YASUO TSUTSUMI

Last Updated :2024/05/15

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
E-mail
yasuo223hiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi, Minami, Hiroshima 734-8551 JAPAN, Japan
TEL : (+81)82-257-5267 FAX : (+81)

Basic Information

Major Professional Backgrounds

  • 2019/.6, Hiroshima University, Anesthesiology and Critical Care, Professor
  • 2015/.2, 2019/.5, Tokushima University, Anesthesiology, Associate Professor
  • 2010/.1, 2015/.1, Tokushima University, Anesthesiology, Associate Professor
  • 2009/.4, 2009/.1, Tokushima University, Anesthesiology, Assistant Professor
  • 2008/.7, 2009/.3, Tokushima University Hospital, Anesthesiology, Assistant Professor

Educational Backgrounds

  • The University of Tokushima, Japan
  • The University of Tokushima, Japan

Academic Degrees

  • The University of Tokushima

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Anesthesiology

Research Keywords

  • Perioperative Management、Cardiac Ischemia-Reperfusion Injury

Affiliated Academic Societies

  • Japanese Society of Anesthesiologists、The Japan Society for Clinical Anesthesia、American Society of Anesthesiologists

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Year, Systemic Disease Control
  2. 2024, Undergraduate Education, Intensive, Introduction to clinical clerkship
  3. 2024, Undergraduate Education, Intensive, Practice for medical research
  4. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  5. 2024, Undergraduate Education, Intensive, Practice of Medicine II
  6. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Anesthesiology and Critical Care
  7. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Anesthesiology and Critical Care
  8. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Anesthesiology and Critical Care
  9. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Anesthesiology and Critical Care

Research Activities

Academic Papers

  1. Saturated fatty acids intake is associated with muscle atrophy in rheumatoid arthritis., 5, 86-101, 20220401
  2. Genetic screening for malignant hyperthermia and comparison of clinical symptoms in Japan., Hiroshima J Med Sci, 71, 128-135, 20220401
  3. Perioperative Management of Recurrent Hemophagocytic Syndrome in a Pregnant Woman: A Case Report, AMERICAN JOURNAL OF CASE REPORTS, 24, 20230321
    Link to Paper Search Results by DOI
  4. Remimazolam Requires Less Vasopressor Support during Induction and Maintenance of General Anesthesia in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Retrospective Analysis from a Single Center, BIOMED RESEARCH INTERNATIONAL, 2022, 20221022
    Link to Paper Search Results by DOI
  5. Rapid cyclic fluctuations in blood pressure during two surgeries associated with pheochromocytoma: a case report, JA CLINICAL REPORTS, 8(1), 20221005
    Link to Paper Search Results by DOI
  6. Subacute postoperative myofascial pain diagnosed and treated successfully by ultrasound: a case after laparoscopic hepatectomy, JA CLINICAL REPORTS, 8(1), 20220719
    Link to Paper Search Results by DOI
  7. Postoperative Tracheal Compression Requiring Transposition of the Brachiocephalic Artery After Bentall Surgery Combined With Total Arch Replacement in a Patient With Loeys-Dietz Syndrome, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 36(8), 2532-2535, 202208
    Link to Paper Search Results by DOI
  8. Awake craniotomy with intraoperative open magnetic resonance imaging under anesthesia management using an anesthesia information management system via a wireless local area network: Case report, INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT, 29, 202209
    Link to Paper Search Results by DOI
  9. Age-Specific Clinical Features of Pediatric Malignant Hyperthermia: A Review of 187 Cases Over 60 Years in Japan, ANESTHESIA AND ANALGESIA, 135(1), 128-135, 202207
    Link to Paper Search Results by DOI
  10. The effects of dantrolene in the presence or absence of ryanodine receptor type 1 variants in individuals predisposed to malignant hyperthermia, ANAESTHESIA AND INTENSIVE CARE, 50(4), 312-319, 202207
    Link to Paper Search Results by DOI
  11. Electroencephalogram evaluation of accidental cerebral congestion during unexpected superior vena cava clamping: a case report, JA CLINICAL REPORTS, 8(1), 20220609
    Link to Paper Search Results by DOI
  12. Venous cannula occlusion during cardiopulmonary bypass recognized by ultrasonography of the internal jugular vein, JA CLINICAL REPORTS, 8(1), 20220412
    Link to Paper Search Results by DOI
  13. Remimazolam decreased the incidence of early postoperative nausea and vomiting compared to desflurane after laparoscopic gynecological surgery, JOURNAL OF ANESTHESIA, 36(2), 265-269, 202204
    Link to Paper Search Results by DOI
  14. Real-time assessment of swallowing sound using an electronic stethoscope and an artificial intelligence system, CLINICAL AND EXPERIMENTAL DENTAL RESEARCH, 8(1), 225-230, 202202
    Link to Paper Search Results by DOI
  15. Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic, PLOS ONE, 17(2), 2022
    Link to Paper Search Results by DOI
  16. ★, Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes., Anesthesiology, 92, 1154-1159, 2000
  17. Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes., Anesthesiology, 95, 766-770, 2001
  18. Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice., Anesthesiology, 104, 495-502, 2006
  19. Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice., Am J Physiol Heart Circ Physiol, 291, H979-H983, 2006
  20. ★, Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1., FASEB J, 21, 1565-1574, 2007
  21. ★, Reactive oxygen species trigger ischemic and pharmacological postconditioning: In vivo and in vitro characterization., Life Sciences, 81, 1223-1227, 2007
  22. ★, Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning., Circulation, 118, 1979-1988, 2008
  23. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection., Anesthesiology, 112, 1136-1145, 2010
  24. Opioid-induced preconditioning is dependent on caveolin-3 expression., Anesthesia and Analgesia, 111, 1117-1121, 2010
  25. Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/PI3K pathway., Life Sciences, 88, 725-729, 2011
  26. Neurokinin-1 receptor antagonism, aprepitant, effectively post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures., Journal of Medical Investigation, 58, 246-251, 2011
  27. Geranylgeranylacetone protects the heart via caveolae and caveolin-3., Life Sciences, 101, 43-48, 2014
  28. Geranylgeranylacetone and volatile anesthetic induced cardiac protection synergism is dependent on caveolae and caveolin-3., Journal of Anesthesia, 28, 733-739, 2014
  29. The effects of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in neurosurgery patients: a prospective, randomized, double-blinded study., BioMed Research International, 2014, 307025, 2014
  30. Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3, Cardiovascular Diabetology, 13, 132, 2014
  31. Exendin-4, glucagon-like peptide-1 receptor agonist, enhances isoflurane-induced preconditioning against myocardial infarction via caveolins-3 expression., European Review for Medical and Pharmacological Sciences, 19, 1285-1290, 2015
  32. Whey-protein based formulas with omega-3 fatty acids are protective in LPS mediated sepsis., Journal of Parenteral and Enteral Nutrition, 39, 552-561, 2015
  33. Fosaprepitant versus ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo gynecologic abdominal surgery with patient-controlled epidural analgesia: a prospective, randomized, double-blind study., Journal of Anesthesia, 29, 696-701, 2015
  34. The effects of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in patients who undergo lower limb surgery. –A prospective, randomized, double-blind study–, Journal of Anesthesia, 29, 836-841, 2015
  35. Plasma substance P concentrations in patients undergoing general anesthesia: an objective marker associated with postoperative nausea and vomiting., JA Clinical Reports, 2, 9, 2016
  36. Effects of oral carbohydrate with amino acid solution on the metabolic status of patients in the preoperative period: a randomized, prospective clinical trial., Journal of Anesthesia, 30, 842-849, 2016
  37. Effect of oral carbohydrate with amino acid solution on serum oxidative/anti-oxidative status in healthy volunteers., Journal of Anesthesia, 31, 472-475, 2017
  38. ★, A comparison of fosaprepitant and ondansetron for preventing postoperative nausea and vomiting in moderate to high risk patients: a retrospective database analysis., BioMed Research International, 2017, 5703528, 2017
  39. Noninvasive continuous blood pressure monitoring by the ClearSight system during robot-assisted laparoscopic radical prostatectomy., Journal of Medical Investigation, 65, 69-73, 2018
  40. Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improves their satisfactions., Clinical Nutrition Experimental, 19, 1-11, 2018
  41. The efficacy of programmed intermittent epidural bolus for postoperative analgesia after open gynecological surgery: a randomized double-blind study., BioMed Research International, 2018, 6297247, 2018
  42. Caveolins: targeting pro-survival signaling in the heart and brain., Frontiers in Physiology, 3, 393, 2012
  43. ★, Signaling epicenters: the role of caveolae and caveolins in volatile anesthetic induced cardiac protection., Current Pharmaceutical Design, 20, 5681-5689, 2014
  44. Postoperative nausea and vomiting following lower limb surgery: a comparison between single-injection intraarticular anesthesia and continuous epidural anesthesia, JOURNAL OF MEDICAL INVESTIGATION, 66(3-4), 303-307, 201908
    Link to Paper Search Results by DOI
  45. Monitoring of muscle mass in critically ill patients: comparison of ultrasound and two bioelectrical impedance analysis devices, JOURNAL OF INTENSIVE CARE, 7(1), 20191216
    Link to Paper Search Results by DOI
  46. Branched-chain amino acids-induced cardiac protection against ischemia/reperfusion injury, LIFE SCIENCES, 245, 20200315
    Link to Paper Search Results by DOI
  47. Assessment of postoperative nutritional status and physical function between open surgical aortic valve replacement and transcatheter aortic valve implantation in elderly patients, JOURNAL OF MEDICAL INVESTIGATION, 67(1-2), 139-144, 202002
  48. Early Diagnosis of the Cardiopulmonary Collapse Type of Amniotic Fluid Embolism with Obstetrical Disseminated Intravascular Coagulation during Elective Cesarean Section : A Case Report, JOURNAL OF MEDICAL INVESTIGATION, 67(1-2), 207-210, 202002
  49. The effect of 1% glucose loading on metabolism in the elderly patients during remifentanil-induced anesthesia: a randomized controlled trial, BMC ANESTHESIOLOGY, 20(1), 20200606
    Link to Paper Search Results by DOI
  50. Anesthetic management of patient with Dravet Syndrome: a case report., Anesth Prog, 66, 156-158, 2019
  51. Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria, EUROPEAN JOURNAL OF PHARMACOLOGY, 884, 20201005
    Link to Paper Search Results by DOI
  52. Evaluation of a new face mask concept for oxygen administration: a crossover study in healthy volunteers, JOURNAL OF ANESTHESIA, 34(6), 950-952, 202012
    Link to Paper Search Results by DOI
  53. Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis, REVISTA BRASILEIRA DE ANESTESIOLOGIA, 70(5), 508-519, 2020
    Link to Paper Search Results by DOI
  54. Intraoperative responses of motor evoked potentials to the novel intravenous anesthetic remimazolam during spine surgery: a report of two cases, JA CLINICAL REPORTS, 6(1), 20201209
    Link to Paper Search Results by DOI
  55. An outcome study of adult in-hospital cardiac arrests in non-monitored areas with resuscitation attempted using AED, AMERICAN JOURNAL OF EMERGENCY MEDICINE, 38(12), 2524-2530, 20201209
    Link to Paper Search Results by DOI
  56. Effects of Remimazolam and Propofol on Ca2+ Regulation by Ryanodine Receptor 1 with Malignant Hyperthermia Mutation, BIOMED RESEARCH INTERNATIONAL, 2021, 20210104
    Link to Paper Search Results by DOI
  57. Novel technique for identification of the pulmonary intersegmental plane using manual jet ventilation during pulmonary segmentectomy, VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES, 16(1), 169-174, 202103
    Link to Paper Search Results by DOI
  58. Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats, JOURNAL OF ANESTHESIA, 35(2), 168-174, 202104
    Link to Paper Search Results by DOI
  59. Malignant hyperthermia in a 16-day-old infant with congenital diaphragmatic hernia: a case report, JOURNAL OF ANESTHESIA, 35(2), 311-314, 202104
    Link to Paper Search Results by DOI
  60. Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy, SCIENTIFIC REPORTS, 11(1), 20210304
    Link to Paper Search Results by DOI
  61. Concurrent positive skin tests to prophylactic antibiotics and rocuronium in two patients with life-threatening anaphylaxis after induction of anesthesia, JA CLINICAL REPORTS, 7(1), 20210420
    Link to Paper Search Results by DOI
  62. Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold, SCIENTIFIC REPORTS, 11(1), 20210505
    Link to Paper Search Results by DOI
  63. Acute-onset paraplegia as an unexpected complication under general anesthesia in supine position during abdominal endovascular aneurysm repair: a case report, JA CLINICAL REPORTS, 7(1), 20210602
    Link to Paper Search Results by DOI
  64. Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10(5), 5119-5127, 202105
    Link to Paper Search Results by DOI
  65. Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling, NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 31(10), 2979-2986, 20210922
    Link to Paper Search Results by DOI
  66. Relationship Between the Loaded Pressure and Flow Rate of Packed Red Blood Cells and Various Infusion Solutions in Normal Infusion Lines and Catheters, ANESTHESIA AND ANALGESIA, 133(5), 1107-1115, 202111
    Link to Paper Search Results by DOI
  67. Paradoxical increase in the photoplethysmography amplitude in response to nociceptive stimulation induced by tracheal intubation : A case report, JOURNAL OF MEDICAL INVESTIGATION, 68(3-4), 383-385, 202108
  68. Intravenous patient-controlled analgesia does not increase the risk of postoperative delirium compared to patient-controlled epidural analgesia: a propensity score-matched retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10(10), 10160-10169, 202110
    Link to Paper Search Results by DOI
  69. Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model, DIABETOLOGY & METABOLIC SYNDROME, 13(1), 20211120
    Link to Paper Search Results by DOI
  70. Rocuronium-induced respiratory paralysis refractory to sugammadex in Charcot-Marie-Tooth disease, CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 69(3), 364-368, 202203
    Link to Paper Search Results by DOI
  71. Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora, TRANSLATIONAL RESEARCH, 237, 16-30, 202111
    Link to Paper Search Results by DOI

External Funds

Acceptance Results of Competitive Funds

  1. 2009, 2012
  2. 2009, 2010
  3. 2010, 2011
  4. 2013, 2015
  5. 2016, 2018
  6. 2016
  7. 2017, 2018
  8. 2019, 2021
  9. 2019, 2020
  10. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024