Kouichi Funato

Last Updated :2020/08/03

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
Web Site

Basic Information

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, The University of Tokushima
  • Master of Pharmaceutical Science, The University of Tokushima

Research Fields

  • Agricultural sciences;Agricultural chemistry;Applied microbiology
  • Agricultural sciences;Agricultural chemistry;Applied biochemistry

Research Keywords

  • yeast
  • lipids
  • synthesis
  • traffic
  • funtions

Educational Activity

Course in Charge

  1. 2020, Liberal Arts Education Program1, 3Term, Cell Science
  2. 2020, Liberal Arts Education Program1, 2Term, Life, food, and environmental sciences
  3. 2020, Undergraduate Education, Intensive, Laboratory Work in General Chemistry
  4. 2020, Undergraduate Education, 2Term, Reading of Foreign Literature
  5. 2020, Undergraduate Education, 2Term, Introduction to Applied Biological Science I
  6. 2020, Undergraduate Education, Intensive, Laboratory Work in Molecular Agro-life ScienceIII
  7. 2020, Undergraduate Education, 4Term, Molecular Cell Biology
  8. 2020, Undergraduate Education, Academic Year, Graduation Thesis
  9. 2020, Undergraduate Education, Intensive, Biotechnology
  10. 2020, Undergraduate Education, 4Term, Bio-Analytical Science
  11. 2020, Undergraduate Education, 3Term, Reading of Foreign Literature in Molecular Agro-Life Science
  12. 2020, Graduate Education (Doctoral Program) , First Semester, Exercises in Molecular and Applied Biosciences (B)
  13. 2020, Graduate Education (Doctoral Program) , Second Semester, Exercises in Molecular and Applied Biosciences (B)
  14. 2020, Graduate Education (Master's Program) , 2Term, Applied Microbiology
  15. 2020, Graduate Education (Master's Program) , 4Term, Applied Microbiology Seminar
  16. 2020, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  17. 2020, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  18. 2020, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  19. 2020, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  20. 2020, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  21. 2020, Graduate Education (Master's Program) , 2Term, Applied Molecular Cell Biology I
  22. 2020, Graduate Education (Master's Program) , 4Term, Applied Molecular Cell Biology II

Research Activities

Academic Papers

  1. A defect in GPI synthesis as a suggested mechanism for the role of ARV1 in intellectual disability and seizures., Neurogenetics, 2020
  2. Cold-sensitive phenotypes of a yeast null mutant of ARV1 support its role as a GPI flippase., FEBS Lett., 2020
  3. Expression of two glutamate decarboxylase genes in Lactobacillus brevis during gamma-aminobutyric acid production with date residue extract., Biosci Biotechnol Biochem., 14, 1-4, 2020
  4. Vesicular and non-vesicular lipid export from the ER to the secretory pathway., Biochim Biophys Acta Mol Cell Biol Lipids., 2020
  5. Sphingolipid/Pkh1/2-TORC1/Sch9 Signaling Regulates Ribosome Biogenesis in Tunicamycin-Induced Stress Response in Yeast., Genetics, 2019
  6. Lysophospholipids Facilitate COPII Vesicle Formation., Curr Biol., 28(12), 1950-1958, 20180618
  7. Gamma-aminobutyric acid fermentation with date residue by a lactic acid bacterium, Lactobacillus brevis., J. Biosci. Bioeng., 125(3), 316-319, 201803
  8. Protection mechanisms against aberrant metabolism of sphingolipids in budding yeast., Curr Genet., 64(5), 1021-1028, 2018
  9. Protective role of the HOG pathway against the growth defect caused by impaired biosynthesis of complex sphingolipids in yeast Saccharomyces cerevisiae, MOLECULAR MICROBIOLOGY, 107(3), 363-386, 201802
  10. Arp2/3 complex and Mps3 are required for regulation of ribosome biosynthesis in the secretory stress response., Yeast, 34(4), 155-163, 201704
  11. Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis., Yeast, 33, 37-42, 201602
  12. A lipid regulator working at the cleavage furrow, Cell Cycle, 15(10), 1315-1316, 20160518
  13. Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy., Hum Mol Genet., 25(14), 3042-3054, 20160715
  14. COPII Coat Composition Is Actively Regulated by Luminal Cargo Maturation, Curr. Biol., 25(2), 152-162, 20150119
  15. SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations, Biosci. Biotechnol. Biochem., 79(9), 1481-1483, 20150902
  16. Sphingolipids regulate telomere clustering by affecting the transcription of genes involved in telomere homeostasis, J. Cell Sci., 128(14), 2454-2467, 20150715
  17. The essential function of Rrs1 in ribosome biogenesis is conserved in budding and fission yeasts, Yeast, 32(9), 607-614, 2015
  18. Producing human ceramide-NS by metabolic engineering using yeast Saccharomyces cerevisiae, SCIENTIFIC REPORTS, 5, 20151117
  19. Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast, J. Cell Sci., 127(2), 376-387, 20140115
  20. Metabolic labeling of yeast sphingolipids with radioactive D-erythro-[4,5-3H]dihydrosphingosine., Bio-Protocol (http://www.bio-protocol.org), 3(16), 201308
  21. Perturbation of sphingolipid metabolism induces endoplasmic reticulum stress-mediated mitochondrial apoptosis in budding yeast, Mol. Microbiol., 86(5), 1246-1261, 2012
  22. The yeast p24 complex regulates GPI-anchored protein transport and quality control by monitoring anchor remodeling, Mol. Biol. Cell, 22(16), 2924-2936, 20110815
  23. Functional Interactions between Sphingolipids and Sterols in Biological Membranes Regulating Cell Physiology, Mol. Biol. Cell, 20(7), 2083-2095, 2009
  24. Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum., Mol. Biol. Cell, 19, 2069-2082, 20080501
  25. Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway, FEBS Lett., 581(16), 2935-2942, 20070626
  26. Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae, Mol. Biol. Cell, 17(3), 1164-1175, 2006
  27. Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces cerevisiae., J. Biol. Chem., 278(9), 7325-7334, 20030228
  28. Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae., Biochemistry, 41(51), 15105-15114, 20021224
  29. Sphingolipid biosynthesis and traffic in yeast., Seikagaku, 74(4), 317-321, 20020401
  30. Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast., J. Biol. Chem., 277(51), 49538-49544, 20021220
  31. Vesicular and nonvesicular transport of ceramide from ER to the Golgi apparatus in yeast., J. Cell Biol., 155(6), 949-959, 20011210
  32. Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae., EMBO J., 19(12), 2824-2833, 20000615
  33. A Salmonella virulence protein inhibits cellular trafficking., EMBO J., 18(14), 3924-3933, 19990715
  34. A novel plasma factor initiating complement activation on cetylmannoside-modified liposomes in human plasma., Int J Pharm, 164, 91-102, 1998
  35. Enhancing effect of cholesterol on the elimination of liposomes from circulation is mediated by complement activation., Int J Pharm, 156, 27-37, 1997
  36. Sequential actions of Rab5 and Rab7 regulate endocytosis in the Xenopus Oocyte., J. Cell Biol., 136(6), 1227-1237, 19970324
  37. Rab7 regulates transport from early to late endocytic compartments in Xenopus Oocytes., J. Biol. Chem., 272(20), 13055-13059, 19970516
  38. Reconstitution of phagosome-lysosome fusion in streptolysin O-permeabilized cells., J. Biol. Chem., 272(26), 16147-16151, 19970627
  39. Biopharmaceutical evaluation of the liposomes prepared by rehydration of freeze-dried empty liposomes (FDELs) with an aqueous solution of a drug., Biopharm Drug Dispos., 17(7), 589-605, 199610
  40. The complement- but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ., J Drug Target, 2, 141-146, 1994
  41. Plasma factor triggering alternative complement pathway activation by liposomes., Pharm Res., 11, 372-376, 199403
  42. Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes., Pharm Res., 11(3), 402-406, 199403
  43. Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma., Biochem. Biophys. Acta, 1103, 198-204, 199201
  44. Effect of species differences on complement activation by cetylmannoside-modified liposomes in fresh plasma., Drug Delivery System, 7, 165-168, 1992

Publications such as books

  1. 2006, Sphingolipid Biology, [Sphingolipid Trafficking] pp.123-139, 2006, 0, 4431341986, 531
  2. 2018, Advances in Industrial Applications of Yeast, Koji-molds, and Lactic Acid Bacteria, 2018, 1月, J