, 6号, 201706
  109. Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology, JOURNAL OF GENERAL VIROLOGY, 98巻, 5号, pp. 1040-1047, 201705
  110. The risks of hepatocellular carcinoma development after HCV eradication are similar between patients treated with peg-interferon plus ribavirin and direct-acting antiviral therapy, PLOS ONE, 12巻, 8号, 2017
  111. Emergence of drug resistance-associated variants and changes in serum lipid profiles in sofosbuvir plus ledipasvir-treated chronic hepatitis C patients, JOURNAL OF MEDICAL VIROLOGY, 89巻, 11号, pp. 1963-1972, 201711
  112. Three patients treated with sofosbuvir plus ledipasvir for recurrent hepatitis C after liver transplantation, CLINICAL JOURNAL OF GASTROENTEROLOGY, 10巻, 2号, pp. 179-184, 201704
  113. Wisteria floribunda agglutinin positive Mac-2-binding protein level increases in patients with acute liver injury, JOURNAL OF GASTROENTEROLOGY, 52巻, 12号, pp. 1252-1257, 201712
  114. Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy, JOURNAL OF GASTROENTEROLOGY, 53巻, 1号, pp. 107-118, 201801
  115. Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease, JOURNAL OF GASTROENTEROLOGY, 53巻, 2号, pp. 269-280, 201802
  116. Efficacy and safety of ledipasvir/sofosbuvir with ribavirin in chronic hepatitis C patients who failed daclatasvir/asunaprevir therapy: pilot study, JOURNAL OF GASTROENTEROLOGY, 53巻, 4号, pp. 548-556, 201804
  117. IL-28B predicts response to chronic hepatitis C therapy - fine-mapping and replication study in Asian populations, JOURNAL OF GENERAL VIROLOGY, 92巻, pp. 1071-1081, 201105
  118. Persistent Loss of Hepatitis B Virus Markers in Serum without Cellular Immunity by Combination of Peginterferon and Entecavir Therapy in Humanized Mice, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61巻, 9号, 201709
  119. Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 500巻, 2号, pp. 152-157, 20180602
  120. Limitations of daclatasvir/asunaprevir plus beclabuvir treatment in cases of NS5A inhibitor treatment failure, JOURNAL OF GENERAL VIROLOGY, 99巻, 8号, pp. 1058-1065, 201808
  121. Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure, RADIATION RESEARCH, 190巻, 4号, pp. 424-432, 201810
  122. Advanced liver fibrosis effects on the response to sofosbuvir-based antiviral therapies for chronic hepatitis C, JOURNAL OF MEDICAL VIROLOGY, 90巻, 12号, pp. 1834-1840, 201812
  123. Molecular Mechanisms of Hepatocarcinogenesis Following Sustained Virological Response in Patients with Chronic Hepatitis C Virus Infection, VIRUSES-BASEL, 10巻, 10号, 201810
  124. CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients, JOURNAL OF VIRAL HEPATITIS, 25巻, 12号, pp. 1555-1564, 201812
  125. Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes, VIROLOGY, 525巻, pp. 48-61, 201812
  126. The association between serum cytokine and chemokine levels and antiviral response by entecavir treatment in chronic hepatitis B patients, ANTIVIRAL THERAPY, 23巻, 3号, pp. 239-248, 2018
  127. Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures, JOURNAL OF GASTROENTEROLOGY, 54巻, 3号, pp. 291-296, 201903

著書等出版物

  1. 2019年10月24日, Hepatocellular Carcinoma, Chapter 5. The Role of Lipids in Hepatocellular Carcinoma, Codon Publications, 2019年, 2019, 単行本(学術書), 共著, English, C. Nelson Hayes, Peiyi Zhang, and Kazuaki Chayama

招待講演、口頭・ポスター発表等

  1. A comparison of male and female responses to inbreeding in Cucurbita texana. Poster., Hayes, C.N.,, Winsor, J.A., Stephenson, A.G., Symposium: Frontiers in Sexual Plant Reproduction in Honor of Prof. Joseph Mascarenhas, 2001年01月05日, 通常, 英語
  2. Challenges in somatic mutation calling in virus-induced hepatocellular carcinoma, C. Nelson Hayes, Atsushi Ono, Sakura Akamatsu, Eisuke Murakami, Hiroshi Aikata, Michio Imamura, Daiki Miki, Hidenori Ochi, and Kazuaki Chayama, JCUP V, 2014年06月14日, 招待, 英語
  3. Hepatitis B virus infection leads to activation of interferon-stimulated genes in primary cultured human hepatocytes, but infection efficiency decreases monotonically with decreasing cell density, C. Nelson Hayes, Hiromi Abe, Sakura Akamatsu, Nobuhiko Hiraga, Michio Imamura, Masataka Tsuge, Daiki Miki, Hiroshi Aikata, , Hidenori Ochi, Yuji Ishida, Chise Tateno, and Kazuaki Chayama, HBV Single topic conference 2014, 2014年11月18日, 通常, 英語
  4. Hepatitis B virus infection efficiency and immune response decreases with cell density in primary cultured hepatocytes, C. Nelson Hayes, Hiromi Abe, Sakura Akamatsu, Nobuhiko Hiraga, Michio Imamura, Masataka Tsuge, Daiki Miki, Hiroshi Aikata, , Hidenori Ochi, Yuji Ishida, Chise Tateno, and Kazuaki Chayama, AASLD, 2014年11月14日, 通常, 英語
  5. Characterizing the early immune response to hepatitis B virus infection using the human hepatocyte chimeric mouse model, C. Nelson Hayes, Sakura Akamatsu, Masataka Tsuge, Daiki Miki, Hiromi Abe-Chayama, Michio Imamura, Hidenori Ochi, Kazuaki Chayama, AASLD, 2017年10月22日, 通常, 英語
  6. Estimating HBV gene expression levels based on RNAseq data in a human hepatocyte chimeric mouse mode, 高効率感染細胞系と長期持続肝炎マウスモデルを用いたHBV排除への創薬研究, 2017年12月08日, 通常, 英語, 平成29年度茶山班班会議, 広島大学大学院 消化器・代謝内科学 
  7. Prediction of hepatitis B virus co-receptors using semi-supervised learning, Peiyi Zhang、茶山 一彰, AASLSD conference 2019, 2019年11月09日, 通常, 英語, American Association for the Study of Liver Diseases
  8. Inbreeding depression in male and female functions in Cucurbita texana., Hayes, C.N., Winsor, J.A., Stephenson, A.G., 16th Annual Penn State Symposium in Plant Physiology: Plant Reproduction 2002: From evolutionary and physiological analyses to molecular genetic studies., 2002年05月01日, 通常, 英語
  9. Male vs. female inbreeding depression in Cucurbita texana, Hayes, C.N., Winsor, J.A., Stephenson, A.G., Ecological Society of America Annual Meeting, 2002年08月01日, 通常, 英語
  10. Assessing undergraduate learning in web-based biology instruction, Cyr, R., Harris, S., Hayes, C.N. Woodward, D, National Association for Research in Science Teaching, 2002年10月01日, 通常, 英語
  11. Inbreeding depression in male and female functions in Cucurbita texana., Hayes, C.N., Winsor, J.A., Stephenson, A.G., Royal Society Discussion Meeting on Mechanisms Regulating Gene Flow in Flowering Plants. London, UK., 2002年12月15日, 通常, 英語
  12. varDB: a sequence database of protein families involved in antigenic variation in pathogens., Hayes, C.N., Diez, D., Kanehisa, M., Wahlgren, M., Wheelock, C., Goto, S., Genome Informatics Workshop 2007. Singapore, SINGAPORE., 2007年12月10日, 通常, 英語
  13. Tools for investigating mechanisms of antigenic variation: new extensions to varDB, Hayes CN, Diez D, Joannin N, Kanehisa M, Wahlgren M, Wheelock CE, Goto S, Genome Informatics Workshop 2009, Yokohama, Japan, 2009年12月06日, 通常, 英語
  14. Serum miRNAs and the hepatitis B virus life cycle, C. Nelson Hayes, Sakura Akamatsu, Masataka Tsuge, Daiki Miki, Nobuhiko Hiraga, Michio Imamura, Shoichi Takahashi, Hidenori Ochi, Kazuaki Chayama, AASLD, 2012年11月05日, 通常, 英語
  15. Early and late changes in gene expression profiles following infection with hepatitis B or C virus in human hepatocyte chimeric mice, Hayes, C. Nelson, Sakura Akamatsu, Masataka Tsuge, Daiki Miki, Nobuhiko Hiraga, Hiromi Abe, Michio Imamura1, Shoichi Takahashi, Hidenori Ochi, Kazuaki Chayama, AALSD 2013, 2013年11月04日, 通常, 英語

受賞

  1. 1992年09月01日, Presidential Scholarship, Washington and Jefferson College
  2. 1999年08月01日, J. Ben and Helen D. Hill graduate student award, Pennsylvania State University
  3. 1999年07月15日, Eberly College of Science Braddock Fellowship, Pennsylvania State University
  4. 2002年05月15日, Graduate Assistant Outstanding Teaching Award, Pennsylvania State University
  5. 2006年04月01日, 日本学術振興会研究員, 日本学術振興会
  6. 2009年12月16日, Best paper award, Genome Informatics Workshop
  7. 2019年11月09日, Presidential poster of distinction, American Association for the Study of Liver Diseases

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業(若手研究(B)), 次世代シーケンサーを用いたHCVに対する3者併用療法中の耐性株の動態の解析, 2012年, 2013年