KOUICHIHASHIMOTO

Last Updated :2019/10/06

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), ., Professor
E-mail
hashikhiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 1998/04/01, 2001/03/31, Kanazawa University, Faculty of Medicine, Research Associate
  • 2001/04/01, 2005/05/31, Kanazawa University, Research Associate
  • 2005/06/01, 2007/03/31, Osaka University, Research Associate
  • 2007/04/01, 2008/03/31, Osaka University, Assistant Professor
  • 2008/04/01, 2010/06/30, The University of Tokyo, Associate Professor
  • 2010/07/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences , Professor
  • 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Professor

Educational Backgrounds

  • Osaka University, Japan, 1988/04, 1992/03
  • Osaka University, Japan, 1992/04, 1994/03
  • Jichi Medical School, Japan, 1994/04, 1998/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Jichi Medical School
  • Master of Engineering, Osaka University

Research Fields

  • Biological Sciences;Neuroscience;Neurophysiology / General neuroscience
  • Biological Sciences;Neuroscience;Nerve anatomy / Neuropathology

Research Keywords

  • development
  • synapse
  • neuron

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2019, Liberal Arts Education Program1, 2Term, Cell Science
  2. 2019, Undergraduate Education, Year, Physiology and Biochemistry
  3. 2019, Undergraduate Education, 2Term, Introduction for medical research
  4. 2019, Undergraduate Education, 4Term, Medical Neuroscience I
  5. 2019, Undergraduate Education, First Semester, Medical Neuroscience II
  6. 2019, Undergraduate Education, Intensive, Practice for medical research
  7. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  8. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  9. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  10. 2019, Graduate Education (Master's Program) , First Semester, Methods in biomedical sciences
  11. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  12. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  13. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  14. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  15. 2019, Graduate Education (Master's Program) , First Semester, Physiology and biological chemistry
  16. 2019, Graduate Education (Master's Program) , First Semester, Seminar on Neurophysiology
  17. 2019, Graduate Education (Master's Program) , Second Semester, Seminar on Neurophysiology
  18. 2019, Graduate Education (Master's Program) , First Semester, Research on Neurophysiology
  19. 2019, Graduate Education (Master's Program) , Second Semester, Research on Neurophysiology
  20. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Neurophysiology
  21. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Neurophysiology
  22. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced research on Neurophysiology
  23. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Neurophysiology
  24. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  25. 2019, Graduate Education (Master's Program) , First Semester, Seminar
  26. 2019, Graduate Education (Master's Program) , Second Semester, Seminar
  27. 2019, Graduate Education (Master's Program) , First Semester, Research
  28. 2019, Graduate Education (Master's Program) , Second Semester, Research
  29. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  30. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  31. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  32. 2019, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry
  33. 2019, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  34. 2019, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  35. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Neurophysiology
  36. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Neurophysiology
  37. 2019, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Neurophysiology
  38. 2019, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Neurophysiology

Research Activities

Academic Papers

  1. Task-dependent function of striatal cholinergic interneurons in behavioural flexibility, EUROPEAN JOURNAL OF NEUROSCIENCE, 47(10), 1174-1183, MAY 2018
  2. Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum, NATURE COMMUNICATIONS, 9, JUL 19 2018
  3. Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(28), 7438-7443, JUL 11 2017
  4. Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice, SCIENCE ADVANCES, 3(6), JUN 2017
  5. Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive., CELL REPORTS, 16(4), 994-1004, JUL 26
  6. Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(8), 2282-2287, FEB 23 2016
  7. The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus, NEURON, 91(5), 1097-1109, SEP 7 2016
  8. CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis, CELL REPORTS, 17(8), 2004-2014, NOV 15 2016
  9. Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells, CELL REPORTS, 10(4), 537-550, FEB 3 2015
  10. A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance, NATURE COMMUNICATIONS, 6, DEC 2015
  11. A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia, MOLECULAR BRAIN, 8, DEC 29 2015
  12. The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function., JOURNAL OF NEUROSCIENCE, 34(7), 2702-2712, FEB 2014
  13. Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism, NATURE COMMUNICATIONS, 5, 2014
  14. Global Scaling Down of Excitatory Postsynaptic Responses in Cerebellar Purkinje Cells Impairs Developmental Synapse Elimination, CELL REPORTS, 8(4), 1119-1129, 2014
  15. Spike timing-dependent selective strengthening of single climbing fiber inputs to Purkinje cells during cerebellar development. , NATURE COMMUNICATIONS, 4, JUN 2013
  16. Synapse elimination in the developing cerebellum, CELLULAR AND MOLECULAR LIFE SCIENCES, 70(24), 4667-4680, DEC 2013
  17. Calcium-dependent regulation of climbing fibre synapse elimination during postnatal cerebellar development, JOURNAL OF PHYSIOLOGY-LONDON, 591(13), 3151-3158, 2013
  18. Postnatal refinement of the cerebellar climbing fiber to Purkinje cell synapse, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S37-S37, 2013
  19. Difference in synaptic strengths among competing inputs and absolute synaptic strengths contribute to distinct phase of climbing fiber synapse development in cerebellum, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S188-S188, 2013
  20. Synapse elimination in the developing cerebellum, CELLULAR AND MOLECULAR LIFE SCIENCES, 70(24), 4667-4680, 2013
  21. Ca(v)2.1 in Cerebellar Purkinje Cells Regulates Competitive Excitatory Synaptic Wiring, Cell Survival, and Cerebellar Biochemical Compartmentalization, JOURNAL OF NEUROSCIENCE, 32(4), 1311-1328, 20120125
  22. Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(30), 12195-12200, 2012
  23. Organotypic Coculture Preparation for the Study of Developmental Synapse Elimination in Mammalian Brain, JOURNAL OF NEUROSCIENCE, 32(34), 11657-11670, 2012
  24. GABAergic Inhibition Regulates Developmental Synapse Elimination in the Cerebellum, NEURON, 74(2), 384-396, 2012
  25. Activity-Dependent Maturation of Climbing Fiber to Purkinje Cell Synapses during Postnatal Cerebellar Development, CEREBELLUM, 11(2), 449-450, 2012
  26. A Role for Myosin Va in Cerebellar Plasticity and Motor Learning: A Possible Mechanism Underlying Neurological Disorder in Myosin Va Disease, JOURNAL OF NEUROSCIENCE, 31(16), 6067-6078, 2011
  27. Developmental switching of perisomatic innervation from climbing fibers to basket cell fibers in cerebellar Purkinje cells., The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(47), 16916-16927, 20111123
  28. Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(24), 9987-9992, 2011
  29. Synapse "non-specific" degradation of the endocannabinoid 2-arachidonoylglycerol mediating depolarization-induced retrograde synaptic suppression in cerebellar Purkinje cells, NEUROSCIENCE RESEARCH, 71, E56-E56, 2011
  30. Glutamate transporter GLAST is essential for cytodifferentiation of Bergmann glia and maintenance of excitatory synaptic wiring in the cerebellum, NEUROSCIENCE RESEARCH, 71, E63-E63, 2011
  31. Postsynaptic P/Q type voltage-dependent Ca2+ channel is involved in refinement of cerebellar climbing fiber to Purkinje cell synapses in early postnatal development, NEUROSCIENCE RESEARCH, 71, E322-E322, 2011
  32. TARPs gamma-2 and gamma-7 are essential for AMPA receptor expression in the cerebellum, EUROPEAN JOURNAL OF NEUROSCIENCE, 31(12), 2204-2220, 20100601
  33. The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase alpha Mediates Retrograde Suppression of Synaptic Transmission, NEURON, 65(3), 320-327, 20100201
  34. Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour, EMBO JOURNAL, 28(23), 3717-3729, 20091201
  35. INFLUENCE OF PARALLEL FIBER-PURKINJE CELL SYNAPSE FORMATION ON POSTNATAL DEVELOPMENT OF CLIMBING FIBER-PURKINJE CELL SYNAPSES IN THE CEREBELLUM, NEUROSCIENCE, 162(3), 601-611, 20090901
  36. Not glutamate but endocannabinoids mediate retrograde suppression of cerebellar parallel fiber to Purkinje cell synaptic transmission in young adult rodents, NEUROPHARMACOLOGY, 57(2), 157-163, 20090801
  37. Translocation of a ""Winner"" Climbing Fiber to the Purkinje Cell Dendrite and Subsequent Elimination of ""Losers"" from the Soma in Developing Cerebellum, NEURON, 63(1), 106-118, 20090701
  38. Synapse elimination in the central nervous system, CURRENT OPINION IN NEUROBIOLOGY, 19(2), 154-161, 20090401
  39. Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells: a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 363(1500), 2173-2186, 20080601
  40. Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression, EUROPEAN JOURNAL OF NEUROSCIENCE, 26(8), 2269-2278, 20071001
  41. Motor discoordination of transgenic mice overexpressing a microtubule destabilizer, stathmin, specifically in Purkinje cells, NEUROSCIENCE RESEARCH, 59(1), 93-100, 20070901
  42. Diminished climbing fiber innervation of purkinje cells in the cerebellum of myosin Va mutant mice and rats, DEVELOPMENTAL NEUROBIOLOGY, 67(7), 909-923, 20070601
  43. G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells, JOURNAL OF PHYSIOLOGY-LONDON, 581(2), 693-708, 20070601
  44. Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity, EMBO JOURNAL, 26(7), 1924-1933, 20070401
  45. Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum, JOURNAL OF NEUROSCIENCE, 27(3), 496-506, 20070101
  46. Depolarization-induced suppression of inhibition mediated by endocannabinoids at synapses from fast-spiking interneurons to medium spiny neurons in the striatum, EUROPEAN JOURNAL OF NEUROSCIENCE, 24(8), 2246-2252, 20061001
  47. Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family, FEBS LETTERS, 580(17), 4057-4064, 20060701
  48. Endocannabinoid-mediated short-term suppression of excitatory synaptic transmission to medium spiny neurons in the striatum, NEUROSCIENCE RESEARCH, 54(3), 159-164, 20060501
  49. Miniature synaptic events elicited by presynaptic Ca2+ rise are selectively suppressed by cannabinoid receptor activation in cerebellar Purkinje cells, JOURNAL OF NEUROSCIENCE, 26(1), 86-95, 20060101
  50. Postnatal development and synapse elimination of climbing fiber to Purkinje cell projection in the cerebellum, NEUROSCIENCE RESEARCH, 53(3), 221-228, 20051101
  51. Ca2+ activity at GABA(B) receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(48), 16952-16957, 20041101
  52. Altered agonist sensitivity and desensitization of neuronal mGluR1 responses in knock-in mice by a single amino acid substitution at the PKC phosphorylation site, EUROPEAN JOURNAL OF NEUROSCIENCE, 20(4), 947-955, 20040801
  53. P/Q-type Ca2+ channel alpha 1A regulates synaptic competition on developing cerebellar Purkinje cells, JOURNAL OF NEUROSCIENCE, 24(7), 1734-1743, 20040201
  54. ORP150/HSP12A regulates Purkinje cell survival: A role for endoplasmic reticulum stress in cerebellar development, JOURNAL OF NEUROSCIENCE, 24(6), 1486-1496, 20040201
  55. Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup, JOURNAL OF NEUROBIOLOGY, 56(3), 252-265, 20030101
  56. Functional differentiation of multiple climbing fiber inputs during synapse elimination in the developing cerebellum, NEURON, 38(5), 785-796, 20030601
  57. A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration, NEURON, 34(6), 905-919, 20020601
  58. Motor discoordination in mutant mice lacking junctophilin type 3, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 292(2), 318-324, 20020501
  59. The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells, JOURNAL OF NEUROSCIENCE, 22(5), 1690-1697, 20020501
  60. Roles of glutamate receptor delta 2 subunit (GluR delta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse elimination during postnatal cerebellar development, JOURNAL OF NEUROSCIENCE, 21(24), 9701-9712, 20011201
  61. Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors, NEURON, 31(3), 463-475, 20010801
  62. Deficient long-term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C beta 4 mutant mice, EUROPEAN JOURNAL OF NEUROSCIENCE, 13(10), 1945-1954, 20010501
  63. PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum, JOURNAL OF NEUROSCIENCE, 21(9), 3085-3091, 20010501
  64. Roles of phospholipase C beta 4 in synapse elimination and plasticity in developing and mature cerebellum, MOLECULAR NEUROBIOLOGY, 23(1), 69-82, 20010201
  65. Local calcium release in dendritic spines required for long-term synaptic depression, NEURON, 28(1), 233-244, 20001001
  66. mGLuR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination, SCIENCE, 288(5472), 1832-1835, 20000601
  67. Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer, JOURNAL OF NEUROSCIENCE, 19(14), 6027-6036, 19990701
  68. Corticotropin-releasing factor plays a permissive role in cerebellar long-term depression, NEURON, 22(4), 763-775, 19990401
  69. Phospholipase C beta 4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95(26), 15724-15729, 19981201
  70. Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination, CELL, 95(1), 17-27, 19981001
  71. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice, EUROPEAN JOURNAL OF NEUROSCIENCE, 10(3), 976-988, 19980501
  72. Presynaptic origin of paired-pulse depression at climbing fibre Purkinje cell synapses in the rat cerebellum, JOURNAL OF PHYSIOLOGY-LONDON, 506(2), 391-405, 19980101
  73. Impaired parallel fiber->Purkinje cell synapse stabilization during cerebellar development of mutant mice lacking the glutamate receptor delta 2 subunit, JOURNAL OF NEUROSCIENCE, 17(24), 9613-9623, 19971201
  74. Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking G alpha q, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 94(25), 14089-14094, 19971201
  75. Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1, NEURON, 18(1), 71-79, 19970101
  76. Impaired synapse elimination during cerebellar development in PKC gamma mutant mice, CELL, 83(7), 1223-1231, 19951201
  77. Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice, CELL, 83(7), 1233-1242, 19951201
  78. The anatomical pathway from the mesodiencephalic junction to the inferior olive relays perioral sensory signals to the cerebellum in the mouse, JOURNAL OF PHYSIOLOGY-LONDON, 596(16), 3775-3791, AUG 15 2018

Invited Lecture, Oral Presentation, Poster Presentation

  1. Type 1 metabotropic glutamate receptor regulates experience-dependent maintenance of mature synaptic connectivity in the visualthalamus, Madoka Narushima, Motokazu Uchigashima, Takeshi Harada, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Mariko Miyata, Masanobu Kano, 2015/03/21, Without Invitation
  2. CDC42EP4/septin-based perisynaptic glial scaffold that facilitates glutamate clearance, Natsumi Ageta-Ishihara, Maya Yamazaki, Kohtarou Konno, Hisako Nakayama, Manabu Abe, Kenji Hashimoto, Tomoki Nishioka, Kozo Kaibuchi, Tsuyoshi Miyakawa, Kouichi Hashimoto, Masahiko Watanabe, Kenji Sakimura, Makoto Kinoshita, 2015/03/23, Without Invitation
  3. Analysis of spontaneous slow currents in inferior olivary neurons, Yoshiko Matsumoto, Hisako Nakayama, Kouichi Hashimoto, 2015/03/21, Without Invitation
  4. The change of morphology and distribution of microglia in the postnatal developing mouse cerebellum, Chie Morimoto, Hisako Nakayama, Kouichi Hashimoto, 2015/03/23, Without Invitation
  5. Molecular mechanism of sensory experience-dependent maintenance of neuronal circuits, Mariko Miyata, MADOKA NARUSHIMA, Motokazu Uchigashima, Kouichi Hashimoto, Takeshi Harada, Atsu Aiba, Masahiko Watanabe, Masanobu Kano, 2014/09/11, Without Invitation
  6. Type 1 metabotropic glutamate receptor is involved in experience-dependent maintenance of retinogeniculate synapses in the mouse visual system, Madoka Narushima, Motokazu Uchigashima, Motokazu Uchigashima, Kouichi Hashimoto, Takeshi Harada, Atsu Aiba, Masahiko Watanabe, Mariko Miyata, Masanobu Kano, 2014/09/11, Without Invitation
  7. CDC42EP4/septin-dependent localization of GLAST to parasynaptic domains of Bergmann glia facilitates glutamate clearance from the parallel fiber-Purkinje cell synapses and motor learning, Natsumi Ageta-Ishihara, Maya Yamazaki, Kohtarou Konno, Hisako Nakayama, Manabu Abe, Kenji Hashimoto, Tomoki Nishioka, Kozo Kaibuchi, Tsuyoshi Miyakawa, Kouichi Hashimoto, Masahiko Watanabe, Kenji Sakimura, Makoto Kinoshita, 2014/09/11, Without Invitation

Social Activities

Organizing Academic Conferences, etc.

  1. 2017/11, 2018/12