広島大学

Basic Information

Academic Degrees

• Hiroshima University
• Hiroshima University

Research Fields

• Biology;Biological Science;Molecular biology

Research Keywords

• Molecular genetics, Disease model

Affiliated Academic Societies

• The Japan Society for Genome Editing
• The Molecular Biology Society of Japan

Educational Activity

Course in Charge

1. 2024, Undergraduate Education, Second Semester, Seminar for Molecular Genetics
2. 2024, Undergraduate Education, Second Semester, Practice for Fundamental Biology II
3. 2024, Undergraduate Education, First Semester, Practice for Fundamental Biology III
4. 2024, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
5. 2024, Graduate Education (Master's Program) , 1Term, Special Lectures in Integrated Sciences for Life
6. 2024, Graduate Education (Master's Program) , 2Term, Molecular Genetics
7. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
8. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
9. 2024, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science
10. 2024, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
11. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
12. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
13. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E
14. 2024, Graduate Education (Master's Program) , 2Term, Basics and Practical Applications of Genome Editing
15. 2024, Graduate Education (Master's Program) , OutOfTerm(1st), Basic Training of Genome Editing

Research Activities

Academic Papers

1. Generation of a novel disease model mouse for mucopolysaccharidosis type VI via c. 252T>C human ARSB mutation knock-in, BIOCHEMISTRY AND BIOPHYSICS REPORTS, 31, 202209
   Link to Paper Search Results by DOI
2. High-efficient CRISPR/Cas9-mediated gene targeting in mammalian cultured cells with primary cilia, Methods in Cell Biology, in press, 2022
3. PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation., Human Molecular Genetics, 26(22), 4429-4440, 20171115
4. Cytoskeleton-related regulation of primary cilia shortening mediated by melanin-concentrating hormone receptor 1., General and Comparative Endocrinology, 253, 44-52, 20171101
5. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells., Scientific Reports, 7(1), 20170720
6. ★, Phosphorylation of myosin II regulatory light chain by ZIP kinase is responsible for cleavage furrow ingression during cell division in mammalian cultured cells., Biochemical and Biophysical Research Communications, 459, 686-691, 20150417
7. ★, The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation., Cell Reports, 20150204
8. TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome., Proceedings of the National Academy of Sciences of the United States of America, 111, 1461-1466, 20140128
9. ★, Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome, EMBO Journal, 39, 20200617
10. Imaging of the ciliary cholesterol underling the sonic hedgehog signal transduction., Methods in Molecular Biology ,, in press

Awards

1. 2015, Hiroshima University excellent student scholarship, Hiroshima University
2. 2011, Hiroshima University excellent student scholarship, Hiroshima University

External Funds

Acceptance Results of Competitive Funds

1. Support promotion business for drug discovery, Search of novel therapeutic drug for polycystic kidney disease
2. 2021, 2021
3. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2017, 2020
4. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2019, 2021