KOICHI KATO

Last Updated :2024/05/15

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
Web Site
E-mail
kokatohiroshima-u.ac.jp
Other Contact Details
1-2-3,Kasumi,Minami-ku,Hiroshima, Japan
TEL : (+81)82-257-5645 FAX : (+81)82-257-5649

Basic Information

Major Professional Backgrounds

  • 1996/05/01, 2001/03/31, Kobe University, Department of Chemical Science and Engineering, Research Associate
  • 1999/02/01, 2000/02/29, University of Freiburg, Institute for Polymer Chemistry, Humboldt Postdoctoral Fellow
  • 2001/04/01, 2007/03/31, Kyoto University, Institute for Frontier Medical Sciences, Associate Professor
  • 2007/04/01, 2011/03/31, Kyoto University, Institute for Frontier Medical Sciences, Associate Professor
  • 2011/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Professor
  • 2012/03/01, Hiroshima University, Research Institute for Nanodevice and Bio Systems, Professor
  • 2012/04/01, Hiroshima University, Center for Medical Specialist Graduate Education & Research, Director
  • 2013/04/01, Hiroshima University, Institute of Biomedical & Health Sciences, Vice Dean (International Affairs)
  • 2013/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Vice Dean (International Affairs)
  • 2014/04/01, Hiroshima University, Basic Life Sciences, Institute of Biomedical & Health Sciences, Chairman
  • 2014/04/01, Hiroshima University, Center for International Collaboration Development for Dentistry, Institute of Biomedical & Health Sciences, Director
  • 2016/04/01, Hiroshima University, School of Dentistry, Dean
  • 2016, 2016, University of Airlangga, Faculty of Dental Medicine, Visiting Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Professor
  • 2021/06/01, Hiroshima University, Research Institute for Nanodevices, Vice Director
  • 2022, 2022, Brawijaya University, Faculty of Dentistry, Visiting Professor

Educational Backgrounds

  • Kyoto University, Graduate School, Division of Engineering, Department of Polymer Chemistry, Japan, 1991/04, 1994/03
  • Kyoto University, Graduate School of Agriculture, Department of Wood Science and Technology, Japan, 1988/04, 1990/03
  • Kyoto University, Faculty of Agriculture, Department of Wood Science and Technology, Japan, 1984/04, 1988/03

Academic Degrees

  • Doctor of Engineering, Kyoto University
  • Master of Agriculture, Kyoto University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

Research Fields

  • Complex systems;Biomedical engineering;Biomedical engineering / Biomaterial science and engineering

Research Keywords

  • Biomaterials
  • Regenerative medicine
  • Stem cells
  • Protein engineering

Affiliated Academic Societies

  • The Japanese Society for Regenerative Medicine
  • Japanese Society for Biomaterials, 1994
  • The Japanese Society for Dental Materials and Devices, 2011
  • The Society for Polymer Science, Japan, 1994
  • The Chemical Society of Japan, 1996
  • The Society of Nano Science and Technology, 2000
  • American Chemical Society, 2006
  • Japanese Association of Regenerative Dentistry
  • Japan Nanomedicine Society

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 2Term, General Chemistry
  2. 2024, Undergraduate Education, 4Term, Life Science
  3. 2024, Undergraduate Education, 1Term, Dental Materials and Devices I
  4. 2024, Undergraduate Education, 2Term, Dental Materials and Devices II
  5. 2024, Undergraduate Education, 3Term, Dental Materials and Devices Practice I
  6. 2024, Undergraduate Education, 4Term, Dental Materials and Devices Practice II
  7. 2024, Undergraduate Education, 2Term, Topics in Dental Research II
  8. 2024, Undergraduate Education, 2Term, Oral Implantology
  9. 2024, Undergraduate Education, First Semester, Dental Research Practices I
  10. 2024, Undergraduate Education, Second Semester, Dental Research Practices II
  11. 2024, Undergraduate Education, 2Term, International Future Dentistry with the Outcomes of Researches
  12. 2024, Undergraduate Education, 2Term, Basic and clinical integrated theory
  13. 2024, Undergraduate Education, First Semester, Dental Research Practices III
  14. 2024, Undergraduate Education, 1Term, Dental Material
  15. 2024, Undergraduate Education, 1Term, Dental Material
  16. 2024, Undergraduate Education, 2Term, Biomaterials
  17. 2024, Graduate Education (Master's Program) , First Semester, Seminar
  18. 2024, Graduate Education (Master's Program) , Second Semester, Seminar
  19. 2024, Graduate Education (Master's Program) , First Semester, Research
  20. 2024, Graduate Education (Master's Program) , Second Semester, Research
  21. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  22. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  23. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  24. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  25. 2024, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
  26. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Biomaterials
  27. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Biomaterials
  28. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Biomaterials
  29. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Biomaterials

Research Activities

Academic Papers

  1. International education at Hiroshima University School of Dentistry: Bilingual education enabled diverse initiatives, J. Jpn. Dent. Edu. Assoc., 40(1), 20-23, 2024
  2. Structure and function of engineered stromal cell-derived factor-1alpha, Dent. Mater. J., 43(2), 286-293, 2024
  3. Bioengineering challenges in regenerative medicine: Biofunctional materials design, Biomedical Engineering: Imaging Systems, Electric Devices, and Medical Materials, 283-299, 2024
  4. Regenerative nanotechnology: Engineered surfaces for stem cell production, Nanomedicine, 605-622, 2023
  5. Solid-phase cytometry using antibody microarrays, J. Hiroshima Univ. Dent. Soc., 54(1), 1-10, 2022
  6. Recombinant protein synthesis for nanomaterial assembly: Technical overview, Bull. Soc. Nano Sci. Technol., 20(2), 31-37, 2022
  7. Enhancement of intercellular interaction between iPSC-derived neural progenitor cells and activated endothelial cells using cell surface modification with functional oligopeptides, Biomater. Sci., 10(4), 925-938, 2022
  8. Quantitative cell subset analysis using antibody microarrays, ACS Appl. Bio Mater., 4(10), 7673-7681, 2021
  9. Mucoadhesion of polyamphoteric hydrogels synthesized from acrylic acid and N,N-dimethylaminopropyl acrylamide, Int. J. Adhes. Adhes., 104, 102746, 2021
  10. Evaluation of a peptide motif designed for protein tethering to polymer surfaces, J. Biomater. Sci., Polym. Ed., 32(1), 76-92, 2021
  11. Epidermal growth factor-immobilized surfaces for the selective cultivation of neural progenitor cells derived from induced pluripotent stem cells, Biotechnol. Bioeng., 117(9), 2741-2748, 2020
  12. Oriented immobilization of basic fibroblast growth factor: Bioengineered surface design for the expansion of human mesenchymal stromal cells, Sci. Rep., 10, 8762-8762, 2020
  13. Optimization of culture conditions for the efficient differentiation of mouse induced pluripotent stem cells into dental epithelial-like cells, In Vitro Cell. Dev. Biol. Animal, 56, 816-824, 2020
  14. Effect of laser groove treatment on shear bond strength of adhesive resin cement to polyetheretherketone (PEEK), J. Prosthodontic Res., 63, 52-57, 2019
  15. Differentiation of mouse induced pluripotent stem cells into dental epithelial-like cells in the absence of added serum, In Vitro Cell. Dev. Biol. Animal, 55(2), 130-137, 2019
  16. Enhancement of calcification by osteoblasts cultured on hydroxyapatite surfaces with adsorbed inorganic polyphosphate, In Vitro Cell. Dev. Biol. Animal, 54, 449-457, 2018
  17. Wnt3a promotes differentiation of bone marrow-derived mesenchymal stem cells into cementoblast-like cells, In Vitro Cell. Dev. Biol. Animal, 54, 468-476, 2018
  18. Formation of chemical bonds at zirconia surfaces with acidic functional monomers, J. Oral Sci., 60, 187-193, 2018
  19. Molecular level analyses of mechanical properties of PTFE sterilized by Co-60 gamma-ray irradiation for clinical use, Radiation Phys. Chem., 139, 126-131, 201710
  20. Seeding of mesenchymal stem cells into inner part of interconnected porous biodegradable scaffold by a new method with a filter paper, Dent. Mater. J., 34(1), 78-85, 2015
  21. Antibody arrays for quality control of mesenchymal stem cells, ACS Appl. Mater. Interfaces, 7(30), 16828-16836, 2015
  22. Optimization of surface-immobilized extracellular matrices for the proliferation of neural progenitor cells derived from induced pluripotent stem cells, Biotechnol. Bioeng., 112(11), 2388-2396, 2015
  23. Biodental engineering, JOURNAL OF ORAL BIOSCIENCES, 57(2), 80-85, 2015
  24. New development of carbonate apatite-chitosan scaffold based on lyophilization technique for bone tissue engineering, DENTAL MATERIALS JOURNAL, 32(2), 317-325, 2013
  25. Cell orientation and regulation of cell-cell communication in human mesenchymal stem cells on different patterns of electrospun fibers, BIOMEDICAL MATERIALS, 8(5), 55002, 2013
  26. In Vivo Study on the Survival of Neural Stem Cells Transplanted into the Rat Brain with a Collagen Hydrogel That Incorporates Laminin-Derived Polypeptides, BIOCONJUGATE CHEMISTRY, 24(11), 1798-1804, 2013
  27. Influence of alkyl chain length on calcium phosphate deposition onto titanium surfaces modified with alkylphosphonic acid monolayers, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 101(8), 2267-2272, 2013
  28. Selective and rapid expansion of human neural progenitor cells on substrates with terminally anchored growth factors, BIOMATERIALS, 34(25), 6008-6014, 2013
  29. Monitoring neural stem cell differentiation using PEDOT-PSS based MEA, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1830(9), 4329-4333, 2013
  30. Improvement of neural stem cell survival in collagen hydrogels by incorporating laminin-derived cell adhesive polypeptides, Bioconjugate Chemistry, 23(2), 212-221, 2012
  31. Design of Biointerfaces for Regenerative Medicine, ADVANCES IN POLYMER SCIENCE, POLYMERS IN NANOMEDICINE, 247, 167-200, 2012
  32. Synthesis of Functional Artificial Lymphoid Tissues, DISCOVERY MEDICINE, 65, 351-362, 2011
  33. Design of culture substrates for large-scale expansion of neural stem cells, BIOMATERIALS, 32(4), 992-1001, 2011
  34. Enhanced proliferation of neural stem cells in a collagen hydrogel incorporating engineered epidermal growth factor, BIOMATERIALS, 32(21), 4737-4743, 2011
  35. Array-based functional screening of growth factors toward optimizing neural stem cell microenvironments, BIOMATERIALS, 32(22), 5015-5022, 2011
  36. High-throughput analyses of gene functions on a cell chip by electroporation, METHODS IN MOLECULAR BIOLOGY; CELL-BASED MICROARRAYS, 706, 181-190, 2011
  37. Layer-by-layer assembly of small interfering RNA and poly(ethyleneimine) for substrate-mediated electroporation with high efficiency, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 397(2), 571-578, 2010
  38. Prolonged durability of electroporation microarrays as a result of addition of saccharides to nucleic acids, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 393(2), 607-614, 2009
  39. Surface-Anchoring of Spontaneously Dimerized Epidermal Growth Factor for Highly Selective Expansion of Neural Stem Cells, BIOCONJUGATE CHEMISTRY, 20(1), 102-110, 2009
  40. Enhanced Survival of Neural Cells Embedded in Hydrogels Composed of Collagen and Laminin-Derived Cell Adhesive Peptide, BIOCONJUGATE CHEMISTRY, 20(5), 976-983, 2009
  41. Surface-Displayed Antibodies as a Tool for Simultaneously Controlling the Arrangement and Morphology of Multiple Cell Types with Microscale Precision, ACS APPLIED MATERIALS & INTERFACES, 1(1), 53-55, 2009
  42. Hyaluronic acid hydrogel loaded with genetically-engineered brain-derived neurotrophic factor as a neural cell carrier, BIOMATERIALS, 30(27), 4581-4589, 2009
  43. Use of microarrays in transfection of mammalian cells with dicer-digested small interfering RNAs, ANALYTICAL BIOCHEMISTRY, 374(2), 417-422, 2008
  44. Multifunctional chimeric proteins for the sequential regulation of neural stem cell differentiation, BIOCONJUGATE CHEMISTRY, 19(2), 516-524, 2008
  45. Self-assembling chimeric protein for the construction of biodegradable hydrogels capable of interaction with Integrins expressed on neural stem/progenitor cells, BIOMACROMOLECULES, 9(5), 1411-1416, 2008
  46. A collagen-binding mimetic of neural cell adhesion molecule, BIOCONJUGATE CHEMISTRY, 19(6), 1119-1123, 2008
  47. Essential role of structural integrity and firm attachment of surface-anchored epidermal growth factor in adherent culture of neural stem cells, BIOMATERIALS, 29(33), 4403-4408, 2008
  48. Electroporation microarray for parallel transfer of small interfering RNA into mammalian cells, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 392(7-8), 1309-1316, 2008
  49. Combinatorial protein display for the cell-based screening of biomaterials that direct neural stem cell differentiation, BIOMATERIALS, 28(6), 1048-1060, 2007
  50. Antibody arrays for quantitative immunophenotyping, BIOMATERIALS, 28(6), 1289-1297, 2007
  51. Oriented immobilization of epidermal growth factor onto culture substrates for the selective expansion of neural stem cells, BIOMATERIALS, 28(24), 3517-3529, 2007
  52. High-throughput immunophenotyping by surface plasmon resonance imaging, ANALYTICAL CHEMISTRY, 79(22), 8616-8623, 2007
  53. Array-based functional screening for genes that regulate vascular endothelial differentiation of Flk1-positive progenitors derived from embryonic stem cells, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1770(8), 1085-1097, 2007
  54. Ultrastructural study on the specific binding of genetically engineered epidermal growth factor to type I collagen fibrils, BIOCONJUGATE CHEMISTRY, 18(6), 2137-2143, 2007
  55. Fabrication of cell-based arrays using micropatterned alkanethiol monolayers for the parallel silencing of specific genes by small interfering RNA, BIOCONJUGATE CHEMISTRY, 17(6), 1404-1410, 2006
  56. Layer-by-layer assembly of cationic lipid and plasmid DNA onto gold surface for stent-assisted gene transfer, BIOMATERIALS, 27(18), 3497-3504, 2006
  57. A thin carboxymethyl cellulose culture substrate for the cellulase-induced harvesting of an endothelial cell sheet, JOURNAL OF BIOMATERIALS SCIENCE, POLYMER EDITION, 16(10), 1277-1292, 2005
  58. Layer-by-layer assembly of poly(ethyleneimine) and plasmid DNA onto transparent indium-tin oxide electrodes for temporally- and spatially-specific gene transfe, LANGMUIR, 21(18), 8360-8367, 2005
  59. Immobilization of histidine-tagged recombinant proteins onto micropatterned surfaces for cell-based functional assays, LANGMUIR, 21(16), 7071-7075, 2005
  60. Parallel analysis of multiple surface markers expressed on rat neural stem cells using antibody microarrays, BIOMATERIALS, 26(23), 4882-4891, 2005
  61. Antibody microarray for correlating cell phenotype with surface marker, BIOMATERIALS, 26(6), 687-696, 2005
  62. Synthesis and characterization of stimuli-sensitive hydrogels having a different length of ethylene glycol chains carrying phosphate groups: loading and release of lysozyme, JOURNAL OF BIOMATERIALS SCIENCE, POLYMER EDITION, 15(11), 1435-1446, 2004
  63. Spatially and temporally controlled electroporation of adherent cells on plasmid DNA-loaded electrode, NUCLEIC ACIDS RESEARCH, 32(22), e187, 2004
  64. Drug permeation through temperature-sensitive microfiltration membranes prepared from poly(vinylidene fluoride) with grafted poly(N-isopropylacrylamide) side chains, JOURNAL OF MEMBRANE SCIENCE, 243(1,2), 253-262, 2004
  65. Adsorption of enantiomeric poly(lactide)s on surface-grafted poly(L-lactide), LANGMUIR, 20(16), 6748-6753, 2004
  66. Micropatterned, self-assembled monolayers for fabrication of transfected cell microarrays, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1672(3), 138-147, 2004
  67. Polymer surface with graft chains, PROGRESS IN POLYMER SCIENCE, 28(2), 209-259, 2003
  68. The interplay between surface micro-topography and -mechanics of type I collagen fibrils in air and aqueous media: An atomic force microscopy study, EUROPEAN PHYSICAL JOURNAL E, 6(1), 7-14, 2001
  69. Glistening formation in an AcrySof lens initiated by spinodal decompositionof the polymer network by temperature change, JOURNAL OF CATARACT AND REFRACTIVE SURGERY, 27(9), 1493-1498, 2001
  70. Synthesis of bioadhesive hydrogels from chitin derivatives, INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES, 21(3), 227-232, 2001
  71. Optical and atomic force microscopy of an explanted AcrySof intraocular lens with glistenings, JOURNAL OF CATARACT AND REFRACTIVE SURGERY, 26(4), 571-575, 2000
  72. Collagen immobilization onto the surface of artificial hair for improving the tissue adhesion, JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, 14(5), 635-650, 2000
  73. Preparation of DNA-immobilized immunoadsorbents for treatment of systemic lupus erythematosus, JOURNAL OF BIOMATERIALS SCIENCE, POLYMER EDITION, 10(3), 341-350, 1999
  74. Surface oxidation of cellulose fibers by vacuum ultraviolet irradiation, JOURNAL OF POLYMER SCIENCE, PART A: POLYMER CHEMISTRY, 37(3), 357-361, 1999
  75. Lysozyme loading and release from hydrogels carrying pendant phosphate groups, JOURNAL OF BIOMATERIALS SCIENCE, POLYMER EDITION, 9(1), 43-53, 1998
  76. Surface modification of polymers by grafting, ADVANCES IN POLYMER SCIENCE, 137, 1-39, 1998
  77. Histologic and mechanical evaluation for bone bonding of polymer surfaces grafted with a phosphate-containing polymer, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 37(3), 384-393, 1997
  78. In situ hydroxyapatite crystallization for the formation of hydroxyapatite / polymer composites, JOURNAL OF MATERIALS SCIENCE, 32(20), 5533-5543, 1997
  79. Ultrastructure of the interface between cultured osteoblasts and surface-modified polymer substrates, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 37(1), 29-36, 1997
  80. Studies on tumor-promoting activity of polyethylene: Inhibitory activity of metabolic cooperation on polyethylene surfaces is markedly decreased by surface modification with collagen but not with RGDS peptide, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 35(3), 391-397, 1997
  81. Polymeric supports for immunoadsorption, RECENT RESEARCH DEVELOPMENTS IN MACROMOLECULAR RESEARCH, 2, 157-173, 1997
  82. Effect of the structure of bone morphogenetic protein carriers on ectopic bone regeneration, TISSUE ENGINEERING, 2(4), 315-326, 1996
  83. Deposition of a hydroxyapatite thin layer onto a polymer surface carrying grafted phosphate polymer chains, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 32(4), 687-691, 1996
  84. Surface modification and functionalization of polytetrafluoroethylene films, MACROMOLECULES, 29(21), 6872-6879, 1996
  85. Plasma treatment of polyaniline films: Effect on the intrinsic oxidation states, JOURNAL OF MATERIALS RESEARCH, 11(6), 1570-1573, 1996
  86. XPS Characterization of surface functionalized electroactive polymers, SURFACE AND INTERFACE ANALYSIS, 24(9), 597-604, 1996
  87. Immobilization of DNA onto a polymer support and its potentiality as immunoadsorbent, BIOTECHNOLOGY AND BIOENGINEERING, 51(5), 581-590, 1996
  88. Surface graft polymerization of glycidyl methacrylate onto polyethylene and the adhesion with epoxy resin, JOURNAL OF POLYMER SCIENCE, PART A: POLYMER CHEMISTRY, 33(15), 2629-2638, 1995
  89. Selective adsorption of proteins to their ligands covalently immobilized onto microfibers, BIOTECHNOLOGY AND BIOENGINEERING, 47(5), 557-566, 1995
  90. Protein adsorption onto ionic surfaces, COLLOIDS AND SURFACES B: BIOINTERFACES, 4(4), 221-230, 1995
  91. Peroxide generation and decomposition on polymer surface, JOURNAL OF POLYMER SCIENCE, PART A: POLYMER CHEMISTRY, 33(2), 323-330, 1995
  92. In vitro hydroxyapatite deposition onto a film surface-grafted with organophosphate polymer, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 28(11), 1365-1373, 1994
  93. Introduction of functional groups onto the surface of polyethylene for protein immobilization, BIOMATERIALS, 14(11), 817-822, 1993
  94. Trypsin immobilization on to polymer surface through grafted layer and its reaction with inhibitors, BIOMATERIALS, 14(10), 763-769, 1993

Publications such as books

  1. 2016, Synthetic Immunology, Engineering of artificial lymph node, Springer, 2016, Scholarly Book, Joint work, English, Makoto Nakamura, Kenichi Arai, Takahito Mimura, Jungo Tagawa, Hirotoshi Yoshida, Koichi Kato, Tadashi Nakaji-Hirabayashi, Yuka Kobayashi, Takeshi Watanabe
  2. 2016, Synthetic Immunology, Synthesis of functional tertiary lymphoid organs, Springer, 2016, Scholarly Book, Joint work, English, Y. Kobayashi, K. Kato, M. Nakamura, T. Watanabe

Awards

  1. 1998, Young Investigator Award from the Society of Polymer Science, Japan, 1998
  2. 2004, The Award for Young Investigator of Japanese Society for Biomaterials, 2004