ShinyaMatsuura

Last Updated :2019/10/10

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, ., Professor
Web Site
E-mail
shinyahiroshima-u.ac.jp
Other Contact Details
1-2-3, Kasumi, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5809 FAX : (+81)

Basic Information

Major Professional Backgrounds

  • 1990/04/01, 1991/03/31, Yamaguchi University Hospital, Medical Staff
  • 1991/04/01, 1993/03/31, Japan Society for the Promotion of Science for Japanese Junior Scientists, Fellow
  • 1993/08/01, 1995/07/31, University of London, St. Marys Hospital medical School, Visiting Scientist
  • 1995/08/01, 1999/03/31, Hiroshima University, RIRBM, Research associate
  • 1999/04/01, 2002/07/31, Hiroshima University, RIRBM, Assistant professor
  • 2002/08/01, Hiroshima University, RIRBM, Professor

Educational Backgrounds

  • Yamaguchi University, Faculty of Medicine, Japan, 1979/04, 1985/03
  • Yamaguchi University, Graduate School, Division of Medicine, Japan, 1986/04, 1990/03

Academic Degrees

  • Doctor of Medicine, Yamaguchi University

Educational Activity

  • 【Bachelor Degree Program】School of Medicine : Program of Medicine
  • 【Master's Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science

Research Fields

  • Biological Sciences;Genome science;Medical genome science
  • Medicine,dentistry, and pharmacy;Basic medicine;Pathological medical chemistry

Research Keywords

  • DNA double strand break repair
  • Spindle assembly checkpoint
  • Radiosensitivity
  • Ciliopathy
  • Genome editing

Affiliated Academic Societies

  • Japan Pediatric Society, 1985
  • Molecular Biology Society of Japan, 1990
  • American Society of Human Genetics, 1990
  • Japanese Society of Human Genetics, 1991
  • Japan Radiation Research Society, 1995
  • Japanese Cancer Association, 1995

Educational Activity

Course in Charge

  1. 2019, Liberal Arts Education Program1, 2Term, War and Peace from the Viewpoint of Medicine
  2. 2019, Undergraduate Education, First Semester, Radiation Biology & Radiation Health Risk Sciences
  3. 2019, Undergraduate Education, Intensive, Practice for medical research
  4. 2019, Graduate Education (Master's Program) , First Semester, Medical ethics
  5. 2019, Graduate Education (Master's Program) , First Semester, Medical ethics
  6. 2019, Graduate Education (Master's Program) , First Semester, Medical ethics
  7. 2019, Graduate Education (Master's Program) , First Semester, Medical ethics
  8. 2019, Graduate Education (Master's Program) , First Semester, Medical ethics
  9. 2019, Graduate Education (Master's Program) , First Semester, Medical ethics
  10. 2019, Graduate Education (Master's Program) , First Semester, Medical ethics
  11. 2019, Graduate Education (Master's Program) , First Semester, Medical ethics
  12. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced course of biomedical ethics
  13. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced course of biomedical ethics
  14. 2019, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  15. 2019, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  16. 2019, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  17. 2019, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  18. 2019, Graduate Education (Master's Program) , First Semester, Seminar on Genetics and Cell Biology
  19. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on Genetics and Cell Biology
  20. 2019, Graduate Education (Master's Program) , First Semester, Research on Genetics and Cell Biology
  21. 2019, Graduate Education (Master's Program) , Second Semester, Research on Genetics and Cell Biology
  22. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Genetics and Cell Biology
  23. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Genetics and Cell Biology
  24. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced research on Genetics and Cell Biology
  25. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Genetics and Cell Biology
  26. 2019, Graduate Education (Doctoral Program) , Second Semester, An Introduction to Radiation Biology
  27. 2019, Graduate Education (Doctoral Program) , First Semester, Radiation Genome Science
  28. 2019, Graduate Education (Doctoral Program) , Intensive, Interdisciplinary Integrated Seminars
  29. 2019, Graduate Education (Doctoral Program) , Intensive, Interdisciplinary Integrated Seminars
  30. 2019, Graduate Education (Doctoral Program) , Second Semester, Long-term Fieldwork/Long-term Internship
  31. 2019, Graduate Education (Doctoral Program) , First Semester, Radiation Disaster Recovery Studies
  32. 2019, Graduate Education (Master's Program) , First Semester, Seminar
  33. 2019, Graduate Education (Master's Program) , Second Semester, Seminar
  34. 2019, Graduate Education (Master's Program) , First Semester, Research
  35. 2019, Graduate Education (Master's Program) , Second Semester, Research
  36. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  37. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  38. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  39. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  40. 2019, Graduate Education (Master's Program) , 1Term, Medical Ethics A
  41. 2019, Graduate Education (Doctoral Program) , 1Term, Medical Ethics B
  42. 2019, Graduate Education (Doctoral Program) , 1Term, Medical Ethics B
  43. 2019, Graduate Education (Doctoral Program) , 1Term, Integrated Radiation Medical Science
  44. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Genetics and Cell Biology
  45. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Genetics and Cell Biology
  46. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Genetics and Cell Biology
  47. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Genetics and Cell Biology

Research Activities

Academic Papers

  1. Ciliopathy in PCS (MVA) syndrome, ONCOTARGET, 6(28), 24582-24583, 2015
  2. YAP is essential for tissue tension to ensure vertebrate 3D body shape, NATURE, 521(7551), 217-+, 20150514
  3. The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation, CELL REPORTS, 10(5), 664-673, 20150210
  4. TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS ( MVA) syndrome, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(4), 1461-1466, 20140128
  5. Exome sequencing reveals a novel MRE11 mutation in a patient with progressive myoclonic ataxia, JOURNAL OF THE NEUROLOGICAL SCIENCES, 337(1-2), 219-223, 20140215
  6. Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity, SCIENTIFIC REPORTS, 3, 20131129
  7. Efficient TALEN construction and evaluation methods for human cell and animal applications, GENES TO CELLS, 18(4), 315-326, 201304
  8. Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(27), 10915-10920, 20120703
  9. Nucleolin Participates in DNA Double-Strand Break-Induced Damage Response through MDC1-Dependent Pathway, PLOS ONE, 7(11), 20121107
  10. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates, HUMAN MOLECULAR GENETICS, 20(10), 2058-2070, 20110515
  11. Two unrelated patients with MRE1 1A mutations and Nijmegen breakage syndrome-like severe microcephaly, DNA REPAIR, 10(3), 314-321, 20110307
  12. NBS1 Recruits RAD18 via a RAD6-like Domain and Regulates Pol eta-Dependent Translesion DNA Synthesis, MOLECULAR CELL, 43(5), 788-797, 20110902
  13. HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development., Mechanisms of development, 127(3-4), 235-245, 2010
  14. Sporadic neonatal Fanconi's anemia with VACTERL association, PEDIATRICS INTERNATIONAL, 52(1), 141-142, 201002
  15. Mutations of optineurin in amyotrophic lateral sclerosis, NATURE, 465(7295), 223-U109, 20100513
  16. WRN participates in translesion synthesis pathway through interaction with NBS1, MECHANISMS OF AGEING AND DEVELOPMENT, 131(6), 436-444, 201006
  17. Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380(4), 752-757, 20090320
  18. BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells, ONCOGENE, 28(31), 2806-2820, 200908
  19. Absence of Ku70 gene obliterates X-ray-induced lacZ mutagenesis of small deletions in mouse tissues, RADIATION RESEARCH, 170(2), 216-223, 200808
  20. NBS1 regulates a novel apoptotic pathway through Bax activation, DNA REPAIR, 7(10), 1705-1716, 20081001
  21. Combined BubR1 protein down-regulation and RASSF1A hypermethylation in Wilms tumors with diverse cytogenetic changes, MOLECULAR CARCINOGENESIS, 47(9), 660-666, 200809
  22. Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells, BRITISH JOURNAL OF CANCER, 98(2), 345-355, 20080122
  23. NBS1 prevents chromatid-type aberrations through ATM-dependent interactions with SMC1, RADIATION RESEARCH, 170(3), 345-352, 200809
  24. Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions, ONCOGENE, 26(41), 6002-6009, 200709
  25. TopBP1 associates with NBS1 and is involved in homologous recombination repair, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 362(4), 872-879, 20071103
  26. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome, AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 140A(4), 358-367, 20060215
  27. Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas, JOURNAL OF NEURO-ONCOLOGY, 77(3), 273-277, 200605
  28. R352Q mutation of the DHCR7 gene is common among Japanese Smith-Lemli-Opitz syndrome patients, JOURNAL OF HUMAN GENETICS, 50(7), 353-356, 200507
  29. NBS1 and its functional role in the DNA damage response, DNA REPAIR, 3(8-9), 855-861, 2004
  30. Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex, Advances in Biophysics, 38, 65-80, 20040401
  31. The Nijmegen breakage syndrome gene and its role in genome stability, CHROMOSOMA, 113(2), 53-61, 200409
  32. p16 gene transfer increases cell killing with abnormal nucleation after ionising radiation in glioma cells, BRITISH JOURNAL OF CANCER, 89(9), 1802-1811, 20031103
  33. Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability, ONCOGENE, 21(58), 8967-8980, 20021216
  34. NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain, CURRENT BIOLOGY, 12(21), 1846-1851, 20021029
  35. Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells, NATURE, 420(6911), 93-98, 20021107
  36. Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability., Oncogene, 21, 8967-8980, 20020401
  37. Studies of mutagenesis caused by low dose rate tritium radiation using a novel hyper-sensitive detection system, FUSION SCIENCE AND TECHNOLOGY, 41(3), 413-416, 200205
  38. The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50 center dot hMRE11 center dot NBS1 complex DNA repair activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 276(1), 12-15, 20010105
  39. Combined immunodeficiency, chromosomal instability, and postnatal growth deficiency in a Japanese girl, AMERICAN JOURNAL OF MEDICAL GENETICS, 100(1), 9-12, 20010415
  40. Comparative genomic hybridization analysis suggests a gain of chromosome 7p associated with lymph node metastasis in non-small cell lung cancer, ONCOLOGY REPORTS, 8(1), 83-88, 2001
  41. Japanese family with an autosomal dominant chromosome instability syndrome: A new neurodegenerative disease?, AMERICAN JOURNAL OF MEDICAL GENETICS, 94(4), 265-270, 20001002
  42. Chromosomal instability syndrome of total premature chromatid separation with mosaic variegated aneuploidy is defective in mitotic-spindle checkpoint, AMERICAN JOURNAL OF HUMAN GENETICS, 67(2), 483-486, 200008
  43. Absence of mutations in the NBS1 gene in B-cell malignant lymphoma patients, ANTICANCER RESEARCH, 20(3B), 1897-1900, 2000
  44. Nijmegen breakage syndrome, ARCHIVES OF DISEASE IN CHILDHOOD, 82(5), 400-406, 200005
  45. Cell cycle and LET dependence for radiation-induced mutation: possible mechanism for reversed dose-rate effect., J. Rad. Res., 40, 45-52, 20000401
  46. Neutron Generator (HIRRAC) and Dosimetry study., J. Rad. Res., 40, 14-20, 19990401
  47. A polymorphic CA repeat marker at the human 27-kD calbindin (CALB1) locus., J. Hum. Genet., 44, 414-415, 19990401
  48. Four novel mutations of the Fanconi anemia group A gene (FAA) in Japanese patients., J. Hum. Genet., 44, 48-51, 19990401
  49. Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21, which contains the Nijmegen breakage syndrome, NBS1., Genomics, 55, 242-247, 19990401
  50. Expression of Full-Length NBS1 Protein Restors Normal Radiation Responses in Cells from Nijmegen Breakage Syndrome Patients, Biochemical and Biophysical Reseach Communications, 265, 716-721, 19990601
  51. Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer., Oncogene, 18, 3422-3426, 19990401
  52. Radiation induction of p53 in cells from Nijmegen breakage syndrome is defective but not similar to ataxia-telangiectasia., Biochem. Biophys. Res. Commun., 242, 602-607, 19980401
  53. Radiation induction of p53 in cells from Nijmegen Breakage Syndrome and functional mapping of the underlying gene at 8q21., Disease Markers., 14, 26-27, 19980401
  54. Estimation of Dose absorbed fraction for 131I-beta rays in rat thyroid., J. Radiat. Res., 39, 223-230, 19980401
  55. Positional cloning of the gene for Nijmegen breakage syndrome, Nature genetics, 19(2), 179, 19980401
  56. Genetic Mapping using Microcell-mediated chromosome transfer suggests a Locus for Nijmegen Breakage syndrome at Chromosome 8q21-24, American Journal of Human Genetics, 60(6), 1487, 19970401
  57. Inhibitory action of (-)-epigallocatechin gallate on radiation-induced mouse oncogenic transformation., Cancer lett., 112, 135-139, 19970401
  58. The gene for Nijmegen breakage syndrome (V2) is not located on chromosome 11., Am.J.Hum.Genet., 58, 885-888, 19960401
  59. Xist expression from an Xist YAC transgene carried on the Mouse Y chromosome, Human molecular genetics, 5(4), 451-459, 19960401
  60. Tricho-rhino-phalangeal syndrome type III., Am J Med Genet, 49, 349-350, 19940401
  61. Investigation of the polymorphic Avall site by a PCR-based assay at the human CD18 gene locus., Human Genetics, 93, 721, 19940401
  62. Leukocyte Adhesion Deficiency : identification of novel mutations in two Japanese patients with a severe form, Biochem. Biophys. Res. Commun., 184, 1460-1467, 19920401
  63. Leukocyte adhesion molecules and immunodeficiency., 427-331, 19920401
  64. Telomere association of human chromosomes induced by aphidicolin, Mutation Research, 269, 107-111, 19920401
  65. Y-derived sequence detected in minute chromosomes by polymerase chain reaction and in situ hybridization., Clin. Genet., 42, 80-83, 19920401
  66. Prenatal diagnosis of infantile hypophosphatasia., Prenatal Diagnosis, 11, 305-309, 19910401
  67. Diagnostic hand anomalies in Smith-Magenis syndrome: four new patients with del (17)(p11.2p11.2)., Am J Med Genet, 41, 225-229, 19910401
  68. Characterization of a 5'-flanking region of the human liver/bone/kidney alkaline phosphatase gene: two kinds of a mRNA from a single gene., Biochem. Biophys. Res. Commun., 168, 993-1000, 19900401
  69. Isolation of a Y chromosomal DNA sequence and its clinical application., Jpn J Hum Genet, 35, 331-339, 19900401
  70. Radiographic measurements of metacarpophalangeal lengths in Japanese children., Jpn J Hum Genet, 34, 159-168, 19890401
  71. Nucleotide sequence of the human liver-type alkaline phosphatase cDNA., Nucl. Acids Res., 17, 2129-2129, 19890401
  72. Human adenylate kinase deficiency associated with hemolytic anemia: a single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase., J. Biol. Chem., 264, 10148-10155, 19890401
  73. Inverted insertion (9) (q34.3q22.3q21.2) and its recombination product: duplication 9q21.2q22.3., Jpn J Hum Genet, 3, 45-48, 19870401
  74. Obituary: a eulogy to the late Professor Tadashi Kajii (1929-2016), JOURNAL OF HUMAN GENETICS, 61(8), 677-677, 2016
  75. Wilms tumor accompanied by premature chromatid separation, PEDIATRIC BLOOD & CANCER, 64(3), 2017
  76. Cloning of the NBS1 geng for Nijmegen breakage syndrome, 21, 19981201
  77. Nijmegen breakage syndrome : Analysis of an 800-kb genomic sequence, 21, 19981201
  78. High LET radiation-indcued cellular transformation and analysis of inversed dose rate effects by using(hamster x human X-chromosome) hybrid cells., Biological sciences in space, 13(3), 248-249, 199909
  79. Proton W-value calculation using a developped proton track structure code, 57, 182-185, 19980918
  80. Enhanced mutation of HPRT locus by ionizing radiation in combination with high gravity., Biological sciences in space, 14(3), 224-224, 200010
  81. Four novel mutations of the Fanconi anemia group A gene (FAA) in Japanese patients, Journal of Human Genetics, 44(1), 48-51, 19990101
  82. A polymorphic CA repeat marker at the human 27-kD calbindin (CALB1) locus, 44(6), 414-415, 19991101
  83. Establishment of new cell lines from patients with Nijmegen Breakage Syndrome and the genetic complementation group, Tissue culture research communications : the journal of experimental & applied cell culture research, 15(1), 19960331
  84. Sporadic neonatal Fanconi's anemia with VACTERL association, Pediatrics international : official journal of the Japan Pediatric Society, 52(1), 141-142, 20100201
  85. Activation of ATM kinase in NBS lymphoblastoid cells, Nagasaki Igakkai zasshi = Nagasaki medical journal, 75, 281-284, 200009
  86. A new chromosomal instability syndrome with defective mitotic-spindle checkpoints, Nagasaki Igakkai zasshi = Nagasaki medical journal, 75, 297-299, 200009
  87. Neutron Generator (HIRRAC) and Dosimetry Study :, Journal of radiation research, 40(0), 14-20, 1999
  88. Cell Cycle and LET Dependence for Radiation-induced Mutation : A Possible Mechanism for Reversed Dose-rate Effect :, Journal of radiation research, 40(0), 45-52, 1999
  89. NBS1 is involved in recognition of DNA damage and initiation of homologous recombination., Journal of radiation research, 43(4), 200212
  90. Dissociation of ATM/NBS1 functions in telomere maintenance, Journal of radiation research, 43(4), 200212
  91. Histone H2AX regulates the formation of NBS1 foci on DNA damage sites, Journal of radiation research, 43(4), 200212
  92. Analysis of the function of NBS1 in DNA double-strand break repair, Journal of radiation research, 43(4), 200212
  93. Mutation screening for a novel cancer-predisposition syndrome of total PCS, Journal of radiation research, 43(4), 200212
  94. Reversed dose-rate effect of high LET radiation in mutation induction, Journal of radiation research, 42(4), 200112
  95. The function of NBS1 and histone H2AX in the early process of DNA repair., Journal of radiation research, 42(4), 200112
  96. Association of DNA repair protein NBS1 with telomere maintenance, Journal of radiation research, 42(4), 200112
  97. Association of cells from Fanconi anemia patients with radiation sensitivity, Journal of radiation research, 42(4), 200112
  98. Establishement of mouse Nbs1-deficient cell lines by gene targeting, Journal of radiation research, 42(4), 200112
  99. Complementation studies of immortalized cell lines from infants with total PCS, Journal of radiation research, 42(4), 200112
  100. Somatic Mutation Caused by Low Dose Rate Tritium Radiation : Studies Using A Hyper-sensitive DetectionSystem, Journal of radiation research, 42(4), 200112
  101. Bystander mutagenic effect of alpha particle in human-hamster hybrid cells, Journal of radiation research, 42(4), 200112
  102. Inhibition of radiation-induced oncogenic transformation in C3H10T1/2 cells by green tea component, (-)-epigallocatechin gal late., Journal of radiation research, 36(4), 199512
  103. The genetic complementation assay of Nijmegen breakage syndrome witit ataxia telangiectasia on the basis of radiation sensitivity to cell killing., Journal of radiation research, 36(4), 199512
  104. Genetic heterogeneity of ataxia-telangiectasia-like hamster mutant irs2 with Nijmegen breakage syndrome., Journal of radiation research, 36(4), 199512
  105. DNA-dependent protein kinase restores mouse scid mutation, Journal of radiation research, 36(4), 199512
  106. Genetic heterogeneity of ataxia-telangiectasia-like hamster mutant irs2 with Nijmegen breakage syndrome, Journal of radiation research, 37(4), 199612
  107. Radiation-induced HPRT mutation of a radiation sensitive hamster cell line irs1SF, Journal of radiation research, 37(4), 199612
  108. The Genetic Homogeneity of Nijmegen Breakage Syndrome V1 and V2., Journal of radiation research, 37(4), 199612
  109. Cell cycle and LET dependence for 6-thioguanine-resistant mutation induced by heavy ion beam in mouse L5178Y cells, Journal of radiation research, 38(4), 199712
  110. Complementation Assay between Radiation-Sensitive irs2 Mutant and Ataxia-Telangiectasia Cell, Journal of radiation research, 38(4), 199712
  111. Haplotype Analysis of Nijmegen Breakage Syndrome and Construction of Physical Map of Candidate Region., Journal of radiation research, 38(4), 199712
  112. Genetic Mapping of Nijmegen Breakage Syndrome using Functional Complementation Assays and Homozygosity Mapping, Journal of radiation research, 38(4), 199712
  113. Mutation Analysis of the Fanconi Anemia Genes in Japanese Patients, Journal of radiation research, 38(4), 199712
  114. LET, cell cycle dependence for mutation induction and spectrum in HPRT locus, Journal of radiation research, 40(4), 199912
  115. Development of a Radio-sensitive Mutation System for the Study of Dose Rate Effects of Space High LET Radiation, Journal of radiation research, 40(4), 199912
  116. Mapping of the underlying gene for rare genetic complementation group Fanconi anemia, Journal of radiation research, 40(4), 199912
  117. Functionally important domain analysis of the Nijimegen breakage syndrome gene. NBS1, Journal of radiation research, 40(4), 199912
  118. Mutation screening of the NBS1 gene in sporadic malignant lymphoma, Journal of radiation research, 40(4), 199912
  119. NBS1 Regulates Apoptosis induced by ɤ-irradiation in Lymphoblastoid, Journal of radiation research, 40(4), 199912
  120. Function of NBS1 in Activation of ATM kinase in Response to IR., Journal of radiation research, 41(4), 200012
  121. Construction of Nbs1 knockout cell line using chicken DT40, Journal of radiation research, 41(4), 200012
  122. Accelerated telomere shortening by disruption of DNA repair protein NBS1, Journal of radiation research, 41(4), 200012
  123. NBS1, the Nijmegen breakage syndrome protein, regulates the localization of DNA repair complex hRAD50/hMRE11/NBS1, Journal of radiation research, 41(4), 200012
  124. Screening of protein interacting with FANCG by Yeast two-hybrid system, Journal of radiation research, 41(4), 200012
  125. Chromosomal instability syndrome of total premature chromatid separation with mosaic variegated aneuploidy is defective in mitotic spindle checkpoint, Journal of radiation research, 41(4), 200012
  126. Positional cloning of the gene for Nijmegen breakage syndrome, Journal of radiation research, 39(4), 199812
  127. Nijmegen breakage syndrome : Sequence analysis of an 800-kb genomic region on chromosome 8q21., Journal of radiation research, 39(4), 199812
  128. The relationship between NBS1 and cell death induced by ɤ-ray irradiation in lymphoblastoid, Journal of radiation research, 39(4), 199812
  129. Mutation Analysis of the Fanconi Anemia Gene FAA in Japanese patients, Journal of radiation research, 39(4), 199812
  130. Radiation-induced teratogenicity and embryo lethality in the scid mice., Journal of radiation research, 39(4), 199812
  131. O-11. The optimal conditions for cytological diagnosis of total premature chromatid separation (PCS), a novel cancer-prone genetic trait associated with mitotic checkpoint defect(Abstracts of the oral and poster presentations)(The 53rd Annual Meeting of the Society of Chromosome Research), Chromosome science, 6(4), 2002
  132. S-3-1 Mechanisms of DNA double-strand break repair(Biological Effects of Low Dose and Low Dose-rate Irradiations, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society), Journal of radiation research, 44(4), 20031215
  133. 98 Localization of Rad51 protein in cells from patients with Fanconi Anemia D1 group(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society), Journal of radiation research, 44(4), 20031215
  134. 206 Functional Domain Analysis of NBS1 Gene in Homologous Recombinational Repair(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society), Journal of radiation research, 44(4), 20031215
  135. 242 Analysis of apoptosis induction in Nbs1 deficient cells(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society), Journal of radiation research, 44(4), 20031215
  136. O-15. Chromosome instability and cancer predisposition in the PCS (premature chromatid separation) syndrome(Abstracts of the oral and poster presentations,Abstracts of the 55th Annual Meeting of the Society of Chromosome Research), Chromosome science, 8(4), 2004
  137. The cancer prone PCS syndrome : relationship between chromosome dynamics aberration and centrosome amplification(Minireviews with the main theme: "Past, Current and Perspective Studies of the Genome, Chromosomes, and Chromatin") :, Chromosome science, 11(1), 25-28, 2008
  138. WRN participates in translesion synthesis pathway through interaction with NBS1., Mechanisms of ageing and development, 131(6), 436-444, 201006
  139. Nucleolin Participates in DNA Double-Strand Break-Induced Damage Response through MDC1-Dependent Pathway., PloS one, 7(11), 20121107
  140. Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity., Scientific reports, 3, 20131129
  141. NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain., Current biology : CB, 12(21), 2002
  142. Analysis of cells from the patients with PCS (premature chromatid separation) syndrome, The Japan Radiation Research Society Annual Meeting Abstracts, 2004(0), 63-63, 2004
  143. Cell cycle abnormalities in patients with Pericentrin-Seckel syndrome, The Japan Radiation Research Society Annual Meeting Abstracts, 2009(0), 93-93, 2009
  144. NBS1 and its functional role in the DNA damage response., DNA repair, 3(8-9)
  145. Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex., Advances in biophysics, 38(Complete), 65-80, 2004
  146. R352Q mutation of the DHCR7 gene is common among Japanese Smith-Lemli-Opitz syndrome patients., Journal of human genetics, 50(7), 353-356, 2005
  147. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome., American journal of medical genetics. Part A, 140(4), 358-367, 2006
  148. Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas., Journal of neuro-oncology, 77(3), 273-277, 2006
  149. [Smith-Lemli-Opitz syndrome]., Nihon rinsho. Japanese journal of clinical medicine, Suppl 3, 488-491, 2006
  150. TopBP1 associates with NBS1 and is involved in homologous recombination repair., Biochemical and biophysical research communications, 362(4), 872-879, 2007
  151. Cancer predisposition and ciliopathy caused by loss of BUBR1, a mitotic spindle checkpoint regulator, 65(4), 308-310, 201204
  152. Identification of mutation causing cancer-prone hereditary disease using a novel method for the introduction of single-nucleotide substitution, 252(2), 153-158, 20150110
  153. TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS ( MVA) syndrome, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(4), 1461-1466, 2014
  154. YAP is essential for tissue tension to ensure vertebrate 3D body shape, NATURE, 521(7551), 217-+, 2015
  155. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly., DNA repair, 10(3), 2011
  156. Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos., Proceedings of the National Academy of Sciences of the United States of America, 109(27), 2012
  157. The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation., Cell reports, 2015
  158. Efficient TALEN construction and evaluation methods for human cell and animal applications., Genes to cells : devoted to molecular & cellular mechanisms, 18(4), 2013
  159. Ciliopathy in PCS (MVA) syndrome., Oncotarget, 6(28), 2015
  160. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates., Human molecular genetics, 20(10), 2011
  161. Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity., Scientific reports, 3, 2013
  162. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells, SCIENTIFIC REPORTS, 7, 20170720
  163. PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation, HUMAN MOLECULAR GENETICS, 26(22), 4429-4440, 20171115
  164. Updated summary of genome editing technology in human cultured cells linked to human genetics studies, JOURNAL OF HUMAN GENETICS, 63(2), 133-143, 201802
  165. Induction of somatic mutations by low-dose X-rays: the challenge in recognizing radiation-induced events, JOURNAL OF RADIATION RESEARCH, 59, 201804
  166. Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology, JOURNAL OF RADIATION RESEARCH, 59, 201804
  167. Albatross/FBF1 contributes to both centriole duplication and centrosome separation, GENES TO CELLS, 23(12), 1023-1042, 201812

Publications such as books

  1. 2006/06, Nijmegen Breakage Syndrome and Functions of the Responsible Protein, NBS1. Volff J-N (ed): Genome and Disease. , Karger, 2006, 06, 3805580290, 246

Invited Lecture, Oral Presentation, Poster Presentation

  1. Analysis of individual differences in radiosensitivity using genome editing , Shinya Matsuura, Ekaterina Royba, Silvia Natsuko Akutsu, Hiromi Yanagihara, Hiroshi Ochiai, Yoshiki Kudo, Satoshi Tashiro, Tatsuo Miyamoto, 3rd International Symposium on the System of Radiological Protection, ICRP2015, 2015/10, With Invitation, International Commission of Radiological Protection, Seoul, Korea
  2. 1) Gene and function in microcephaly. 2) Mosaic Variegated Aneuploidy (Premature Chromatid Separation) Syndrome., Shinya Matsuura, 2010/10, With Invitation
  3. PCS (MVA) SYNDROME AND DUAL ROLES OF BUBR1, Shinya Matsuura, 25th RBC International Symposium “Genomic Instability: mechanisms and diseases”, 2009/11, With Invitation
  4. Genetic characterization of a patient with a progeroid phenotype and mosaic variegated aneuploidy, Harumi Fujita, Takashi Sasaki, Tatsuo Miyamoto, Takehiko Mori, Kazuhiko Nakabayashi, Kenichiro Hata, Shinya Matsuura, Yoichi Matsubara, Masayuki Amagai, Akiharu Kubo, KEYSTONE SYMPOSIA MEETING, Aging and Mechanism of Aging-Related Disease, 2017/05/15, Without Invitation, Yokohama
  5. Inflammatory response in primary human endothelial cells subjected to acute or protracted gamma irradiation, Elena Zaharieva, Hidehiko Kawai, Toshiya Inaba, Shinya Matsuura, Kenji Kamiya, 2017/06/04, Without Invitation, Hiroshima
  6. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells, 2017/07/27, Without Invitation
  7. PLK1-mediated phosphorylation of WDR62/MCPH2 is required for proper mitotic spindle orientation, Miyamoto T, Hosoba K, Silvia Natsuko Akutsu, Morino H, Fukumitsu A, Masatsuna Y, Kawakami H, Yamamoto T, Shimizu K, Ohashi H, Shinya Matsuura, 2017/09/29, Without Invitation, Yokohama
  8. Inflammatory response to acute and chronic gamma irradiation in primary human endothelial cell, Elena Zaharieva, Hidehiko Kawai, Megumi Sasatani, Toshiya Inaba, Shinya Matsuura, Kenji Kamiya, 2017/10/25, Without Invitation
  9. Identification of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing technology, Miyamoto T, Royba E, Akutsu SN, Hosoba K, Tauchi H, Kudo Y, Tashiro S, Yamamoto T, Matsuura S, 2017/11/16, Without Invitation
  10. Trial for correction of trisomy 21 in a Down syndrome patient-derived induced pluripotent stem cells, Silvia Natsuko Akutsu, Miyamoto T, Ochiai H, Suzuki K, Shimamoto A, Yamamoto T ,Shinya Matsuura, 2017/11/16, Without Invitation
  11. Unravelling the pathological mechanisms of structure-chromosomal instability post IR in PCS(MVA) syndrome., Akutsu SN, Miyamoto T, Matsuura S, The 7th International symposium of Phoenix Leader Education Program for Renaissance from Radiation Disaster, 2018/02/27, Without Invitation, Hiroshima

External Funds

Acceptance Results of Competitive Funds

  1. The Center of World Intelligence Project for Nuclear S&T and Human Resource Development, 2015/04/01, 2016/03/31
  2. KAKENHI, 2015, 2017
  3. KAKENHI, 2015, 2016
  4. The Initiatives for Atomic Energy Basic and Generic Strategic Research, 2014/09/30, 2015/03/31
  5. KAKENHI, 2013, 2014
  6. The Initiatives for Atomic Energy Basic and Generic Strategic Research, 2013/10/01, 2014/03/31
  7. KAKENHI, 2012, 2014
  8. KAKENHI, 2012, 2014
  9. KAKENHI, 2010, 2011
  10. KAKENHI, Epigenetic dysregulation in disorder with defective ATR signaling, 2010, 2011
  11. KAKENHI, 2008, 2009
  12. KAKENHI, 2008, 2009
  13. KAKENHI, Toward the identification of the genes for hereditary microcephaly, 2008, 2010
  14. KAKENHI, Molecular cloning of the gene on chromosome 8, which suppresses centrosome re-duplication, 2007, 2008
  15. KAKENHI, Effect of centrosome amplification/chromosome instability on the radiosensitivity in human glioma cells, 2007, 2009
  16. KAKENHI, Induction of DNA double strand break by environmental genotoxic and carcinogenic agents, 2006, 2010
  17. KAKENHI, 2006, 2007
  18. KAKENHI, Identification and characterization of centrosome re-duplication suppressor gene(s), 2005, 2006
  19. KAKENHI, 2004, 2004
  20. KAKENHI, 2004, 2004
  21. KAKENHI, 2003, 2003
  22. KAKENHI, 2003, 2003
  23. KAKENHI, Origin of radiation-induced genomic instability, 2002, 2005
  24. KAKENHI, Molecular cloning of the gene for cancer-prone syndrome characterized by abnormal mitotic spindle checkpoint., 2002, 2004
  25. KAKENHI, DNA double strand break repair by NBS1 complex., 2001, 2002
  26. KAKENHI, Cancersusceptibility disease Nijmegen Breakage Syndrome and the function of underlying gene., 2000, 2004
  27. KAKENHI, Molecular mechanism for chromosome stability using Nbs1 knockout mice, 2000, 2001
  28. KAKENHI, Role of NBS1 in Repair of DNA damage Induced by Ionizing Radiation, 2000, 2001
  29. KAKENHI, Generation of knockout mice for Nijmegen breakage syndrome gene, NBS1., 1999, 1999
  30. KAKENHI, 1998, 1998
  31. KAKENHI, Novel developments on genetic recombination : DNA double-strand break and DNA end-joining, 1998, 2003
  32. KAKENHI, Study on underlying gene of Nijmegen Breakage Syndrome, 1998, 2000
  33. KAKENHI, Complementation assisted positional cloning of the gene for AT variant., 1998, 1999
  34. KAKENHI, Development of (a human X-chromosome * hamster) hybrid cell assay system, which is sensitive to tritium exposure., 1997, 1998
  35. KAKENHI, 1997, 1997
  36. KAKENHI, Molecular mechanism of initiation of X inactivation using Xist YAC transgenic mouse, 1996, 1997
  37. KAKENHI, Molecular study on Nijmegen breakage sybdrome, 1996, 1997
  38. KAKENHI, Multi-functions of DNA-dependent protein kinase (DNA-PK) and the association of radiation sensitivity, 1996, 1997
  39. KAKENHI, Research and development of transgenic mouse for biological effect assesment of tritium, 1995, 1996
  40. KAKENHI, 2015, 2018
  41. The Center of World Intelligence Project for Nuclear S&T and Human Resource Development, 2016/04/01, 2017/03/31
  42. Drug Discovery Support Promotion Project , 2018/01/01, 2018/03/31

Social Activities

Organizing Academic Conferences, etc.

  1. 2011/07
  2. 2010/07
  3. 2009/07
  4. 2008/07
  5. 2007/07
  6. 2006/07
  7. 2005/07
  8. 2004/07