Shinya Matsuura

Last Updated :2017/09/01

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, ., Professor
E-mail
shinyahiroshima-u.ac.jp
Other Contact Details
1-2-3, Kasumi, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5809 FAX : (+81)

Basic Information

Major Professional Backgrounds

  • 1990/04/01, 1991/03/31, Yamaguchi University Hospital, Medical Staff
  • 1991/04/01, 1993/03/31, Japan Society for the Promotion of Science for Japanese Junior Scientists, Fellow
  • 1993/08/01, 1995/07/31, University of London, St. Marys Hospital medical School, Visiting Scientist
  • 1995/08/01, 1999/03/31, Hiroshima University, RIRBM, Research associate
  • 1999/04/01, 2002/07/31, Hiroshima University, RIRBM, Assistant professor
  • 2002/08/01, Hiroshima University, RIRBM, Professor

Educational Backgrounds

  • Yamaguchi University, Faculty of Medicine, Japan, 1979/04, 1985/03
  • Yamaguchi University, Graduate School, Division of Medicine, Japan, 1986/04, 1990/03

Academic Degrees

  • Doctor of Medicine, Yamaguchi University

Educational Activity

  • School of Medicine:Program of Medicine, Graduate School of Biomedical & Health Sciences:Medical and Dental Sciences Major, Graduate School of Biomedical & Health Sciences:Biomedical Sciences Major

Research Fields

  • Biological Sciences;Genome science;Medical genome science
  • Medicine,dentistry, and pharmacy;Basic medicine;Pathological medical chemistry

Research Keywords

  • DNA double strand break repair
  • Spindle assembly checkpoint
  • Radiosensitivity
  • Ciliopathy
  • Genome editing

Affiliated Academic Societies

  • Japan Pediatric Society, 1985
  • Molecular Biology Society of Japan, 1990
  • American Society of Human Genetics, 1990
  • Japanese Society of Human Genetics, 1991
  • Japan Radiation Research Society, 1995
  • Japanese Cancer Association, 1995

Educational Activity

Course in Charge

  1. 2017, Liberal Arts Education Program1, 2Term, War and Peace from the Viewpoint of Medicine
  2. 2017, Undergraduate Education, First Semester, Radiation Biology & Radiation Health Risk Sciences
  3. 2017, Undergraduate Education, Intensive, Practice for medical research
  4. 2017, Graduate Education (Master's Program) , First Semester, Advanced course of biomedical ethics
  5. 2017, Graduate Education (Master's Program) , First Semester, Advanced course of biomedical ethics
  6. 2017, Graduate Education (Master's Program) , First Semester, Advanced course of biomedical ethics
  7. 2017, Graduate Education (Master's Program) , First Semester, Advanced course of biomedical ethics
  8. 2017, Graduate Education (Master's Program) , First Semester, Advanced course of biomedical ethics
  9. 2017, Graduate Education (Master's Program) , First Semester, Advanced course of biomedical ethics
  10. 2017, Graduate Education (Master's Program) , First Semester, Advanced course of biomedical ethics
  11. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced course of biomedical ethics
  12. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced course of biomedical ethics
  13. 2017, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  14. 2017, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  15. 2017, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  16. 2017, Graduate Education (Doctoral Program) , First Semester, Integrated radiation medical science
  17. 2017, Graduate Education (Master's Program) , First Semester, Seminar on Genetics and Cell Biology
  18. 2017, Graduate Education (Master's Program) , Second Semester, Seminar on Genetics and Cell Biology
  19. 2017, Graduate Education (Master's Program) , First Semester, Research on Genetics and Cell Biology
  20. 2017, Graduate Education (Master's Program) , Second Semester, Research on Genetics and Cell Biology
  21. 2017, Graduate Education (Doctoral Program) , First Semester, Radioactivity Social Recovery Course
  22. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Genetics and Cell Biology
  23. 2017, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Genetics and Cell Biology
  24. 2017, Graduate Education (Doctoral Program) , First Semester, Advanced research on Genetics and Cell Biology
  25. 2017, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Genetics and Cell Biology
  26. 2017, Graduate Education (Doctoral Program) , Second Semester, An Introduction to Radiation Biology
  27. 2017, Graduate Education (Doctoral Program) , First Semester, English Rhetoric
  28. 2017, Graduate Education (Doctoral Program) , Second Semester, English Presentation
  29. 2017, Graduate Education (Doctoral Program) , Intensive, Interdisciplinary Integrated Seminars
  30. 2017, Graduate Education (Doctoral Program) , Intensive, Interdisciplinary Integrated Seminars
  31. 2017, Graduate Education (Doctoral Program) , First Semester, Short-term Internship
  32. 2017, Graduate Education (Doctoral Program) , Second Semester, Short-term Internship
  33. 2017, Graduate Education (Doctoral Program) , Second Semester, Long-term Fieldwork/Long-term Internship

Research Activities

Academic Papers

  1. Ciliopathy in PCS (MVA) syndrome, Oncotarget, 6(28), 24582-24583, 2015 Sep 22
  2. YAP is essential for tissue tension to ensure vertebrate 3D body shape, NATURE, 521(7551), 217-+, MAY 14 2015
  3. The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation, CELL REPORTS, 10(5), 664-673, FEB 10 2015
  4. TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS ( MVA) syndrome, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(4), 1461-1466, JAN 28 2014
  5. Exome sequencing reveals a novel MRE11 mutation in a patient with progressive myoclonic ataxia, JOURNAL OF THE NEUROLOGICAL SCIENCES, 337(1-2), 219-223, FEB 15 2014
  6. Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity, SCIENTIFIC REPORTS, 3, NOV 29 2013
  7. Efficient TALEN construction and evaluation methods for human cell and animal applications, GENES TO CELLS, 18(4), 315-326, APR 2013
  8. Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(27), 10915-10920, JUL 3 2012
  9. Nucleolin Participates in DNA Double-Strand Break-Induced Damage Response through MDC1-Dependent Pathway, PLOS ONE, 7(11), NOV 7 2012
  10. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates, HUMAN MOLECULAR GENETICS, 20(10), 2058-2070, MAY 15 2011
  11. Two unrelated patients with MRE1 1A mutations and Nijmegen breakage syndrome-like severe microcephaly, DNA REPAIR, 10(3), 314-321, MAR 7 2011
  12. NBS1 Recruits RAD18 via a RAD6-like Domain and Regulates Pol eta-Dependent Translesion DNA Synthesis, MOLECULAR CELL, 43(5), 788-797, SEP 2 2011
  13. HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development, MECHANISMS OF DEVELOPMENT, 127(3-4), 235-245, MAR-APR 2010
  14. Sporadic neonatal Fanconi's anemia with VACTERL association, PEDIATRICS INTERNATIONAL, 52(1), 141-142, FEB 2010
  15. Mutations of optineurin in amyotrophic lateral sclerosis, NATURE, 465(7295), 223-U109, MAY 13 2010
  16. WRN participates in translesion synthesis pathway through interaction with NBS1, MECHANISMS OF AGEING AND DEVELOPMENT, 131(6), 436-444, JUN 2010
  17. Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380(4), 752-757, MAR 20 2009
  18. BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells, ONCOGENE, 28(31), 2806-2820, AUG 2009
  19. Absence of Ku70 gene obliterates X-ray-induced lacZ mutagenesis of small deletions in mouse tissues, RADIATION RESEARCH, 170(2), 216-223, AUG 2008
  20. NBS1 regulates a novel apoptotic pathway through Bax activation, DNA REPAIR, 7(10), 1705-1716, OCT 1 2008
  21. Combined BubR1 protein down-regulation and RASSF1A hypermethylation in Wilms tumors with diverse cytogenetic changes, MOLECULAR CARCINOGENESIS, 47(9), 660-666, SEP 2008
  22. Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells, BRITISH JOURNAL OF CANCER, 98(2), 345-355, JAN 22 2008
  23. NBS1 prevents chromatid-type aberrations through ATM-dependent interactions with SMC1, RADIATION RESEARCH, 170(3), 345-352, SEP 2008
  24. Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions, ONCOGENE, 26(41), 6002-6009, SEP 2007
  25. TopBP1 associates with NBS1 and is involved in homologous recombination repair, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 362(4), 872-879, NOV 3 2007
  26. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome, AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 140A(4), 358-367, FEB 15 2006
  27. Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas, JOURNAL OF NEURO-ONCOLOGY, 77(3), 273-277, MAY 2006
  28. R352Q mutation of the DHCR7 gene is common among Japanese Smith-Lemli-Opitz syndrome patients, JOURNAL OF HUMAN GENETICS, 50(7), 353-356, JUL 2005
  29. NBS1 and its functional role in the DNA damage response, DNA REPAIR, 3(8-9), 855-861, AUG-SEP 2004
  30. Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex, Advances in Biophysics, 38, 65-80, 20040401
  31. The Nijmegen breakage syndrome gene and its role in genome stability, CHROMOSOMA, 113(2), 53-61, SEP 2004
  32. p16 gene transfer increases cell killing with abnormal nucleation after ionising radiation in glioma cells, BRITISH JOURNAL OF CANCER, 89(9), 1802-1811, NOV 3 2003
  33. Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability, ONCOGENE, 21(58), 8967-8980, DEC 16 2002
  34. NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain, CURRENT BIOLOGY, 12(21), 1846-1851, OCT 29 2002
  35. Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells, NATURE, 420(6911), 93-98, NOV 7 2002
  36. Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability., Oncogene, 21, 8967-8980, 20020401
  37. Studies of mutagenesis caused by low dose rate tritium radiation using a novel hyper-sensitive detection system, FUSION SCIENCE AND TECHNOLOGY, 41(3), 413-416, MAY 2002
  38. The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50 center dot hMRE11 center dot NBS1 complex DNA repair activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 276(1), 12-15, JAN 5 2001
  39. Combined immunodeficiency, chromosomal instability, and postnatal growth deficiency in a Japanese girl, AMERICAN JOURNAL OF MEDICAL GENETICS, 100(1), 9-12, APR 15 2001
  40. Comparative genomic hybridization analysis suggests a gain of chromosome 7p associated with lymph node metastasis in non-small cell lung cancer, ONCOLOGY REPORTS, 8(1), 83-88, JAN-FEB 2001
  41. Japanese family with an autosomal dominant chromosome instability syndrome: A new neurodegenerative disease?, AMERICAN JOURNAL OF MEDICAL GENETICS, 94(4), 265-270, OCT 2 2000
  42. Chromosomal instability syndrome of total premature chromatid separation with mosaic variegated aneuploidy is defective in mitotic-spindle checkpoint, AMERICAN JOURNAL OF HUMAN GENETICS, 67(2), 483-486, AUG 2000
  43. Absence of mutations in the NBS1 gene in B-cell malignant lymphoma patients, ANTICANCER RESEARCH, 20(3B), 1897-1900, MAY-JUN 2000
  44. Nijmegen breakage syndrome, ARCHIVES OF DISEASE IN CHILDHOOD, 82(5), 400-406, MAY 2000
  45. Cell cycle and LET dependence for radiation-induced mutation: possible mechanism for reversed dose-rate effect., J. Rad. Res., 40, 45-52, 20000401
  46. Neutron Generator (HIRRAC) and Dosimetry study., J. Rad. Res., 40, 14-20, 19990401
  47. A polymorphic CA repeat marker at the human 27-kD calbindin (CALB1) locus., J. Hum. Genet., 44, 414-415, 19990401
  48. Four novel mutations of the Fanconi anemia group A gene (FAA) in Japanese patients., J. Hum. Genet., 44, 48-51, 19990401
  49. Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21, which contains the Nijmegen breakage syndrome, NBS1., Genomics, 55, 242-247, 19990401
  50. Expression of Full-Length NBS1 Protein Restors Normal Radiation Responses in Cells from Nijmegen Breakage Syndrome Patients, Biochemical and Biophysical Reseach Communications, 265, 716-721, 19990601
  51. Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer., Oncogene, 18, 3422-3426, 19990401
  52. Radiation induction of p53 in cells from Nijmegen breakage syndrome is defective but not similar to ataxia-telangiectasia., Biochem. Biophys. Res. Commun., 242, 602-607, 19980401
  53. Radiation induction of p53 in cells from Nijmegen Breakage Syndrome and functional mapping of the underlying gene at 8q21., Disease Markers., 14, 26-27, 19980401
  54. Estimation of Dose absorbed fraction for 131I-beta rays in rat thyroid., J. Radiat. Res., 39, 223-230, 19980401
  55. Positional cloning of the gene for Nijmegen breakage syndrome, Nature genetics, 19(2), 179, 19980401
  56. Genetic Mapping using Microcell-mediated chromosome transfer suggests a Locus for Nijmegen Breakage syndrome at Chromosome 8q21-24, American Journal of Human Genetics, 60(6), 1487, 19970401
  57. Inhibitory action of (-)-epigallocatechin gallate on radiation-induced mouse oncogenic transformation., Cancer lett., 112, 135-139, 19970401
  58. The gene for Nijmegen breakage syndrome (V2) is not located on chromosome 11., Am.J.Hum.Genet., 58, 885-888, 19960401
  59. Xist expression from an Xist YAC transgene carried on the Mouse Y chromosome, Human molecular genetics, 5(4), 451-459, 19960401
  60. Tricho-rhino-phalangeal syndrome type III., Am J Med Genet, 49, 349-350, 19940401
  61. Investigation of the polymorphic Avall site by a PCR-based assay at the human CD18 gene locus., Human Genetics, 93, 721, 19940401
  62. Leukocyte Adhesion Deficiency : identification of novel mutations in two Japanese patients with a severe form, Biochem. Biophys. Res. Commun., 184, 1460-1467, 19920401
  63. Leukocyte adhesion molecules and immunodeficiency., 427-331, 19920401
  64. Telomere association of human chromosomes induced by aphidicolin, Mutation Research, 269, 107-111, 19920401
  65. Y-derived sequence detected in minute chromosomes by polymerase chain reaction and in situ hybridization., Clin. Genet., 42, 80-83, 19920401
  66. Prenatal diagnosis of infantile hypophosphatasia., Prenatal Diagnosis, 11, 305-309, 19910401
  67. Diagnostic hand anomalies in Smith-Magenis syndrome: four new patients with del (17)(p11.2p11.2)., Am J Med Genet, 41, 225-229, 19910401
  68. Isolation of a Y chromosomal DNA sequence and its clinical application., Jpn J Hum Genet, 35, 331-339, 19900401
  69. Radiographic measurements of metacarpophalangeal lengths in Japanese children., Jpn J Hum Genet, 34, 159-168, 19890401
  70. Nucleotide sequence of the human liver-type alkaline phosphatase cDNA., Nucl. Acids Res., 17, 2129-2129, 19890401
  71. Human adenylate kinase deficiency associated with hemolytic anemia: a single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase., J. Biol. Chem., 264, 10148-10155, 19890401
  72. Inverted insertion (9) (q34.3q22.3q21.2) and its recombination product: duplication 9q21.2q22.3., Jpn J Hum Genet, 3, 45-48, 19870401

Invited Lecture, Oral Presentation, Poster Presentation

  1. Analysis of individual differences in radiosensitivity using genome editing , Shinya Matsuura, Ekaterina Royba, Silvia Natsuko Akutsu, Hiromi Yanagihara, Hiroshi Ochiai, Yoshiki Kudo, Satoshi Tashiro, Tatsuo Miyamoto, 3rd International Symposium on the System of Radiological Protection, ICRP2015, 2015/10, With Invitation, International Commission of Radiological Protection, Seoul, Korea
  2. 1) Gene and function in microcephaly. 2) Mosaic Variegated Aneuploidy (Premature Chromatid Separation) Syndrome., Shinya Matsuura, 2010/10, With Invitation
  3. PCS (MVA) SYNDROME AND DUAL ROLES OF BUBR1, Shinya Matsuura, 25th RBC International Symposium “Genomic Instability: mechanisms and diseases”, 2009/11, With Invitation