TAKASHI UMEHARA

Last Updated :2020/09/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
E-mail
pd7221hiroshima-u.co.jp

Basic Information

Major Professional Backgrounds

  • 2015/04/01, 2018/03/31, Japan Society for the Promotion of Science, Research Fellowships for Young Scientists, DC1
  • 2018/04/01, 2019/03/31, Hiroshima University, Special Postdoctral Researcher
  • 2019/04/01, Hiroshima university, Graduate School of Integrated Sciences for Life, Assistant professor
  • 2019/09/02, Robinson Research Institute; The University of Adelaide, Robinson Research Institute, Visiting research fellow

Educational Backgrounds

  • Hiroshima University, 2009/04/01, 2013/03/23
  • Hiroshima University, 2013/04/01, 2015/03/23
  • Hiroshima University, 2015/04/01, 2018/03/23

Academic Degrees

  • Hiroshima University
  • Hiroshima University

In Charge of Primary Major Programs

  • Applied Animal and Plant Science Program

Research Fields

  • Agricultural sciences;Animal life science;Animal production science

Research Keywords

  • Animal reproduction, Reproductive biology, Reproductive technology

Affiliated Academic Societies

  • Japan Society for Ova Research
  • Japan Society of Fertilization and Implantation
  • Japan Society for Reproductive Medicine

Research Activities

Academic Papers

  1. The expression and roles of Semaphorin Type 3C in granulosa cells during the luteinization process., Journal of Mammalian Ova Research, 31, 31-39
  2. Targeted disruption of Nrg1 in granulosa cells alters the temporal progression of oocyte maturation., Molecular Endocrinology, 706-720
  3. Neuregulin 1 regulates proliferation of Leydig cells to support spermatogenesis and sexual behavior in adult mice., Endocrinology, 157, 4899-4913
  4. The acceleration of reproductive aging in Nrg1flox/flox; Cyp19-Cre female mice., Aging cell, 1288-1299
  5. Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice., PloS one, e0192458
  6. Creatine enhances the duration of sperm capacitation: a novel factor for improving in vitro fertilization with small numbers of sperm., Human Reproduction, 1117-1129
  7. The stromal fibrosis in aging ovary., Aging, 8-10
  8. Roles of epidermal growth factor (EGF)-like factor in the ovulation process., Reproductive Medicine and Biology, 201-216
  9. Gene Expression and Protein Synthesis in Mitochondria Enhance the Duration of High-Speed Linear Motility in Boar Sperm, FRONTIERS IN PHYSIOLOGY, 10, 20190312
  10. Activation of Toll-like receptor 7/8 encoded by the X chromosome alters sperm motility and provides a novel simple technology for sexing sperm, PLOS BIOLOGY, 17(8), 201908
  11. Negative effects of ROS generated during linear sperm motility on gene expression and ATP generation in boar sperm mitochondria, FREE RADICAL BIOLOGY AND MEDICINE, 141, 159-171, 201909

Invited Lecture, Oral Presentation, Poster Presentation

  1. Targeted disruption of neuregulin 1 in granulosa cells reveals an important role in oocyte maturation in vivo, Masayuki Shimada, Ikko Kawashima, Takashi Umehara, JoAnne S.Richards, SSR 46th Annual Meeting, 2013/.7, Without Invitation, Montreal, Canada
  2. The abnormal estrus cycle in aged granulosa-cell-specific Nrg1 KO mice, Takashi Umehara, JoAnne S. Richards, Masayuki Shimada, SSR 47th Annual Meeting, 2014/.7, Without Invitation, Grand rapids, U.S.A
  3. LH-induced NRG1 is essential for adult Leydig cell proliferation in the infant testis that determines androgen production and spermatogenesis in adult male mice., Takashi Umehara, Wenxian Zeng, JoAnne S. Richards, Masayuki Shimada, SSR 49th Annual Meeting, 2016/.7, Without Invitation, San diego, U.S.A
  4. Creatine enhances sperm capacitation and is associated with successful in vivo and in vitro fertilization in mice., Takashi Umehara, Satoshi Okuda, Tomoko Kawai, JoAnne S. Richards, Masayuki Shimada, SSR 50th Annual Meeting, 2017/.7, Without Invitation, Washington D.C, U.S.A

Awards

  1. THE 2018 AWARDS OF THE DIMITRIS N. CHORAFAS FOUNDATION, THE DIMITRIS N. CHORAFAS FOUNDATION, A study on the role of Neuregulin 1 in mammalian fertility

External Funds

Acceptance Results of Competitive Funds

  1. 2015/.4, 2018/.3
  2. Oversea research fellowship, A study on the treatment of reproductive disorder focusing on ovarian fibrosis, 2019/09/01, 2021/08/31