YUHKI YANASE

Last Updated :2025/06/16

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Associate Professor
E-mail
yyanasehiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Bioscience, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Pharmacology in pharmacy

Research Keywords

  • Allergy
  • Biosensor

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  2. 2025, Undergraduate Education, Second Semester, Biostatistics
  3. 2025, Undergraduate Education, 1Term, Pharmacotherapy A
  4. 2025, Undergraduate Education, 2Term, Outline of Immunology
  5. 2025, Undergraduate Education, 3Term, Clinical Pharmacology A
  6. 2025, Undergraduate Education, 2Term, Pharmaceutical Affairs Related Laws
  7. 2025, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  8. 2025, Graduate Education (Doctoral Program) , 4Term, Pharmacotherapeutic Research
  9. 2025, Graduate Education (Master's Program) , First Semester, Seminar on Molecular Pharmacotherapeutics
  10. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Molecular Pharmacotherapeutics

Research Activities

Academic Papers

  1. Pancreatic β cell-secreted factor FGF23 attenuates Alzheimer's disease-related amyloid β-induced neuronal death, PNAS NEXUS, 4(1), 20250128
    Link to Paper Search Results by DOI
  2. Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells, FRONTIERS IN PHARMACOLOGY, 14, 20231107
    Link to Paper Search Results by DOI
  3. Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching, FRONTIERS IN IMMUNOLOGY, 14, 20231116
    Link to Paper Search Results by DOI
  4. Mathematical-based morphological classification of skin eruptions corresponding to the pathophysiological state of chronic spontaneous urticaria, COMMUNICATIONS MEDICINE, 3(1), 20231204
    Link to Paper Search Results by DOI
  5. Identification of protein kinase C domains involved in its translocation induced by propofol, EUROPEAN JOURNAL OF PHARMACOLOGY, 955, 20230915
    Link to Paper Search Results by DOI
  6. Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(12), 202306
    Link to Paper Search Results by DOI
  7. Time Course of Priming Effect of TF Inducers on Synergistic TF Expression and Intra-Cellular Gap Formation of Human Vascular Endothelial Cells via the Extrinsic Coagulation Cascade, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(15), 202308
    Link to Paper Search Results by DOI
  8. P2Y2 receptor mediates dying cell removal via inflammatory activated microglia, JOURNAL OF PHARMACOLOGICAL SCIENCES, 153(1), 55-67, 202309
    Link to Paper Search Results by DOI
  9. Flow length-dependent evaluation of separation and concentration functions of microfluidic chips for allergy testing using pseudo-cells, JAPANESE JOURNAL OF APPLIED PHYSICS, 62(SG), 20230601
    Link to Paper Search Results by DOI
  10. Homocysteine causes neuronal leptin resistance and endoplasmic reticulum stress, PLOS ONE, 17(12), 20221213
    Link to Paper Search Results by DOI
  11. ★, Basophils activation of patients with chronic spontaneous urticaria in response to C5a despite failure to respond to IgE-mediated stimuli, FRONTIERS IN IMMUNOLOGY, 13, 20220928
    Link to Paper Search Results by DOI
  12. Immunological Changes of Basophil Hyperreactivity to Sweat in Patients With Well-Controlled Atopic Dermatitis, FRONTIERS IN IMMUNOLOGY, 13, 20220629
    Link to Paper Search Results by DOI
  13. Coagulation factors induce human skin mast cell and basophil degranula-tion via activation of complement 5 and the C5a receptor, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(3), 1101-+, 202103
    Link to Paper Search Results by DOI
  14. Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic, PLOS ONE, 17(2), 2022
    Link to Paper Search Results by DOI
  15. Cellulose Sulfate Suppresses Immunoglobulin E Production by Murine B Lymphocytes In Vitro, JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 22(3), 180-187, 2012
    Link to Paper Search Results by DOI
  16. Aspirin Augments IgE-Mediated Histamine Release from Human Peripheral Basophils via Syk Kinase Activation, ALLERGOLOGY INTERNATIONAL, 62(4), 503-511, 201312
    Link to Paper Search Results by DOI
  17. Fucoidan prevents C epsilon germline transcription and NFkappaB p52 translocation for IgE production in B cells., Biochemical and Biophysical Research Commumicarion, 350(3), 501-507, 20061124
  18. The SPR signal in living cells reflects changes other than the area of adhesion and the formation of cell constructions., 22(6), 1081-1086, 20070115
  19. Protein kinase C ? mediates TNF release process in RBL-2H3 mast cells., Br. J. Pharmacol., 145, 415-423, 20051001
  20. Living cell positioning on the surface of gold film for SPR analysis, 23, 562-567, 20071130
  21. 10. Cutaneous mast cell receptors., Dermatologic Clinics, 25(4), 563-575, 20070401
  22. A critical role of conventional protein kinase C in morphological changes of rodent mast cells., Immunol. Cell. Biol., 20100601
  23. A critical role for conventional protein kinase C in morphological changes of rodent mast cells., Immunol. Cell Biol., 89, 149-151, 20110101
  24. Protein kinase C-alpha a mediates TNF release process in RBL-2H3 mast cells, BRITISH JOURNAL OF PHARMACOLOGY, 145(4), 415-423, 200506
    Link to Paper Search Results by DOI
  25. Fucoidan prevents C epsilon germline transcription and NF kappa B p52 translocation for IgE production in B cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 350(3), 501-507, 20061124
    Link to Paper Search Results by DOI
  26. The SPR signal in living cells reflects changes other than the area of adhesion and the formation of cell constructions, BIOSENSORS & BIOELECTRONICS, 22(6), 1081-1086, 20070115
    Link to Paper Search Results by DOI
  27. Living cell positioning on the surface of gold film for SPR analysis, BIOSENSORS & BIOELECTRONICS, 23(4), 562-567, 20071130
    Link to Paper Search Results by DOI
  28. Cutaneous mast cell receptors, DERMATOLOGIC CLINICS, 25(4), 563-+, 200710
    Link to Paper Search Results by DOI
  29. Surface plasmon resonance biosensor detects the downstream events of active PKC beta in antigen-stimulated mast cells, BIOSENSORS & BIOELECTRONICS, 23(11), 1652-1658, 20080615
    Link to Paper Search Results by DOI
  30. Peritoneal injection of fucoidan suppresses the increase of plasma IgE induced by OVA-sensitization, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 387(3), 435-439, 20090925
    Link to Paper Search Results by DOI
  31. Development of an optical fiber SPR sensor for living cell activation, BIOSENSORS & BIOELECTRONICS, 25(5), 1244-1247, 20100115
    Link to Paper Search Results by DOI
  32. Hydrolyzed Konjac Glucomannan Suppresses IgE Production in Mice B Cells, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 152(2), 122-130, 2010
    Link to Paper Search Results by DOI
  33. Detection of refractive index changes in individual living cells by means of surface plasmon resonance imaging, BIOSENSORS & BIOELECTRONICS, 26(2), 674-681, 20101015
    Link to Paper Search Results by DOI
  34. A critical role of conventional protein kinase C in morphological changes of rodent mast cells, IMMUNOLOGY AND CELL BIOLOGY, 89(1), 149-159, 201101
    Link to Paper Search Results by DOI
  35. Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitis, ARCHIVES OF DERMATOLOGICAL RESEARCH, 303(6), 425-431, 201108
    Link to Paper Search Results by DOI
  36. Evaluation of peripheral blood basophil activation by means of surface plasmon resonance imaging, BIOSENSORS & BIOELECTRONICS, 32(1), 62-68, 20120215
    Link to Paper Search Results by DOI
  37. Surface plasmon resonance-biosensor detects the diversity of responses against epidermal growth factor in various carcinoma cell lines, BIOSENSORS & BIOELECTRONICS, 32(1), 202-207, 20120215
    Link to Paper Search Results by DOI
  38. Germ line Mutation in ATR in Autosomal-Dominant Oropharyngeal Cancer Syndrome, AMERICAN JOURNAL OF HUMAN GENETICS, 90(3), 511-517, 20120309
    Link to Paper Search Results by DOI
  39. Histamine release-neutralization assay for sera of patients with atopic dermatitis and/or cholinergic urticaria is useful to screen type I hypersensitivity against sweat antigens, ARCHIVES OF DERMATOLOGICAL RESEARCH, 304(8), 647-654, 201210
    Link to Paper Search Results by DOI
  40. Application of SPR Imaging Sensor for Detection of Individual Living Cell Reactions and Clinical Diagnosis of Type I Allergy, ALLERGOLOGY INTERNATIONAL, 62(2), 163-169, 201306
    Link to Paper Search Results by DOI
  41. Fungal protein MGL_1304 in sweat is an allergen for atopic dermatitis patients, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(3), 608-+, 201309
    Link to Paper Search Results by DOI
  42. Elevated Serum IgE against MGL_1304 in Patients with Atopic Dermatitis and Cholinergic Urticaria, ALLERGOLOGY INTERNATIONAL, 63(1), 83-93, 201403
    Link to Paper Search Results by DOI
  43. Surface Plasmon Resonance for Cell-Based Clinical Diagnosis, SENSORS, 14(3), 4948-4959, 201403
    Link to Paper Search Results by DOI
  44. Tissue factor expression on the surface of monocytes from a patient with hereditary angioedema, JOURNAL OF DERMATOLOGY, 41(10), 929-932, 201410
    Link to Paper Search Results by DOI
  45. Establishment of a mast cell line, NCL-2, without Kit mutation, derived from NC mouse bone marrow, FEBS OPEN BIO, 4, 342-346, 2014
    Link to Paper Search Results by DOI
  46. Evaluation of recombinant MGL_1304 produced by Pichia pastoris for clinical application to sweat allergy, ALLERGOLOGY INTERNATIONAL, 64(3), 266-271, 201507
    Link to Paper Search Results by DOI
  47. Visualization of Refractive Index Distribution in Living Cells by Means of SPR, 44(6), 227-232, 201506
  48. Clinical Diagnosis of Type I Allergy by Means of SPR Imaging, 65(8), 582-587, 201408
  49. Mast cell activation by monomeric IgE antibodies, 57(6), 639-644, 201206
  50. ★, Clinical diagnosis of type I allergy by means of SPR imaging with less than a microliter of peripheral blood, Sens and Bio-Sens Res., 2014
  51. A human monoclonal IgE antibody that binds to MGL_1304, a major allergen in human sweat, without activation of mast cells and basophils, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 468(1-2), 99-104, 20151204
    Link to Paper Search Results by DOI
  52. The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling, NEUROCHEMISTRY INTERNATIONAL, 93, 82-94, 201602
    Link to Paper Search Results by DOI
  53. ★, Diagnosis of immediate-type allergy using surface plasmon resonance, OPTICAL MATERIALS EXPRESS, 6(4), 1339-1348, 20160401
    Link to Paper Search Results by DOI
  54. Oral administration of -carotene or lycopene prevents atopic dermatitis-like dermatitis in HR-1 mice, JOURNAL OF DERMATOLOGY, 43(10), 1188-1192, 201610
    Link to Paper Search Results by DOI
  55. High-resolution imaging of a cellattached nanointerface using a gold-nanoparticle two-dimensional sheet, SCIENTIFIC REPORTS, 7, 20170616
    Link to Paper Search Results by DOI
  56. Remission rate of patients with wheat allergy sensitized to hydrolyzed wheat protein in facial soap, Allergol Int, 2016
  57. Micro cell isolation column for allergic diagnosis, Jpn. J. Appl. Phys, 2016
  58. A case of erythritol allergy studied by basophil histamine release and CD203c expression in vitro in addition to a challenge test in vivo, J Investig Allergol Clin Immunol, 2016
  59. ★, Impedance-Based Living Cell Analysis for Clinical Diagnosis of Type I Allergy, SENSORS, 17(11), 201711
    Link to Paper Search Results by DOI
  60. Nonoptical Detection of Allergic Response with a Cell-Coupled Gate Field-Effect Transistor, ANALYTICAL CHEMISTRY, 89(23), 12918-12923, 20171205
    Link to Paper Search Results by DOI
  61. LSPR-mediated high axial-resolution fluorescence imaging on a silver nanoparticle sheet, PLOS ONE, 12(12), 20171215
    Link to Paper Search Results by DOI
  62. ★, Chronic spontaneous urticaria and the extrinsic coagulation system, ALLERGOLOGY INTERNATIONAL, 67(2), 191-194, 201804
    Link to Paper Search Results by DOI
  63. ★, Activation of Human Peripheral Basophils in Response to High IgE Antibody Concentrations without Antigens, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(1), 20190101
    Link to Paper Search Results by DOI
  64. Staphylococcus aureus from atopic dermatitis skin accumulates in the lysosomes of keratinocytes with induction of IL-1 alpha secretion via TLR9, ALLERGY, 74(3), 560-571, 201903
    Link to Paper Search Results by DOI
  65. ★, Histamine and Toll-like receptor ligands synergistically induce endothelial cell gap formation by the extrinsic coagulating pathway, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(3), 1115-1118, 201803
    Link to Paper Search Results by DOI
  66. ★, Development of SPR Imaging-Impedance Sensor for Multi-Parametric Living Cell Analysis, SENSORS, 19(9), 20190501
    Link to Paper Search Results by DOI
  67. Neuromedin-U directly induces degranulation of skin mast cells, presumably via MRGPRX2, allergy, 73(11), 2256-2260, 2018
  68. The role of adenosine for IgE receptor-dependent degranulation of human peripheral basophils and skin mast cells., Allergol Int., 67(4), 524-526, 2018
  69. Decreased intracellular histamine concentration and basophil activation in anaphylaxis, ALLERGOLOGY INTERNATIONAL, 69(1), 78-83, 202001
    Link to Paper Search Results by DOI
  70. A single reaction-diffusion equation for the multifarious eruptions of urticaria, PLOS COMPUTATIONAL BIOLOGY, 16(1), 202001
    Link to Paper Search Results by DOI
  71. Type-I-hypersensitivity to 15 kDa, 28 kDa and 54 kDa proteins in vitellogenin specific to Gadus chalcogrammus roe, ALLERGOLOGY INTERNATIONAL, 69(2), 253-260, 202004
    Link to Paper Search Results by DOI
  72. Simulation and Experiment for Electrode Coverage Evaluation by Electrochemical Impedance Spectroscopy Using Parallel Facing Electrodes, ANALYTICAL SCIENCES, 36(7), 853-858, 202007
    Link to Paper Search Results by DOI
  73. Successful treatment of refractory dermal pain with etizolam and clonazepam in a patient with acquired idiopathic generalized anhidrosis, J dermatol., 46(10), 351-353, 2019
  74. Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria, EUROPEAN JOURNAL OF PHARMACOLOGY, 884, 20201005
    Link to Paper Search Results by DOI
  75. Histamine- or vascular endothelial growth factor-induced tissue factor expression and gap formation between vascular endothelial cells are synergistically enhanced by lipopolysaccharide, tumor necrosis factor-alpha, interleukin (IL)-33 or IL-1 beta, JOURNAL OF DERMATOLOGY, 47(11), 1293-1300, 202011
    Link to Paper Search Results by DOI
  76. Increase of tissue factor expression on the surface of peripheral monocytes of patients with chronic spontaneous urticaria, ALLERGY, 75(4), 971-974, 202004
    Link to Paper Search Results by DOI
  77. The Role of Coagulation and Complement Factors for Mast Cell Activation in the Pathogenesis of Chronic Spontaneous Urticaria, CELLS, 10(7), 202107
    Link to Paper Search Results by DOI
  78. The Pathogenesis of Chronic Spontaneous Urticaria: The Role of Infiltrating Cells, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 9(6), 2195-2208, 202106
    Link to Paper Search Results by DOI

Publications such as books

  1. 2015, Label-free biosensor methods in drug discovery, Surface plasmon resonance for clinical diagnosis of type I allergy, 2015, Scholarly Book, Joint work, Yanase Y, Hide M.

Invited Lecture, Oral Presentation, Poster Presentation

  1. SPR Imaging Sensor for Visualization of Individual Cell Reactions and Clinical Diagnosis of Allergy, Yuhki Yanase, Pacific Rim Symposium on Surfaces, coating and interfaces 2014, 2014/12/08, With Invitation, English, published
  2. Clinical diagnosis of type I allergy by means of SPR imaging with a drop of peripheral blood, Yuhki Yanase, Kaori Ishii, Tomoko Kawaguchi, Michihiro Hide, Biosensors 2014, 2014/05/27, Without Invitation, English, published
  3. SPR imaging sensor for visualization of individual cell activations and clinical　diagnosis of allergy, Yuhki Yanase, Tomoko Kawaguchi, Kaori Ishii, Michihiro Hide, SSDM2014 (Solid State Devices and Materials), 2014/09/08, Without Invitation, English, published
  4. Fiber-optic Biosensor based on Multimode Interference using Small-core Single-mode Fiber, M. Doi, S. Taue, Y. Yanase and H. Fukano, SSDM2014 (Solid State Devices and Materials), 2014/09/08, Without Invitation, English, published
  5. PARALLEL SPR-IMAGING OF CELL RESPONSES: PROOF-OF-CONCEPT OF CELL-BASED SPR ASSAY FOR TYPE I ALLERGY, Takayuki Obara, Yuhki Yanase, Nobutaka Kumazaki, Tomoko Kawaguchi and Michihiro Hide, MicroTAS 2014, 2014/10/26, Without Invitation, English, published
  6. INTEGRATED ALLERGIC DIAGNOSTIC CHIP APPLIED WITH HUMAN BASOPHILS ACTIVATIONK, K. Sakamoto, Y. Yanase, M. Hide and R. Miyake, MicroTAS 2014, 2014/10/26, Without Invitation, English, published
  7. Effective Micro-isolation column of basophilic leukocyte for new allergic diagnostic system, Kenji Sakamoto, Yuhki Yanase, Michihiro Hide, Ryo Miyake, Biosensors 2014, 2014/05/27, Without Invitation, English, published
  8. Effective micro-isolation column of basophilic leukocyte for allergic diagnosis., Kenji Sakamoto, Yuhki Yanase, Michihiro Hide, Ryo Miyake, The 6th International Symposium on Microchemistry and Microsystems, 2014/07/30, Without Invitation, English, published
  9. Mechanism of TLR4-mediated survival of microglia: Roles of GM-CSF self-production and the activation of JAK2/STAT5 signaling pathways., Mayumi Kamigaki, Izumi Hide, Yuhki Yanase, Shigeru Tanaka, Toshihiko Shirafuji, Michihiro Hide, Norio Sakai., 米国神経科学学会　(Neuroscience 2014), 2014/11/15, Without Invitation, English
  10. Clinical diagnosis of type I allergy by means of SPR imaging with less than a microliter of peripheral blood, Yuhki Yanase, Tomoko Kawaguchi, Michihiro Hide, 2015/05/10, Without Invitation, English, other
  11. Multi-well SPR imaging sensor for clinical diagnosis of allergy, Yuhki Yanase, Koichiro Kobayashi, Kenji Sakamoto, Tomoko Kawaguchi, Michihiro Hide, 8th International conference on molecularelectronics and bioelectronics, 2015/06/22, Without Invitation, English, published
  12. Visualization of individual living cell reactions by means of surface plasmon resonance imaging sensor, Yuhki Yanase, Tomoko Kawaguchi, Michihiro Hide, 2015/09/13, Without Invitation, English, published
  13. Surface plasmon resonance for living cell analysis and clinical diagnosis, Yuhki Yanase, The 17th TAkayanagi Kenjiro Memorial symposium, 2016/11/15, With Invitation, English
  14. High depth imaging of refractive index changes in living cells by means of long range SPR imaging, Yuhki Yanase, Tomoko Kawaguchi, Kaoru Tamada, Michihiro Hide, Biosensors 2016, 2016/05/22, Without Invitation, English
  15. Development of multi-well SPR imaging sensor for clinical test of allergy, Yuhki Yanase, Tomoko Kawaguchi, and Michihiro Hide, KJF-ICOMEP 2016, 2016/09/04, Without Invitation, English
  16. Diagnosis of immediate-type allergy using SPR imaging sensor, Yuhki Yanase, Tomoko Kawaguchi, Kenji Sakamoto, Michihiro Hide, SSDM 2016, 2016/09/26, Without Invitation, English
  17. SPR imaging sensor for living-cell analysis, Yuhki Yanase, Michihiro Hide, International Symposium on Biomedical Engineering, 2016/11/10, Without Invitation, English
  18. Synergistic expression of tissue factor on vascular endothelial cells by histamine and LPS triggers the extrinsic coagulation pathway followed by vascular hyperpermeability, Yuhki Yanase, Satoshi Morioke, Kazumasa Iwamoto, Takaaki Hiragun, Kazue Uchida, Tomoko Kawaguchi, Kaori Ishii, Michihiro Hide, The 19th Takeda Science Foundation Symposium on Bioscience, 2017/01/20, Without Invitation, English
  19. Synergistically expressed tissue factors on vascular endothelial cells by histamine and LPS trigger the extrinsic coagulation pathway followed by inter-cell gap formation, Yuhki Yanase, Satoshi Morioke, Kazumasa Iwamoto, Shunsuke Takahagi, Kazue Uchida, Tomoko Kawaguchi, Kaori Ishii, Michihiro Hide, EAACI2017, 2017/06/19, Without Invitation, English
  20. Synergistic expression of tissue factors on vascular endothelial cells induce intercellular gap formation in the presence of plasma via extrinsic coagulation cascade and PAR-1, Yuhki Yanase, Satoshi Morioke, Kazumasa Iwamoto, Shunsuke Takahagi, Kazue Uchida, Tomoko Kawaguchi, Kaori Ishii, Michihiro Hide, WCP2018, 2018/06/05, Without Invitation, English, experimental

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2021, 2023
  2. Strategic Basic Research Programs(CREST), 2021/10/01, 2027/03/31
  3. Science and technology research promotion program for agriculture forestry fisheries and food industry, 2015/04/09, 2016/03/22
  4. 2014/12/01, 2015/11/30
  5. KAKENHI, 2014, 2016
    Permalink
  6. Science and technology research promotion program for agriculture, forestry, fisheries and food industry, 2014/04/01, 2015/03/23
  7. KAKENHI, Development of a functional diagnostic system for angiosarcoma by surface plasmon resonance, 2012, 2013
    Permalink
  8. Programme for Promotion of Basic and Applied Researches for Innovations in Bio-oriented Industry, 2011/07/29, 2014/03/31
  9. KAKENHI, 2008, 2009
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  10. 2011
  11. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020