Noriyoshi Mizuno

Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
E-mail
mizunohiroshima-u.ac.jp
Self-introduction
There is a disease called aggressive periodontitis that develops at an early age and progresses rapidly. Currently, the cause is not well understood. However, the involvement of genes is suspected due to the accumulation of patient with this disease in the family. I am identifying the causative gene of this disease and elucidating its pathophysiology.

Basic Information

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Periodontology

Research Keywords

  • aggressive periodontitis
  • responsible gene
  • neurotrophin
  • periodontal ligament cell
  • stem cell

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 2Term, General Health and Oral Sciences I
  2. 2024, Undergraduate Education, 4Term, Overview of Dentistry
  3. 2024, Undergraduate Education, 1Term, Medical Ethics
  4. 2024, Undergraduate Education, First Semester, Early Clinical Exposure I
  5. 2024, Undergraduate Education, First Semester, Biodental English
  6. 2024, Undergraduate Education, 2Term, Topics in Dental Research II
  7. 2024, Undergraduate Education, 3Term, Periodontology I
  8. 2024, Undergraduate Education, 4Term, Periodontology II
  9. 2024, Undergraduate Education, Second Semester, Early Clinical Exposure II
  10. 2024, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  11. 2024, Undergraduate Education, 1Term, Basic Practice of Periodontics I
  12. 2024, Undergraduate Education, 2Term, Basic Practice of Periodontics II
  13. 2024, Undergraduate Education, 2Term, Oral Implantology
  14. 2024, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  15. 2024, Undergraduate Education, First Semester, Dental Research Practices I
  16. 2024, Undergraduate Education, Second Semester, Early Clinical Exposure III
  17. 2024, Undergraduate Education, Second Semester, Dental Research Practices II
  18. 2024, Undergraduate Education, 2Term, Advanced Course in Applied Oral Biology and Medicine
  19. 2024, Undergraduate Education, 2Term, General Seminar on Clinical Dentistry
  20. 2024, Undergraduate Education, 2Term, General Dentistry III
  21. 2024, Undergraduate Education, First Semester, Dental Research Practices III
  22. 2024, Undergraduate Education, Academic Year, Clinical Practice (Periodontics)
  23. 2024, Undergraduate Education, 1Term, Medical ethics
  24. 2024, Undergraduate Education, 4Term, Periodontology
  25. 2024, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  26. 2024, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  27. 2024, Undergraduate Education, First Semester, Biodental English
  28. 2024, Undergraduate Education, Second Semester, Clinical Practice on Oral Health
  29. 2024, Undergraduate Education, Intensive, Clinical practice on oral health
  30. 2024, Undergraduate Education, Intensive, Clinical Practice on Oral Health Management
  31. 2024, Undergraduate Education, 1Term, Medical ethics
  32. 2024, Undergraduate Education, 4Term, Periodontology
  33. 2024, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  34. 2024, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  35. 2024, Undergraduate Education, First Semester, Overview of Oral Engineering
  36. 2024, Undergraduate Education, First Semester, Biodental English
  37. 2024, Graduate Education (Master's Program) , 3Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance B
  38. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Periodontal Medicine
  39. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Periodontal Medicine
  40. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Periodontal Medicine
  41. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Periodontal Medicine

Research Activities

Academic Papers

  1. Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 58(1), 83-96, 202302
    Link to Paper Search Results by DOI
  2. Periapical lesion following Cnm-positive Streptococcus mutans pulp infection worsens cerebral hemorrhage onset in an SHRSP rat model, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 210(3), 321-330, 20221231
    Link to Paper Search Results by DOI
  3. Anti-Inflammatory Effects of Geniposidic Acid on Porphyromonas gingivalis-Induced Periodontitis in Mice, BIOMEDICINES, 10(12), 202212
    Link to Paper Search Results by DOI
  4. Clumps of mesenchymal stem cells/extracellular matrix complexes directly reconstruct the functional periodontal tissue in a rat periodontal defect model, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 16(10), 945-955, 202210
    Link to Paper Search Results by DOI
  5. Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study, PLOS ONE, 17(6), 2022
    Link to Paper Search Results by DOI
  6. Xenotransplantation of cryopreserved human clumps of mesenchymal stem cells/extracellular matrix complexes pretreated with IFN-? induces rat calvarial bone regeneration, REGENERATIVE THERAPY, 20, 117-125, 202206
    Link to Paper Search Results by DOI
  7. Cancellous bone-like tissue replacement from calcinosis in patients with systemic sclerosis with multiple external root resorption, BONE REPORTS, 16, 202206
    Link to Paper Search Results by DOI
  8. Cytokines regulate stemness of mesenchymal stem cells via miR-628-5p during periodontal regeneration, JOURNAL OF PERIODONTOLOGY, 93(2), 269-286, 202202
    Link to Paper Search Results by DOI
  9. Comprehensive characterization of sortase A-dependent surface proteins in Streptococcus mutans, MICROBIOLOGY AND IMMUNOLOGY, 66(3), 145-156, 202203
    Link to Paper Search Results by DOI
  10. Proteome analysis of proteins related to aggressive periodontitis combined with neutrophil chemotaxis dysfunction, JOURNAL OF CLINICAL PERIODONTOLOGY, 38(4), 310-317, 201104
    Link to Paper Search Results by DOI
  11. Molecular cloning and characterization of rat trp homologues from brain, Molecular Brain Research, 64(1), 41-51, 19990101
  12. Mediation by platelate-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in rabbit and human neutrophils, 62, 385-394, 20000401
  13. Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in rabbit and human neutrophils, 62(4), 385-394, 20001001
  14. Molecular cloning and characterization of rat trp homologues from brain, Mol. Brain Res., 64(1), 41-51, 19990101
  15. The sites of origin and termination of afferent and efferent components in the lingual and pharyngeal branches of the glossopharyngeal nerve in the Japanese monkey (Macaca fuscata)., Neurosci. Res., 24, 385-392, 19960401
  16. An anterograde-retrograde labeling study of the carotid sinus nerve of the Japanese monkey (Macaca fuscata)., Neurosci. Res., 22, 381-387, 19950401
  17. Re-examination of the topographical distribution of motoneurons innervating the digastric muscle in the rabbit and guinea pig., Anat. Anz., 173, 9-16, 19910401
  18. Distribution of axons showing calcitonin gene-related peptide- and/or substance P-like immunoreactivity in the sensory trigeminal nuclei of the cat., Neurosci. Res., 11, 119-133, 19910401
  19. Retinofugal projections in the house musk shrew， Suncus murinus., Neurosci. Lett., 125, 133-135, 19910401
  20. Localization of motoneurons innervating the stylohyoid muscle in the monkey， cat，rabbit，rat and shrew., J. Hirnforsch., 31, 731-737, 19900401
  21. Infrahyoid and accessory motoneurons in the Japanese monkey (Macaca fuscata)., J. Comp. Neurol., 291, 373-382, 19900401
  22. Representation of the tensor veli palatini muscle in the trigeminal motor nucleus of the Japanese monkey (macaca fuscata)., Neurosci. Lett., 113, 7-11, 19900401
  23. Possible origins of substance P-like immunoreactive axons within Onuf’s nucleus of the cat., Brain Res., 497, 177-182, 19890401
  24. Convergence of serotonin-， enkephalin- and substace P-like immunoreactive afferent fibers onto cat medullary dorsal horn projection neurons: a triple immunocytochemical staining technique combined with the retrograde HRP-tracing method., Brain Res., 491, 360-365, 19890401
  25. The distribution of infrahyoid motoneurons in the cat: a retrograde horseradish peroxidase study., Anat Embryol, 177, 445-450, 19880401
  26. Distribution of axons exhibiting both enkephalin- and serotonin-like immunoreactivities in the lumbar cord segments: an immunohistochemical study in the cat., Brain Res., 440, 357-362, 19880401
  27. Amygdaloid pathway to the trigeminal motor nucleus via the pontine reticular formation in the rat., Brain Res Bull., 21, 829-833, 19880401
  28. Somatotopic organization of facial nucleus of rabbit. With particular reference to intranuclear representation of perioral branches of the facial nerve., Anat. Anz., 165, 83-90, 19880401
  29. Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils, 62(4), 385-94
  30. Molecular cloning and characterization of rat trp homologues from brain, Molecular Brain Research, 64, 41-51
  31. The sites of origin of projection fibers from the cerebral cortex to the jaw region of the striatum of the rat, Neurosci. Lett., 332, 9-12, 20020401
  32. The sites of origin of projection fibers from the cerebral cortex to the jaw region of the striatum of the rat., Neurosci. Lett., 332(1), 9-12, 20020401
  33. Proliferative ability and alkarine posphatase activity with in vivo cellular aging in human pulp cells., Journal of Endodontics, 29(1), 9-11, 20030401
  34. Expression of endothelins and their receptors in cells from human periodontal tissues., Journal of Periodontal Research, 38(3), 269-275, 20030401
  35. Differential gene expression of bone-related proteins in epithelial and fibroblastic cells derived from human periodontal ligam,ent., Biochemical and Molecular Biology International, 27(7), 519-24, 20030401
  36. Enhancement of alkaline phosphatase synthesis in pulp cells co-cultured with epithelial cells derived from lower rabbit incisors., Cell Biology International, 27(10), 815-23, 20030401
  37. The effect of extracellular calcium ion on gene expression of bone-related proteins in human pulp cells., J Endodntics, 29(2), 104-107, 20030401
  38. Syntheses of prostaglandin E2 and E-cadherin and gene expression of beta-defensin-2 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans., Inflammation, 27(6), 341-349, 20030401
  39. Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells., Cell Biology Internathional, 28(10), 675-682, 20040401
  40. Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins., Cell Biology Internathional, 29(2), 111-117, 20050401
  41. Cell transplantation for periodontal diseases. A novel periodontal tissue regenerative therapy using bone marrow mesenchymal stem cells, Clinical Calcium, 15(7), 99-104, 20050401
  42. Brain-derived neurotrophic factor enhances periodontal tissue regeneration., Tissue Engineering, 11(9-10), 1618-1629, 20050401
  43. ★, Human autologous serum obtained using a completely closed bag system as a substitute for foetal calf serum in human mesenchymal stem cell cultures., Cell Biology Internathional, 30(6), 521-524, 20060301
  44. Promotion of functioning of human periodontal ligament cells and human endothelial cells by nerve growth factor., J Periodontlogy, 77(5), 800-807, 20060501
  45. Behavior of transplanted bone marrow-derived mesenchymal stem cells in periodontal defects., J. Periodontology, 77(6), 1003-1007, 20060601
  46. Verification of Aseismic Design Model by using Experimental Results, Trans. 16th International Conference on Structural Mechanics in Reactor Technology, Vol.K, 293-298, 19850801
  47. The effect of extracellular calcium ion on gene expression of bone-related proteins in human pulp cells., J. Endodontics, 29, 104-107, 20030401
  48. Brain-derived neurotrophic factor enhances periodontal tissue regeneration:, Tissue eng., 11(9-10), 1619-1630, 20051101
  49. Expression of endothelins and their receptors in cells from human periodontal tissues, J. Periodontal. Res., 38(3), 269-275, 20030301
  50. Behavior of transplanted bone marrow-derived mesenchymal stem cells in periodontal defects, J. Periodontol, 77, 1003-1007, 20060401
  51. Cell cycle analysis of human dermal fibroblasts cultured on or in hydrated type i collagen lattices, Archives of Dermatological Research, 282, 1-5, 19890401
  52. Parallel arrangement, growth inhibition and cell cycle phase analysis of human dermal fibroblasts cultured in collagen lattice, Journal of Dermatology, 17(1), 2-10, 19900401
  53. Cell cycle analysis of human dermal fibroblasts cultured on or in hydrated type i collagen lattices, Archives for Dermatological Research, 282(4), 258-262, 19900401
  54. Correlation of contractility and proliferative potential with the extent of differentiation in mouse fibroblastic cell lines cultured in collagen lattices, Journal of Dermatology, 17(3), 149-154, 19900401
  55. Effect of tretinoin on collagen gel contraction induced by mouse 3t3 fibroblasts, Journal of Dermatological Science, 2(1), 45-49, 19910401
  56. Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts., J Periodontal Res., 42(3), 283-6, 20070601
  57. Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts,, J Periodontal Res, 42(3), 283-286, 20070601
  58. Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells, Cell Biol Int, 31(12), 1462-1469, 20071201
  59. Effect of bone morphogenetic proteins -4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells, Cell Biol. Int., 28(10), 675-682, 20041001
  60. Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins., Cell Biol. Int., 29(2), 111-117, 20050201
  61. Promotion of functioning of human periodontal ligament cells and human endothelial cells by nerve growth factor., J. Periodontol., 77(5), 800-807, 20060501
  62. Human autologous serum obtained using a completely closed bag system as a substitute for foetal calf serum in human mesenchymal stem cell cultures., Cell Biol. Int., 30(6), 521-524, 20060601
  63. Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts., J Periodontal. Res., 42(3), 283-286, 20070601
  64. Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells, Cell Biol Int., 20070701
  65. Molecular cloning and characterization of rat trp homologues from brain., Molecular Brain Research, 64((1)), 41-51, 19990101
  66. Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins, Cell Biol Int., 29(2), 111-117, 20050201
  67. Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins., Cell Biol Int., 29(2), 111-117, 20050201
  68. Effect of bone morphogenetic proteins-4,-5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells., Cell Biol Int., 28(10), 675-682, 20041001
  69. 6. Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins, Cell Biol Int., 29(2), 111-117, 20050201
  70. Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins, Cell Biol Int, 29(2), 111-117, 20050201
  71. Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells., Cell Biol Int., 28(10), 675-682, 20041001
  72. Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts., J Periontal Res, 42(3), 283-286, 20070601
  73. Synthesis of prostaglandin E2 and E-cadherin and gene expression of beta-defensin-2 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans., Inflammation, 27(6), 341-349, 20031201
  74. Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts, The Journal of Biological Chemistry, 283(23), 16259-16267, 20080601
  75. Effect of Neurotrophin-4/5 on Bone/Cementum-Related Protein Expressions and DNA Synthesis in Cultures of Human Periodontal Ligament Cells, Journal of Periodontology, 79(11), 2182-2189, 20081101
  76. Humoral factors released from human periodontal ligament cells influence calcification and proliferation in human bone marrow mesenchymal stem cells, Journal of Periodontology, 79(12), 2361-2370, 20081201
  77. Detecting gene mutations in Japanese Alzheimer's patients by semiconductor sequencing, NEUROBIOLOGY OF AGING, 35(7), 201407
    Link to Paper Search Results by DOI
  78. Enhanced TLR-MYD88 Signaling Stimulates Autoinflammation in SH3BP2 Cherubism Mice and Defines the Etiology of Cherubism, CELL REPORTS, 8(6), 1752-1766, 20140925
    Link to Paper Search Results by DOI
  79. Bone marrow transplantation improves autoinflammation and inflammatory bone loss in SH3BP2 knock-in cherubism mice, BONE, 71, 201-209, 201502
    Link to Paper Search Results by DOI
  80. Introduction of a Mixture of beta-Tricalcium Phosphate Into a Complex of Bone Marrow Mesenchymal Stem Cells and Type I Collagen Can Augment the Volume of Alveolar Bone Without Impairing Cementum Regeneration, JOURNAL OF PERIODONTOLOGY, 86(3), 456-464, 201503
    Link to Paper Search Results by DOI
  81. LL37 induces VEGF expression in dental pulp cells through ERK signalling, INTERNATIONAL ENDODONTIC JOURNAL, 48(7), 673-679, 201507
    Link to Paper Search Results by DOI
  82. Brain-Derived Neurotrophic Factor Inhibits Intercellular Adhesion Molecule-1 Expression in Interleukin-1 beta-Treated Endothelial Cells, CELL BIOCHEMISTRY AND BIOPHYSICS, 74(3), 399-406, 201609
    Link to Paper Search Results by DOI
  83. Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 186(2), 177-189, 201611
    Link to Paper Search Results by DOI
  84. Brain-Derived Neurotrophic Factor Inhibits Peptidoglycan-Induced Inflammatory Cytokine Expression in Human Dental Pulp Cells, INFLAMMATION, 40(1), 240-247, 201702
    Link to Paper Search Results by DOI
  85. Xenotransplantation of interferon-gamma-pretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration, STEM CELL RESEARCH & THERAPY, 8, 20170426
    Link to Paper Search Results by DOI
  86. MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration, JOURNAL OF DENTAL RESEARCH, 96(9), 984-991, 201708
    Link to Paper Search Results by DOI
  87. Regulation of defensive function on gingival epithelial cells can prevent periodontal disease, JAPANESE DENTAL SCIENCE REVIEW, 54(2), 66-75, 201805
    Link to Paper Search Results by DOI
  88. The induced RNA-binding protein, HuR, targets 3-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 192(3), 325-336, 201806
    Link to Paper Search Results by DOI
  89. Reparative bone-like tissue formation in the tooth of a systemic sclerosis patient, INTERNATIONAL ENDODONTIC JOURNAL, 51(9), 1059-1066, 201809
    Link to Paper Search Results by DOI
  90. The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice, ARTHRITIS RESEARCH & THERAPY, 20, 20181103
    Link to Paper Search Results by DOI
  91. BDNF/HMW-HA complex as an adjunct to nonsurgical periodontal treatment of ligature-induced periodontitis in dogs, JOURNAL OF PERIODONTOLOGY, 90(1), 98-109, 201901
    Link to Paper Search Results by DOI
  92. Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice, INTERNATIONAL IMMUNOPHARMACOLOGY, 68, 30-38, 201903
    Link to Paper Search Results by DOI
  93. Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(16), 20190802
    Link to Paper Search Results by DOI
  94. Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population, CLINICAL ORAL INVESTIGATIONS, 23(11), 4099-4105, 201911
    Link to Paper Search Results by DOI
  95. Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis-A Cross-Sectional Study in Japan, JOURNAL OF CLINICAL MEDICINE, 8(10), 201910
    Link to Paper Search Results by DOI
  96. Periodontal ligament cells regulate osteogenesis via miR-299-5p in mesenchymal stem cells, DIFFERENTIATION, 112, 47-57, 202003
    Link to Paper Search Results by DOI
  97. Optineurin regulates osteoblastogenesis through STAT1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4), 889-894, 20200514
    Link to Paper Search Results by DOI
  98. Biallelic mutation of HSD17B4 induces middle age-onset spinocerebellar ataxia, NEUROLOGY-GENETICS, 6(1), 202002
    Link to Paper Search Results by DOI
  99. Regulation of osteogenesis via miR-101-3p in mesenchymal stem cells by human gingival fibroblasts, JOURNAL OF BONE AND MINERAL METABOLISM, 38(4), 442-455, 202007
    Link to Paper Search Results by DOI
  100. Aggressive periodontitis and NOD2 variants, JOURNAL OF HUMAN GENETICS, 65(10), 841-846, 202010
    Link to Paper Search Results by DOI
  101. Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 530(2), 448-454, 20200917
    Link to Paper Search Results by DOI
  102. IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood-Brain Barrier, BRAIN SCIENCES, 10(10), 202010
    Link to Paper Search Results by DOI
  103. Effect ofPorphyromonas gingivalisinfection on gut dysbiosis and resultant arthritis exacerbation in mouse model, ARTHRITIS RESEARCH & THERAPY, 22(1), 20201019
    Link to Paper Search Results by DOI
  104. Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 56(1), 69-82, 202101
    Link to Paper Search Results by DOI
  105. Functional Regulatory Mechanisms Underlying Bone Marrow Mesenchymal Stem Cell Senescence During Cell Passages, CELL BIOCHEMISTRY AND BIOPHYSICS, 79(2), 321-336, 202106
    Link to Paper Search Results by DOI
  106. The role of nuclear receptor 4A1 (NR4A1) in drug-induced gingival overgrowth, FASEB JOURNAL, 35(7), 202107
    Link to Paper Search Results by DOI
  107. Involvement of Rac1 in macrophage activation by brain-derived neurotrophic factor, MOLECULAR BIOLOGY REPORTS, 48(6), 5249-5257, 202106
    Link to Paper Search Results by DOI
  108. Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Generated with Xeno-Free Chondro-Inductive Medium Induce Bone Regeneration via Endochondral Ossification, BIOMEDICINES, 9(10), 202110
    Link to Paper Search Results by DOI

Publications such as books

  1. 2023/02/20, The Periodontology, The Periodontology, 2023, Scholarly Book, Contributor, Noriyoshi Mizuno, 291, 5
  2. 2020, Introduction of local efforts; nationwide selection! Infection control activity report of regional cooperation] Original efforts; Audit System via the Internet of Hiroshima Safety Dental Service Support Network, Introduction of local efforts; nationwide selection! Infection control activity report of regional cooperation] Original efforts; Audit System via the Internet of Hiroshima Safety Dental Service Support Network, 2020, Scholarly Book, Joint work, Tomoyuki Iwata, Noriyoshi Mizuno, Akihiro Sawa, Hidemi Kurihara

Invited Lecture, Oral Presentation, Poster Presentation

  1. The inhibitory effect of geniposidic acid in Porphyromonas gingivalis induced halitosis and mouse periodontitis model, 2021/11/14, Without Invitation, Japanese
  2. Building a foundation for genetic diagnosis of aggressive periodontitis, Noriyoshi Mizuno, he 14th annual Meeting of the Japanese Society for Evidence and the Dental Professional, 2021/08, With Invitation, Japanese
  3. Identification of a causative gene in a family case with aggressive periodontitis Verification by creating KI mice, Noriyoshi Mizuno, 6th Joint Scientific Meeting in Dentistry, 2021/07/31, With Invitation, English
  4. The immunological analysis of rheumatoid arthritis model mouse with Porphyromonas gingivalis orally infection, Syuichi Munenaga, Kazuhisa Ouhara, Mikihito Kajiya, Masahiro Yamakawa, Katsuhiro Takeda, Manabu Takewaki, Shu Ishida, Yushi Uchida, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, 2015/09/12, Without Invitation, Japanese
  5. Elucidation of the mechanisms of calcineurin inhibitors-induced gingival hyperplasia, A. Okanobu, S. Matsuda, M. Kajiya, Y. Uchida, N. Mizuno, T. Fujita, and H. Kurihara, 2015/09/12, Without Invitation, Japanese
  6. Usability of AUDIT System of Hiroshima Safety Dental service Support network to improve the prevention step for nosocomial infection in the dental clinic, Tomoyuki Iwata, Noriyoshi Mizuno, Miyuki Nakaoka, Takayoshi Nagahara, Yumi Irie, Koji Ohta, Hideki Shiba, Akihiro Sawa, Kazuhiro Tsuga and Hidemi Kurihara, The 30th Annual meeting of the Japanese Society for Infection Prevention and Control, 2015/02, Without Invitation, Japanese
  7. The oral infection of Porphyromonas gingivalis exacerbates the joint destruction in the model mice of rheumatoid arthritis, Syuichi Munenaga, Kazuhisa Ouhara, Masahiro Yamakawa, Mikihito Kajiya, Katsuhiro Takeda, Yushi Uchida, Kei Takeshita, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 142nd Meeting of the Japanese Society of Conservative Dentistry, 2015/06, Without Invitation, Japanese
  8. Elucidation of the mechanisms of Calcineurin inhibitor-induced gingival hyperplasia, A. Okanobu, S. Matsuda, M. Kajiya, N. Mizuno, T. Fujita, and H. Kurihara, The 142nd Meeting of the Japanese Society of Conservative Dentistry, 2015/06, Without Invitation, Japanese
  9. Development of Calcineurin Inhibitor Induced Gingival Hyperplasia Mice Model, A. Okanobu S. Matsuda, M. Kajiya, N. Mizuno, T. Fujita, and H. Kurihara, The 6th Hiroshima Conference, 2015/10, Without Invitation, Japanese
  10. Trial of Examination of several Oral Functions in Periodontal Patients, Yuushi Uchida, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, Chugoku-Shikoku regional branch of the Japanese academy of clinical periodontology, 2015/10, Without Invitation, Japanese
  11. The analysis of rheumatoid arthritis model mouse with Porphyromonas gingivalis orally infection, Syuichi Munenaga, Kazuhisa Ouhara, Mikihito Kajiya, Masahiro Yamakawa, Katsuhiro Takeda, Manabu Takewaki, Shu Ishida, Yushi Uchida, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 99th Hiroshima University Dental Society, 2015/11, Without Invitation, Japanese
  12. "the case report of periodontal regenerative therapy using cone beam CT and 3D model in the patient of aggressive periodontitis", Kazuhisa Ouhara, Yuushi Uchida, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 59th spring meting of the Japanese society of periodontology, 2016/05, Without Invitation, Japanese
  13. Investigation of micro RNA for regulation of cell function on mesenchymal stem cells, Tomoyuki Iwata, Takayoshi Nagahara, Eri Kaneda, Minami Yoshioka, Noriyoshi Mizuno, Hideki Shiba, Hidemi Kurihara, The 59th spring meeting of the Japanese society of Periodontology, 2016/05, Without Invitation, Japanese
  14. The effects of optineurin on periodontal tissue destruction, Shinobu Matsui, Noriyoshi Mizuno, Shinji Matsuda, Mikihito Kajiya, Kazuhisa Ouhara,Tsuyoshi Fujita,Hidemi Kurihara, The 59th spring meeting of the Japanese society of Periodontology, 2016/05, Without Invitation, Japanese
  15. Evaluation of periodontitis with Porphyromonas gulae infection in debetes model mice, Keiichi Akutagawa, Tsuyoshi Fujita, Yuushi Uchida, Tasuku Takemura, Kazuhisa Ouhara, Mikihito Kajiya, Shinji Matsuda, Noriyoshi Mizuno, Hidemi Kurihara, The 59th spring meeting of the Japanese society of Periodontology, 2016/05, Without Invitation, Japanese
  16. The effects of optineurin on periodontal tissue destruction, Noriyoshi Mizuno (Shinobu Matsui), Shinji Matsuda, Manabu Takewaki, Masahiro Yamakawa, Mikihito Kajiya, Kazuhisa Ouhara,Katsuhiro Takeda,Tomoyuki Iwata,Tsuyoshi Fujita,Hidemi Kurihara, 94ｔｈ Annual Meeting of the International Association for Dental Research, 2016/06, Without Invitation, English
  17. Road to board certified member of the japanese society of periodontology, Noriyoshi Mizuno, The 8th meting of the Japanese society of periodontology in Cyugoku, 2016/07, Without Invitation, Japanese
  18. The reactivity of surface antigen ofporphyromonas gingivalis and serumderived from the patient with rheumatois arthritis, Kazuhisa Ouhara, Shuichi Munenaga, Masahiro Yamakawa, Yuta Hamamoto, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 8th meting of the Japanese society of periodontology in Cyugoku, 2016/07, Without Invitation, Japanese
  19. A case report; inflammation of periodontal tissue was improved by enhancement of patient’s motivation for periodontal treatment., Eri Takano, Yukiko Nagatani, Noriyoshi Mizuno, Miyuki Nakaoka, Hidemi Kurihara, The 8th meting of the Japanese society of periodontology in Cyugoku, 2016/07, Without Invitation, Japanese
  20. A case report: Gingival recession treatment utilizing a connective tissue graft, Takayoshi Nagahara, Katsuhiro Takeda, Chika Kozono, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 8th meting of the Japanese society of periodontology in Cyugoku, 2016/07, Without Invitation, Japanese
  21. The effects of optineurin on osteoblast differentiation, Noriyoshi Mizuno, Shinji Matsuda, Tetsuya Yoshimoto, Tomoyuki Iwata, Mikihito Kajiya, Kazuhisa Ouhara,Katsuhiro Takeda,Tsuyoshi Fujita,Hidemi Kurihara, The 59th fall meeting of the Japanese society of Periodontology, 2016/10, Without Invitation, Japanese
  22. Investigation of regulatory genes for differentiative commitment to periodontal cells on mesenchymal stem cells, Tomoyuki Iwata, Takayoshi Nagahara, Eri Ikeda, Ryoichi Yagi, Yusuke Aida, Akihiro Konishi, Minami Yoshioka, Shu Ishida, Noriyoshi Mizuno, Hideki Shiba, Hidemi Kurihara, The 59th fall meeting of the Japanese society of Periodontology, 2016/10, Without Invitation, Japanese
  23. Effectiveness of the combination of SRP and brain-derived neurotrophic factor (BDNF) in the treatment of ligature-induced small periodontal defect in dogs, Shinya Sasaki, Takeda Katsuhiro, Takewaki Mnabu, Aida usukeY, Kajiya Mikihito, Matsuda Shinji, Mizuno Noriyoshi, Fujita Tsuyoshi, Kurihara Hidemi., The 59th fall meeting of the Japanese society of Periodontology, 2016/10, Without Invitation, Japanese
  24. The oriental medicine, magnoliaceae (Kouboku), inhibits the production of methyl mercaptan via mgl mRNA inhibition., Yoko Sato, Kazuhisa Ouhara, Shuichi Munenaga, Mikihito Kajiya, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi  Kurihara, the 145th Meeting of The Japanese Society of Conservation Dentistry, 2016/10, Without Invitation, Japanese
  25. The oriental medicine, magnoliaceae (Kouboku), inhibits the production of methyl mercaptan via mgl mRNA inhibition., Yoko Sato, Kazuhisa Ouhara, Shuichi Munenaga, Masahiro Yamakawa, Mikihito Kajiya, Noriyoshi Mizuno, Tsuyoshi Fujita,Hidemi  Kurihara, the 100th Hiroshima University Dental Society, 2016/10, Without Invitation, Japanese
  26. The C5a involvement in rheumatoid arthritis with P.gingivalis-infection in SKG-mice., Shuichi Munenaga, Kazuhisa Ouhara, Mikihito Kajiya, Katsuhiro Takeda, Yuushi Uchida, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, 95th General Session & Exhibition of the IADR, 2017/03, Without Invitation, English
  27. Identification and functional analysis of aggressie periodontitis in familial case, Noriyodhi Mizuno, Tomoyuki Iwata, Mikihito Kajiya, Hideshi Kawakami, Hidemi Kurihara, The 36th Annual Meeting of the Japanese Society or Bone and Mineral Research, 2018/07/28, With Invitation, Japanese, Nagasaki
  28. The C5a involvement in rheumatoid arthritis with P.gingivalis-infection in SKG-mice, 2017/03, Without Invitation, English
  29. Involvement of C5a in the progression of experimental arthritis in SKG mice induced by Porphyromonas gingivalis infection., Syuichi Munenaga, Kazuhisa Ouhara, Mikihito Kajiya, Katsuhiro Takeda, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, 7th Hiroshima Conference on Education and Science in Dentistry, 2018/03, Without Invitation, English, Hiroshima
  30. Effects of Brain-derived Neurotrophic Factor (BDNF) as an Adjunct to Non-surgical Periodontal Treatment on Ligature-induced Periodontitis in Dogs, Shinya Sasaki, Katsuhiro Takeda, Manabu Takewaki, Mikihito Kajiya, Shinji Matsuda, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, 7th Hiroshima Conference on Education and Science in Dentistry, 2018/03, Without Invitation, English, Hiroshima
  31. Effects of brain-derived neurotrophic factor (BDNF) on macrophage activation, Shinya Sasaki, Katsuhiro Takeda, Kazuhisa Ouhara, Souta Motoike, Mikihito Kajiya, Shinji Matsuda, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 61th Spring Meeting of the Japanese Society of Periodontology, 2018/06, Without Invitation, English
  32. The effect of dysbiosis in gut for aggravation of synovitis in the mouse models of rheumatoid arthritis with Porphyromonas gingivalis infection, Yuta Hamamoto, Kazuhisa Ouhara，Syuichi Munenaga，Mikihito Kajiya，Noriyoshi Mizuno， Tsuyoshi Fujita，Hidemi Kurihara, The 61th Spring Meeting of the Japanese Society of Periodontology, 2018/06, Without Invitation, English
  33. The analysis of cellular response on periodontal tissue in ligature-induced experimental periodontitis in mice, Saki Hatano, Shinji Matsuda, Ai Okanobu, Mikihito Kajiya, Daisuke Furutama, Kazuhisa Ouhara, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 61th Spring Meeting of the Japanese Society of Periodontology, 2018/06, Without Invitation, English, Tokyo
  34. The analysis of cellular response on periodontal tissue in ligature-induced experimental periodontitis in mice, Tasuku Takemura, Tsuyoshi Fujita, Shinji Matsuda, Mikihito Kajiya, Keiichi Akutagawa, Misako Tari, Kazuhisa Ouhara, Katsuhiro Takeda, Noriyoshi Mizuno, Hidemi Kurihara, The 61th Spring Meeting of the Japanese Society of Periodontology, 2018/06, Without Invitation, English, Tokyo
  35. Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration, Souta Motoike, Mikihito Kajiya, Nao Komatsu, Manabu Takewaki, Susumu Horikoshi, Shinji Matsuda, Kazuhisa Ouhara, Tomoyuki Iwata, Katsuhiro Takeda, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara., The 51st meeting of the Hiroshima University Dental Society, 2018/06, Without Invitation, English, Hiroshima
  36. Morphological analysis of junctional epithelium on ligature-induced experimental periodontitis in mice, Tasuku Takemura, Tsuyoshi Fujita, Shinji Matsuda, Mikihito Kajiya, Keiichi Akutagawa, Kazuhisa Ouhara, Katsuhiro Takeda, Noriyoshi Mizuno, Hidemi Kurihara, The 51st meeting of the Hiroshima University Dental Society, 2018/06, Without Invitation, English, Hiroshima
  37. A case of multiple root resorption in a systemic sclerosis patient, Shinji Matsuda, Takumi Memida, Noriyoshi Mizuno, Kazuhisa Ouhara, Mikihito Kajiya, Tsuyoshi Fujita, Hidemi Kurihara, The 148th Meeting of The Japanese Society of Conservative dentistry, 2018/06, Without Invitation, English, Yokohama
  38. Effects of glycyrrhizin on ligature-induced periodontitis with Porphyromonas gulae infection in diabetes model mice, Keiichi Akutagawa, Tsuyoshi Fujita, Kazuhisa Ouhara, Mikihito Kajiya, Shinji Matsuda, Noriyoshi Mizuno, Hidemi Kurihara, The 148th Meeting of The Japanese Society of Conservative dentistry, 2018/06, Without Invitation, English, yokohama
  39. The oriental medicine, magnoliaceae (Kouboku), inhibits the production of methyl mercaptan via mgl mRNA inhibition., Yoko Sato, Choki Taku, Kazuhisa Ouhara, Misako Tari, Tomoaki Shintani, Masae Kitagawa, Ikuko Ogawa, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 102nd Hiroshima university dental society, 2018/09, Without Invitation, English, Hiroshima
  40. Causative bacteria of apical periodontitis and their susceptibility to antibiotics, Kozono C, Ouhara K., Kitagawa M., Ogawa I., Shindo S., Saito N., Akutagawa K., Nakaoka M., Mizuno N., Fujita T., Kurihara H., The 102nd Hiroshima university dental society, 2018/09, Without Invitation, English, Hiroshima
  41. The case report of multiple root resorption in a systemic sclerosis patient, Takumi Memida, Noriyoshi Mizuno, The 102nd Hiroshima university dental society, 2018/09, Without Invitation, English, Hiroshima
  42. Morphological change and cellular response of periodontal tissues in ligature-induced experimental periodontitis in mice, Tasuku Takemura, Tsuyoshi Fujita, Shinji Matsuda, Mikihito Kajiya, Keiichi Akutagawa, Misako Tari, Kazuhisa Ouhara, Katsuhiro Takeda, Noriyoshi Mizuno, Hidemi Kurihara, The 5th joint scientific meeting in dentistry, 2018/10, Without Invitation, English, Surabaya, Indonesia
  43. Identification of a causative gene in a family case with aggressive periodontitis by exome sequencing and linkage analysis, Noriyoshi Mizuno, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Mikihito Kajiya, Katsuhiro Takeda, Tsuyoshi Fujita, Hidemi Kurihara, The 58th General Session of Korean Academy of Periodontology, 2018/10, With Invitation, English, Seoul
  44. Inflammatory response in Hippocampal region induced by experimental periodontitis in mice., Daisuke Furutama, Shinji　Matsuda, Tsuyoshi Fujita, Yousuke Yamawaki, Mikihito Kajiya, Saki Hatano, Ai Okanobu, Noriyoshi Mizuno, Takashi Kanematsu, Hidemi Kurihara, The 61th Autumn Meeting of the Japanese Society of Periodontology, 2018/10, Without Invitation, English, Osaka
  45. Effect of High Fat Diet on inflammatory response in periodontal tissue, Misako Tari, Tsuyoshi Fujita, Keiichi Akutagawa, Shinji Matsuda, Mikihito Kajiya, Kazuhisa Ouhara, Noriyoshi Mizuno, Hidemi Kurihara, The 149th Meeting of the Japanese Society of Conservative Dentistry, 2018/11, Without Invitation, English, Kyoto
  46. Investigation for usability of AUDIT System of Hiroshima Safety Dental service Support network to improve the countermeasure against dental safety in the dental clinic, Tomoyuki Iwata, Noriyoshi Mizuno, Miyuki Nakaoka, Hiroyuki Kawaguchi, Kazuhiro Tsuga, Hidemi Kurihara, The 13th Annual Congress of Japanese Society for Quality and Safety in Healthcare, 2018/11, Without Invitation, Japanese, Nagoya
  47. Identification and functional analysis of a causative gene in a family case with aggressive periodontitis, Noriyoshi Mizuno, Tomoyuki Iwata, Mikihito Kajiya, Hideshi Kawakami, Hidemi Kurihara, The 36th Annual Meeting of the Japanese Society for Bone and Mineral Research, 2018/07, With Invitation, English, Nagasaki
  48. The Elucidation of Developmental Process on Ligature-Induced Experimental Periodontitis in Mice, 2019/06, Without Invitation, English

Awards

  1. 2018/11, Best practice award first place, Annual Congress of Japanese Society for Quality and Safety in Healthcare, Tomoyuki Iwata, Noriyoshi Mizuno, Miyuki Nakaoka, Hiroyuki Kawaguchi, Kazuhiro Tsuga, Hidemi Kurihara

Patented

  1. Patent, 特願2003-316719

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2012, 2014
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  2. KAKENHI, Identification of responsible gene involved with aggressive periodontitis by homozygosity haplotype analysis, 2011, 2013
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  3. KAKENHI, Detection of disease causing genes of aggressive periodontitis by recessive analysis, 2011, 2012
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  4. KAKENHI, Identification of responsible gene involved with aggressive periodontitis in consanguinity, 2009, 2010
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  5. KAKENHI, The basic study for the progression of the order-made medicine by cytokines for periodontal tissue regeneration, 2009, 2011
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  6. KAKENHI, Development of periodontal tissue regeneration using leptin, 2007, 2008
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  7. KAKENHI, 2006, 2008
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  8. KAKENHI, Investigation of the mechanism of osteogenic induction by clock genes, 2006, 2007
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  9. KAKENHI, 2004, 2005
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  10. KAKENHI, 2004, 2005
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  11. KAKENHI, Periodontal tissue regeneration by transplantation of own bone marrow mesenchymal stem cells, 2003, 2005
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  12. KAKENHI, 2002, 2003
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  13. KAKENHI, Study of roles of epithelial cell rests of Malassez in periodontal regeneration, 2002, 2003
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  14. KAKENHI, A new regenerative therapy of periodontal tissue using periostium and molecular chaperones induction, 2001, 2002
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  15. KAKENHI, 2015, 2018
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  16. KAKENHI, 2015, 2018
  17. KAKENHI, 2015, 2018
  18. 2015, 2017
  19. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2018, 2020

Social Activities

History as Peer Reviews of Academic Papers

  1. 2023, Scientific Reports, Others, 1
  2. 2023, Bioactive Materials, Others, 1
  3. 2023, Japanese Dental Science Review, Others, reviewer, 1
  4. 2023, Japanese Dental Science Review, Others, 1
  5. 2023, Journal of Periodontal Research, Others, 1
  6. 2023, Journal of Periodontal Research, Others, 1
  7. 2023, Frontiers in Genetics, Others, 1
  8. 2022, Heliyon, Others, 1
  9. 2022, Journal of Periodontal Research, 1
  10. 2022, Archives of Oral Biology, Others, Reviewer, 1
  11. 2022, Japanese Dental Science Review, Others, 4
  12. 2021, Archives of Oral Biology, Others, reviewer, 1
  13. 2021, Journal of Periodontal Research, Others, reviewer, 1
  14. 2021, In Vitro Cellular & Developmental Biology - Animal, Others, reviewer, 1
  15. 2020, Journal of Periodontal Research, Others, reviewer, 2
  16. 2020, Journal of Periodontal Research, Others, reviewer, 1
  17. 2020, BMC Oral Health, Others, reviewer, 1
  18. 2019, Journal of periodontal resarch, Others, reviewer, 3
  19. 2019, BMC oral health, Others, reviewer, 1
  20. 2019, In Vitro Cellular & Developmental Biology - Animal, Others, reviewer, 1
  21. 2018, Archives of Oral Biology, Others, reviewer, 1
  22. 2018, Journal of periodontal research, Others, reviewer, 1
  23. 2017, Journal of periodontal resarch, Others, reviewer, 1
  24. 2017, Journal of oral science, Others, reviewer, 1