合田 光寛MITSUHIRO GODA

Last Updated :2025/07/02

所属・職名
大学院医系科学研究科（薬）　教授
メールアドレス
mitsuhirogodahiroshima-u.ac.jp

教育活動

授業担当

  1. 2025年, 学部専門, ３ターム, 薬学概論
  2. 2025年, 学部専門, セメスター（前期）, 薬学研究方法論演習Ａ
  3. 2025年, 学部専門, セメスター（後期）, 薬学研究方法論演習Ｂ
  4. 2025年, 学部専門, セメスター（前期）, 臨床薬学演習
  5. 2025年, 学部専門, セメスター（後期）, 生物統計学
  6. 2025年, 学部専門, １ターム, 臨床薬物治療学Ａ
  7. 2025年, 学部専門, ３ターム, 臨床薬理学Ａ
  8. 2025年, 学部専門, ２ターム, 薬事関係法規
  9. 2025年, 学部専門, １ターム, 臨床薬理学Ｃ
  10. 2025年, 学部専門, ３ターム, 日本薬局方演習
  11. 2025年, 学部専門, ３ターム, 薬学英語
  12. 2025年, 学部専門, ３ターム, 臨床事前実習
  13. 2025年, 学部専門, 通年, 臨床実習Ａ
  14. 2025年, 学部専門, 通年, 臨床実習Ｂ
  15. 2025年, 学部専門, 通年, 基礎研究I
  16. 2025年, 学部専門, 通年, 基礎研究II
  17. 2025年, 学部専門, セメスター（後期）, 基礎研究III
  18. 2025年, 学部専門, 通年, 臨床研究I
  19. 2025年, 学部専門, 通年, 臨床研究II
  20. 2025年, 学部専門, 通年, 臨床研究III
  21. 2025年, 博士課程・博士課程後期, ４ターム, 薬物治療学
  22. 2025年, 博士課程・博士課程後期, セメスター（前期）, 治療薬効学特別演習
  23. 2025年, 博士課程・博士課程後期, セメスター（後期）, 治療薬効学特別演習
  24. 2025年, 博士課程・博士課程後期, セメスター（前期）, 治療薬効学特別研究
  25. 2025年, 博士課程・博士課程後期, セメスター（後期）, 治療薬効学特別研究
  26. 2025年, 修士課程・博士課程前期, １ターム, 治療薬効学特論
  27. 2025年, 修士課程・博士課程前期, セメスター（前期）, 治療薬効学特論演習
  28. 2025年, 修士課程・博士課程前期, セメスター（後期）, 治療薬効学特論演習
  29. 2025年, 修士課程・博士課程前期, セメスター（前期）, 治療薬効学特別研究
  30. 2025年, 修士課程・博士課程前期, セメスター（後期）, 治療薬効学特別研究
  31. 2025年, 博士課程・博士課程後期, セメスター（前期）, 治療薬効学特別演習
  32. 2025年, 博士課程・博士課程後期, セメスター（後期）, 治療薬効学特別演習
  33. 2025年, 博士課程・博士課程後期, セメスター（前期）, 治療薬効学特別研究
  34. 2025年, 博士課程・博士課程後期, セメスター（後期）, 治療薬効学特別研究

研究活動

学術論文（★は代表的な論文）

  1. Rifampicin in combination treatments for methicillin-resistant staphylococcal prosthetic joint infections: Claims database evaluation using a cohort of 52,588 hip arthroplasty patients., International journal of clinical pharmacology and therapeutics, 2025
  2. Malfunction of vascular control in lifestyle-related diseases: distribution of adrenomedullin-containing perivascular nerves and its alteration in hypertension., Journal of pharmacological sciences, 96巻, 4号, 2004
  3. Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP)-containing nerves in spontaneously hypertensive rats., Hypertension research : official journal of the Japanese Society of Hypertension, 28巻, 5号, 2005
  4. [Effect of propolis on insulin resistance in fructose-drinking rats]., Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 127巻, 12号, 2007
  5. Royal jelly ameliorates insulin resistance in fructose-drinking rats., Biological & pharmaceutical bulletin, 31巻, 11号, 2008
  6. Neurotrophic effect of hepatic growth factor (HGF) on reinnervation of perivascular calcitonin gene-related peptide (CGRP)-containing nerves following phenol-induced nerve injury in the rat mesenteric artery., Journal of pharmacological sciences, 108巻, 4号, 2008
  7. [Functional alteration of nervous system in renovascular hypertension]., Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 129巻, 2号, 2009
  8. Nerve growth factor suppresses prostate tumor growth., Journal of pharmacological sciences, 112巻, 4号, 2010
  9. Altered function of nitrergic nerves inhibiting sympathetic neurotransmission in mesenteric vascular beds of renovascular hypertensive rats., Hypertension research : official journal of the Japanese Society of Hypertension, 33巻, 5号, 2010
  10. [Regeneration of perivascular nerve and role of angiotensin receptors]., Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 130巻, 9号, 2010
  11. [Role of angiontensin receptors in remodeling perivascular nerves]., Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 130巻, 11号, 2010
  12. [Pharmacologic research for bridging drug development and treatment strategy--pharmacological approach to treatment by clarification of pathology]., Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 131巻, 4号, 2011
  13. [Influence of nerve growth factor (NGF) on distribution of perivascular nerves in tumor neovasculatures of mouse corneal]., Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 132巻, 2号, 2012
  14. Neurogenic vascular responses in male mouse mesenteric vascular beds., Journal of pharmacological sciences, 119巻, 3号, 2012
  15. Do cholinergic nerves innervating rat mesenteric arteries regulate vascular tone?, American journal of physiology. Regulatory, integrative and comparative physiology, 303巻, 11号, 2012
  16. Protons modulate perivascular axo-axonal neurotransmission in the rat mesenteric artery., British journal of pharmacology, 171巻, 24号, 2014
  17. Characterization of Perivascular Nerve Distribution in Rat Mesenteric Small Arteries., Biological & pharmaceutical bulletin, 38巻, 11号, 2015
  18. Nerve growth factor facilitates redistribution of adrenergic and non-adrenergic non-cholinergic perivascular nerves injured by phenol in rat mesenteric resistance arteries., European journal of pharmacology, 770巻, 2016
  19. Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries., Journal of pharmacological sciences, 130巻, 1号, 2016
  20. Nerve growth factor facilitates perivascular innervation in neovasculatures of mice., Journal of pharmacological sciences, 131巻, 4号, 2016
  21. Nerve Growth Factor Facilitates the Innervation of Perivascular Nerves in Tumor-Derived Neovasculature in the Mouse Cornea., Pharmacology, 99巻, 1-2号, 2017
  22. Effect of Nerve Growth Factor on Innervation of Perivascular Nerves in Neovasculatures of Mouse Cornea., Biological & pharmaceutical bulletin, 40巻, 4号, 2017
  23. Involvement of the Multidrug and Toxic Compound Extrusion Transporter in Testosterone Release from Cultured Pig Leydig Cells., Pharmacology, 100巻, 1-2号, 2017
  24. Evaluation of the Benefits of De-Escalation for Patients with Sepsis in the Emergency Intensive Care Unit., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 21巻, 1号, 2018
  25. Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis., American journal of hypertension, 32巻, 3号, 2019
  26. Association Between Immune-Related Adverse Events and Clinical Efficacy in Patients with Melanoma Treated With Nivolumab: A Multicenter Retrospective Study., Clinical therapeutics, 41巻, 1号, 2019
  27. Pharmacovigilance evaluation of the relationship between impaired glucose metabolism and BCR-ABL inhibitor use by using an adverse drug event reporting database., Cancer medicine, 8巻, 1号, 2019
  28. Nerve growth factor (NGF) has an anti-tumor effects through perivascular innervation of neovessels in HT1080 fibrosarcoma and HepG2 hepatitis tumor in nude mice., Journal of pharmacological sciences, 140巻, 1号, 2019
  29. Prophylactic administration of granulocyte colony-stimulating factor in epirubicin and cyclophosphamide chemotherapy for Japanese breast cancer patients: a retrospective study., Cancer chemotherapy and pharmacology, 84巻, 5号, 2019
  30. Effect of serum concentration and concomitant drugs on vancomycin-induced acute kidney injury in haematologic patients: a single-centre retrospective study., European journal of clinical pharmacology, 75巻, 12号, 2019
  31. Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway., Toxicology letters, 318巻, 2020
  32. Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database., Frontiers in pharmacology, 10巻, 2019
  33. Rho-associated protein kinase and cyclophilin a are involved in inorganic phosphate-induced calcification signaling in vascular smooth muscle cells., Journal of pharmacological sciences, 142巻, 3号, 2020
  34. Fibroblast-specific ERK5 deficiency changes tumor vasculature and exacerbates tumor progression in a mouse model., Naunyn-Schmiedeberg's archives of pharmacology, 393巻, 7号, 2020
  35. Deletion of H-ferritin in macrophages alleviates obesity and diabetes induced by high-fat diet in mice., Diabetologia, 63巻, 8号, 2020
  36. Risk factors of immune checkpoint inhibitor-related interstitial lung disease in patients with lung cancer: a single-institution retrospective study., Scientific reports, 10巻, 1号, 2020
  37. Successful Vancomycin Dose Adjustment in a Sepsis patient with Bacterial Meningitis Using Cystatin C., Acta medica Okayama, 74巻, 4号, 2020
  38. Preventive Effects of Quercetin against the Onset of Atherosclerosis-Related Acute Aortic Syndromes in Mice., International journal of molecular sciences, 21巻, 19号, 2020
  39. Investigation of drugs affecting hypertension in bevacizumab-treated patients and examination of the impact on the therapeutic effect., Cancer medicine, 10巻, 1号, 2021
  40. Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity., Kidney international, 99巻, 4号, 2021
  41. Effects of Palonosetron on Nausea and Vomiting Induced by Multiple-Day Chemotherapy: A Retrospective Study., Biological & pharmaceutical bulletin, 44巻, 4号, 2021
  42. Involvement of Human Multidrug and Toxic Compound Extrusion (MATE) Transporters in Testosterone Transport., Biological & pharmaceutical bulletin, 44巻, 4号, 2021
  43. Examination of the antiepileptic effects of valacyclovir using kindling mice- search for novel antiepileptic agents by drug repositioning using a large medical information database., European journal of pharmacology, 902巻, 2021
  44. Evaluation of potential complication of interstitial lung disease with abemaciclib and palbociclib treatments., Cancer reports (Hoboken, N.J.), 5巻, 1号, 2022
  45. Effects of 5-HT₃ receptor antagonists on cisplatin-induced kidney injury., Clinical and translational science, 14巻, 5号, 2021
  46. Academic investigators' interest in promoting specified clinical trials : Questionnaire survey before and after implementation of the Clinical Trial Act., The journal of medical investigation : JMI, 68巻, 1.2号, 2021
  47. Assessment of Adherence to Post-exposure Prophylaxis with Oseltamivir in Healthcare Workers: A Retrospective Questionnaire-Based Study., Biological & pharmaceutical bulletin, 44巻, 6号, 2021
  48. Evaluation of Potential Complications of Interstitial Lung Disease Associated With Antiandrogens Using Data From Databases Reporting Spontaneous Adverse Effects., Frontiers in pharmacology, 12巻, 2021
  49. Impact of Area Under the Concentration-Time Curve on the Prevalence of Vancomycin-Induced Nephrotoxicity in Combination With Tazobactam/Piperacillin or Cefepime: A Single-Institution Retrospective Study., Clinical therapeutics, 43巻, 11号, 2021
  50. Drug-Repositioning Approaches Based on Medical and Life Science Databases., Frontiers in pharmacology, 12巻, 2021
  51. Atenolol and mortality events in patients with chronic kidney disease: Analysis of data from the Japanese Adverse Drug Event Report database., Basic & clinical pharmacology & toxicology, 130巻, 4号, 2022
  52. Trends in Investigator-Initiated Clinical Studies at a University Hospital after Enforcement of the 2018 Clinical Trials Act in Japan., Biological & pharmaceutical bulletin, 45巻, 3号, 2022
  53. Identification of prophylactic drugs for oxaliplatin-induced peripheral neuropathy using big data., Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 148巻, 2022
  54. Association Between Statin Use and Daptomycin-related Musculoskeletal Adverse Events: A Mixed Approach Combining a Meta-analysis and a Disproportionality Analysis., Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 75巻, 8号, 2022
  55. Prevention of Pemetrexed-Induced Rash Using Low-Dose Corticosteroids: A Phase II Study., The oncologist, 27巻, 7号, 2022
  56. Discovery of preventive drugs for cisplatin-induced acute kidney injury using big data analysis., Clinical and translational science, 15巻, 7号, 2022
  57. A web-based survey of educational opportunities of medical professionals based on changes in conference design during the COVID-19 pandemic., Education and information technologies, 27巻, 7号, 2022
  58. Investigation of drugs for the prevention of doxorubicin-induced cardiac events using big data analysis., European journal of pharmacology, 928巻, 2022
  59. Evaluation of the potential complication of interstitial lung disease associated with antifibrotic drugs using data from databases reporting spontaneous adverse effects., Clinical and translational science, 15巻, 12号, 2022
  60. Clinical Impact of a Pharmacist-Driven Prospective Audit with Intervention and Feedback on the Treatment of Patients with Bloodstream Infection., Antibiotics (Basel, Switzerland), 11巻, 9号, 2022
  61. Non-recovery of vancomycin-associated nephrotoxicity is related to worsening survival outcomes: Combined retrospective analyses of two real-world databases., Basic & clinical pharmacology & toxicology, 131巻, 6号, 2022
  62. Characterization of Immune Checkpoint Inhibitor-Induced Myasthenia Gravis Using the US Food and Drug Administration Adverse Event Reporting System., Journal of clinical pharmacology, 63巻, 4号, 2023
  63. Differential effects of proton pump inhibitors and vonoprazan on vascular endothelial growth factor expression in cancer cells., Drug development research, 84巻, 1号, 2023
  64. Clinical Impact of Antipolyethylene Glycol (PEG) Antibody in Hematological Patients Administered PEGylated-Granulocyte Colony-Stimulating Factor., Clinical pharmacology in drug development, 12巻, 8号, 2023
  65. Effects of vonoprazan and proton pump inhibitors on the efficacy of bevacizumab: a multicentre retrospective study., Clinical and experimental medicine, 23巻, 6号, 2023
  66. Cardiovascular Toxicities Associated with Anaplastic Lymphoma Kinase Inhibitors: A Disproportionality Analysis of the WHO Pharmacovigilance Database (VigiBase)., Drug safety, 46巻, 6号, 2023
  67. Structural characterization of the optical isomers esomeprazole and omeprazole using the JADER and FAERS databases., Toxicology and applied pharmacology, 475巻, 2023
  68. Valproic acid treatment attenuates cisplatin-induced kidney injury by suppressing proximal tubular cell damage., Clinical and translational science, 16巻, 11号, 2023
  69. Angiogenesis inhibitor-specific hypertension increases the risk of developing aortic dissection., Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 167巻, 2023
  70. Effect of pre-treatment with EGFR-TKIs on immune checkpoint inhibitor-associated interstitial lung disease in lung cancer patients: Analysis using a Japanese claims database., International journal of clinical pharmacology and therapeutics, 62巻, 2号, 2024
  71. Concomitant Use of Multiple Nephrotoxins including Renal Hypoperfusion Medications Causes Vancomycin-Associated Nephrotoxicity: Combined Retrospective Analyses of Two Real-World Databases., Acta medica Okayama, 77巻, 6号, 2023
  72. [Development of Preventive Methods for Drug-induced Cardiotoxicity Using a Large-scale Medical Information Database]., Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 144巻, 3号, 2024
  73. The Association between PDE5 Inhibitors and Aneurysm/Arterial Dissection:A Pharmacovigilance Study Using WHO Safety Database., The journal of medical investigation : JMI, 71巻, 1.2号, 2024
  74. Atractylodes lancea (Thunb.) DC. [Asteraceae] rhizome-derived exosome-like nanoparticles suppress lipopolysaccharide-induced inflammation in murine microglial cells., Frontiers in pharmacology, 15巻, 2024
  75. Effects of renin-angiotensin system inhibitor and beta-blocker use on mortality in older patients with heart failure with reduced ejection fraction in Japan., Frontiers in cardiovascular medicine, 11巻, 2024
  76. Asciminib, a novel allosteric inhibitor of BCR-ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance., Pharmacology research & perspectives, 12巻, 4号, 2024
  77. A network-based trans-omics approach for predicting synergistic drug combinations., Communications medicine, 4巻, 1号, 2024
  78. Unveiling the association between fluoroquinolones and aortic diseases using real-world database analysis and pharmacological experiments., Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 179巻, 2024
  79. Statins ameliorate oxaliplatin- and paclitaxel-induced peripheral neuropathy via glutathione S-transferase., Neurochemistry international, 180巻, 2024
  80. Assessing the effects of interprofessional education by hospital pharmacists on pharmaceutical students using a self-evaluation scale., Journal of pharmaceutical health care and sciences, 10巻, 1号, 2024
  81. Cardiovascular Toxicity Profile of Macrolides Investigated Using VigiBase Data: A Pharmacovigilance Study., Cardiovascular toxicology, 25巻, 3号, 2025
  82. Evaluation of Interstitial Lung Disease Complications Caused by Biologic Agents Using a Spontaneous Adverse Drug Reaction Reporting Database., Pharmacology research & perspectives, 13巻, 2号, 2025
  83. Novel predictors of infection-related rehospitalization in older patients with heart failure in Japan., Geriatrics & gerontology international, 25巻, 4号, 2025
  84. Risk factors for clazosentan-induced fluid retention in subarachnoid hemorrhage from the Japanese adverse event database., Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 34巻, 6号, 2025
  85. Influence of statin intervention on peripheral neuropathy in patients treated with anticancer drugs identified from the insurer database., Journal of pharmaceutical health care and sciences, 11巻, 1号, 2025
  86. Incidence of Myocarditis Caused by Drugs Used for Ulcerative Colitis as Examined Using VigiBase, a Spontaneous Adverse Drug Reaction Reporting Database., Biological & pharmaceutical bulletin, 48巻, 4号, 2025
  87. [Promotion of the appropriate use of antimicrobial agents by utilizing medical big data]., Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 160巻, 3号, 2025
  88. [Analysis of the therapeutic efficacy of bacterial infections through medical big data]., Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 160巻, 3号, 2025
  89. Potential Role of Upadacitinib in Cytomegalovirus Colitis Recurrence., European journal of case reports in internal medicine, 12巻, 5号, 2025
  90. Factors Associated with Long-Term Hospitalization in Older Patients with Heart Failure in Japan., International heart journal, 66巻, 3号, 2025
  91. Unravelling the cardioprotective effects of calcitriol in Sunitinib-induced toxicity: A comprehensive in silico and in vitro study., Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 188巻, 2025