Kozue Hamao

Last Updated :2024/05/08

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
E-mail
kozuehiroshima-u.ac.jp
Self-introduction
I am studying the regulatory mechanism of cytoskeleton. In particular, I am focusing on the regulation of microtubule stability by dynamin-2.

Basic Information

Academic Degrees

  • Doctor of Science, Hiroshima University
  • Master of Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Science : Biological Sciences : Biology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

Research Fields

  • Biology;Biological Science;Functional biochemistry

Research Keywords

  • dynamin
  • microtubules
  • cytokinesis
  • contractile ring
  • myosin II

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  2. 2024, Undergraduate Education, Second Semester, English Seminar on Biological Science
  3. 2024, Undergraduate Education, 2Term, Advanced Biology
  4. 2024, Undergraduate Education, 2Term, Cell Biology A
  5. 2024, Undergraduate Education, Second Semester, Seminar for Cell Biology
  6. 2024, Undergraduate Education, First Semester, Special Study for Graduation
  7. 2024, Undergraduate Education, Second Semester, Special Study for Graduation
  8. 2024, Undergraduate Education, Second Semester, Practice for Fundamental Biology II
  9. 2024, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  10. 2024, Graduate Education (Doctoral Program) , Second Semester, Career Development for Life Science
  11. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Basic Biology
  12. 2024, Graduate Education (Master's Program) , 1Term, Cellular life science
  13. 2024, Graduate Education (Master's Program) , First Semester, Exercises in Basic Biology A
  14. 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Basic Biology B
  15. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  16. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  17. 2024, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science
  18. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  19. 2024, Graduate Education (Master's Program) , First Semester, Exercises in Biomedical Science A
  20. 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Biomedical Science B
  21. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  22. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  23. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. Dynamin-2 regulates microtubule stability via an endocytosis-independent mechanism, CYTOSKELETON, 79(9-11), 94-104, 202209
    Link to Paper Search Results by DOI
  2. 2-(4-Nitrophenyl)-1H-indolyl-3-methyl Chromophore: A Versatile Photocage that Responds to Visible-light One-photon and Near-infrared-light Two-photon Excitations, CHEMISTRY LETTERS, 51(2), 153-156, 202202
    Link to Paper Search Results by DOI
  3. ★, Impairment of cytokinesis by cancer-associated DAPK3 mutations, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 533(4), 1095-1101, 20201217
    Link to Paper Search Results by DOI
  4. ★, ZIP kinase phosphorylated and activated by Rho kinase/ROCK contributes to cytokinesis in mammalian cultured cells, EXPERIMENTAL CELL RESEARCH, 386(1), 20200101
    Link to Paper Search Results by DOI
  5. Phospholipase C-related catalytically inactive protein regulates cytokinesis by protecting phosphatidylinositol 4,5-bisphosphate from metabolism in the cleavage furrow, SCIENTIFIC REPORTS, 9, 20190904
    Link to Paper Search Results by DOI
  6. ★, Characterization of myosin II regulatory light chain isoforms in HeLa cells, CYTOSKELETON, 72(12), 609-620, 201512
    Link to Paper Search Results by DOI
  7. ★, Phosphorylation of myosin II regulatory light chain by ZIP kinase is responsible for cleavage furrow ingression during cell division in mammalian cultured cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 459(4), 686-691, 20150417
    Link to Paper Search Results by DOI
  8. Aurora B but Not Rho/MLCK Signaling Is Required for Localization of Diphosphorylated Myosin II Regulatory Light Chain to the Midzone in Cytokinesis, PLOS ONE, 8(8), 20130807
    Link to Paper Search Results by DOI
  9. Phosphorylation of myosin II regulatory light chain controls its accumulation, not that of actin, at the contractile ring in HeLa cells., Experimental cell research, 318(8), 915-924, 2012
    Link to Paper Search Results by DOI
  10. Diphosphorylated but not monophosphorylated myosin II regulatory light chain localizes to the midzone without its heavy chain during cytokinesis., Biochemical and biophysical research communications, 417(2), 20120113
    Link to Paper Search Results by DOI
  11. Enhancement of myosin II/actin turnover at the contractile ring induces slower furrowing in dividing HeLa cells, BIOCHEMICAL JOURNAL, 435, 569-576, 20110501
    Link to Paper Search Results by DOI
  12. ★, Proline-rich domain in dynamin-2 has a low microtubule-binding activity: how is this activity controlled during mitosis in HeLa cells?, JOURNAL OF BIOCHEMISTRY, 148(5), 533-538, 201011
    Link to Paper Search Results by DOI
  13. Direct evidence for roles of phosphorylated regulatory light chain of myosin II in furrow ingression during cytokinesis in HeLa cells, GENES TO CELLS, 14(5), 555-568, 200905
    Link to Paper Search Results by DOI
  14. ★, New function of the proline rich domain in dynamin-2 to negatively regulate its interaction with microtubules in mammalian cells, EXPERIMENTAL CELL RESEARCH, 315(7), 1336-1345, 20090415
    Link to Paper Search Results by DOI
  15. Dvl regulates endo- and exocytotic processes through binding to synaptotagmin, GENES TO CELLS, 12, 49-61, 20070112
    Link to Paper Search Results by DOI
  16. Traction forces of fibroblasts are regulated by the Rho-dependent kinase but not by the myosin light chain kinase, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 456(2), 224-231, 20061215
    Link to Paper Search Results by DOI
  17. The carboxy-terminal pleckstrin homology domain of ROCK interacts with filamin-A, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 301(4), 886-890, 2003
  18. Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edge, BIOCHEMICAL JOURNAL, 370, 551-556, 2003
  19. Spatial localization of mono- and diphosphorylated myosin II regulatory light chain at the leading edge of motile HeLa cells, CELL STRUCTURE AND FUNCTION, 27(6), 479-486, 2002
  20. Characterization of Ca2+/calmodulin-dependent protein kinase I as a myosin II regulatory light chain kinase in vitro and in vivo, BIOCHEMICAL JOURNAL, 367, 335-345, 2002
  21. Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells, ONCOGENE, 21(38), 5852-5860, 2002
  22. Phosphorylation at threonine-18 in addition to phosphorylation at serine-19 on myosin-II regulatory light chain is a mitosis-specific event, CYTOMETRY, 47(3), 150-157, 2002
  23. HeLa ZIP kinase induces diphosphorylation of myosin II regulatory light chain and reorganization of actin filaments in nonmuscle cells, ONCOGENE, 20(57), 8175-8183, 2001
  24. Differential localization of non-muscle myosin II isoforms and phosphorylated regulatory light chains in human MRC-5 fibroblasts, FEBS LETTERS, 509(3), 365-369, 2001
  25. Activation of actin-activated MgATPase activity of myosin II by phosphorylation with MAPK-activated protein kinase-1b (RSK-2), JOURNAL OF BIOCHEMISTRY, 128(3), 435-440, 2000