松原 知康TOMOYASU MATSUBARA

Last Updated :2026/01/07

所属・職名
病院（医）　助教
メールアドレス
tomoyasumatsubarahiroshima-u.ac.jp

基本情報

学位

  • 博士（医学）　(広島大学)

教育活動

授業担当

  1. 2025年, 学部専門, 通年, 脳神経医学III

研究活動

学術論文（★は代表的な論文）

  1. ★, A Novel Neuropathological Subtype of Amyotrophic Lateral Sclerosis Characterised by Prominent Astroglial TDP-43 Pathology., Neuropathology and applied neurobiology, 51巻, 5号, 2025
  2. Identification of Hasegawa Dementia Scale-Revised Cutoff Scores Associated With Mini-Mental State Examination Thresholds for Anti-Amyloid β Therapies in Patients With Amnesia., Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 25巻, 6号, 2025
  3. Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies., Molecular neurodegeneration, 20巻, 1号, 2025
  4. Argyrophilic grain disease: epidemiology and association with cognitive decline and parkinsonism., Brain communications, 7巻, 5号, 2025
  5. An autopsy case of type A FTLD-TDP with a GRN mutation presenting with the logopenic variant of primary progressive aphasia at onset and with corticobasal syndrome subsequently., Neuropathology : official journal of the Japanese Society of Neuropathology, 45巻, 1号, 2025
  6. Argyrophilic Grain Disease Clinically Presenting as Progressive Supranuclear Palsy with Progressive Gait Freezing., Movement disorders clinical practice, 12巻, 8号, 2025
  7. Association of rare APOE missense variants with Alzheimer's disease in the Japanese population., Journal of Alzheimer's disease : JAD, 106巻, 1号, 2025
  8. Evaluation of the diagnostic performance of brachial plexus ultrasound in amyotrophic lateral sclerosis., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 175巻, 2025
  9. Magnetic Susceptibility and Area in the Subthalamic Nucleus Measured by QSM for Diagnosis of Progressive Supranuclear Palsy., Movement disorders clinical practice, 12巻, 10号, 2025
  10. A DRPLA-Affected Family: Clinical Course and Autopsy Findings in a Long-Surviving Case., Neuropathology : official journal of the Japanese Society of Neuropathology, 45巻, 4号, 2025
  11. Sarcoid Neuropathy Presenting with Two Novel Ultrasound Findings of Increased Intraneural Blood Flow and Small Saphenous Vein Wall Thickening., Internal medicine (Tokyo, Japan), 64巻, 18号, 2025
  12. Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer's disease and other neurodegenerative diseases., Acta neuropathologica communications, 12巻, 1号, 2024
  13. Clinicopathological study of dementia with grains presenting with parkinsonism compared with a typical case., Neuropathology : official journal of the Japanese Society of Neuropathology, 44巻, 5号, 2024
  14. Complete nanopore repeat sequencing of SCA27B (GAA-FGF14 ataxia) in Japanese., Journal of neurology, neurosurgery, and psychiatry, 95巻, 12号, 2024
  15. Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy., Acta neuropathologica communications, 12巻, 1号, 2024
  16. Clinical characteristics and pathophysiological properties of newly discovered LRRK2 variants associated with Parkinson's disease., Neurobiology of disease, 199巻, 2024
  17. Dynamic aphasia as an early sign of corticobasal degeneration: Clinico-radio-pathological correlation., eNeurologicalSci, 37巻, 2024
  18. An autopsy case of MM1-type sporadic Creutzfeldt-Jakob disease with long survival of 7 years, Neurology and Clinical Neuroscience, 13巻, 2号, pp. 137-140, 2024
  19. Analysis and comparison of post-translational modifications of α-synuclein filaments in multiple system atrophy and dementia with Lewy bodies., Scientific reports, 14巻, 1号, 2024
  20. A case of argyrophilic grain disease with an initial clinical diagnosis of Parkinson's disease., Journal of neurology, 271巻, 12号, 2024
  21. CSF P-Tau181 and Other Biomarkers in Patients With Neuronal Intranuclear Inclusion Disease., Neurology, 100巻, 10号, 2023
  22. Proteomic profile of nuclei containing p62-positive inclusions in a patient with neuronal intranuclear inclusion disease., Neurobiology of disease, 177巻, 2023
  23. Correlations between cerebrospinal fluid homovanillic acid and dopamine transporter SPECT in degenerative parkinsonian syndromes., Journal of neural transmission (Vienna, Austria : 1996), 130巻, 4号, 2023
  24. Bilateral tonic-clonic seizure and focal cortical hyperexcitability in familial Creutzfeldt-Jakob disease with E200K mutation of the prion protein., Epileptic disorders : international epilepsy journal with videotape, 25巻, 3号, 2023
  25. Morphological study of the phrenic nerve to determine a reference value for the myelinated fiber density in elderly individuals., Neuropathology : official journal of the Japanese Society of Neuropathology, 43巻, 2号, 2023
  26. Parkinson's disease in a patient with olfactory hypoplasia: a model case of "body-first Lewy body disease" providing insights into the progression of α-synuclein accumulation., Journal of neurology, 270巻, 10号, 2023
  27. High sensitivity of asymmetric 18F-THK5351 PET abnormality in patients with corticobasal syndrome., Scientific reports, 13巻, 1号, 2023
  28. Onlinization of a simulation course that includes minor emergency procedures., Acute medicine & surgery, 10巻, 1号, 2023
  29. An autopsied case report of spastic paraplegia with thin corpus callosum carrying a novel mutation in the SPG11 gene: widespread degeneration with eosinophilic inclusions., BMC neurology, 22巻, 1号, 2022
  30. ★, Autopsy Validation of the Diagnostic Accuracy of 123I-Metaiodobenzylguanidine Myocardial Scintigraphy for Lewy Body Disease., Neurology, 98巻, 16号, 2022
  31. Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases., Acta neuropathologica, 141巻, 1号, 2021
  32. An autopsy report of a familial amyotrophic lateral sclerosis case carrying VCP Arg487His mutation with a unique TDP-43 proteinopathy., Neuropathology : official journal of the Japanese Society of Neuropathology, 41巻, 2号, 2021
  33. Case report of anorexia nervosa showing periventricular gliosis at autopsy., Neuropathology : official journal of the Japanese Society of Neuropathology, 41巻, 2号, 2021
  34. Improvement of physician's confidence in handling minor emergencies before/after triage and action minor emergency course., Acute medicine & surgery, 8巻, 1号, 2021
  35. Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy., FEBS open bio, 11巻, 4号, 2021
  36. ELISA Evaluation of Tau Accumulation in the Brains of Patients with Alzheimer Disease., Journal of neuropathology and experimental neurology, 80巻, 7号, 2021
  37. Neuropathy/intranuclear inclusion bodies in oculopharyngodistal myopathy: A case report., eNeurologicalSci, 24巻, 2021
  38. Distinct phosphorylation profiles of tau in brains of patients with different tauopathies., Neurobiology of aging, 108巻, 2021
  39. Development of Clinical Skills and Confidence Questionnaire for Triage and Action Minor Emergency Course: Test-Retest Exam., Cureus, 13巻, 9号, 2021
  40. Lewy pathology of the submandibular gland in Lewy body disease: A report of autopsy cases., Neuropathology : official journal of the Japanese Society of Neuropathology, 41巻, 6号, 2021
  41. Parkinson's disease with a typical clinical course of 17 years overlapped by Creutzfeldt-Jakob disease: an autopsy case report., BMC neurology, 21巻, 1号, 2021
  42. Novel tau filament fold in corticobasal degeneration., Nature, 580巻, 7802号, 2020
  43. Structures of α-synuclein filaments from multiple system atrophy., Nature, 585巻, 7825号, 2020
  44. Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies., Frontiers in neuroscience, 14巻, 2020
  45. The epidemiology of minor surgical problems during specialists' absence: Single center, descriptive study., Journal of general and family medicine, 21巻, 6号, 2020
  46. Triage and action minor emergency: A simulation course to learn the initial treatment of minor emergencies., Journal of general and family medicine, 21巻, 6号, 2020
  47. Occult mucin-producing urothelial-type adenocarcinoma of the prostate with elevated serum levels of carcinoembryonic antigen and carbohydrate antigen 19-9: Report of an autopsy-proven case., Urology case reports, 23巻, 2019
  48. Amyotrophic lateral sclerosis of long clinical course clinically presenting with progressive muscular atrophy., Neuropathology : official journal of the Japanese Society of Neuropathology, 39巻, 1号, 2019
  49. Citrullinated histone H3 expression in anti-neutrophil cytoplasmic antibody-associated vasculitis in older Japanese autopsy patients., Geriatrics & gerontology international, 19巻, 3号, 2019
  50. Acute Liver Failure Associated with Influenza A Virus Infection: an Autopsy Case Report., Japanese journal of infectious diseases, 72巻, 5号, 2019
  51. Co-morbidity of progressive supranuclear palsy and amyotrophic lateral sclerosis: a clinical-pathological case report., BMC neurology, 19巻, 1号, 2019
  52. Clinical value of autoantibodies for lupus myelitis and its subtypes: A systematic review., Seminars in arthritis and rheumatism, 48巻, 2号, 2018
  53. Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons., Brain research, 1697巻, 2018
  54. The Gilliatt-Sumner hand: a diagnostic clue of neurogenic thoracic outlet syndrome., QJM : monthly journal of the Association of Physicians, 111巻, 11号, 2018
  55. 4',6-Diamidino-2-Phenylindole Distinctly Labels Tau Deposits., The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 66巻, 10号, 2018
  56. Distinct Incidence of Takotsubo Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study., Frontiers in neurology, 9巻, 2018
  57. The origins of rimmed vacuoles and granulovacuolar degeneration bodies are associated with the Wnt signaling pathway., Neuroscience letters, 638巻, 2017
  58. Neurological Complications in Eosinophilic Granulomatosis with Polyangiitis (EGPA): The Roles of History and Physical Examinations in the Diagnosis of EGPA., Internal medicine (Tokyo, Japan), 56巻, 22号, 2017
  59. Bilateral papilledema associated with spinal schwannoma., Neurology, 83巻, 24号, 2014
  60. Granulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders., PloS one, 6巻, 11号, 2011

著書等出版物

  1. 2023年, マイナーエマージェンシー : はじめの一歩, メディカル・サイエンス・インターナショナ, 9784815730864
  2. 2023年, 病棟指示と頻用薬の使い方決定版 : 持参薬対応や病棟でのマイナートラブル対処まで、意外と教わらない一生使える知識の詰め合わせ, 羊土, 松原知康, 宮崎紀樹編, 9784758123976
  3. 2021年, ルーティンを見直す!病棟指示と頻用薬の使い方, 羊土, 松原知康編 ; 宮崎紀樹編, 9784758116619
  4. 2016年, 内科救急診療のロジック : 動きながら考える!, 南山, 松原知康, 吉野俊平著, 9784525410810

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業（若手研究）, グリア細胞に着目した新たなTDP-43プロテイノパチーの病態解明, 2025年
  2. 科学研究費助成事業（若手研究）, ドパミントランスポーターイメージングの病理学的基盤の解明, 2022年

社会活動

委員会等委員歴

  1. 日本神経病理学会 代議員, 2023年
  2. 日本神経病理学会 広報委員, 2022年

学術雑誌論文査読歴

  1. 2025年, Molecular neurodegeneration, その他
  2. 2025年, Annals of Neurology, その他
  3. 2025年, Neurology, その他
  4. 2024年, Neurology, その他
  5. 2023年, Neurology, その他
  6. 2023年, Journal of neurology, neurosurgery and psychiatry., その他
  7. 2022年, Journal of neurology, neurosurgery and psychiatry., その他