白石 成二SEIJI SHIRAISHI

Last Updated :2024/12/02

所属・職名
病院（医）　寄附講座教授
メールアドレス
seishirahiroshima-u.ac.jp

基本情報

学位

  • 博士（医学）　(宮崎医科大学)

研究分野

  • 医歯薬学 / 境界医学 / 疼痛学
  • 医歯薬学 / 外科系臨床医学 / 麻酔科学

研究活動

学術論文（★は代表的な論文）

  1. Intravenous administration of human mesenchymal stem cells derived from adipose tissue and umbilical cord improves neuropathic pain via suppression of neuronal damage and anti-inflammatory actions in rats, PLoS ONE, 17巻, 2号, pp. e0262892, 2022
  2. Taxane-induced sensory peripheral neuropathy is associated with an SCN9A single nucleotide polymorphism in Japanese patients, BMC Cancer, 20巻, 1号, pp. 325, 2020
  3. A novel method for evaluating activity of transient receptor potential channels using a cellular dielectric spectroscopy, Journal of Pharmacological Sciences, 143巻, 4号, pp. 320-324, 2020
  4. Carboplatin enhances the activity of human transient receptor potential ankyrin 1 through the cyclic AMP-protein kinase A-A-kinase anchoring protein (AKAP) pathways, International Journal of Molecular Sciences, 20巻, 13号, pp. 3271, 2019
  5. ★, Relief from neuropathic pain by blocking of the platelet-activating factor–pain loop, FASEB Journal, 31巻, 7号, pp. 2973-2980, 2017
  6. Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the Kampo medicine rikkunshito on the model, PLoS ONE, 12巻, 3号, pp. e0173113, 2017
  7. Therapeutic potential of ghrelin and des-acyl ghrelin against chemotherapy-induced cardiotoxicity, Endocrine Journal, 64巻, pp. S35-S39, 2017
  8. The atypical antipsychotic, olanzapine, potentiates ghrelin-induced receptor signaling: An in vitro study with cells expressing cloned human growth hormone secretagogue receptor, Neuropeptides, 58巻, pp. 93-101, 2016
  9. Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca2+ influx through transient receptor potential V1 (TRPV1) channels, Journal of Pharmacological Sciences, 130巻, 2号, pp. 72-77, 2016
  10. Metabolism of AM404 from acetaminophen at human therapeutic dosages in the rat brain, Anesthesiology and Pain Medicine, 6巻, 1号, pp. e32873, 2016
  11. Pain relieving effect of platelet-activating factor (PAF) antagonists in a bone cancer pain model, Folia Pharmacologica Japonica, 146巻, 2号, pp. 87-92, 2015
  12. Tramadol and Its Metabolite M1 Selectively Suppress Transient Receptor Potential Ankyrin 1 Activity, but Not Transient Receptor Potential Vanilloid 1 Activity, Anesthesia and Analgesia, 120巻, 4号, pp. 790-798, 2015
  13. ★, Palliation of bone cancer pain by antagonists of platelet-activating factor receptors, PLoS ONE, 9巻, 3号, pp. e91746, 2014
  14. New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line, American Journal of Physiology - Endocrinology and Metabolism, 306巻, 4号, pp. E373-E387, 2014
  15. Mechanisms of the opioid-resistant abdominal pain induced by peritoneal carcinomatosis and selection of effective analgesics for such pain based on mechanisms of action, Japanese Journal of Anesthesiology, 63巻, pp. S95-S102, 2014
  16. Relief of cancer pain by glycine transporter inhibitors, Anesthesia and Analgesia, 119巻, 4号, pp. 988-995, 2014
  17. Intrathecal adrenomedullin modulates acute inflammatory pain in the rat formalin test, Neuroscience Letters, 552巻, pp. 1146-1150, 2013
  18. Pain-releasing action of Platelet-activating factor (PAF) antagonists in neuropathic pain animal models and the mechanisms of action, European Journal of Pain, 17巻, 8号, pp. 1156-1167, 2013
  19. A review of traditional Japanese medicines and their potential mechanism of action, Current Pharmaceutical Design, 18巻, 31号, pp. 4839-4853, 2012
  20. Lidocaine treatment during synapse reformation periods permanently inhibits NGF-induced excitation in an identified reconstructed synapse of Lymnaea stagnali, Journal of Anesthesia, 26巻, 1号, pp. 45-53, 2012
  21. Clinical dose of lidocaine destroys the cell membrane and induces both necrosis and apoptosis in an identified Lymnaea neuron, Journal of Anesthesia, 26巻, 1号, pp. 54-61, 2012
  22. Increased expression of aquaporin-4 with methylmercury exposure in the brain of the common marmoset, Journal of Toxicological Sciences, 37巻, 4号, pp. 749-763, 2012
  23. S(+)-ketamine supresses desensitization of r-aminobutylic acid type B receptor-mediated signaling by inhibition of the interaction of r-aminobutylic acid type B receptors with G protein-coupled receptor kinase 4 or 5, Anesthesiology, 114巻, 2号, pp. 401-411, 2011
  24. Activation of the neurokinin-1 receptor in rat spinal astrocytes induces Ca 2+ release from IP 3-sensitive Ca 2+ stores and extracellular Ca 2+ influx through TRPC3, Neurochemistry International, 57巻, 8号, pp. 923-934, 2010
  25. Analysis of the effects of anesthetics and ethanol on u-Opioid receptor, Journal of Pharmacological Sciences, 112巻, 4号, pp. 424-431, 2010
  26. Prothrombotic roles of substance-P, neurokinin-1 receptors and leukocytes in the platelet-dependent clot formation in whole blood, Journal of Thrombosis and Thrombolysis, 27巻, 3号, pp. 280-286, 2009
  27. Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats, European Journal of Pharmacology, 554巻, 1号, pp. 12-17, 2007
  28. Spinal orexin-1 receptors mediate anti-hyperalgesic effects of intrathecally-administered orexins in diabetic neuropathic pain model rats, Brain Research, 1044巻, 1号, pp. 76-86, 2005
  29. Analgesic effect of intrathecal administration of orexin on neuropathic pain in rats, In Vivo, 18巻, 2号, pp. 119-124, 2004
  30. Destabilization of Nav1.7 sodium channel a-subunit mRNA by constitutive phosphorylation of extracellular signal-regulated kinase: Negative regulation of steady-state level of cell surface functional sodium channels in adrenal chromaffin cells, Molecular Pharmacology, 63巻, 5号, pp. 1125-1136, 2003
  31. ★, Differential effects of bupivacaine enantiomers, ropivacaine and lidocaine on up-regulation of cell surface voltage-dependent sodium channels in adrenal chromaffin cells, Brain Research, 966巻, 2号, pp. 175-184, 2003
  32. Distinct effects of ketone bodies on down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation in adrenal chromaffin cells, Journal of Pharmacology and Experimental Therapeutics, 304巻, 3号, pp. 994-1002, 2003
  33. Down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation by inhibitor of 90-kDa heat-shock protein family: Endoplasmic reticulum retention of monomeric insulin receptor precursor with calnexin in adrenal chromaffin cells, Molecular Pharmacology, 62巻, 4号, pp. 847-855, 2002
  34. Regulation of voltage-dependent sodium channel expression in adrenal chromaffin cells: Involvement of multiple calcium signaling pathways, Annals of the New York Academy of Sciences, 971巻, pp. 127-134, 2002
  35. Serum deprivation-induced upregulation of voltage-dependent sodium channels in adrenal chromaffin cells: Selective involvement of extracellular signal-regulated kinase pathway, Annals of the New York Academy of Sciences, 971巻, pp. 153-155, 2002
  36. Selective expression of aquaporin 1, 4 and 5 in the rat middle ear, Hearing Research, 158巻, 1-2号, pp. 51-56, 2001
  37. ★, Up-regulation of cell surface sodium channels by cyclosporin A, FK506, and rapamycin in adrenal chromaffin cells, Journal of Pharmacology and Experimental Therapeutics, 297巻, 2号, pp. 657-665, 2001
  38. ★, Down-regulation of cell surface insulin receptors by sarco(endo)plasmic reticulum Ca2+-ATPase inhibitor in adrenal chromaffin cells, Brain Research, 898巻, 1号, pp. 152-157, 2001
  39. Selective inhibition of nicotinic cholinergic receptors by proadrenomedullin N-terminal 12 peptide in bovine adrenal chromaffin cells, Molecular Brain Research, 87巻, 2号, pp. 175-183, 2001
  40. Adrenomedullin receptors in rat choroid plexus, Neuroscience Letters, 297巻, 3号, pp. 167-170, 2001
  41. Aquaporin subtypes in rat cerebral microvessels, Neuroscience Letters, 297巻, 3号, pp. 163-166, 2001
  42. ★, Heterogeneous increases of cytoplasmic calcium: Distinct effects on down-regulation of cell surface sodium channels and sodium channel subunit mRNA levels, British Journal of Pharmacology, 132巻, 7号, pp. 1455-1466, 2001
  43. ★, Post-translational reduction of cell surface expression of insulin receptors by cyclosporin A, FK506 and rapamycin in bovine adrenal chromaffin cells, Neuroscience Letters, 293巻, 3号, pp. 211-215, 2000
  44. Short- and long-term differential effects of neuroprotective drug NS-7 on voltage-dependent sodium channels in adrenal chromaffin cells, British Journal of Pharmacology, 131巻, 4号, pp. 779-787, 2000
  45. a1-Adrenergic receptor subtypes in rat cerebral microvessels, Brain Research, 878巻, 1-2号, pp. 183-187, 2000
  46. Up-regulation of cell surface insulin receptor by protein kinase C-a in adrenal chromaffin cells: Involvement of transcriptional and translational events, Journal of Neurochemistry, 75巻, 2号, pp. 672-682, 2000
  47. Inhibition by neuroprotective drug NS-7 of nicotine-induced 22Na+ influx, 45Ca2+ influx and catecholamine secretion in adrenal chromaffin cells, Brain Research, 873巻, 1号, pp. 149-154, 2000
  48. Protein kinase C-a and -e down-regulate cell surface sodium channels via differential mechanisms in adrenal chromaffin cells, Journal of Neurochemistry, 74巻, 4号, pp. 1674-1684, 2000
  49. Adrenomedullin inhibits spontaneous and bradykinin-induced but not oxytocin- or prostaglandin F(2a)-induced periodic contraction of rat uterus, British Journal of Pharmacology, 130巻, 8号, pp. 1727-1730, 2000
  50. Selective inhibition by riluzole of voltage-dependent sodium channels and catecholamine secretion in adrenal chromaffin cells, Naunyn-Schmiedeberg's Archives of Pharmacology, 357巻, 5号, pp. 526-531, 1998
  51. Bupivacaine-induced convulsion is suppressed by MK-801, Regional Anesthesia, 23巻, 1号, pp. 71-76, 1998
  52. Comparison of Analgesic Effect of Lidocaine Tape versus Eutectic Mixture of Lidocaine and Tetracaine during Infiltration of Local Anesthetics before Epidural Block, Japanese Journal of Anesthesiology, 45巻, 9号, pp. 1077-1081, 1996
  53. Effect of atropine and pirenzepine on bronchoconstriction during vagus nerve stimulation in dogs, Japanese Journal of Anesthesiology, 41巻, 12号, pp. 1923-1926, 1992
  54. Effects of high-dose fentanyl anesthesia on auditory brainstem responses, Japanese Journal of Anesthesiology, 41巻, 9号, pp. 1414-1418, 1992

招待講演、口頭・ポスター発表等

  1. Th細胞パラダイムを介した腫瘍免疫に及ぼす麻酔薬の影響, 鬼塚信, 白石成二, 日本麻酔科学会第69回学術集会, 2022年, 通常, 日本語, 発表資料