TAKAHIRO SHIRAI

Last Updated :2024/12/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Assistant Professor
E-mail
tshiraihiroshima-u.ac.jp
Self-introduction
The objective of research Organic chemistry contributes to the field of pharmacy Major field Fluorine chemistry, Silicon chemistry, Transition metal chemistry, Total synthesis, SAR(medicinal chemistry)

Basic Information

Major Professional Backgrounds

  • 2018/04, 2020/03, Research Foundation ITSUU Laboratory, Department of Chemistry, Researcher
  • 2020/04, Graduate school of Biomedical and Health Sciences, Department of Synthetic Organic Chemistry, Assistant professor

Educational Backgrounds

  • University of tokyo, Graduate school of Pharmaceutical Sciences, Japan, 2015/04, 2018/03
  • University of tokyo, Graduate school of Pharmaceutical sciences, Japan, 2013/04, 2015/03

Academic Degrees

  • The University of Tokyo
  • The University of Tokyo

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
  2. 2024, Undergraduate Education, 4Term, Organic Chemistry IIB
  3. 2024, Undergraduate Education, 2Term, General Organic Chemistry and Practice
  4. 2024, Undergraduate Education, Second Semester, Experiments in Organic Chemistry
  5. 2024, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  6. 2024, Graduate Education (Master's Program) , First Semester, Lecture on Synthetic Organic Chemistry
  7. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Synthetic Organic Chemistry
  8. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Synthetic Organic Chemistry
  9. 2024, Graduate Education (Master's Program) , First Semester, Research on Synthetic Organic Chemistry
  10. 2024, Graduate Education (Master's Program) , Second Semester, Research on Synthetic Organic Chemistry
  11. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Synthetic Organic Chemistry
  12. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Synthetic Organic Chemistry
  13. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Synthetic Organic Chemistry

Research Activities

Academic Papers

  1. ★, (Featured Article) Study of Palladium-Catalyzed Site and Regioselective Reductive Heck Hydroarylation of Unactivated Alkene, CHEMICAL & PHARMACEUTICAL BULLETIN, 72(10), 890-893, 202410
    Link to Paper Search Results by DOI
  2. Synthesis of Novel Pseudo-Enantiomeric Phase-Transfer Catalysts from Cinchona Alkaloids and Application to the Hydrolytic Dynamic Kinetic Resolution of Racemic 3-Phenyl-2-oxetanone, Chemical and Pharmaceutical Bulletin, 72(10), 913-916, 20241022
    Link to Paper Search Results by DOI
  3. ★, Palladium-Catalyzed Site-Selective Hydrogenation of Unactivated Alkenes Directed by 8-Aminoquinoline Amides, Chemical and Pharmaceutical Bulletin, 72(10), 909-92, 20241022
    Link to Paper Search Results by DOI
  4. Hydrolytic dynamic kinetic resolution of racemic 3-phenyl-2-oxetanone to chiral tropic acid, RSC ADVANCES, 14(9), 6121-6126, 20240214
    Link to Paper Search Results by DOI
  5. ★, Palladium-Catalyzed Reductive Heck Hydroarylation of Unactivated Alkenes Using Hydrosilane at Room Temperature, The Journal of Organic Chemistry, 20240201
    Link to Paper Search Results by DOI
  6. Frontier Researches in Medicinal Chemistry Contribute to the Field of Pharmacy, YAKUGAKU ZASSHI, 142(4), 345, 2022
  7. ★, Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1, Cell Reports, 19, 969-980, 2017
  8. ★, 2-Position-Selective C-H Perfluoroalkylation of Quinoline Derivatives, Organic Letters, 20, 1593-1596, 2018
    Link to Paper Search Results by DOI
  9. DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation, Biochemical and Biophysical Research Communications, 497(1), 298-304, 2018

Invited Lecture, Oral Presentation, Poster Presentation

  1. Palladium-Catalyzed Reductive Heck Hydroarylation of Unactivated Alkenes using Hydrosilane at Room Temperature, 2024/09, Without Invitation, Japanese
  2. Development of Chemoselective Removal of Prenyl Group by Hydroboration, Ryota Yara, Ryo Nakajima, Takahiro Shirai, Takuya Kumamoto, 2022/03/26, Without Invitation, Japanese
  3. Development of trifluoromethylation of heteroaromatics using acid catalysts, Takahiro SHIRAI, HU-CSIR Joint International Workshop 2021, 2021/09/29, With Invitation, English, ILDP Program Office, Hiroshima University, online
    Related URL
  4. Nickel-Catalyzed Regioselective Olefin Migration Reaction, Takahiro SHIRAI, THE 47 th NAITO CONFERENCE, 2019/07/02, With Invitation, English
    Related URL
  5. Nickel-Catalyzed Regioselective Olefin Migration Reaction, Takahiro SHIRAI, 27 th International Society of Heterocyclic Chemistry Congress, 2019/09/01, Without Invitation, English, International Society of Heterocyclic Chemistry, Osaka
    Related URL
  6. 2-Position-Selective C-H Trifluoromethylation of Quinoline Derivatives, Takahiro SHIRAI, Motomu KANAI, Yoichiro KUNINOBU., The Power of Chemical Transformations, 2021/05/20, Without Invitation, English, American Chemical Society, Online
    Related URL

Patented

  1. Patent, WO/2016/136985

External Funds

Acceptance Results of Competitive Funds

  1. 2021, 2024
  2. 2019, 2021

Social Activities

Organizing Academic Conferences, etc.

  1. 2023/09, 2023/09

History as Peer Reviews of Academic Papers

  1. 2022, Organic & Biomolecular Chemistry, Others, 1
  2. 2022, Bioorganic & Medicinal Chemistry, Others, 1
  3. 2021, New Journal of Chemistry, Others, The rviewer, 1
  4. 2021, Journal of Carbohydrate Chemistry, Others, The reviewer, 1
  5. 2021, Organic & Biomolecular Chemistry, Others, The reviewer, 2
  6. 2020, Organic & Biomolecular Chemistry, Others, The reviewer, 3
  7. 2019, Organic & Biomolecular Chemistry, Others, The reviewer, 1
  8. 2018, Organic & Biomolecular Chemistry, Others, The reviewer, 1