Takashi Irie

Last Updated :2020/10/08

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor
E-mail
tiriehiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Ph.D., Kyoto University
  • Master of Pharmaceutical Science, Kyoto University

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Virology

Research Keywords

  • pathogenesis
  • viral replication
  • negative-sense RNA viruses

Educational Activity

Course in Charge

  1. 2020, Graduate Education (Master's Program) , 3Term, Seminar on Host Defense

Research Activities

Academic Papers

  1. The YLDL sequence within Sendai virus m protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein, JOURNAL OF VIROLOGY, 81(5), 2263-2273, 200703
  2. Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation, NEUROSCIENCE LETTERS, 505(3), 279-281, 20111121
  3. Inhibition of Interferon Regulatory Factor 3 Activation by Paramyxovirus V Protein, JOURNAL OF VIROLOGY, 86(13), 7136-7145, 201207
  4. Passage of a Sendai Virus Recombinant in Embryonated Chicken Eggs Leads to Markedly Rapid Accumulation of U-to-C Transitions in a Limited Region of the Viral Genome, PLOS ONE, 7(11), 20121121
  5. Inactivation of Pathogenic Viruses by Plant-Derived Tannins: Strong Effects of Extracts from Persimmon (Diospyros kaki) on a Broad Range of Viruses, PLOS ONE, 8(1), 20130125

Invited Lecture, Oral Presentation, Poster Presentation

  1. A novel anti-apoptotic role of Sendai virus V protein via its interaction with IRF3, 2017/10/25, Without Invitation, English
  2. A regulatory role of intergenic trinucleotides in Sendai viral gene expression, 2017/10/25, Without Invitation, English
  3. Sendai virus V protein plays an antiapoptotic role during infection, The 17th International Congress of Virology, 2017/07, Without Invitation, English, International Union of Microbiological Societies, Singapore
  4. Detailed functional mapping of the paramyxovirus accessory proteins in viral infection, 2018/10/28, Without Invitation, English
  5. Characterization of a Sendai virus isolate producing copyback-type defective viral RNA and its potential as a vaccine adjuvant, The 17th Awaji International Forum in Infection and Immunity, 2018/09, Without Invitation, English
  6. Detailed functional mapping of the paramyxovirus accessory proteins in viral infection, 16th International Conference of Negative Strand Viruses, 2018/06, Without Invitation, English, Verona, Italy
  7. Selective manipulation of multi-functional Sendai virus C protein by single amino acid substitutions, 2016/10, Without Invitation, English
  8. Characterization of the interaction of Sendai virus V protein with multiple host interferon-inducing factors, RIG-I, MDA5 and IRF3, 2015/11, Without Invitation, English
  9. Sendai virus V protein plays an antiapoptotic role during infection, 2015/11, Without Invitation, Japanese
  10. IFN-beta-inducible, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner, The 13th Awaji International Forum in Infection and Immunity in Nara, 2014/09, Without Invitation, Japanese
  11. Paramyxovirus Sendai virus N protein plays a critical role in restricted production of copyback-type defective-interfering genomes to escape from detection by host innate immunity, The 16th International Congress of Virology, 2014/07, Without Invitation, English
  12. Stress granule-like structures are not involved in recognition of Sendai virus infection, The 16th International Congress of Virology, 2014/07, Without Invitation, English
  13. Paramyxovirus Sendai virus N protein plays a critical role on restricted production of copyback-type DI genomes to escape from detection by host innate immunity, The 12th Awaji International Forum in Infection and Immunity, 2013/09, Without Invitation, English
  14. Stress granule-like structures are not involved in recognition of Sendai virus infection, The 12th Awaji International Forum in Infection and Immunity, 2013/09, Without Invitation, English
  15. A novel regulatory mechanism determining the genome polarity in the Mononegavirales, 15th International Conference of Negative Strand Viruses, 2013/06, Without Invitation, English
  16. Different production of a viral RNA species between Sendai virus strains Z and Cantell causes their remarkable difference in interferon inducibility, 15th International Conference of Negative Strand Viruses, 2013/06, Without Invitation, English
  17. A novel regulatory mechanism for polarity of mononegavirus RNA synthesis, The 11th Awaji International Forum in Infection and Immunity, 2012/09, Without Invitation, English
  18. The accessory C protein of Sendai virus is involved in folding of the N protein, The 11th Awaji International Forum in Infection and Immunity, 2012/09, Without Invitation, Japanese
  19. Sendai virus C protein regulates genomic and antigenomic RNA synthesis during the course of infection, The 15th International Congress of Virology, 2011/10, Without Invitation, English
  20. The accessory C protein of Sendai virus is involved in folding of the N protein, The 15th International Congress of Virology, 2011/10, Without Invitation, English
  21. Characterization of a Sendai virus isolate producing copyback-type defective viral RNA and its potential as an effective vaccine adjuvant, Takashi Irie, Asuka Yoshida, Kouji Sakai, Ryoko Kawabata, Takemasa Sakaguchi, Influenza and Other Infections Symposium, 2019/02/19, Without Invitation, English

Social Activities

Organizing Academic Conferences, etc.

  1. 2018/04

History as Peer Reviews of Academic Papers

  1. 2018, Frontiers in Microbiology, Editor, 7
  2. 2018, Journal of Virualized Experiments, Editor, 1