Takemasa Sakaguchi

Last Updated :2025/06/18

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Professor
E-mail
tsakahiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan, Japan
TEL : (+81)82-257-5157 FAX : (+81)82-257-5159
Self-introduction
I have been working in the field of virology for 35 years. I have been doing basic research on RNA viruses, mainly paramyxoviruses and influenza viruses, and hepatitis B virus, and more recently applied research on disinfectants and antiviral agents. Currently, we are working hard to combat the novel coronavirus. (April 20, 2021)

Basic Information

Major Professional Backgrounds

  • 1987/04/01, 1996/08/31, Hiroshima University, Research Associate
  • 1993/10/23, 1996/02/28, Northwestern University, Postdoctrol fellow
  • 1996/09/01, 1998/04/30, Hiroshima University, Assistant Professor
  • 1998/05/01, 2007/03/31, Hiroshima University, Associate Professor
  • 2007/04/01, 2009/03/31, Hiroshima University, Associate Professor
  • 2009/04/01, 2019/03/31, Hiroshima University, Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Professor

Educational Backgrounds

  • Nagoya University, Faculty of Medicine, School of Medicine, Japan, 1979/04, 1985/03
  • Nagoya University, Graduate School of Medical Sciences, Laboratory of Molecular Pathogenesis, Japan, 1986/04, 1987/03

Academic Degrees

  • Doctor of Medicine, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Virology

Research Keywords

  • Sendai virus (HVJ)
  • SARS-CoV-2
  • influenza virus
  • hepatitis B virus
  • Protein three dimensional structure
  • morphogenesis
  • interferon
  • accessory protein
  • anti-virus
  • persimmon tannin

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Biological Responses
  2. 2025, Undergraduate Education, 2Term, Introduction for medical research
  3. 2025, Undergraduate Education, Intensive, Practice for medical research
  4. 2025, Undergraduate Education, 4Term, Microbiology II
  5. 2025, Graduate Education (Master's Program) , First Semester, Seminar
  6. 2025, Graduate Education (Master's Program) , Second Semester, Seminar
  7. 2025, Graduate Education (Master's Program) , First Semester, Research
  8. 2025, Graduate Education (Master's Program) , Second Semester, Research
  9. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  10. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  11. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  12. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  13. 2025, Graduate Education (Master's Program) , 3Term, Seminar on Host Defense
  14. 2025, Graduate Education (Master's Program) , 1Term, Seminar on Health Policy & Global Health
  15. 2025, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  16. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Virology
  17. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Virology
  18. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Virology
  19. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Virology
  20. 2025, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science

Research Activities

Academic Papers

  1. In vitro to clinical efficacy: Neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 strains, JOURNAL OF INFECTION AND CHEMOTHERAPY, 31(4), 102604, 20250401
    Link to Paper Search Results by DOI
  2. Viral coexistence and insertional mutations in the ORF8 region of SARS-CoV-2: A possible mechanism of nucleotide insertion, VIRUS RESEARCH, 350, 199478, 20241201
    Link to Paper Search Results by DOI
  3. Hiroshima Prefectural Animal Infectious Disease Surveillance System and Severe Fever Thrombocytopenia Syndrome (SFTS) Outbreak, Hiroshima Journal of Veterinary Medicine, 37, 75-79, 20230701
  4. Quite powerful! Kakishibu's virus-killing effect "Kaki-Livelihood", Gendai Agriculture Supplement, 56-57, 20231001
  5. The two-component regulatory systems GraRS and SrrAB mediate Staphylococcus aureus susceptibility to Pep5 produced by clinical isolate of Staphylococcus epidermidis, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 90(7), e0030024, 20240724
    Link to Paper Search Results by DOI
  6. Structure Transformation of Methylammonium Polyoxomolybdates via In-Solution Acidification and Solid-State Heating from Methylammonium Monomolybdate and Application as Negative Staining Reagents for Coronavirus Observation, INORGANIC CHEMISTRY, 63(22), 10207-10220, 20240520
    Link to Paper Search Results by DOI
  7. Evolutionary engineering and characterization of Sendai virus mutants capable of persistent infection and autonomous production, FRONTIERS IN VIROLOGY, 4, 20240402
    Link to Paper Search Results by DOI
  8. Synthesis and Cell-Based Evaluation of Umifenovir Analogues as Anti-SARS-CoV-2 Agents, HELVETICA CHIMICA ACTA, 107(2), 20240201
    Link to Paper Search Results by DOI
  9. Synergistic VSV Virotherapy and Carbon Nanotube Photothermal Therapy for Osteosarcoma in Murine Models, ANTICANCER RESEARCH, 44(1), 99-105, 20240101
    Link to Paper Search Results by DOI
  10. In vitro anti-severe acute respiratory syndrome coronavirus 2 effect of Ephedra przewalskii Stapf extract, JOURNAL OF ETHNOPHARMACOLOGY, 319(Pt3), 117341, 20240130
    Link to Paper Search Results by DOI
  11. Tumor Necrosis Factor and Interleukin-1 beta Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation, VIRUSES-BASEL, 15(7), 20230701
    Link to Paper Search Results by DOI
  12. Viable SARS-CoV-2 detected in the air of hospital rooms of patients with COVID-19 with an early infection, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 126, 73-78, 20230101
    Link to Paper Search Results by DOI
  13. Virus purification highlights the high susceptibility of SARS-CoV-2 to a chlorine-based disinfectant, chlorous acid, PLOS ONE, 18(7), 20230714
    Link to Paper Search Results by DOI
  14. Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection, PLOS ONE, 18(6), 20230623
    Link to Paper Search Results by DOI
  15. Capture and neutralization of SARS-CoV-2 and influenza virus by algae-derived lectins with high-mannose and core fucose specificities, MICROBIOLOGY AND IMMUNOLOGY, 67(7), 334-344, 20230701
    Link to Paper Search Results by DOI
  16. Solid-state Thermal Transformation of Methylammonium Monomolybdate to Polyoxomolybdates and their Applications as Staining Reagents for Transmission Electron Microscopy Observations of Viruses, CHEMISTRY LETTERS, 52(3), 167-171, 20230301
    Link to Paper Search Results by DOI
  17. Vaccines in Japan, 6-10, 20230301
  18. Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants, COMMUNICATIONS BIOLOGY, 6(1), 20230411
    Link to Paper Search Results by DOI
  19. Oncolytic Effect of a Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppressor MicroRNA in an Osteosarcoma Mouse Model, ANTICANCER RESEARCH, 43(3), 1185-1191, 20230301
    Link to Paper Search Results by DOI
  20. Accuracy Management Survey of Nucleic Acid Amplification Tests Using Inactivated SARS-CoV-2 in Hiroshima Prefecture., Hiroshima Journal of Medical Science, 71(3-4), 1-5, 20221201
  21. Synergistic effect of TONS504-mediated photodynamic antimicrobial chemotherapy and additives widely contained in ophthalmic solutions: benzalkonium chloride and ethylenediaminetetraacetic acid, PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 21(11), 1895-1905, 20221101
    Link to Paper Search Results by DOI
  22. Roles of peptidyl prolyl isomerase Pin1 in viral propagation, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 10, 20221025
    Link to Paper Search Results by DOI
  23. Thermal Structure Transformation of Methylammonium Vanadate and it's Application as a Negative Staining Reagent for Observing SARS-CoV-2, EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2022(26), 20220919
    Link to Paper Search Results by DOI
  24. Complex formation of potassium salt of highly fatty acid with hemagglutinin protein in influenza virus via exothermic interaction, BIOCHEMISTRY AND BIOPHYSICS REPORTS, 31, 20220901
    Link to Paper Search Results by DOI
  25. Duration of infectious viral shedding in patients with mild to moderate COVID-19 treated with REGN-CoV2?, JOURNAL OF INFECTION AND CHEMOTHERAPY, 28(7), 912-917, 20220701
    Link to Paper Search Results by DOI
  26. Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor, PROTEIN SCIENCE, 31(6), 20220601
    Link to Paper Search Results by DOI
  27. In vitro Suppression of SARS-CoV-2 Infection by Existing Kampo Formulas and Crude Constituent Drugs Used for Treatment of Common Cold Respiratory Symptoms, FRONTIERS IN PHARMACOLOGY, 13, 20220329
    Link to Paper Search Results by DOI
  28. Sequential dynamics of virological and serological changes in the serum of SARS-CoV-2 infected patients, JOURNAL OF MEDICAL VIROLOGY, 94(4), 1734-1737, 20220401
    Link to Paper Search Results by DOI
  29. Crystal structure of O-ureidoserine racemase found in the d-cycloserine biosynthetic pathway, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 90(4), 912-918, 20220401
    Link to Paper Search Results by DOI
  30. Novel Coronavirus Variants, Hiroshima Igaku, 75(2), 56-60, 20220228
  31. Mass Screening of SARS-CoV-2 Variants using Sanger Sequencing Strategy in Hiroshima, Japan, SCIENTIFIC REPORTS, 12(1), 20220214
    Link to Paper Search Results by DOI
  32. Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation, NATURE, 602(7896), 300-+, 20220210
    Link to Paper Search Results by DOI
  33. Duration of infectious virus shedding in patients with severe coronavirus disease 2019 who required mechanical ventilation, JOURNAL OF INFECTION AND CHEMOTHERAPY, 28(1), 19-23, 20220101
    Link to Paper Search Results by DOI
  34. Exopolysaccharide Produced by Plant-Derived Lactobacillus plantarum SN35N Exhibits Antiviral Activity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 44(12), 1886-1890, 20211201
    Link to Paper Search Results by DOI
  35. Structural Insight into the Interaction of Sendai Virus C Protein with Alix To Stimulate Viral Budding, JOURNAL OF VIROLOGY, 95(19), 20211001
    Link to Paper Search Results by DOI
  36. ★, Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic target, SCIENTIFIC REPORTS, 11(1), 18581, 20210917
    Link to Paper Search Results by DOI
  37. Ethanol Susceptibility of SARS-CoV-2 and Other Enveloped Viruses, BIOCONTROL SCIENCE, 26(3), 177-180, 20210910
    Link to Paper Search Results by DOI
  38. The Association between Wearing a Mask and COVID-19, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(17), 9131, 20210901
    Link to Paper Search Results by DOI
  39. Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal, SCIENTIFIC REPORTS, 11(1), 16629, 20210817
    Link to Paper Search Results by DOI
  40. Molecular characteristics of the photosensitizer TONS504: Comparison of its singlet oxygen quantum yields and photodynamic antimicrobial effect with those of methylene blue, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 221, 112239, 20210801
    Link to Paper Search Results by DOI
  41. Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination, AMERICAN JOURNAL OF INFECTION CONTROL, 49(3), 299-301, 20210301
    Link to Paper Search Results by DOI
  42. Effect of intermittent irradiation and dose-response of 222 nm ultraviolet light on SARS-CoV-2 contamination., Photodiagnosis and Photodynamic Therapy, 33, 102184, 20210301
  43. Molecular characterization and the mutation pattern of SARS-CoV-2 during first and second wave outbreaks in Hiroshima, Japan, PLOS ONE, 16(2), 20210205
    Link to Paper Search Results by DOI
  44. Efficacy of photodynamic antimicrobial chemotherapy on Acanthamoeba keratitis in vivo., Lasers in Surgery and Medicine, 20201201
  45. Development of an Oncolytic Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppressor MicroRNA, ANTICANCER RESEARCH, 40(11), 6319-6325, 20201101
    Link to Paper Search Results by DOI
  46. Characterization of a unique Sendai virus isolate and its potential as an effective vaccine adjuvant., BIO Clinica, 35(2), 78-81, 20200201
  47. Effects of Traditional Kampo Drugs and Their Constituent Crude Drugs on Influenza Virus Replication In Vitro: Suppression of Viral Protein Synthesis by Glycyrrhizae Radix, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2019, 20191203
    Link to Paper Search Results by DOI
  48. Antimicrobial Photodynamic Therapy with the photosensitizer TONS504 eradicates Acanthamoeba, PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 28, 166-171, 20191201
    Link to Paper Search Results by DOI
  49. Development of new concept viral vectors exerting both vaccine and adjuvant activities., IMPACT, 2019(7), 9-11, 20190801
    Link to Paper Search Results by DOI
  50. Antifungal efficacy of photodynamic therapy with TONS 504 for pathogenic filamentous fungi, LASERS IN MEDICAL SCIENCE, 34(4), 743-747, 20190601
    Link to Paper Search Results by DOI
  51. Novel Near-Infrared Fluorescence-Guided Surgery With Vesicular Stomatitis Virus for Complete Surgical Resection of Osteosarcomas in Mice, JOURNAL OF ORTHOPAEDIC RESEARCH, 37(5), 1192-1201, 20190501
    Link to Paper Search Results by DOI
  52. Current Status and Prospects of Viral Vector Vaccines, BIO Clinica, 34(2), 107-111, 20190201
  53. How Sendai virus counteracts interferon, 50, 7-12, 20190101
  54. Inactivation of human and avian influenza viruses by potassium oleate of natural soap component through exothermic interaction, PLOS ONE, 13(9), 20180927
    Link to Paper Search Results by DOI
  55. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction, PLOS ONE, 13(5), 20180521
    Link to Paper Search Results by DOI
  56. Time-dependent antimicrobial effect of photodynamic therapy with TONS 504 on Pseudomonas aeruginosa, LASERS IN MEDICAL SCIENCE, 33(7), 1455-1460, 20180901
    Link to Paper Search Results by DOI
  57. Metastatic tumor cells detection and anti-metastatic potential with vesicular stomatitis virus in immunocompetent murine model of osteosarcoma, JOURNAL OF ORTHOPAEDIC RESEARCH, 36(9), 2562-2569, 20180901
    Link to Paper Search Results by DOI
  58. Eligibility of Feline Calicivirus for a Surrogate of Human Norovirus in Comparison with Murine Norovirus, Poliovirus and Coxsackievirus, BIOCONTROL SCIENCE, 23(3), 145-149, 20180901
    Link to Paper Search Results by DOI
  59. A Single Amino Acid Substitution within the Paramyxovirus Sendai Virus Nucleoprotein Is a Critical Determinant for Production of Interferon-Beta-Inducing Copyback-Type Defective Interfering Genomes, JOURNAL OF VIROLOGY, 92(5), 20180501
    Link to Paper Search Results by DOI
  60. Structural analysis of the STAT1:STAT2 heterodimer revealed the mechanism of Sendai virus C protein-mediated blockade of type 1 interferon signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 292(48), 19752-19766, 20171201
    Link to Paper Search Results by DOI
  61. Inactivation of the influenza virus by a supplemental fermented plant product (Manda Koso)., Hiroshima Journal of Medical Sciences, 66(4), 97-101, 20171201
  62. High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120, MARINE BIOTECHNOLOGY, 18(2), 215-231, 20160401
    Link to Paper Search Results by DOI
  63. Nonstructural protein p39 of feline calicivirus suppresses host innate immune response by preventing IRF-3 activation, VETERINARY MICROBIOLOGY, 185, 62-67, 20160101
  64. High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120 (vol 18, pg 144, 2016), MARINE BIOTECHNOLOGY, 18(3), 448-448, 20160101
  65. Temporal antimicrobial effect of photodynamic therapy with TONS504 on Pseudomonas aeruginosa, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(12), 20160101
  66. Airborne virus detection by a sensing system using a disposable integrated impaction device, JOURNAL OF BREATH RESEARCH, 10(3), 20160101
  67. ★, Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein, Journal of Virology, 89(22), 11487-11499, 20151115
    Link to Paper Search Results by DOI
  68. Inactivation of acyclovir-sensitive and -resistant strains of herpes simplex virus type 1 in vitro by photodynamic antimicrobial chemotherapy., Molecular Vision, 21, 532-537, 20150502
  69. Antimicrobial action from a novel porphyrin derivative in photodynamic antimicrobial chemotherapy in vitro., Lasers in Medical Science, 30(1), 383-387, 20150101
    Link to Paper Search Results by DOI
  70. Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin, MARINE DRUGS, 13(6), 3454-3465, 20150101
  71. IFN-beta-inducing, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner, FRONTIERS IN MICROBIOLOGY, 6, 20150101
  72. Sendai virus C proteins regulate viral genome and antigenome synthesis to dictate the negative genome polarity., Journal of Virology, 88(1), 690-698, 20140101
    Link to Paper Search Results by DOI
  73. Clustered basic amino acids of the small Sendai virus C protein Y1 are critical to its Ran GTPase-mediated nuclear localization., PLoS One, 8(8), 20130809
    Link to Paper Search Results by DOI
  74. The potential of recombinant vesicular stomatitis virus-mediated virotherapy against metastatic colon cancer., International Journal of Molecular Medicine, 31(2), 299-306, 20130201
    Link to Paper Search Results by DOI
  75. ★, Inactivation of pathogenic viruses by plant-derived tannins: strong effects of extracts from persimmon (Diospyros kaki) on a broad range of viruses., PLoS One, 8(1), 20130125
    Link to Paper Search Results by DOI
  76. Passage of a Sendai virus recombinant in embryonated chicken eggs leads to markedly rapid accumulation of U-to-C transitions in a limited region of the viral genome., PLoS One, 7(11), 20121121
    Link to Paper Search Results by DOI
  77. Inhibition of virus-like particle release of Sendai virus and Nipah virus, but not that of mumps virus, by tetherin/CD317/BST-2., Hiroshima Journal of Medical Sciences, 61(3), 59-67, 20120901
  78. Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein., Journal of Virology, 86(13), 7136-7145, 20120701
    Link to Paper Search Results by DOI
  79. Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation., Neuroscience Letters, 505(3), 279-281, 20111121
    Link to Paper Search Results by DOI
  80. Analysis of interaction of Sendai virus V protein and melanoma differentiation-associated gene 5., Microbiology and Immunology, 55(11), 760-767, 20111101
    Link to Paper Search Results by DOI
  81. Decreased expression in nuclear factor-kB essential modulator due to a novel splice-site mutation causes X-linked ectodermal dysplasia with immunodeficiency., Journal of Clinical Immunology, 31(5), 762-772, 20111001
  82. Oncolytic vesicular stomatitis virus administered by isolated limb perfusion suppresses osteosarcoma growth., Journal of Orthopaedic Research, 29(5), 795-800, 20110501
  83. Paramyxovirus assembly and budding: building particles that transmit infections., The International Journal of Biochemistry & Cell Biology, 42(9), 1416-1429, 20100901
    Link to Paper Search Results by DOI
  84. Significance of the YLDL motif in the M protein and Alix/AIP1 for Sendai virus budding in the context of virus infection., Virology, 405(2), 334-341, 20100901
    Link to Paper Search Results by DOI
  85. Conserved charged amino acids within Sendai virus C protein play multiple roles in the evasion of innate immune responses., PLoS ONE, 5(5), e10719, 20100501
  86. Studies on the paramyxovirus accessory genes by reverse genetics in the Sendai virus?mouse system., Proceedings of the Japan Academy, Series B-Physical and Biological Sciences, 84(10), 439-451, 20090105
  87. Paramyxovirus Sendai virus C proteins are essential for maintenance of negative-sense RNA genome in virus particles., Virology, 374(2), 495-505, 20080501
  88. Contribution of the leader sequence to homologous viral interference among Sendai virus strains., Virology, 372(1), 64-71, 20080301
    Link to Paper Search Results by DOI
  89. Recruitment of Alix/AIP1 to the plasma membrane by Sendai virus C protein facilitates budding of virus-like particles., Virology, 371(1), 108-120, 20080101
    Link to Paper Search Results by DOI
  90. Persistent and stable gene expression by a cytoplasmic RNA replicon based on a noncytopathic variant Sendai virus., Journal of Biological Chemistry, 282(37), 27383-27391, 20070914
  91. Paramyxovirus budding, Virus, 57(1), 1-7, 20070601
  92. The YLDL sequence within Sendai virus m protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein., Journal of Virology, 81(5), 2263-2273, 20070401
    Link to Paper Search Results by DOI
  93. Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice., Virology, 359(1), 82-91, 20070301
  94. Gene delivery of paraoxonase-1 inhibits neointimal hyperplasia after arterial balloon-injury in rabbits fed a high-fat diet., Hypertension Research, 30(1), 85-91, 20070101
  95. Suppression of interferon-related promoter activation by hepatitis C virus proteins expressed in cultured cells., Hiroshima Journal of Medical Sciences, 55(3), 71-77, 20060901
  96. Cell-specific inhibition of paramyxovirus maturation by proteasome inhibitors., Microbiology and Immunology, 49(9), 835-844, 20050901
  97. ★, AIP1/Alix is a binding partner of Sendai virus C protein and facilitates virus budding., Journal of Virology, 79(14), 8933-8941, 20050715
  98. Generation of Sendai virus nucleocapsid-like particles in yeast., Virus Research, 108(1-2), 221-224, 20050301
  99. Characterization of the amino acid residues of Sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation., Journal of Virology, 78(14), 7443-7454, 20040701
  100. Paramyxovirus Sendai virus-like particle formation by expression multiple viral proteins and acceleration of its release by C protein., Virology, 325(1), 1-10, 20040701
  101. Masking of the contribution of V protein to Sendai virus pathogenesis in an infection model with a highly virulent field isolate., Virology, 313(2), 581-587, 20030901
  102. Safety and growth suppressive effect of intra-hepatic arterial injection of AdCMV p53 combine with CDDP to Rat liver metastatic tumors., Journal of Experimental & Clinical Cancer Research, 22(3), 339-406, 20030901
  103. Identification of mutations associated with attenuation of virulence of a field Sendai virus isolate by egg passage., Virus Genes, 25(2), 189-193, 20021001
  104. Involvement of the leader sequence in Sendai virus pathogenesis revealed by recovery of a pathogenic field isolate from cDNA., Journal of Virology, 76(17), 8540-8547, 20020901
  105. Mutational analysis of the Sendai virus V protein: Importance of the conserved residues for Zn binding, virus pathogenesis, and efficient RNA editing., Virology, 299(2), 172-181, 20020801
  106. Augmentation of local antitumor immunity in liver by interleukin-2 gene transfer via portal vein., Cancer Gene Therapy, 9(8), 655-664, 20020801
  107. Alteration of Sendai virus morphogenesis and nucleocapsid incorporation due to mutation of cystein residues of the matrix protein., Journal of Virology, 76(4), 1682-1690, 20020201
  108. Molecular and epidemiological analyses of human adenovirus type 7 strains isolated from the nationwide outbreak of 1995 in Japan., Journal of Clinical Microbiology, 40(1), 140-145, 20020101
  109. Matrix proteins of envelope viruses., Virus, 51(1), 11-19, 20010601
  110. Attenuation of a field Sendai virus isolate through egg-passages is associated with an impediment of viral genome replication in mouse respiratory cells., Archives of Virology, 146(5), 893-908, 20010501
  111. Differential expression of CD45 isoforms in tolerant and rejecting rat liver transplant recipients., Transplantation Proceedings, 33(1-2), 544, 20010301
  112. Emergence of anti-inflammatory monocytes in long-term surviving hosts of IL-10-transduced liver allografts., Cytokine, 13(3), 183-187, 20010201
  113. Conserved and non-conserved regions in the Sendai virus genome: evolution of a gene possessing overlapping reading frames., Virus Genes, 22(1), 47-52, 20010101
  114. Adenovirus-mediated interleukin-10 overexpression: Comparison between intraportal and intramuscular gene transfer., Transplantation Proceedings, 32(7), 2006, 20001101
  115. Involvement of the zinc-binding capacity of Sendai virus V protein in viral pathogenesis., Journal of Virology, 74(17), 7834-7841, 20000901
  116. Adenovirus-mediated interleukin-10 overexpression: Comparison between intraportal and intramuscular gene transfer., Transplantation Proceedings, 32(7), 2006, 20000401
  117. p53 gene therapy for rat liver tumor by intrahepatic arterial injection of AdCMV-p53 in combination with CDDP., Molecular Therapy, 1(5), S326, 20000401
  118. Effects of adenovirus-mediated IL-10 gene transfer on liver transplantation., Molecular Therapy, 1(5), 176-177, 20000401
  119. Adenovirus-mediated allograft transduction of Interleukin-10: Role in the induction phase of liver allograft acceptance., Transplantation Proceedings, 32, 247-248, 20000301
  120. Double-layered membrane vesicles released from mamalian cells infected with Sendai virus expressing the matrix protein of vesicular stomotitis virus., Virology, 263(1), 230-243, 19991001
  121. Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation., Gene Therapy, 6(5), 816-822, 19990501
  122. The genome nucleotide sequence of a contemporary wild strain of measles virus and its comparison with the classical Edmonston strain genome., Virology, 256(2), 340-350, 19990401
  123. Comparison of substrate specificities against the fusion glycoprotein of virulent Newcastle disease virus between a chick embryo fibroblast processing protease and mammalian subtilisin-like proteases., Microbiology and Immunology, 43(2), 133-140, 19990201
  124. Infulenza virus M2 ion channel-two functions for virus replication., Experimental Medicine, 15(19), 114-118, 19971201
  125. Viral ion channel : structure and function of the infuluenza virus M2 protein., Virus, 47(2), 177-186, 19971201
  126. Structure and function of the influenza virus M2 ion channel protein., Japanese Journal of Clinical Medicine, 55(10), 89-94, 19971001
  127. ★, The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer., Proc. Natl. Acad. Sci. USA, 94(10), 5000-5005, 19970501
  128. ★, Phosphorylation of the Sendai virus M protein is not essential for virus replication either in vitro or in vivo., Virology, 235(2), 360-366, 19970401
  129. Protection of mice from respiratory Sendai virus infections by recombinant vaccinia viruses., Journal of Virology, 71(1), 832-838, 19970101
  130. HLA-DR8 subtyping by polymerase chain reaction (PCR)-DNA conformation polymorphism(DCP) analysis; a simple and practical genotyping method., Hiroshima J. Med. Sci., 45(3), 85-92, 19960901
  131. ★, The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus., Journal of Cell Biology, 133(4), 733-747, 19960501
  132. Correlation of proteolytic cleavage of paramyxovirus F protein precursors with expression of the fur, PACE4 and PC6 genes in mammalian cells., Journal of General Virology, 75(10), 2821-2827, 19941001
  133. Monitoring for rejection and engraftment by means of the polymerase chain reaction after rat orthotopic liver transplantation., Transplantation, 58(6), 745-748, 19940901
  134. Monitoring for engraftment following rat orthotopic liver transplantation by the polymerase chain reaction., Transplantation Proceedings, 26(2), 902-903, 19940401
  135. Sequence specificity of furin, a proprotein processing endoprotease, for the Hemagglutinin of a virulent avian influenza virus., Journal of Virology, 68(2), 1213-1218, 19940201
  136. A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains., Arhieves of Virology, 135(1-2), 159-164, 19940101
  137. Fo-containing noninfectious Sendai virus can initiate replication in mouse lungs but requires a relatively long incubation period., Journal of Virology, 67(12), 7618-7622, 19931201
  138. Expression of the HN, F, NP and M proteins of Sendai virus by recombinant vaccinia viruses and their contribution to protective immunity against Sendai virus infections in mice., Journal of General Virology, 74, 479-484, 19930301
  139. Location and character of the cellular enzyme that cleaves the hemagglutinin of a virulent avian influenza virus., Virology, 190(1), 278-289, 19920901
  140. Detection of cytomegalovirus in urine samples by an enzyme-linked immunosorbent assay using a monoclonal antibody against the viral 150-kilodalton protein., Journal of Clinical Microbiology, 30(3), 685-690, 19920301
  141. Distribution and substrate specificity of intracellular proteolytic processing enzyme(s) for paramyxovirus fusion glycoproteins., Journal of General Virology, 73(3), 583-590, 19920301
  142. ★, Identification of endoprotease activity in the trans Golgi membranes of rat liver cells that specifically processes in vitro the fusion glycoprotein precursor of virulent Newcastle disease virus., Virology, 184(2), 504-512, 19911001
  143. Immediate protection of mice from lethal wild-type Sendai virus (HVJ) infections by a temperature-sensitive mutant, HVJpi, possessing homologous intefering capacity., Virology, 177(1), 65-74, 19900701
  144. Endoproteolytic activiation of Newcastle disease virus fusion proteins requires an intracellular acidic environment., Virology, 170(2), 571-574, 19890601
  145. Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene., Virology, 169(2), 260-272, 19890401
  146. Newcastle disease virus evolution. II. Lack of gene recombination in generating virulent and avirulent strains., Virology, 169(2), 273-282, 19890401
  147. Identification of amino acids relevant to three antigenic determinants on the fusion protein of Newcastle disease virus that are involved in fusion inhibition and neutralization., Journal of Virology, 62(11), 4427-4430, 19881101
  148. Structural features unique to each of the three antigenic sites on the hemagglutinin-neuraminidase protein of Newcastle disease virus., Virology, 163(1), 174-182, 19880301
  149. Structural comparison of the cleavage-activation site of the fusion glycoprotein between virulent and avirulent strains of Newcastle disease virus., Virology, 158(1), 242-247, 19870501

Publications such as books

  1. 2024/04/12, Biomedical Engineering, 1st Ed., Development of Etak, an ethoxysilane-based immobilized antibacterial and antiviral agent, Jenny Stanford Publishing, New York, 2024, 2024 April, Scholarly Book, Joint work, 英語, Hiroshi Nikawa, Takemasa Sakaguchi, ISBN-10:9815129163, ISBN-13: 978-9815129168
  2. 2023/10/18, Body and Mind: A Comprehensive Encyclopedia of Health (Junior High and High School Edition) 2023, Countermeasures against the novel coronavirus infection in schools, 2023, 2023 Oct, Book(general), Joint work, 日本語, Takemasa Sakaguchi, ISBN978-4-87981-770-9 C0347, 236

Patented

  1. Patent, 7183477, 2022/11/25