ATSUKO HAMADA

Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
E-mail
hamacohiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2020/05/01, 2024/01/31, Hiroshima University Hospital Oral and Maxillofacial surgery, Assistant professor
  • 2009/04/01, 2011/03/31, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Oral maxillofacial surgery, Dental Resident
  • 2011/04/01, 2012/03/31, Hiroshima University Hospital, Oral & Maxillofacial Surgery,, Senior resident
  • 2013/04/01, 2015/03/31, Hiroshima University Hospital, Oral & Maxillofacial Surgery, Staff Clinical Dentist
  • 2015/04/01, 2020/04/30, Hiroshima University Hospital, Oral & Maxillofacial Surgery, Staff Clinical Dentist

Educational Backgrounds

  • Hiroshima University, Graduate School of Biomedical Sciences, Japan, 2011/04, 2015/03
  • Hiroshima University, School of Dentistry , Japan, 2003/04, 2009/03

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Surgical dentistry

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 2Term, General Health and Oral Sciences I
  2. 2024, Undergraduate Education, 1Term, Oral and Maxillofacial Surgery I
  3. 2024, Undergraduate Education, 2Term, Oral and Maxillofacial Surgery II
  4. 2024, Undergraduate Education, First Semester, Dental Research Practices I
  5. 2024, Undergraduate Education, 3Term, Basic Practice of Oral and Maxillofacial Medicine I
  6. 2024, Undergraduate Education, 4Term, Basic Practice of Oral and Maxillofacial Medicine II
  7. 2024, Undergraduate Education, Second Semester, Dental Research Practices II
  8. 2024, Undergraduate Education, 2Term, Advanced Course in Applied Oral Biology and Medicine
  9. 2024, Undergraduate Education, 2Term, Advanced Course in Oral and Maxillofacial Medicine
  10. 2024, Undergraduate Education, 2Term, Basic and clinical integrated theory
  11. 2024, Undergraduate Education, First Semester, Dental Research Practices III
  12. 2024, Undergraduate Education, Academic Year, Clinical Practice (Oral Surgery I)

Research Activities

Academic Papers

  1. A case of primary neuroendocrine carcinoma of the mandibular gingiva treated using multimodal therapy, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 20220808
  2. Identification of a Cowden syndrome patient with a novel PTEN mutation and establishment of patient-derived induced pluripotent stem cells, In Vitro Cellular & Developmental Biology - Animal, 58, 69-78, 20220103
  3. VEGF-A promotes the motility of human melanoma cells through the VEGFR1–PI3K/Akt signaling pathway, In Vitro Cellular & Developmental Biology - Animal, 20220823
  4. Identification of a familial cleidocranial dysplasia with a novel RUNX2 mutation and establishment of patient-derived induced pluripotent stem cells, ODONTOLOGY, 110(3), 444-451, 202207
    Link to Paper Search Results by DOI
  5. Induction of integration-free human-induced pluripotent stem cells under serum- and feeder-free conditions, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 56(1), 85-95, 202001
  6. Eldecalcitol (ED-71)-induced exosomal miR-6887-5p suppresses squamous cell carcinoma cell growth by targeting heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1), IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 56(3), 222-233, 202005
  7. Metastasis of carcinoma ex pleomorphic adenoma to the brain without previous metastasis to the lungs or bones: a case report, BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 57(9), 926-928, 201911
  8. Novel PTCH1 mutations in Japanese familial nevoid basal cell carcinoma syndrome, HUMAN GENOME VARIATION, 7(1), 20201218
    Link to Paper Search Results by DOI
  9. Induction of Noonan syndrome-specific human-induced pluripotent stem cells under serum-, feeder-, and integration-free conditions, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 56(10), 888-895, 202012
    Link to Paper Search Results by DOI
  10. Enhanced KRT13 gene expression bestows radiation resistance in squamous cell carcinoma cells, In Vitro Cellular & Developmental Biology - Animal, in press
  11. Clinical investigation of oral cancer in adolescent and young adult generation, ORAL SCIENCE INTERNATIONAL, 18(2), 126-134, 202105
    Link to Paper Search Results by DOI
  12. MICA A5.1 homozygous genotype is associated with a risk for early-onset oral cancer, ORAL ONCOLOGY, 116, 202105
    Link to Paper Search Results by DOI
  13. MICA A5.1 homozygous genotype is associated with a risk for early-onset oral cancer, ORAL ONCOLOGY, 116, 202105
    Link to Paper Search Results by DOI
  14. A case of maxillary ameloblastic carcinoma with atypical histology, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 33(5), 536-545, 202109
    Link to Paper Search Results by DOI

Publications such as books

  1. 2020/09/10, Your Biology, Human biology, Textbook, Joint Translation, 日本語, Artenuis Bos, 978-4-560-09774-8, 234, 20
    Amazon URL

Invited Lecture, Oral Presentation, Poster Presentation

  1. Establishment and Characterization of Disease-specific Human iPSCs in Serum-, Integration- and Feeder-free Cultures., Hamada A,, Nakase Y, Obayashi F, Fukutani T, Nakatao H, Sakaue E, Yamasaki S, Kanda T, Koizumi K, Yoshioka Y, Tani R, Toratani S, JD. Sato, T. Okamoto, Society for In Vitro Biology Meeting, 2019/06/09, With Invitation, English, Society for In Vitro Biology, Tampa, Florida, USA, Human pluripotent stem cells hold great promise for their practical and scientific potential. To improve understanding self-renewal and differentiation, we have reported the successful generation and culture of hiPSCs from dental pulp cells (DPCs) and peripheral blood mononuclear cells (PBMCs) with a non-integrating replication-defective and persistent Sendai virus vector expressing four key reprogramming genes (SeVdp (KOSM)) using hESF9 serum-free medium in feeder-free culture conditions. We found that using this system pluripotent and self-renewing hiPSCs could be easily and stably generated and propagated. We successfully generated hiPSCs from the hereditary disease patients with abnormalities in oral-maxillofacial region, such as Cleidocranial dysplasia (CCD: RUNX2 mutation), Cowden syndrome (PTEN), Noonan syndrome (K-Ras), von Recklinghausen’s disease (NF1), and Nevoid basal cell carcinoma syndrome (PTCH1) . We have found that these patient-derived iPSCs retained disease-specific phenotypes during in vitro embryoid body formation assays and in vivo teratoma formation assays. These disease-specific iPSCs models will help to clarify the molecular mechanisms underlying these diseases, and they will be useful for screening therapeutic drug, and for developing medical applications of iPSCs
    Related URL

External Funds

Acceptance Results of Competitive Funds

  1. 2021/10/07, 2026/03/31
  2. Grants-in-Aid for Scientific Research (C), 2020/04/01, 2024/03/31
  3. Grants-in-Aid for Scientific Research (C), 2018/04/01, 2021/03/31
  4. Grant-in-Aid for Young Scientists, 2019/04/01, 2022/03/31
  5. Grants-in-Aid for Scientific Research (C), 2022/04/01, 2025/03/31