Kazuaki Tanabe

Last Updated :2020/10/08

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Health Sciences), Professor
E-mail
ktanabe2hiroshima-u.ac.jp
Other Contact Details
1-2-3, Kasumi, Minami-ku, Hiroshima, Japan, Japan
TEL : (+81)82-257-5380 FAX : (+81)82-257-5384
Self-introduction
Clinical and basic research for upper gastroenterological surgery

Basic Information

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medicine, Japan, 2000/04, 2003/03
  • Hiroshima University, Faculty of Medicine, Japan, 1988/04, 1994/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Educational Activity

  • 【Bachelor Degree Program】School of Medicine : Program of Health Sciences
  • 【Master's Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • 【Doctoral Program】Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Digestive surgery

Research Keywords

  • Wnt signaling
  • Cancer stem cell
  • Cancer

Affiliated Academic Societies

  • Japan Gastric Cancer Association

Educational Activity

Course in Charge

  1. 2020, Undergraduate Education, Second Semester, Physiology II
  2. 2020, Undergraduate Education, Second Semester, Physiology II
  3. 2020, Undergraduate Education, Year, Clinical diagnosis and treatment I
  4. 2020, Undergraduate Education, Intensive, Symptomatology, Diagnosis and Treatment
  5. 2020, Undergraduate Education, 1Term, Microbiology Immunology
  6. 2020, Undergraduate Education, Intensive, Integrated Clinical Practice
  7. 2020, Undergraduate Education, Second Semester, Practice in Basic Medicine
  8. 2020, Undergraduate Education, 2Term, Clinical pharmacology
  9. 2020, Undergraduate Education, First Semester, Disease Management in Adult
  10. 2020, Undergraduate Education, Year, Graduate thesis
  11. 2020, Undergraduate Education, Intensive, Clinical Practice in Acute Care Nursing
  12. 2020, Undergraduate Education, Second Semester, Anatomy and Physiology II
  13. 2020, Undergraduate Education, 1Term, Lecture of Patho-physiology for Adult Diseases
  14. 2020, Undergraduate Education, Second Semester, Organ Response for Surgical Injury
  15. 2020, Undergraduate Education, 4Term, Principles of Rehabilitation
  16. 2020, Undergraduate Education, 2Term, Introduction to Rehabilitation Science
  17. 2020, Undergraduate Education, 2Term, Introduction to Rehabilitation Science
  18. 2020, Undergraduate Education, Second Semester, Emergency Medicine and Infection Control
  19. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Lecture on Health Promotion
  20. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Health Care for Adults
  21. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Health Care for Adults
  22. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Health Care for Adults
  23. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Health Care for Adults
  24. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Health Care for Adults
  25. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Health Care for Adults
  26. 2020, Graduate Education (Doctoral Program) , Year, Advanced Research on Development of Nursing Science
  27. 2020, Graduate Education (Doctoral Program) , First Semester, Practice of Oncology
  28. 2020, Graduate Education (Doctoral Program) , 1Term, Practice of Oncology
  29. 2020, Graduate Education (Doctoral Program) , Second Semester, Methodology of Education for Health Promotion
  30. 2020, Graduate Education (Master's Program) , First Semester, Advanced Lecture on Health Science 1(Survey Research)
  31. 2020, Graduate Education (Master's Program) , First Semester, Advanced Lecture on Health Science 1(Survey Research)
  32. 2020, Graduate Education (Master's Program) , First Semester, Advanced Lecture on Health Science 3(Experiment Research)
  33. 2020, Graduate Education (Master's Program) , First Semester, Advanced Lecture on Health Science 3(Experiment Research)
  34. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Development of Nursing Science
  35. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Development of Nursing Science
  36. 2020, Graduate Education (Master's Program) , First Semester, Lecture on Health Care for Adults
  37. 2020, Graduate Education (Master's Program) , First Semester, Lecture on Health Care for Adults
  38. 2020, Graduate Education (Master's Program) , First Semester, Seminar on Health Care for Adults
  39. 2020, Graduate Education (Master's Program) , Second Semester, Seminar on Health Care for Adults
  40. 2020, Graduate Education (Master's Program) , First Semester, Seminar on Health Care for Adults
  41. 2020, Graduate Education (Master's Program) , Second Semester, Seminar on Health Care for Adults
  42. 2020, Graduate Education (Master's Program) , Year, Research on Health Care for Adults
  43. 2020, Graduate Education (Master's Program) , Year, Methodology of Education for Health Care for Adults
  44. 2020, Graduate Education (Master's Program) , Year, Educational Practice on Health Care for Adults
  45. 2020, Graduate Education (Master's Program) , Year, Integrated Educational Practice on Health Care for Adults
  46. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Health Care for Adults
  47. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Health Care for Adults
  48. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Health Care for Adults
  49. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Health Care for Adults
  50. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Health Care for Adults
  51. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Health Care for Adults

Research Activities

Academic Papers

  1. ★, Phase II/III study of second-line chemotherapy comparing irinotecan-alone with S-1 plus irinotecan in advanced gastric cancer refractory to first-line treatment with S-1 (JACCRO GC-05)., Ann Oncol, 26, 1916-1922, 2015
  2. Initial experiences of robotic versus conventional laparoscopic surgery for colorectal cancer, focusing on short-term outcomes: a matched case-control study, WORLD JOURNAL OF SURGICAL ONCOLOGY, 13, 20150312
  3. ★, Sequential paclitaxel followed by tegafur and uracil (UFT) or S-1 versus UFT or S-1 monotherapy as adjuvant chemotherapy for T4a/b gastric cancer (SAMIT): a phase 3 factorial randomised controlled trial, LANCET ONCOLOGY, 15(8), 886-893, 201407
  4. ★, Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion., Cancer Science, 105, 1411-1420, 20140901
  5. ★, Fasting Enhances TRAIL-Mediated Liver Natural Killer Cell Activity via HSP70 Upregulation, PLOS ONE, 9(10), 20141030
  6. Risk factors for surgical complications after D2 gastrectomy following neoadjuvant chemotherapy for gastric cancer., J Clin Oncol, 32(Suppl 3), abstr 164, 20140101
  7. ★, Induction of a Pathological Complete Response by Four Courses of Neoadjuvant Chemotherapy for Gastric Cancer: Early Results of the Randomized Phase II COMPASS Trial, ANNALS OF SURGICAL ONCOLOGY, 21(1), 213-219, 201401
  8. Low Creatinine Clearance is a Risk Factor for D2 Gastrectomy after Neoadjuvant Chemotherapy, ANNALS OF SURGICAL ONCOLOGY, 21(9), 3015-3022, 201409
  9. Accuracy of CT Staging of Locally Advanced Gastric Cancer after Neoadjuvant Chemotherapy: Cohort Evaluation within a Randomized Phase II Study, ANNALS OF SURGICAL ONCOLOGY, 21, 385-389, 201406
  10. ★, Postgastrectomy Syndrome Assessment Scale (PGSAS)-45 and Changes in Body Weight are Useful Tools for Evaluation of Reconstruction Methods Following Distal Gastrectomy, ANNALS OF SURGICAL ONCOLOGY, 21, 370-378, 201406
  11. ★, Double-blind, placebo-controlled, randomized phase II study of TJ-14 (hangeshashinto) for gastric cancer chemotherapy-induced oral mucositis, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 73(5), 1047-1054, 201405
  12. ★, The Usefulness of Preoperative 18FDG Positron-Emission Tomography and Computed Tomography for Predicting the Malignant Potential of Gastrointestinal Stromal Tumors, DIGESTIVE SURGERY, 31(2), 79-86, 2014
  13. ★, Addition of docetaxel to S-1 without platinum prolongs survival of patients with advanced gastric cancer: a randomized study (START), JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 140(2), 319-328, 201402
  14. A large esophageal gastrointestinal stromal tumor that was successfully resected after neoadjuvant imatinib treatment: case report, WORLD JOURNAL OF SURGICAL ONCOLOGY, 12, 20140227
  15. A case of gastric cancer following living donor liver transplantation., Hiroshima J Med Sci, 63, 23-26, 2014
  16. Assessment of postoperative quality of life following pylorus-preserving gastrectomy and Billroth-I distal gastrectomy in gastric cancer patients: results of the nationwide postgastrectomy syndrome assessment study, GASTRIC CANCER, 19(1), 302-311, 201601
  17. Specific Features of Dumping Syndrome after Various Types of Gastrectomy as Assessed by a Newly Developed Integrated Questionnaire, the PGSAS-45, DIGESTIVE SURGERY, 33(2), 94-103, 2016
  18. Intraoperative assessment of tissue oxygen saturation of the remnant stomach by near-infrared spectroscopy in two cases of pancreatectomy following gastrectomy, INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 22, 75-78, 2016
  19. Enhanced recovery program is safe and improves postoperative insulin resistance in gastrectomy, WORLD JOURNAL OF GASTROINTESTINAL SURGERY, 8(5), 382-388, 20160527
  20. Survival results of a randomised two-by-two factorial phase II trial comparing neoadjuvant chemotherapy with two and four courses of S-1 plus cisplatin (SC) and paclitaxel plus cisplatin (PC) followed by D2 gastrectomy for resectable advanced gastric cancer, EUROPEAN JOURNAL OF CANCER, 62, 103-111, 201607
  21. Feasibility and Safety of Transhiatal Approach and D2 Total Gastrectomy after Neoadjuvant Chemotherapy for Adenocarcinoma of the Esophago-Gastric Junction: A Subset Analysis of the COMPASS Trial, DIGESTIVE SURGERY, 33(5), 424-430, 2016
  22. Laparoscopic Repair and Percutaneous Endoscopic Gastrostomy to Treat Giant Esophageal Hiatal Hernia with Gastric Obstruction: A Case Report., Hiroshima J Med Sci, 64(1-2), 27-30, 2015
  23. Assessment of postoperative quality of life following pylorus-preserving gastrectomy and Billroth-I distal gastrectomy in gastric cancer patients: results of the nationwide postgastrectomy syndrome assessment study., Gastric Cancer, 19(1), 302-311, 2015
  24. Intrahepatic cholangiocarcinoma coinciding with a liver metastasis from a rectal carcinoma: a case report, SURGICAL CASE REPORTS, 2, 20160909
  25. Overexpression of Transmembrane Protein BST2 is Associated with Poor Survival of Patients with Esophageal, Gastric, or Colorectal Cancer., Ann Surg Oncol
  26. Laparoscopic extra-abdominal suturing technique for the repair of Larrey's diaphragmatic hernia using the port closure needle (Endo Close(R)): A case report., Int J Surg Case Rep, 2016
  27. Possible role of soluble fibrin monomer complex after gastroenterological surgery, WORLD JOURNAL OF GASTROENTEROLOGY, 23(12), 2209-2216, 2017, 5, 28
  28. ★, Predictive factors for body weight loss and its impact on quality of life following gastrectomy, WORLD JOURNAL OF GASTROENTEROLOGY, 23(26), 4823-4830, 2017, 07, 14
  29. ★, Early results of a randomized two-by-two factorial phase II trial comparing neoadjuvant chemotherapy with two and four courses of cisplatin/S-1 and docetaxel/cisplatin/S-1 as neoadjuvant chemotherapy for locally advanced gastric cancer, ANNALS OF ONCOLOGY, 28(8), 1876-1881, 2017, 08
  30. PRESENT STATUS AND PROBLEMATIC POINTS OF DAY SURGERY OF BREAST CANCER, 60(9), 2283-2290, 19990925
  31. Kidney Metastasis of Resected Early Gastric Carcinoma : Report of a Case, 37(3), 248-250, 20070301
  32. A STUDY ON THE ADEQUATE EXTENT OF DISSECTION OF REGIONAL LYMPH NODES FOR t_2 AND t_3 GASTRIC CANCER, 60(12), 3088-3092, 19991225
  33. Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer, JOURNAL OF PATHOLOGY, 243(1), 100-110, 2017, 09
  34. A rare case of spontaneous rupture of an aneurysm of the right gastric artery, INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 40, 27-31, 2017
  35. The gastric carcinosarcoma with severe venous invasion: a case report, SURGICAL CASE REPORTS, 4, 20180130
  36. The long-term survival of stage IV gastric cancer patients with conversion therapy, GASTRIC CANCER, 21(2), 315-323, 201803
  37. Clinicopathological and Prognostic Significance of Epithelial Gremlin1 Expression in Gastric Cancer, ANTICANCER RESEARCH, 38(3), 1419-1425, 201803
  38. The clinical impact of Hangeshashinto (TJ-14) in the treatment of chemotherapy-induced oral mucositis in gastric cancer and colorectal cancer: Analyses of pooled data from two phase II randomized clinical trials (HANGESHA-G and HANGESHA-C), JOURNAL OF CANCER, 9(10), 1725-1730, 2018
  39. A phase II trial of capecitabine plus cisplatin (XP) for patients with advanced gastric cancer with early relapse after S-1 adjuvant therapy: XParTS-I trial, GASTRIC CANCER, 21(5), 811-818, 201809
  40. Revascularization for cavernous transformation radical lymphadenectomy in the treatment of gastric cancer: A case report., Int J Surg Case Rep, 50, 84-87, 2018
  41. Palliative surgery for advanced gastric cancer: Partial gastrectomy using the inverted laparoscopic and endoscopic cooperative surgery method., Int J Surg Case Rep, 50, 42-45, 2018
  42. A randomised phase II trial of capecitabine plus cisplatin versus S-1 plus cisplatin as a first-line treatment for advanced gastric cancer: Capecitabine plus cisplatin ascertainment versus S-1 plus cisplatin randomised PII trial (XParTS II)., Eur J Cancer, 101, 220-228, 2018
  43. Laparoscopic proximal gastrectomy with hinged double flap method using knotless barbed absorbable sutures: A case series., Int J Surg Case Rep, 51, 165-169, 2018
  44. A phase II trial of capecitabine plus cisplatin (XP) for patients with advanced gastric cancer with early relapse after S-1 adjuvant therapy: XParTS-I trial., Gastric Cancer, 21(5), 811-818, 2018

Invited Lecture, Oral Presentation, Poster Presentation

  1. A randomized phase II trial of capecitabine plus cisplatin (XP) versus S-1 plus cisplatin (SP) as a first-line treatment for advanced gastric cancer: XP ascertainment vs. SP randomized PII trial (XParTS II), Kobayashi M, Tanabe K et al., ASCO-GI, 2015/01/15, Without Invitation, English
  2. A randomized 2X2 phase II trial comparing two and four courses of S-1/cisplatin (SC) and paclitaxel/cisplatin (PC) as neoadjuvant chemotherapy for locally resectable advanced gastric cancer: Survival results of COMPASS., Yoshikawa T, Tanabe K et al., ASCO-GI, 2015, 2015/01/15, Without Invitation, English
  3. A phase II trial of capecitabine plus cisplatin (XP) for patients with advanced gastric cancer who relapsed after S-1 adjuvant therapy, XP after TS-1 adjuvant failure (XParTS)., Takahashi M, Tanabe K et al., ASCO-GI, 2015, 2015/01/15, Without Invitation, English

Awards

  1. 2015/11/13, Phoenix Outstanding Researcher Award, Hiroshima University