Ryukichi Takagi

Last Updated :2024/12/04

Affiliations, Positions
Graduate School of Advanced Science and Engineering, Assistant Professor
E-mail
rtakagihiroshima-u.ac.jp
Self-introduction
My research is focused on development of synthetic methodology of organic chemistry.

Basic Information

Major Professional Backgrounds

  • 1998/04/01, 2007/03/31, Department of Chemistry, Graduate School of Science, Assiatant Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Natural Science, 1995/04, 1998/03

Academic Degrees

  • Doctor of Science, Hiroshima University
  • Master of Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Science : Chemistry : Chemistry
  • [Master's Program] Graduate School of Advanced Science and Engineering : Division of Advanced Science and Engineering : Chemistry Program
  • [Doctoral Program] Graduate School of Advanced Science and Engineering : Division of Advanced Science and Engineering : Chemistry Program

Research Fields

  • Chemistry;Applied chemistry;Synthetic chemistry

Research Keywords

  • organic synthesis
  • stereoselectivity
  • organocatalyst
  • natural product

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 3Term, Introduction to Chemistry B
  2. 2024, Undergraduate Education, Second Semester, Exercises in Organic Chemistry
  3. 2024, Undergraduate Education, First Semester, Chemical Experiments I
  4. 2024, Undergraduate Education, Second Semester, Chemical Experiments II
  5. 2024, Undergraduate Education, 3Term, Analytical Organic Chemistry
  6. 2024, Graduate Education (Master's Program) , First Semester, Exercises in Chemistry A
  7. 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Chemistry B
  8. 2024, Graduate Education (Master's Program) , Academic Year, Master's Thesis in Chemistry

Research Activities

Academic Papers

  1. Generation and Characterization of a Tetraradical Embedded in a Curved Cyclic Paraphenylene Unit, CHEMISTRY-A EUROPEAN JOURNAL, 29(42), 20230726
    Link to Paper Search Results by DOI
  2. Enantioselective [2+2] photocycloaddition of quinolone using a C-1-symmetric chiral phosphoric acid as a visible-light photocatalyst, ORGANIC & BIOMOLECULAR CHEMISTRY, 20(19), 3940-3947, 20220518
    Link to Paper Search Results by DOI
  3. 2-(4-Nitrophenyl)-1H-indolyl-3-methyl Chromophore: A Versatile Photocage that Responds to Visible-light One-photon and Near-infrared-light Two-photon Excitations, CHEMISTRY LETTERS, 51(2), 153-156, 202202
    Link to Paper Search Results by DOI
  4. Bis(trifluoromethanesulfonimide) (BSI): Acidity and application to hydrofunctionalization as a Bronsted acid catalyst, TETRAHEDRON, 85, 20210409
    Link to Paper Search Results by DOI
  5. Bis(trifluoromethanesulfonimide) (BSI): Acidity and application to hydrofunctionalization as a Brønsted acid catalyst., Tetrahedron, 2021, 85, 132037., 85, 132037, 2021
  6. Chiral Calcium Bis-Sulfonimide Catalyzed Diels-Alder Reactions of 1-Acryloyl-Pyrazole, Chemstry Letters, 50, 1781-1783, 20211001
  7. Disulfonimide catalyzed asymmetric intramolecular hydroamination of alkenyl thioureas: Concentration effect in the hydroamination, TETRAHEDRON, 94, 20210813
    Link to Paper Search Results by DOI
  8. Computational study on N-triflylphosphoramide-catalyzed enantioselective hydroamination of alkenyl thiourea, ORGANIC & BIOMOLECULAR CHEMISTRY, 19(40), 8806-8811, 20211020
    Link to Paper Search Results by DOI
  9. Chiral Calcium Bis-sulfonimide Catalyzed Diels-Alder Reactions of 1-Acryloyl-pyrazole, CHEMISTRY LETTERS, 50(10), 1781-1783, 202110
    Link to Paper Search Results by DOI
  10. Enantioselective intramolecular [2+2] photocycloaddition using phosphoric acid as a chiral template, ORGANIC & BIOMOLECULAR CHEMISTRY, 18(45), 9261-9267, 20201207
    Link to Paper Search Results by DOI
  11. ★, Enantioselective intramolecular [2 + 2] photocycloaddition using phosphoric acid as a chiral template., Org. Biomol. Chem., 18, 9261-9267, 2020
  12. Photochemical [2+2] cycloaddition reaction of enone derivatives with 2-siloxy-1H-pyrrole derivatives, ARKIVOC, 192-204, 2018
    Link to Paper Search Results by DOI
  13. Enantioselective Michael Reaction of Cyclic beta-Ketoesters with Morita-Baylis-Hillman Derivatives Using a Phase-Transfer Catalyst, JOURNAL OF ORGANIC CHEMISTRY, 83(18), 11191-11203, 20180921
    Link to Paper Search Results by DOI
  14. Paterno-Buchi photochemical [2+2] cycloaddition of aromatic carbonyl compounds with 2-siloxy-1H-pyrrole derivatives(dagger), JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 30(4), 201704
    Link to Paper Search Results by DOI
  15. Two ring opened oxetane taxoids containing a C-20 benzoyloxy group from the roots of Taxus wallichiana Zucc., TETRAHEDRON LETTERS, 58(40), 3897-3900, 20171004
    Link to Paper Search Results by DOI
  16. Artocarmins G-M, Prenylated 4-Chromenones from the Stems of Artocarpus rigida and Their Tyrosinase Inhibitory Activities, JOURNAL OF NATURAL PRODUCTS, 80(12), 3173-3179, 201712
    Link to Paper Search Results by DOI
  17. Paternò–Büchi photochemical [2+2] cycloaddition of aromatic carbonyl compounds with 2-siloxy-1H-pyrrole derivatives., J. Phys. Org. Chem., 30, e3632, 2017
  18. Two ring opened oxetane taxoids containing a C-20 benzoyloxy group from the roots of Taxus wallichiana Zucc., Tetrahderon Lett., 58, 3897-3900, 2017
  19. Artocarmins G-M, prenylated 4-chromenones from the stems of Artocarpus rigida and their tyrosinase Inhibitory activities., Journal of Natural Products, 80, 3172-3178, 2017
  20. Design and Synthesis of a 4-Nitrobromobenzene Derivative Bearing an Ethylene Glycol Tetraacetic Acid Unit for a New Generation of Caged Calcium Compounds with Two-Photon Absorption Properties in the Near-IR Region and Their Application in Vivo, ACS OMEGA, 1(2), 193-201, 201608
    Link to Paper Search Results by DOI
  21. Design and Synthesis of a 4‑Nitrobromobenzene Derivative Bearing an Ethylene Glycol Tetraacetic Acid Unit for a New Generation of Caged Calcium Compounds with Two-Photon Absorption Properties in the Near-IR Region and Their Application in Vivo., ACS Omega, 1, 193-201, 2016
  22. Formation of Isomerized E,Z-Configured 1,3-Dienes in Construction of Macrocyclic Trienes by Diene-Ene RCM, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 88(1), 146-148, 20150115
    Link to Paper Search Results by DOI
  23. Organocatalytic asymmetric desymmetrization of 4,4-disubstituted cyclohexadienones via an intermolecular Diels-Alder reaction, ORGANIC & BIOMOLECULAR CHEMISTRY, 13(45), 11039-11045, 2015
    Link to Paper Search Results by DOI
  24. A novel non-metathetic behavior of Grubbs catalyst: Ruthenium-mediated intramolecular [3+2] cycloaddition of bis-1,3-dienes, JOURNAL OF ORGANOMETALLIC CHEMISTRY, 723, 171-175, 20130101
    Link to Paper Search Results by DOI
  25. Zirconium-catalyzed chemoselective methylalumination of ethers, amines, and sulfides bearing two terminal alkenyl groups, JOURNAL OF ORGANOMETALLIC CHEMISTRY, 696(8), 1556-1564, 20110415
    Link to Paper Search Results by DOI
  26. Concentration and Temperature Dependency of Regio- and Stereoselectivity in a Photochemical [2+2] Cycloaddition Reaction (the Paterno Buchi Reaction): Origin of the Hydroxy-Group Directivity, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(8), 2592-2604, 20110302
    Link to Paper Search Results by DOI
  27. Stereochemical deuterium-labeling study on the denitrogenation of 7,7-diethoxy-2, 3-diazabicyclo[2.2.1]hept-2-ene, JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 24(10), 894-901, 201110
    Link to Paper Search Results by DOI
  28. Alkylalumination of arylacetylene catalyzed by zirconocene catalysts supported on solid materials, Journal of Molecular Catalysis A: Chemical, 321, 71-76, 20100401
  29. Computational study on the cyclopropanation reaction of ylides generated from -pyridiniumacetates, HETEROCYCLES, 81(11), 2479-2495, 20101101
    Link to Paper Search Results by DOI
  30. Stereochemical investigation on the construction of poly-functionalized bicyclo[3.3.1]nonenones by successive Michael reactions of 2-cyclohexenones, ORGANIC & BIOMOLECULAR CHEMISTRY, 5(2), 286-300, 2007
    Link to Paper Search Results by DOI
  31. ★, Stereoselective total synthesis of (+)-scyphostatin via a pi-facially selective Diels-Alder reaction, JOURNAL OF ORGANIC CHEMISTRY, 72(11), 4117-4125, 20070525
    Link to Paper Search Results by DOI
  32. Late acceleration of phosphoric acid-catalyzed Diels-Alder reaction by internal hydrogen-bonding of adjacent hydroxy group, JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 278(1-2), 120-126, 20071214
    Link to Paper Search Results by DOI
  33. Synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative via epoxide ring opening, 1,3-carbonyl transposition and epoxide ring regeneration: a synthetic study on a scyphostatin analogue, Organic ＆ Biomolecular Chemistry, 3, 2031-2036, 20050401
  34. One-pot synthesis of adamantane derivatives by domino Michael reactions from ethyl 2,4-dioxocyclohexanecarboxylate, JOURNAL OF ORGANIC CHEMISTRY, 70(21), 8587-8589, 20051014
    Link to Paper Search Results by DOI
  35. Synthetic study of an analogue of the hydrophilic moiety of Scyphostatin via p-facial selective Diels-Alder reaction, Heterocycles, 64, 75-91, 20040401
  36. Facial Selectivity in Nucleophilic Epoxidation of 3-Aryl-2-phosphonoacrylates Induced by the (-)-8-Phenylmenthyl Moiety as a Chiral Auxiliary, Heterocycles, 62, 251-262, 20040401
  37. Stereoselective Synthesis of the hydophobic side chain of Scyphostatin, Australian Journal of Chemistry, 57, 439-447, 20040401
  38. Stereoselectivity control by oxaspiro rings during Diels-Alder cycloadditions to cross-conjugated cyclohexadienones: The syn oxygen phenomenon, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126(51), 16783-16792, 20041229
    Link to Paper Search Results by DOI
  39. Influence of polymerization degree of poly-l-leucine catalyst and substituent effect on the Julia-Colonna asymmetric epoxidation of benzalacetophenones, HETEROCYCLES, 64, 129-141, 20041231
    Link to Paper Search Results by DOI
  40. pi-Facial selectivity in Diels-Alder reactions of cross-conjugated ketones bearing an oxa-spiro-ring with sterically undemanding dienes, HETEROCYCLES, 60(4), 785-790, 20030401
    Link to Paper Search Results by DOI
  41. Computational study of base-induced skeletal conversion via a spirocyclic intermediate in dibenzodithiocinium derivatives by ab initio MO calculations, JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 16(5), 271-278, 200305
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  42. Efficient synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative bearing a spirolactone via a Diels-Alder reaction with high ?-facial selectivit, Chemical Communications, 2096-2097, 20020401
  43. Stereochemical considerations on the stereoselective cyclopropanation reactions of 3-aryl-2-phosphonoacrylates induced by the (-)-8-phenylmenthyl group as a chiral auxiliary, Journal of the Chemical Society= Perkin Transactions 1, 179-190, 20020101
  44. Stereoselectivity in the Darzens Condensation of Cyclohexanone Derivatives with a-Haloacetate, Heterocycles, 55(1), 9-12, 20010101
  45. Stereoselective Formation of 2,5-Disubstituted Tetrahydropyrans by Intramolecular Hetero-Michael Addition and a Computational Study at AM1 Level, Bulletin of the Chemical Society of Japan, 74(10), 1901-1907, 20011001
  46. Stereoselective cyclopropanation of 3-aryl-2-phosphonoacrylates induced by the (-)-8-phenylmenthyl group as a chiral auxiliary, TETRAHEDRON LETTERS, 42(34), 5891-5895, 20010820
    Link to Paper Search Results by DOI
  47. The Julia Colonna Asymmetric Epoxidation Reaction by Soluble Oligo-L-leucine Containing an a-Aminobutylic Acid Residue; Importance of Helical Structure of the Catalyst on the Asymmetric Induction, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 73(4), 2115-2121, 20000401
  48. The Julia-Colonna type asymmetric epoxidation reaction catalyzed by soluble oligo-L-leucines containing an alpha-aminoisobutyric acid residue: Importance of helical structure of the catalyst on asymmetric induction, CHEMISTRY LETTERS, 366-367, 20000405
    Link to Paper Search Results by DOI
  49. Stereoselective Synthesis of (+)-Rhopaloic Acid A and (-)-ent- and (+-)-rac-Rhopaloic Acid A, Journal of the Chemical Society= Perkin Transactions 1, -(5), 925-934, 19980301
  50. Selective Conversion of Bromo-oxirane into Tetrahydropyranylacrylate by Epoxide ring Opening, Chemical Communications, 875-876, 19970501
  51. Synthesis of Norsesterterpene rac- and ent-Rhopaloic Acid A, Chemical Communications, 1887-1889, 19971001
  52. Stereoselectivity in the Formation of 2,5-Disubstituted Tetrahydropyrans by Intramolecular Hetero-Michael Addition, Heterocycles, 45(12), 2313-2316, 19971201
  53. (-)-Loliolide and other Germination Inhibitory Active Constituents in Equisetum arvense, Natural Product Letters, 10(1), 181-186, 19970101
  54. Excellent Z-selective olefin formation using pentacoordinate pirophosphoranes and aldehydes. Wittig type reaction via hexacoordinate intermediates, Journal of Amnerican Chemical Society, 119(25), 5970-5971, 19970601
  55. Asymmetric Darzens Condensation of Ketones with a-Chloroacetates by Means of (-)-8-Phenylmenthyl Auxiliary, Chemical Communications, 2411-2412, 19961101
  56. Monomeric 10-Sb-5 Pentacoordinate Organoantimony Monohalides and Their Permutational Behavior, Chemistry Letters, 857-858, 19950401
  57. Efficient synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative bearing a spirolactone via a Diels-Alder reaction with high pi-facial selectivity: a synthetic study towards scyphostatin., Efficient synthesis of a 4,5-epoxy-2-cyclohexen-1-one derivative bearing a spirolactone via a Diels-Alder reaction with high pi-facial selectivity: a synthetic study towards scyphostatin., 2002
  58. Stereoselectivity control by oxaspiro rings during Diels-Alder cycloadditions to cross-conjugated cyclohexadienones: the syn oxygen phenomenon., Stereoselectivity control by oxaspiro rings during Diels-Alder cycloadditions to cross-conjugated cyclohexadienones: the syn oxygen phenomenon., 126(51), 2004
  59. One-pot synthesis of adamantane derivatives by domino Michael reactions from ethyl 2,4-dioxocyclohexanecarboxylate., One-pot synthesis of adamantane derivatives by domino Michael reactions from ethyl 2,4-dioxocyclohexanecarboxylate., 70(21), 2005
  60. Stereoselective total synthesis of (+)-Scyphostatin via a pi-facially selective Diels-Alder reaction., Stereoselective total synthesis of (+)-Scyphostatin via a pi-facially selective Diels-Alder reaction., 72(11), 2007
  61. Construction of the adamantane core of plukenetione-type polycyclic polyprenylated acylphloroglucinols., Construction of the adamantane core of plukenetione-type polycyclic polyprenylated acylphloroglucinols., 73(23), 2008
  62. Computational study on the cyclopropanation reaction of ylides generated from α-pyridiniumacetates, Heterocycles, 81(11), 2479-2495, 20101101
  63. ★, Organocatalytic asymmetric desymmetrization of 4,4-disubstituted cyclohexadienones via an intermolecular Diels–Alder reaction, Organic & Biomolecular Chemistry, 13, 11039-11045, 2015
  64. Disulfonimide catalyzed asymmetric intramolecular hydroamination of alkenyl thioureas: Concentration effect in the hydroamination, Tetrahedron, 94, 132332, 20210801