EisoHiyama

Last Updated :2019/10/01

Affiliations, Positions
Natural Science Center for Basic Research and Development, ., Professor
E-mail
eisohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Medical Doctor, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Pediatrics
  • Medicine,dentistry, and pharmacy;Clinical surgery;Pediatric surgery

Research Keywords

  • Digestive Organ
  • Immortalization
  • Cancer
  • Oncogene
  • Telomere
  • microarray
  • Oncogene
  • Neuroblastoma
  • Telomerase

Educational Activity

Course in Charge

  1. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  2. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  3. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  4. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  5. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  6. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  7. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  8. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  9. 2019, Graduate Education (Master's Program) , First Semester, Seminar on Life Science
  10. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on Life Science
  11. 2019, Graduate Education (Master's Program) , First Semester, Research on Life science
  12. 2019, Graduate Education (Master's Program) , Second Semester, Research on Life science
  13. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Life Science
  14. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Life Science
  15. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  16. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced research on Life Science
  17. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Life Science
  18. 2019, Graduate Education (Doctoral Program) , First Semester, Practice of Oncology
  19. 2019, Graduate Education (Master's Program) , First Semester, Seminar
  20. 2019, Graduate Education (Master's Program) , Second Semester, Seminar
  21. 2019, Graduate Education (Master's Program) , First Semester, Research
  22. 2019, Graduate Education (Master's Program) , Second Semester, Research
  23. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  24. 2019, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  25. 2019, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  26. 2019, Graduate Education (Doctoral Program) , 1Term, Practice of Oncology

Research Activities

Academic Papers

  1. Neoplastic transformation by TERT in FGF-2-expanded human mesenchymal stem cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 39(1), 5-11, 201107
  2. Telomerase activation without shortening of telomeric 3 '-overhang is a poor prognostic factor in human colorectal cancer, CANCER SCIENCE, 102(2), 330-335, 201102
  3. Impact of Intratumoral Thymidylate Synthase Expression on Prognosis After Surgical Resection for Ampullary Carcinoma, JOURNAL OF SURGICAL ONCOLOGY, 103(7), 663-668, 20110601
  4. New method for absolute spinal cord ischemia protection in rabbits, JOURNAL OF VASCULAR SURGERY, 54(4), 1109-1116, 201110
  5. Wnt signaling and telomerase activation of hepatoblastoma: correlation with chemosensitivity and surgical resectability, JOURNAL OF PEDIATRIC SURGERY, 46(12), 2221-2227, 201112
  6. Histological Loss of Pancreatic Exocrine Cells Correlates With Pancreatic Exocrine Function After Pancreatic Surgery, PANCREAS, 41(6), 928-933, 201208
  7. Prognostic Significance of Telomerase Activity and Human Telomerase Reverse Transcriptase Expression in Ampullary Carcinoma, ANNALS OF SURGICAL ONCOLOGY, 19(9), 3072-3080, 201209
  8. Telomerase in tumorigenesis and development of solid neoplasias., 13(13), 1515-1520, 19950901
  9. Cellular immortalization and telomerase, 14(4), 551-556, 19960401
  10. Telomerase and Human Diseases, 51(8), 1508-1511, 19960801
  11. Telomerase in Development and Differentiation, 51(11), 2255-2259, 19961101
  12. Telomerase -Detection of Telomerase Activity and Its Clinical Implication-, Biotherapy, 11(1), 67-74, 19970101
  13. Activation of Telomerase in Hematopoietic Progenitor Cells and Lymphocytes, 52(3), 379-384, 19970301
  14. Telomerase and Early Detection of Cancer, 23(1), 21-24, 19970101
  15. Telomere and Telomerase in Human Cancer, 24(2), 196-201, 19970101
  16. Telomerase Activity in Neuroblastoma, 29(3), 445-451, 19970301
  17. Telomerase activity in adult and childhood solid malignant tumors., Surgery Frontier, 4(1), 29-36, 19970401
  18. Telomerase activity as a novel marker of lung cancer, 56(5), 1253-1257, 19980501
  19. Application of telomerase inhibitors for gastrointestinal cancer therapy, 184(12), 907-911, 19980301
  20. Relationship between telomere length and clinical and biological characteristics of the cancer with telomerase reactivation, 56(5), 1139-1145, 19980501
  21. Advance of research on telomerase, 25(8), 1105-1110, 19980701
  22. Telomerae activity in cancers of digestive organs, 59(8), 911-916, 19970801
  23. Telomerase as a novel target for anticancer therapy, Molecular Medicine, 35(11), 1374-1382, 19981001
  24. N-myc gene amplification and other prognosis -associated factors in neuroblastoma, J. Pediatric Surgery, 19900401
  25. Neuroblastoma with DNA amplification and rearrangement in N-myc gene region, Cancer Research, 1946-1651, 19900401
  26. Immunohistochemical analysis of N-myc protein expression in neuroblastoma, Journal of Pediatric Surgery, 838-843, 19910401
  27. Length of telomeric in neuroblastoma, Japanese Journal of Cancer Research, 153-164, 19920401
  28. Length of telomeric repeats in neuroblastoma, Journal of Experimental Medicine, 205, 19930401
  29. Alteration of telomeric repeat length in adult and childhood neoplasias, INTERNATIONAL JOURNAL OF ONCOLOGY, 6, 13-16, 19950401
  30. Surgical management of tracheal ageuesis, Journal of thoracic cardiovascular Surgery, 108, 830-833, 19940401
  31. Alterations in telomeric repeat length in lung cancer are associated with loss of hererozygosity in p53 and Rb, Oncogene, 10, 937-944, 19950401
  32. Alteration of telomeric repear length in neuroblaetoma, Japanese Journal of Pediatrie Surgery, 27(5), 508-513, 19950401
  33. Alterations of telomere length in neuroblastoma., Journal of Experimental Medicine, 164, 205, 19930401
  34. pulmonary hyper tension with portal hypertension., Journal of Experimental Medicine, 164, 205, 19930401
  35. emergent CT scan for abdominal injury in children, Japanese Journal of Pediatric Surgery, 25, 38-45, 19930401
  36. Cancer-cell proliferation and alteration in length of telomeric repeats. Tiss., Cult. Res. Commun=, 12, 291-7, 19930401
  37. Treatments for MRSA infections in pediatric surgery, Journal of Clinical Surgery, 48, 759-66, 19930401
  38. Asepetic surgery in children, Medicament News, 1287, 2-7, 19930401
  39. Antibacterial therapy against surgical infections, Antibiotics and chemotherapy, 9, 2120-30, 19930401
  40. Postoperative infections and multiple organ failure, Surgery Frontier, 1, 29-36, 19940401
  41. Pseudomonas infections in surgical patients, 18, 19-22, 19940401
  42. Treatments for prevention of postoperative infections., Gastroenterological Surgery, 17, 19-25, 19940401
  43. Immarlodeficiency in elder patients and treatments for Surgical infection in these patients, Gastroenterological Surgery, 17, 1577-84, 19940401
  44. Bacterial translocation and multiple organ failure, 18, 259-63, 19940401
  45. trk A gene expression in neuroblastoma., Cancer, 76, 1085-6, 19950401
  46. Alteration in length of telomeric repeats in lung Cancer., Lung Cancer, 11, 29-41, 19940401
  47. Mac-1 expression and superoxide feneration of the peripheral polymorphonuclear leukocyte following gastrectomy and esophagectomy., Hiroshima Journal of Medical Science, 44, 39-46, 19950401
  48. Telomerase activity in small-cell and non-small-cell lung cancers., J ournal of the National Cancer Institute, 87, 895-902, 19950401
  49. Activation if telomerase in humar lymphocytes and hematopoietic progenitor cells., Journal of Immunology, 155, 3711-5, 19950401
  50. Advances in cytokine and anticytokine treatments for sepsis, with special reference to G-CSF replacement therapy., Current Opinion in Surgical Infection, 3, 91-8, 19950401
  51. Purulent liver abscess., The Japanese Journal of Clinical Medicine, 別冊, 39-42, 19950401
  52. telomeric repeat lengths and prognosis in heuroblastoma, Japanese Journal of Pediatric Surgery, 27, 508-13, 19950401
  53. Causatire organisms and toxins of peritonitis, Surgery, 57, 1388-91, 19950401
  54. Penicillins for surgical infections, 95, 56-60, 19950401
  55. G-CSF treatments for severe infections, Surgery Frontier, 2, 295-99, 19950401
  56. Telomerase activity in solid cancers., 13, 1515-20, 19950401
  57. SIRS in surgery, Gastroenterological Surgery, 18, 159-66, 19950401
  58. Basic cares of postoperative patients, Journal of Clinical Surgery, 50, 418-9, 19950401
  59. Activation of Telomerase in Hematopoietic Progenitor Cells and Lymphocytes, 52(3), 81-86, 19970401
  60. Telomere and telomerase in lung cancer for a new target of therapy., 86(1), 95-99, 19970401
  61. Telomerase in Development and Differentiation, 51(11), 117-121, 19960401
  62. Telomerase and Human Diseases, 51(8), 148-151, 19960401
  63. Telomerase activity in adult and Childhood Solid malignant tumors., Surgery Frontier, 4(1), 29-36, 19970401
  64. Telomere and telomerase in cancer, 24(2), 196-201, 19970401
  65. Cell immortalization and telomerase, 14(4), 551-556, 19960401
  66. Telomerase activity as a novel marker of lung cancer, 56(5), 1253-1257, 19980401
  67. Telomerase activity as a novel marker of lung cancer and immune-associated lung diseases., Int. J. Mol. Med., 1(3), 545-549, 19980401
  68. Telmerae activity in cancers of digestive organs, 59(8), 911-916, 19970401
  69. Relationship between telomere length and clinical and biological characteristics of the cancer with telomerase reactivation, 56(5), 1139-1145, 19980401
  70. Advance of research on telomerase, 25(8), 1105-1110, 19980401
  71. Telomerase activity in neuroblastoma : is it a prognostic indicator of clinical behaviour?, Eur. J. Cancer, 33(12), 1932-1936, 19970401
  72. Application of telomerase inhibitors for gastrointestinal cancer therapy, 184(12), 907-911, 19980401
  73. Telomere length for cancer diagnosis., 27(3), 245-254, 19980401
  74. Differential diagnosis of acute abdomen, Current Therapy, 17(4), 621-626, 19990401
  75. Application of telomerase for diagnosis and treatment of cancer, Surgery, 60(12), 1653-1658, 19980401
  76. Emerging of vancomycin resistant hospital strains-mechanism of vancomycin resistant expression, Surgery Frontier, 6(1), 49-53, 19990401
  77. Telomerase as a novel target for anticancer therapy, Molucular Medicine, 35(11), 1374-1382, 19980401
  78. Design and management for medical field, 75(10), 2104-2108, 19980401
  79. Surgical soft tissue infection-infected atheroma, perifollicaulitis(furuncle, furunculosis, carbuncle), cellulitis, Surgical Therapy, 79, 392-397, 19980401
  80. Age-related clanges in immune functions, 10(2), 111-117, 19980401
  81. Telomerase activity in human cancers, 6(6), 605-610, 19980401
  82. Administrations of prophylactic antibiotics for high risk patients, Surgery, 60(8), 870-875, 19980401
  83. Acute gastric mucosal lesion and bacterial translocation, 22(13), 1954-1958, 19980401
  84. Antibacterial treatment for infections by multidrug-resistant strains, Intersive & Critical Care Medicine, 10(11), 1177-1184, 19980401
  85. Expression of telomerase activity in human endometrium is localized to epithelial glandular cells and regulated in a merstrual phase-dependent manner correlated with cell proliferation., American Journal of Pathdogy, 153(6), 1985-1991, 19980401
  86. Telomerase activity in digesrive organ cancers, 22(12), 1783-1798, 19990401
  87. Surgical approaches for pancreatic ascits, Surgery Today, 29(4), 458-461, 19990401
  88. Genetic analysis with calcium-induced calcium release test in Japanese malignant hyperthermia susceptable(MHS)families, Hiroshima Journal of Medical Science, 48(1), 9-15, 19990401
  89. Preoperative diagnosis of early pancreatic caranoma with special attention to telomerase activity, 20(9), 765-769, 19990401
  90. Tolomere and telomerase in human lung cancer, 2(4), 485-492, 19990401
  91. Lack of CD44 variant 6 expression advanced extrahepatic bile duct/ampullary carcinoma, Cancer, 86(9), 1691-1699, 19990401
  92. Inhibitory Effect of Telomere-Mimic Phosphorothioate Oligodeoxy Nucleotides (SODNS) on Human Tumor Cell Lines, Orclogy, 57(Suppl.2), 27-36, 19990401
  93. Telomerase for cancer chiagnosis, 191(3), 227-228, 19990401
  94. Down-regulation of KAI1 messenger RNA expression is not associated with loss of heterozygosity of the KAI1gene region in lung adenocarcinoma., Japanese Journal of Cancer Resesrch, 90, 970-976, 19990401
  95. Chromosomal telomere and telomerase in lung asucer, 25(8), 1550-1553, 19990401
  96. Analysis of mec regulator genes in clinical methicillin-resistant Staphylococcus aureus isolates according to the production of coagulase,types of enterotoxin, and toxic shocl syndrome toxin-1., Hiroshima Journal of Medical Science, 48(2), 49-56, 19990401
  97. Interleukin-10 expression in intesine of Crohn disease, International Journal of Molecular Medicine, 5(3), 389-395, 20000401
  98. Generation of pro-inflammatory and anti-inflammatory cytokines in the gut in zymosaninduced peritonitis, Hirosima Journal of Medical Sciences, 49(1), 43-48, 20000401
  99. Telomerase activity in gastric cancer, Cancer Res., 55(15), 3258-3262, 19950801
  100. Correlating telomerase activity levels with human neuroblastoma outcomes, Nature Med, 1(3), 249-255, 19950301
  101. Progression of primary biliary cirrhosis after proctocolectomy for ulcerative colitis., J. Gastroenterol., 35(6), 870-872, 20000601
  102. High Telomerase Activity Is an Independent Prognostic Indicator of Poor Outcome in Colorectal Cancer., Clinical Cancer Research, 6(10), 2696-2701, 20001001
  103. Telomerase activity as a marker of breast carcinoma in fine-needle aspirated samples, Cancer Cytopathol, 90(4), 235-8, 20000801
  104. Multifocal neuroblastoma: biologic behavior and surgical aspects, Cancer, 88(8), 1955-63, 20000401
  105. Rapid detection of MYCN gene amplification and telomerase expression in neuroblastoma, Clin. Cancer Res., 5(3), 601-9, 19990501
  106. Telomerase activity as a novel marker of lung cancer and immune-associated lung diseases, Int. J. Mol. Med., 1(3), 545-549, 19980301
  107. Telomerase activity in rheumatoid synovium correlates with the mononuclear cell infiltration level and disease aggressiveness of rheumatoid arthritis, J.Rheumatol., 25(2), 214-220, 19980201
  108. Telomerase activity for the preoperative diagnosis of pancreatic cancer, J. Natl. Cancer Inst., 89(21), 1621-1623, 19971101
  109. Telomerase activity in neuroblastoma: is it a prognostic indicator of clinical behaviour?, Eur. J. Cancer, 33(12), 1932-36, 19970101
  110. Re: Telomerase activity in human breast tumors [letter], J. Natl. Cancer Inst., 88(12), 839-840, 19960901
  111. Alterations in telomeric repeat length in lung cancer are associated with loss of heterozygosity in p53 and Rb, Oncogene, 10(5), 937-944, 19950301
  112. Alteration of telomeric repeat length in adult and childhood solid neoplasias, Int J Oncol, 6(1), 13-16, 19950101
  113. N-myc gene amplification and other prognosis-associated factors in neuroblastoma, J Pediatr Surg, 25(10), 1095-1099, 19901001
  114. Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma, Clin. Cancer Res., 7(4), 901-8., 20010401
  115. Kupffer cell function in ischemic and nonischemic livers after hepatic partial ischemia/reperfusion, Surgery Today, 31(2), 140-148, 20010401
  116. Differential diagnosis of Th1/Th2-response by T-cell and monocyte function between sepsis and non-infectious SIRS via fowcytometry, Critical Care, 5(S1), S28, 20010301
  117. Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues, Neoplasia, 3(1), 17-26, 20010201
  118. Biological characteristics of neuroblastoma with partial deletion in the short arm of chromosome 1, Medical and Pediatric Oncology, 36(1), 67-74, 20010101
  119. Telomerase activity as a marker of breast carcinoma in fine-needle aspirated samples, Cancer, 90(4), 235-238, 20000801
  120. Multifocal Neuroblastoma: Biological Features and Surgical Aspects, Cancer, 88(8), 1955-1963, 20000801
  121. High Telomerase Activity Is an Independent Prognostic Indicator of Poor Outcome in Colorectal Cancer, Clinical Cancer Research, 6, 2696-2701, 20000701
  122. Allelotype and loss of heterozygosity around the L-myc gene locus in primary lung cancers, Lung Cancer, 28, 117-125, 20000501
  123. Interleukin-10 expression in intestine of Crohn disease, International Journal of Molecular Medicine, 5(2), 389-395, 20000401
  124. Progression of primary biliary cirrhosis after proctocolectomy for ulcerative colitis, J. Gastroenterol., 35, 870-872, 20001101
  125. Down-regulation of KAI1 messenger RNA expression is not associated with loss of heterozygosity of hte KAI1 gene region in lung adenocarcinoma, Jpn.J.Cancer Res., 90, 970-976, 19990901
  126. Surgical approaches for pancreatic ascites: report of three cases, Surg Today, 29, 458-461, 19990501
  127. An additional dose of cefazolin for intraoperative prophylaxis, Surgery Today, 29, 1233-1236, 19991201
  128. Lack of CD44 variant 6 expression in advanced extrahepatic bile duct/ampullary carcinoma., Cancer, 86(9), 1691-1699, 19991101
  129. Genetic analysis with calcium-induced calcium release test in Japanese malignant hyperthermia susceptable (MHS) families, Hiroshima J. Med. Sci., 48(1), 9-15, 19990301
  130. Rapid detection of MYCN gene amplification and telomerase expression in neuroblastoma, Clinical Cancer Research, 5, 601-609, 19990301
  131. Analysis of mec regulator genes in clinical methicillin-resistant Staphylococcus aureus isolates according to the production of coagulase types of enterotoxin and toxic shock syndrome toxin-1., Hiroshima J. Med. Sci., 48(2), 49-56, 19990101
  132. Inhibitory Effect of Telomere-Mimic Phosphorothioate Oligodeoxy Nucleotides (S-ODNS) on Human Tumor Cell Lines., Oncology, 57(Suppl 2), 27-36, 19990101
  133. Expression of telomerase activity in human endometrium is localized to epithelial glandular cells and regulated in a menstrual phase-dependent manner correlated with cell proliferation, American Journal Pathology, 153(6), 1985-1991, 19981201
  134. Age-dependent telomerase shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress, Life Science, 63(11), 935-948, 19981101
  135. Telomerase activity as a novel marker of lung cancer and immune-associated lung diseases, International Journal of Molecular Medicine, 1, 545-549, 19980301
  136. Telomerase activity in rheumatoid synovium correlates with mononuclear cell infiltration level and disease aggressiveness of rheymatoid arthritis, Journal of Rheumatology, 25, 214-220, 19980201
  137. Postoperative enteritis caused by methicillin-resistant Sthaphylococcus aureus, Surgery Today, 27, 816-825, 19970901
  138. Clinical investigation of neuroblastoma with partial deletion in the short arm of chromosome 1, Clinical Cancer Research, 3, 1221-1228, 19970701
  139. Telomerase activity for the preoperative diganosis of pancreatic cancer, J ournal of the National Cancer Institute, 89(21), 1621-1623, 19971101
  140. Telomerase activity is detected in pancreatic cancer but not in benign tumors, Cancer Research, 57, 326-331, 19970101
  141. Telomerase activity in neuroblastoma: is it a prognostic indicator of clinical behavior, European Journal of Control, 33(12), 1932-1936, 19970101
  142. Telomerase activity in human intestine, INTERNATIONAL JOURNAL OF ONCOLOGY, 9, 453-458, 19960901
  143. Telomerase activity in human breast tumors, Journal of National Cancer Institute, 88(2), 116-122, 19960101
  144. trk A gene expression in neuroblastoma, Cancer, 76, 1086-1095, 19950901
  145. Severity and predicted outcome of postoperative Pseudomonas aeruginosa infections, Surgery Today, 25, 672-678, 19950801
  146. Telomerase activity in gastric cancer, Cancer Research, 55(8), 3258-3262, 19950801
  147. Mac-1 expression and superoxide generation of the peripheral polymorphonuclear leukocyte following gastrectomy and esophagectomy, Hiroshima Journal of Medical Science, 44(2), 39-46, 19950601
  148. Telomerase activity in small-cell and non-small-cell lung cancers, J ournal of the National Cancer Institute, 87(12), 895-902, 19950601
  149. Alterations in telomeric repeat length in lung cancer are associated with loss of heterozygosity in p53 and Rb, Oncogene, 10, 937-944, 19950301
  150. Correlating telomerase activity levels with human neuroblastoma outcomes, Nature Medicine, 1(3), 249-255, 19950301
  151. Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP), Method in Cell Science, 17, 1-15, 19950101
  152. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells, Jouranl of Immunology, 155, 3711-3715, 19950101
  153. Alteration of telomeric repeat length in adult and childhood solid neoplasias, INTERNATIONAL JOURNAL OF ONCOLOGY, 6(1), 13-16, 19950101
  154. Poor outcome in patients with advanced stage neuroblastoma and coincident opsomyoclonus syndrome, Cancer, 74(6), 1824-1826, 19940901
  155. Alteration in length of telomeric repeats in lung cancer, Lung Cancer, 11, 29-41, 19940701
  156. Prognositic Prediction in Neuroblastomas: Clinical significance of combined Analysis for Ha-ras p21 expression and N-myc gene amplification, Cancer Detection and Prevention, 18(4), 283-289, 19940401
  157. Surgical management of tracheal agenesis, The Japanese Journal of Thoracic and Cardiovascular Surgery, 108(11), 830-833, 19941101
  158. Generation of pro-inflammatory and anti-inflammatory cytokines in the gut in zymosan-induced peritonitis, Hiroshima Journal of Medical Science, 49(1), 43-48, 20000301
  159. Long-term survival of peripheral intrahepatic cholangiocarcinoma with metastasis to the para-aortic lymph nodes., Surgery, 126, 105-106, 20000101
  160. Length of telomeric repeats in neuroblastoma: correlation with prognosis and other biological characteristics, Japanese Journal of Cancer Resesrch, 83(2), 159-164, 19920201
  161. Immunohistochemical analysis of N-myc protein expression in neuroblastoma: Correlation with prognosis of patients, J Pediatr Surg, 26(7), 838-843, 19910701
  162. CHARGE association with neuroblastoma, Pediatric Surgery, 5(4), 463-465, 19900401
  163. N-myc gene amplification and other prognosis-associated factors in neuroblastoma, J Pediatr Surg, 25(10), 1095-1099, 19900101
  164. Impending gastric rupture in a neonate with gastric outlet obstruction due to malrotation, Hiroshima Journal of Medical Science, 35, 105-107, 19860601
  165. VIP-producing neruogenic tumors in children: Two case report, Hirosima Journal of Medical Sciences, 33(3), 393-396, 19840901
  166. A case report of postradiation sarcoma, Hiroshima Journal of Mediacal Science, 33(2), 247-250, 19840601
  167. Poor Outcome in Patients with Advanced Stage Neuroblastoma and Coincident Opsomyoclonus Syndrome, Cancer, 74(6), 1821-1826, 19940601
  168. Surgical approachs for pancreatic ascites: report of three cases, Surgery Today, 29(5), 458-461, 19990501
  169. Multifocal Neuroblastoma, Cancer, 88(8), 1955, 20000801
  170. Alterations in telomeric repeat length in lung cancer are associated with loss of heterozygosity in p53 and Rb, Oncogene, 10, 937-944, 19950101
  171. Telomerase and cancer, Human molecular genetics, ?677-685, 20010401
  172. Clinical utility of telomerase in cancer, Oncogene, in press, 20011201
  173. Experience with Internatiional Neuroblastoma Staging Systemand Pathology Classification., British Journal of Cancer, 86, 1110-1116, 20021001
  174. High-dose chemotherapy in children with metastatic hepatoblastoma, Pediatric International, 44, 300-305, 20020401
  175. Detection of telomerase activity in lung cancer tissues, Humana Press, 1(1), 403-414, 20031001
  176. Differential gene expression profiles between neuroblastomas with high telomerase activity and low telomerase activity, J Pediatr Surg, 38(12), 1730-1734, 20031201
  177. Fluorescent-based BAT-26 analysis for distinct screening of microsatellite instability in colorectal cancers, Int J Oncol, 22, 807-813, 20030801
  178. Relevance of antimicrobial agent-induced endotoxin release from in vitro cultured Escherichia coli and in vivo experimental infection with Gram-negative bacilli, Int J Antimicrob Agents, 21, 463-470, 20030401
  179. Comparative analysis of K-ras point mutation, telomerase activity, and p53 overexpression in pancreatic tumours, Oncol.Rep., 10, 177-283, 20030301
  180. Telomerase as tumor marker., Cancer lett., 194, 221-233, 20030601
  181. Differential gene expressions during immortalization of normal human fibroblasts and endothelial cells transfected with human telomerase reverse transcriptase gene., Int J Oncol, 24, 1435-1442, 20040801
  182. Clinical surveillance of surgical imipenem-resistant Pseudomonas aeruginosa infection in a Japanese hospital., J Hosp Infect, 56(2), 111-118, 20040201
  183. Systemic inflammatory response syndrome (SIRS) as a predictor of strangulated small bowel obstruction., Hepatogastroenterology, 51, 1393-1396, 20040701
  184. An evaluation of laparoscopic cholecystectomy after selective percutaneous transhepatic gallbladder drainage for acute cholecystitis., Gastrointest Endosc, 53, 839-844, 20040901
  185. Expression profiling and differential screening between hepatoblastomas the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastoma, Oncogene, 23, 5901-5911, 20040901
  186. Slow-down of age-dependent telomere shortening is executed in human skin keratinocytes by hormesis-like-effects of trace hydrogen peroxide or by anti-oxidative effects of pro-vitamin C in common concurrently with reduction of intracellular oxidative stress., J. Cell. Biochem., 59(6), 588-592, 20040801
  187. High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma., Br J Cancer, 91, 972-979, 20040501
  188. Expression profiling of favorable and unfavorable neuroblastomas, Pediatr Surg Int, 20(1), 33-38, 20040101
  189. Expression profiling of favorable and unfavorable neuroblastomas., Pediatr Surg Int, 20, 33-38, 20040101
  190. Differential gene expression profiles between neuroblastomas with high telomerase activity and low telomerase activity., J Pediatr Surg, 38(12), 1730-1734, 20031201
  191. Differential gene expressions during immortalization of normal human fibroblasts and endothelial cells transfected with human telomerase reverse transcriptase gene., Int J Oncol, 24(6), 1435-1442, 20040601
  192. Telomerase expression in noncancerous bronchial epithelia is a possible marker of early development of lung cancer., Cancer Res., 65(21), 9623-9627, 20050401
  193. Telomerase expression in non-cancerous bronchial epithelia is a possible marker of early development of lung cancer, Cancer Research, 65(21), 1-5, 20051101
  194. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, Oncol. Rep., 17(4), 871-878, 20070401
  195. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, Oncol. Rep., 17(6), 1405-1411, 20070601
  196. Selection of a novel drug-response predictor in esophageal cancer: A novel screening method using microarray and identification of IFITMI as a potent marker gene of CDDP response, Int. J. Oncol., 32(2), 413-423, 20080201
  197. Telomere and telomerase in stem cells, Br. J. Cancer, 96(7), 1020-4, 20070401
  198. A mathematical model for affymetrix genechip probe level data, JP Journal of Biostatics, 1(3), 1431-1438, 20071101
  199. Clinical surveillance of surgical imipenem-resistant Pseudomonas aeruginosa infection in a Japanese hospital., Journal of Hospital Infection, 56, 111-118, 20040401
  200. Expression profiling of favorable and unfavorable neuroblastomas., Pediatr Surg Int, 20, 33-38, 20040401
  201. Hepatic regeneration promotes engraftment of intraportally transplanted islet cells., Surgery, 137, 612-619, 20050401
  202. Hepatic regeneration promotes engraftment of intraportally transplanted islet cells., surgery, 612-619, 20050601
  203. Intracellular cytokine patterns of peripheral blood T cells as a useful indicator of activeness of Crohn's disease., Hiroshima J Med Sci, 1-8, 20050301
  204. Attenuation of telomerase activity by hammerhead ribozymes targeting human telomerase RNA and telomerase reverse transcriptase in pancreatic carcinoma cells., Hiroshima J Med Sci, 21-27, 20050301
  205. Slow-down of age-dependent telomere shortening is executed in human skin keratinocytes by hormesis-like-effects of trace hydrogen peroxide or by anti-oxidative effects of pro-vitamin C in common concurrently with reduction of intracellular oxidativestress., J Cell Biochem, 588-597, 20041001
  206. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas., Oncogene, 23, 5901-5911, 20040801
  207. Systemic inflammatory response syndrome (SIRS) as a predictor of strangulated small bowel obstruction., Hepatogastroenterology, 51, 1393-1396, 20041001
  208. Laparoscopic and open approach in perforated peptic ulcer., Hepatogastroenterology, 51, 1536-1539, 20040901
  209. An evaluation of laparoscopic cholecystectomy after selective percutaneous transhepatic gallbladder drainage for acute cholecystitis., Gastrointest Endosc, 59, 839-844, 20040601
  210. Differential gene expressions during immortalization of normal human fibroblasts and endothelial cells transfected with human telomerase reverse transcriptase gene., Int J Oncol, 24, 1435-1442, 20041201
  211. High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma., Br J Cancer, 91, 972-979, 20040801
  212. Postradiation malignant fibrous histiocytoma and osteosarcoma of a patient with high telomerase activities 25:2951-2955, Anticancer Res, 25, 2951-2955, 20050101
  213. Postradiation malignant fibrous histiocytoma and osteosarcoma of a patient with high telomerase activities, Anticancer Res, 25, 2951-2955, 20050701
  214. Molecular epidemiology of enteritis-causing methicillin-resistant Staphylococcus aureus, J Hosp Infect, 62, 37-43, 20060101
  215. Telomerase expression in noncancerous bronchial epithelia is a possible marker of early development of lung cancer, Cancer Res, 65(21), 9623-9627, 20051101
  216. Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors, Oncology Reports, 15, 551-556, 20060101
  217. Molecular and biological heterogeneity in neuroblastoma, Current Genomi, 3, 319-332, 20050301
  218. Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers, Mol Cancer Ther, 5(3), 767-775, 20060301
  219. Chemosensitivity prediction in esophageal squamous cell carcinoma: Novel marker genes and efficacy-prediction formulae using their expression data, Int J Oncol, 28, 1153-1162, 20060501
  220. Pretreatment and one-shot separating analysis of whole catecholamine metabolites in plasma by using LC/MS, Anal Bioanal Chem, 385, 814-820, 20060701
  221. MYCN gene amplification is a powerful prognostic factor even in infantile neuroblastoma detected by mass screening, Br J Cancer, 94, 1510-1515, 20060502
  222. Single nucleotide polymorphism array analysis to predict clinical outcome in neuroblastoma patients, J Pediatr Surg, 41, 2032-2036, 20061201
  223. Possibility of selection of chondrogenic progenitor cells by telomere length in FGF-2-expanded mesenchymal stromal cells, Cell Prolif, 39, 575-584, 20060101
  224. [Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between April 2003 and March 2004], Jpn J Antibiot, 59, 72-116, 20060401
  225. Reciprocal expression of CCAAT/enhancer binding proteins alpha and beta in hepatoblastomas and its prognostic significance, Oncol Rep, 17, 341-344, 20070201
  226. Telomere and telomerase in stem cells, British Journal of Cancer, 96, 1020-1024, 20070401
  227. Telomere length and telomerase activity in extra-abdominal desmoid tumors, Anticancer Res, 27, 411-415, 20070101
  228. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, Oncology Reports, 17, 871-878, 20070401
  229. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, Oncology Reports, 17, 1405-1411, 20070601
  230. High-dose chemotherapy in children with metastatic hepatoblastoma., Pediatrics International, 44, 300-305, 20020301
  231. Single nucleotide polymorphism array analysis to predict clinical outcome in neuroblastoma patients, Journal of Pediatric Surgery, 41(12), 2032-2036, 20061201
  232. Telomerase detection in the diagnosis and prognosis of cancer, Cytotechnology, 45(1-2), 64-74, 20040601
  233. Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts., Exp Lung Res, 34(7), 373-390, 20080901
  234. Human mismatch repair gene, MLH1, is transcriptionally repressed by hypoxia-inducible transcription factors, DEC1 and DEC2., Oncogene, 27(30), 4200-4209, 20080701
  235. EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma., Cancer Letters, 274(2009), 25-32, 20090201
  236. Effectiveness of screening for neuroblastoma at 6 months of age: a retrospective population-based cohort study, The Lancet, 371, 1173-1180, 20080401
  237. EMP3 as a candidate tumor suppressor gene for solid tumors., Expert Opin. Ther. Targets., 13(7), 811-822, 20090701
  238. Detection of island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array., Pediatr Blood Cancer, 52(7), 777-783, 20090701
  239. Telomere biology in neuroblastoma: telomere binding proteins and alternative strengthening of telomeres., Eur.J.Pediatric, 44(12), 2258-2266, 20091201
  240. Surgical intervention for patent ductus venosus., Pediatric Surgery Int, 26(10), 2010, 20101001
  241. Surgical intervention for patent ductus venosus., Pediatric Surgery Int, 26(10), 1025-1030, 20101001
  242. A robust method for estimating gene expression states using Affymetrix microarray probe level data, BMC Bioinformatics, 11, 20100401
  243. Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between April 2009 and March 2010, The Japanese Journal of Antibiotics, 64(3), 125-69, 20110601
  244. EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma, Cancer Lett, 274(1), 25-32, 20090201
  245. Long-term survival of peripheral intrahepatic cholangiocarcinoma with metastasis to the para-aortic lymph nodes, SURGERY, 127(1), 105-106, 200001
  246. Interleukin-10 expression in intestine of Crohn disease, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 5(4), 389-395, 200004
  247. Multifocal neuroblastoma - Biologic behavior and surgical aspects, CANCER, 88(8), 1955-1963, 20000415
  248. Allelotype and loss of heterozygosity around the L-myc gene locus in primary lung cancers, LUNG CANCER, 28(2), 117-125, 200005
  249. Biological characteristics of neuroblastoma with partial deletion in the short arm of chromosome 1, MEDICAL AND PEDIATRIC ONCOLOGY, 36(1), 67-74, 200101
  250. High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer, CLINICAL CANCER RESEARCH, 6(7), 2696-2701, 200007
  251. Telomerase activity as a marker of breast carcinoma in fine-needle aspirated samples, CANCER CYTOPATHOLOGY, 90(4), 235-238, 20000825
  252. Progression of primary biliary cirrhosis after proctocolectomy for ulcerative colitis, JOURNAL OF GASTROENTEROLOGY, 35(11), 870-872, 200011
  253. Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues, NEOPLASIA, 3(1), 17-26, 2001
  254. Kupffer cell function in ischemic and nonischemic livers after hepatic partial ischemia/reperfusion, SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 31(2), 140-148, 2001
  255. Telomerase and cancer, HUMAN MOLECULAR GENETICS, 10(7), 677-685, 200104
  256. Clinical utility of telomerase in cancer, ONCOGENE, 21(4), 643-649, 20020121
  257. High-dose chemotherapy in children with metastatic hepatoblastoma, PEDIATRICS INTERNATIONAL, 44(3), 300-305, 200206
  258. Fluorescent-based BAT-26 analysis for distinct screening of microsatellite instability in colorectal cancers, INTERNATIONAL JOURNAL OF ONCOLOGY, 22(4), 807-813, 200304
  259. Successful pre-operative diagnosis of malignant intraductal papillary mucinous tumor of the pancreas by detecting telomerase activity, JOURNAL OF GASTROINTESTINAL CANCER, 31(1-3), 117-121, 2002
  260. Comparative analysis of K-ras point mutation, telomerase activity, and p53 overexpression in pancreatic tumours, ONCOLOGY REPORTS, 10(2), 277-283, 2003
  261. Relevance of antimicrobial agent-induced endotoxin release from in vitro cultured Escherichia coli and in vivo experimental infection with Gram-negative bacilli, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 21(5), 463-470, 200305
  262. Telomerase as tumor marker, CANCER LETTERS, 194(2), 221-233, 20030515
  263. Differential gene expression profiles between neuroblastomas with high telomerase activity and low telomerase activity, JOURNAL OF PEDIATRIC SURGERY, 38(12), 1730-1734, 200312
  264. Clinical surveillance of surgical imipenem-resistant Pseudomonas aeruginosa infection in a Japanese hospital, JOURNAL OF HOSPITAL INFECTION, 56(2), 111-118, 200402
  265. Expression profiling of favorable and unfavorable neuroblastomas, PEDIATRIC SURGERY INTERNATIONAL, 20(1), 33-38, 200401
  266. Differential gene expressions during immortalization of normal human fibroblasts and endothelial cells transfected with human telomerase reverse transcriptase gene, INTERNATIONAL JOURNAL OF ONCOLOGY, 24(6), 1435-1442, 200406
  267. An evaluation of laparoscopic cholecystectomy after selective percutaneous transhepatic gallbladder drainage for acute cholecystitis, GASTROINTESTINAL ENDOSCOPY, 59(7), 839-844, 200406
  268. Systemic Inflammatory Response syndrome (SIRS) as a predictor of strangulated small bowel obstruction, HEPATO-GASTROENTEROLOGY, 51(59), 1393-1396, 2004
  269. Laparoscopic and open approach in perforated peptic ulcer, HEPATO-GASTROENTEROLOGY, 51(59), 1536-1539, 2004
  270. High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma, BRITISH JOURNAL OF CANCER, 91(5), 972-979, 20040831
  271. Slow-down of age-dependent telomere shortening is executed in human skin keratinocytes by hormesis-like-effects of trace hydrogen peroxide or by anti-oxidative effects of pro-vitamin C in common concurrently with reduction of intracellular oxidative stress, JOURNAL OF CELLULAR BIOCHEMISTRY, 93(3), 588-597, 20041015
  272. Telomerase detection in the diagnosis and prognosis of cancer, CYTOTECHNOLOGY, 45(1-2), 61-74, 200401
  273. Hepatic regeneration promotes engraftment of intraportally transplanted islet cells, SURGERY, 137(6), 612-619, 200506
  274. Postradiation malignant fibrous histiocytoma and osteosarcoma of a patient, with high telomerase activities, ANTICANCER RESEARCH, 25(4), 2951-2955, 2005
  275. Molecular and biological heterogeneity in neuroblastoma, CURRENT GENOMICS, 6(5), 319-332, 200508
  276. Telomerase expression in noncancerous bronchial epithelia is a possible marker of early development of lung cancer, CANCER RESEARCH, 65(21), 9623-9627, 20051101
  277. Molecular epidemiology of enteritis-causing methicillin-resistant Staphylococcus aureus, JOURNAL OF HOSPITAL INFECTION, 62(1), 37-43, 200601
  278. Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors, ONCOLOGY REPORTS, 15(3), 551-556, 200603
  279. Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers, MOLECULAR CANCER THERAPEUTICS, 5(3), 767-775, 200603
  280. Chemosensitivity prediction in esophageal squamous cell carcinoma: Novel marker genes and efficacy-prediction formulae using their expression data, INTERNATIONAL JOURNAL OF ONCOLOGY, 28(5), 1153-1162, 200605
  281. MYCN gene amplification is a powerful prognostic factor even in infantile neuroblastoma detected by mass screening, BRITISH JOURNAL OF CANCER, 94(10), 1510-1515, 20060522
  282. Pretreatment and one-shot separating analysis of whole catecholamine metabolites in plasma by using LC/MS, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 385(5), 814-820, 200607
  283. Telomere and telomerase in stem cells, BRITISH JOURNAL OF CANCER, 96(7), 1020-1024, 20070410
  284. Telomere length and telomerase activity in extra-abdominal desmoid tumors, ANTICANCER RESEARCH, 27(1A), 411-415, 2007
  285. EGFR activating aberration occurs independently of other genetic aberrations or telomerase activation in adenocarcinoma of the lung, ONCOLOGY REPORTS, 17(6), 1405-1411, 200706
  286. Possibility of selection of chondrogenic progenitor cells by telomere length in FGF-2-expanded mesenchymal stromal cells, CELL PROLIFERATION, 39(6), 575-584, 200612
  287. Single nucleotide polymorphism array analysis to predict clinical outcome in neuroblastoma patients, JOURNAL OF PEDIATRIC SURGERY, 41(12), 2032-2036, 200612
  288. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, ONCOLOGY REPORTS, 17(4), 871-878, 200704
  289. Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fibroblasts derived from exon 2-specific knockout mice, GENES TO CELLS, 13(2), 145-157, 200802
  290. Telomerase activity in giant cell tumors of bone, ANNALS OF SURGICAL ONCOLOGY, 14(10), 2896-2902, 200710
  291. Heterogeneous subgroups in human neuroblastoma for clinically relevant risk stratification, PEDIATRIC SURGERY INTERNATIONAL, 23(11), 1051-1058, 200711
  292. Detection of human telomerase reverse transcriptase (hTERT) expression in tissue and pancreatic juice from pancreatic cancer, SURGERY, 143(1), 113-125, 200801
  293. Telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas, JOURNAL OF GASTROINTESTINAL SURGERY, 12(1), 17-28, 200801
  294. Selection of a novel drug-response predictor in esophageal cancer: A novel screening method using microarray and identification of IFITM1 as a potent marker gene of CDDP response, INTERNATIONAL JOURNAL OF ONCOLOGY, 32(2), 413-423, 200802
  295. Mixed ductal-endocrine carcinoma derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreas identified by human telomerase reverse transcriptase (hTERT) expression, JOURNAL OF SURGICAL ONCOLOGY, 97(5), 469-475, 20080401
  296. Effectiveness of screening for neuroblastoma at 6 months of age: a retrospective population-based cohort study, LANCET, 371(9619), 1173-1180, 20080405
  297. Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2, ONCOGENE, 27(30), 4200-4209, 200807
  298. Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts, EXPERIMENTAL LUNG RESEARCH, 34(7), 373-390, 2008
  299. Evaluation of genes identified by microarray analysis in favorable neuroblastoma, PEDIATRIC SURGERY INTERNATIONAL, 25(11), 931-937, 200911
  300. EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma, CANCER LETTERS, 274(1), 25-32, 20090208
  301. Telomere-Maintenance Mechanisms in Soft-Tissue Malignant Fibrous Histiocytomas, JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 91A(4), 928-937, 200904
  302. Detection of CpG Island Hypermethylation of Caspase-8 in Neuroblastoma Using an Oligonucleotide Array, PEDIATRIC BLOOD & CANCER, 52(7), 777-783, 20090701
  303. Consensus criteria for sensitive detection of minimal neuroblastoma cells in bone marrow, blood and stem cell preparations by immunocytology and QRT-PCR: recommendations by the International Neuroblastoma Risk Group Task Force, BRITISH JOURNAL OF CANCER, 100(10), 1627-1637, 20090512
  304. Changes in the agr Locus Affect Enteritis Caused by Methicillin-Resistant Staphylococcus aureus, JOURNAL OF CLINICAL MICROBIOLOGY, 47(5), 1528-1535, 200905
  305. EMP3 as a candidate tumor suppressor gene for solid tumors, EXPERT OPINION ON THERAPEUTIC TARGETS, 13(7), 811-822, 200907
  306. Usefulness of Human Telomerase Reverse Transcriptase in Pancreatic Juice as a Biomarker of Pancreatic Malignancy, PANCREAS, 38(5), 527-533, 200907
  307. Preimplantation Development of Somatic Cell Cloned Embryos in the Common Marmoset (Callithrix jacchus), CLONING AND STEM CELLS, 11(4), 575-583, 200912
  308. Carcinogenesis and cellular immortalization without persistent inactivation of p16/Rb pathway in lung cancer, INTERNATIONAL JOURNAL OF ONCOLOGY, 36(5), 1217-1227, 201005
  309. Telomere biology in neuroblastoma: telomere binding proteins and alternative strengthening of telomeres, JOURNAL OF PEDIATRIC SURGERY, 44(12), 2258-2266, 200912
  310. Telomere Maintenance as Therapeutic Target in Embryonal Tumours, ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 10(3), 196-212, 201003
  311. A robust method for estimating gene expression states using Affymetrix microarray probe level data, BMC BIOINFORMATICS, 11, 20100412
  312. Surgical intervention for patent ductus venosus, PEDIATRIC SURGERY INTERNATIONAL, 26(10), 1025-1030, 201010
  313. Edaravone, a Free Radical Scavenger, Promotes Engraftment of Intraportally Transplanted Islet Cells, PANCREAS, 40(1), 126-130, 201101
  314. Outcome of hepatoblastomas treated using the Japanese Study Group for Pediatric Liver Tumor (JPLT) protocol-2: report from the JPLT, PEDIATRIC SURGERY INTERNATIONAL, 27(1), 1-8, 201101
  315. Establishment of ES Cells from Inbred Strain Mice by Dual Inhibition (2i), JOURNAL OF REPRODUCTION AND DEVELOPMENT, 58(1), 77-83, 201202
  316. Is the prognosis of stage 4s neuroblastoma in patients 12 months of age and older really excellent?, EUROPEAN JOURNAL OF CANCER, 48(11), 1707-1712, 201207
  317. Clinical feature of anaplastic lymphoma kinase-mutated neuroblastoma, JOURNAL OF PEDIATRIC SURGERY, 47(10), 1789-1796, 201210
  318. A cisplatin plus pirarubicin-based JPLT2 chemotherapy for hepatoblastoma: experience and future of the Japanese Study Group for Pediatric Liver Tumor (JPLT), PEDIATRIC SURGERY INTERNATIONAL, 29(10), 1071-1075, 201310
  319. Detection of MYCN amplification using blood plasma: noninvasive therapy evaluation and prediction of prognosis in neuroblastoma, PEDIATRIC SURGERY INTERNATIONAL, 29(11), 1139-1145, 201311
  320. Hepatoblastoma state of the art: pathology, genetics, risk stratification, and chemotherapy, CURRENT OPINION IN PEDIATRICS, 26(1), 19-28, 201402
  321. Characterization of common marmoset (Callithrix jacchus) bone marrow-derived mesenchymal stem cells, FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, 51(4), 292-299, 2013
  322. Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium, MODERN PATHOLOGY, 27(3), 472-491, 201403
  323. FAST-id system for enrichment of cells with TALEN-induced mutations and large deletions, GENES TO CELLS, 19(5), 419-431, 201405
  324. Clinical features of ATRX or DAXX mutated neuroblastoma, JOURNAL OF PEDIATRIC SURGERY, 49(12), 1835-1838, 201412
  325. Balloon-occluded retrograde transvenous obliteration successfully performed for a large gastric varix in combination with temporary occlusion of the splenic artery in a child, ACTA RADIOLOGICA OPEN, 4(3), 201503
  326. Embolization therapy for bleeding from jejunal loop varices due to extrahepatic portal vein obstruction, MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES, 25(1), 57-61, 20160102
  327. The (C)under-barhildren's (H)under-barepatic tumors (I)under-barnternational (C)under-barollaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model, EUROPEAN JOURNAL OF CANCER, 52, 92-101, 201601
  328. Direct Lipido-Metabolomics of Single Floating Cells for Analysis of Circulating Tumor Cells by Live Single-cell Mass Spectrometry, ANALYTICAL SCIENCES, 31(12), 1215-1217, 201512
  329. Circulating free DNA as non-invasive diagnostic biomarker for childhood solid tumors, JOURNAL OF PEDIATRIC SURGERY, 50(12), 2094-2097, 201512
  330. Mortality and morbidity in primarily resected hepatoblastomas in Japan: Experience of the JPLT (Japanese Study Group for Pediatric Liver Tumor) trials, JOURNAL OF PEDIATRIC SURGERY, 50(12), 2098-2101, 201512
  331. Nerve Growth Factor Expression Is Not Associated with Perineural Invasion in Extrahepatic Cholangiocarcinoma, DIGESTIVE DISEASES AND SCIENCES, 61(3), 774-784, 201603
  332. Prognostic value of circulating tumour DNA in patients undergoing curative resection for pancreatic cancer, BRITISH JOURNAL OF CANCER, 115(1), 59-65, 20160628
  333. Serum-Based Quantification of MYCN Gene Amplification in Young Patients with Neuroblastoma: Potential Utility as a Surrogate Biomarker for Neuroblastoma, PLOS ONE, 11(8), 20160811
  334. Resectability and tumor response after preoperative chemotherapy in hepatoblastoma treated by the Japanese Study Group for Pediatric Liver Tumor (JPLT)-2 protocol, JOURNAL OF PEDIATRIC SURGERY, 51(12), 2053-2057, 201612
  335. Telomere biology including TERT rearrangements in neuroblastoma: a useful indicator for surgical treatments, JOURNAL OF PEDIATRIC SURGERY, 51(12), 2080-2085, 201612
  336. Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration, LANCET ONCOLOGY, 18(1), 122-131, 201701
  337. Hepatoblastoma state of the art: pathology, genetics, risk stratification, and chemotherapy, Current Opinion in Pediatrics, 26(1), 19-28, 2014
  338. Clinical prognostic value of DNA methylation in hepatoblastoma: Four novel tumor suppressor candidates, Cancer Science, 107(6), 812-819, 201606
  339. The Children's Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model, European Journal of Cancer, 1(52), 92-101, 2015
  340. Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene: report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions, HUMAN PATHOLOGY, 66, 177-182, 201708
  341. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLOS ONE, 13(2), 20180221
  342. 2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT), PEDIATRIC RADIOLOGY, 48(4), 536-554, 201804
  343. Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss, NEW ENGLAND JOURNAL OF MEDICINE, 378(25), 2376-2385, 20180621

Publications such as books

  1. 1999, Bacterial adhesion and growth , 1999
  2. 2000, Telomerase as a biomarker and prognositc marker in neuroblastoma , Neuroblastoma KEYWORD Pubishing Services Ltd= Barking= England, 2000
  3. 2000/08, Neuroblastoma , Neuroblastoma KEYWORD Pubishing Services Ltd= Barking= England, 2000, 08
  4. Telomere and telomerase in lung cancer , HChiba University=
  5. 2003/07, Clinical application of microarray as a tool of underestanding cancer biology , Transwprld Research Network, 2003, 07, 18
  6. 2004/12, Telomerase and lung cancer , Lippincott Williams & Wilkins. Lung Cancer -Principles and practice Third ed., 2004, 12, 934
  7. 2010/03, Diagnostic and prognostic molecular markers in neuroblastoma. In: Clinical application of molecular diagnosis -cancer, radiation effects, and human diseases-, 2010, 03, 9788178954080, 220
  8. 2009/03, Diagnostic Value Ⅰ: Solid Tumors. In: Telomeres and telomerase in cancer, 2009, 03, 9781603273060, 373
  9. 2009/03, Role of Telomeres and Telomerase in Cancer. In: Telomeres and telomerase in cancer, 2009, 03, 9781603273060, 373
  10. 2009/03, Telomeres and Telomerase in Humans. In: Telomeres and telomerase in cancer, 2009, 03, 9781603273060, 373
  11. 2009, Clinical application of molecular diagnosis -cancer, radiation effects, and human diseases- , 2009, 9788178954080
  12. 2009/03, Telomere and telomerase for the regulation of stem cells. In: Regulatory Networks in Stem Cells, Humana Press, 2009, 03, 9781603272261, 601
  13. 2010/03, Public databases useful for molecular diagnosis. In: Clinical application of molecular diagnosis -cancer, radiation effects, and human diseases-, Transworld Research Network, 2010, 03, 9788178954080 , 220
  14. 2010/03, Clinical application of molecular diagnosis -cancer, radiation effects, and human diseases-, 2010, 03, 9788178954080, 220
  15. 2014, Translational Pediatrics, Pediatric Hepatoblastoma: diagnosis and treatment, 2014, x

Invited Lecture, Oral Presentation, Poster Presentation

  1. Prediction of prognosis by preoperative chemotherapy response in hepatoblastoma patients treated by JPLT-2 protocol, Hiyama E, Hishiki T, Ida K, Watanabe K, Oue T, Yano M, Hoshino K, Iehara T, Koh K, Tanaka Y, Kurihara S, Ueda Y, SIOP 2015, 2015/10/09, With Invitation, Cape Town, South Africa
  2. Cisplatin plus pirarubicin based chemotherapy for hepatoblastoma: Experience and future in japanese study group for pediatric liver tumor (JPLT), Hiyama E, Kamimatsuse A, ueda Y, Ogura K, Watanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Oue T, Sasaki F, The 7th SIOP Asia Congress, 2012/04/22, Without Invitation, Yogyakarta, Indonesia
  3. Early detection for neuroblastoma: Japanese experience of screening and new strategies for early detection, Hiyama E, Fukuzawa M, Hosoi H, Yano K, Nakayama M, Yoneda A, Iehara T, Masujima T, Ohtaki M, The 7th SIOP Asia Congress, 2012/04/22, Without Invitation, Yogyakarta, Indonesia
  4. Next-generation sequencing: Integrated exotome analysis in human multiple neuroblastoma, Hiyama E, Kamimatsuse A, Ogura K, Ueda Y, Hiyama K, ANR2012, 2012/06/19, Without Invitation, Tronto, Canada
  5. Identification of new candidate biomarkers in progression of neuroblastoma cells using differential transcriptome and proteome analysis, Hiyama E, Kamimatsuse A, Ueda Y, Ogura K, Sueda T, Hiyama K, ANR2012, 2012/06/20, Without Invitation, Tronto, Canada
  6. Echanism of Wnt signal pathway activation in hepatoblastoma, Ueda Y, Kamimatsuse A, Ogura K, Onitake Y, Hiyama K, Hiyama E, SIOP2012, 2012/10/06, Without Invitation, London
  7. ALK activating infant neuroblastoma cases including mass-screening detected cases, Kawashima M, Hiyama E, Kamei N, Kamimatsuse A, Ueda Y, Ogura K, Hiyama K, SIOP2012, 2012/10/06, Without Invitation, London
  8. A genome-wide association study identifies new candidate loci associated with progression of hepatoblastoma in JPLT2 study experience, Hiyama E, SIOP2012, 2012/10/06, Without Invitation, London
  9. FURTHER STUDY: IDENTIFICATION OF NEW CANDIDATE GENES IN PROGRESSION OF HEPATOBLASTOMA USING GENOME-WIDE ASSOCIATION STUDY, Hiyama E, Ueda Y, Onitake Y, Ida K, Ogura K, Kondo S, Kamijyo T, Watanabe K, Oue T, Hishiki T, Tajiri T, Horie H, Inoue T, Tanaka Y, 45th Congress of the International Society of Pediatric Oncology, 2013/09/27, Without Invitation, Hong Kong, China
  10. Detection of Cancer Stem Cells in Childhood Cancers, Hiyama E, BITS 4th Annual World Congress of Molegular & Cel, Without Invitation, Dailen, China
  11. Clinical feature of ATRX or DAXX mutated neuroblastoma, Hiyama E, Kurihara S, Onitake Y, Yamaoka E, Fukuba I, Hiyama K, PAPS2014, 2014/05/25, Without Invitation, Calgary, Canada
  12. Surgical managements for refractory neuroblastoma in young children, Hiyama E, Kurihara S, Onitake Y, Ueda Y, Miki M, Kawaguchi H, Nakamura K, Kobayashi M, BAPS61st Annual Congress, 2014/07/22, Without Invitation, Edinburgh, Scotland.
  13. Outcome and morbidity of primary resection of hepatoblastoma in JPLT-1 and 2 protocols, Hiyama E, Hishiki T, Watanabe K, Ida K, yano M, Oue T, Iehara T, Hoshino K, Koh K, Tanaka Y, Kurihara S., SIOP2014, 2014/10/22, Without Invitation, Toronto, Canada
  14. Molecular diagnosis of lung cancer, Hiyama E, APSR2014, 2014/11/13, Without Invitation, Bali. Indonesia
  15. Telomere biology in neuroblastoma: focusing on alteration of TERT promoter lesion, Hiyama E, Kawashima M, Kurihara S, Ueda Y, Onitake Y, Hiyama K, Advances in Neuroblastoma Research Congress (ANR) 2016, 2016/06/20, Without Invitation, Cairns Convention Centre (Queensland, Australia)
  16. Cancer Fluid Biopsy Using Circulating Tumour Cells and Circulating Free DNA in Childhood Solid Tumors, Hiyama E, Kurihara S, Ueda Y, Kawashima M, Hiyama K, 48th Congress of the International Society of Paediatric Oncology (SIOP), 2016/10/21, Without Invitation, Dublin, Ireland
  17. Two Year Results of a Randomised Phase III Trial for Standard Risk Hepatoblastoma (SR-HB) SIOPEL 6; Cisplatin and Sodium Thiosulfate (STS) Vs Cisplatin Alon, Brock P, Childs M, Rajput K, Maibach R, Brugieres L, Roebuck D, Sullivan M, Laithier V. Rhonge M, dall’Igna P, Hiyama E, Brichard B, Skeen J, Mateos M. E, Capra M, Fabre M, Perilongo G, Czauderna P, Morland B, Neuwelt E., 48th Congress of the International Society of Paediatric Oncology (SIOP), 2016/10/22, Without Invitation, Dublin, Ireland
  18. Surgical Resectability and Tumour Response to Preoperative Chemotherapy in Hepatoblastoma Patients Treated by the Japanese Study Group for Paediatric Liver Tumour (JPLT)-2 Protocol., Hiyama E, Hishiki T, Oue T, Hoshino K, Kurihara S, Kawashima M, Ueda Y, 48th Congress of the International Society of Paediatric Oncology (SIOP), 2016/10/20, Without Invitation, Dublin, Ireland
  19. Congenital Abnormalities and Genetic Backgrounds Associated with Paediatric Malignant Liver Tumour in the Japanese Study Group for Paediatric Liver Tumour, Watanabe K, Hishiki T, Ida K, Oue T, Yano M, Hoshino K, Iehara T, Koh K, Tanaka Y, Hiyama E, 48th Congress of the International Society of Paediatric Oncology (SIOP), 2016/10/20, Without Invitation, Dublin, Ireland
  20. Radiotherapy Quality Management System for Conducting Nationwide Clinical Trials: An Instrument Established by the Japan Chidlren’s Cancer Group, Fuji H, Soejima T, Nozaki M, Masaki H, Nozawa K, Miyazaki O, Kitamura M, Tajiri T, Koshinaga T, Hosoi H, Hiyama E, Takimoto T, Fukuzawa M, Kiyokawa N, Hara J, 48th Congress of the International Society of Paediatric Oncology (SIOP), 2016/10/20, Without Invitation, Dublin, Ireland
  21. Genetic Risk Facotrs of Chemotherapy-Related Ototoxicity and Cardiotoxicity in Hepatoblastoma, Hiyama E, Hishiki T, Ida K, Watanabe K, Oue T, Yano M, Hoshino K, Iehara T, Koh K, Tanaka Y, Kurihara S, Kawashima M, Ueda Y, 48th Congress of the International Society of Paediatric Oncology (SIOP), 2016/10/20, Without Invitation, Dublin, Ireland
  22. NABIGATION SURGERY USING ICG FLUORESCENCE IMAGING FOR HEPATOBLASTOMA LUNG METASECTOMY, Hiyama E, Kurihara S, Ueda Y, Oue T, Kitagawa N, JCCG Liver Tumor Committee(JPLT), Japan, SIOPEL SPRING MEETING 2017, 2017/04/08, Without Invitation, Paris, France
  23. Comprehensive profiling of hepatoblastoma revealed the clinically useful methylation patterns and the ectopic enhancers, 2017/09/28, Without Invitation
  24. DHRS3 and NR0B1 promotes cellular differentiation and growth suppression of neuroblastoma cell lines., 2017/09/29, Without Invitation
  25. PHARMACOGENETICS ANALYSIS for TREATMENT-RELATED TOXICITIES OF HEPATOBLASTOMA PATIENTS IN JAPAN, Hirahara S, Hiyama E, Kimura S,Kuriahra S, Kawashima M, Ueda Y, Onitake Y, The 49th Congress of the International Society of Paediatric Oncology (SIOP2017), 2017/10/13, Without Invitation, Washington, DC, USA
  26. Surgical and Interventional Treatment for ruptured hepatic Tumors in Japanese Study Group Experience, Hiyama E, Hishiki T, Hoshino K, Yokoi A, Tamata T, Kazama T, Honda S, Taguchi T, Kurihara S, Kawashima M, Ueda Y, The 49th Congress of the International Society of Paediatric Oncology (SIOP2017), 2017/10/13, Without Invitation, Washington, DC, USA
  27. Integrated Genetic and Epigenetic Analysis novel Molecular Subgroups in Hepatoblastoma, Hiyama E, Kurihara S, Hirano S, Irisuna F, Ueda Y, Kawashima M, The 49th Congress of the International Society of Paediatric Oncology (SIOP2017), 2017/10/13, Without Invitation, Washington, DC, USA
  28. Sodium Thiosulfate (STS) as Otoprotectant to Reduce the Incidence of Cisplatin-Induced Hearing Loss: Final Results of The SIOPEL6 Trial for Standard Risk Hepatoblastoma (SR-HB), Brock P, Maibach R, Childs M, Rajput K, Fabre M, Roebuck D, Sullivan M, Laithier V, Rhonge M, Dall’lgna P, Hiyama E, Benedicte B, Skeen J, Mateos M, Rangaswami A, Brugieres L, Perliongo G, Czauderna P, Morland B, Neuwelt E, The 49th Congress of the International Society of Paediatric Oncology (SIOP2017), 2017/10/14, Without Invitation, Washington, DC, USA
  29. Survival and Lates Effects of JPLT(Japanese Study Group for Pediatric Liver Tumor)-2 Risk-Stratified Study for Hepatoblastoma, Hiyama E, Hishiki T, Ida K, Watanabe K, Tanaka Y, Aoki Y, Iehara T, Kazama T, Kihira K, Taguchi T, Fujimura J, Hoshino K, Honda S, Matsumoto K, Mori M, Yano M, The 49th Congress of the International Society of Paediatric Oncology (SIOP2017), 2017/10/15, Without Invitation, Washington, DC, USA
  30. Pathological evaluation of ICG navigation surgery for hepatoblastoma pulmonary metastases, Hiyama E, 2018 INTERNATIONAL PEDIATRIC LIVER TUMOR CONFERENCE, 2018/02/16, Without Invitation, Houston, TX , USA
  31. Global clinical trial for childhood liver tumors: PHITT trial, Hiyama E, AMED TR-SPRINT Research Utilization Support Project 3rd Global ARO Network Workshop, 2018/03/07, With Invitation, Tokyo
  32. Telomere biology including rearrangement of TERT promoter lesion in neuroblastoma, Hiyama E, Kawashima M, Kurihara S, Ueda Y, Kimura S, Irisuna A, Morihara N, Hirano S, Hiyama K, Advances in Neuroblastoma Research 2018, 2018/05/12, Without Invitation, San Francisco, California, USA
  33. SingLe cell RNA Sequencing of neuroblastoma, Hiyama E, Kurihara S, Kawashima M, Takemoto M, Ueda Y, Hiyama K, Advances in Neuroblastoma Research 2018, 2018/05/12, Without Invitation, San Francisco, California, USA
  34. Decline of ?-fetoprotein before tumor resection as a prognosis- predicting factor for hepatoblastoma, Eiso Hiyama, 2018 PAPS meeting, 2018/05/17, Without Invitation, Sapporo, Hokkaido
  35. Cancer fluid biopsy using circulating tumor cells in childhood solid tumors, Yuka Ueda, Eiso Hiyama, Sho Kurihara, Masumi Kawashima, Masato Kojima, Satoshi Hirahara, Keiko Hiyama, 2018 PAPS meeting, 2018/05/14, Without Invitation, Sapporo, Hokkaido
  36. Surgical intervention for portosystemic venous shunt in children, Kurihara S, Hiyama E, Ueda Y, Kawashima M, Kojima M, Hirahara S, 2018 PAPS meeting, 2018/05/15, Without Invitation, Sapporo, Hokkaido
  37. Survival and delayed effects of risk-stratified hepatoblastoma patients treated in the JPLT-2 trial, Hiyama E, Kurihara S, Ueda Y, Hishiki T, Ida K, Iehara T, Oue T, Yano M, Watanabe K, Hoshino K, Ko K, Tanaka Y, 2018 ASCO Annual Meeting, 2018/06/02, Without Invitation, Chicago, USA
  38. Genomic landscape of hepatoblastoma, Aburatani H, Nakagawa H, Hiyama E, 2018/09/28, Without Invitation
  39. Clinical limitations, implications and ethical considerations of genetic analysis in hereditary tumors, Hiyama E, 第77回日本癌学会学術集会, 2018/09/28, Without Invitation
  40. Comprehensive analysis of Hepatoblastoma, Yamamoto S, Tatsuno K, Nagae G, Fujita M, Nakagawa H, Hiyama E, Aburatani H, 2018/09/28, Without Invitation, Osaka, Japan