HIROYUKI KAWAGUCHI
Last Updated :2024/03/04
- Affiliations, Positions
- Hiroshima University Hospital, Professor
- E-mail
- hkawarphiroshima-u.ac.jp
- Other Contact Details
- 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan, Japan
TEL : (+81)82-257-5748 FAX : (+81)82-257-5717
Basic Information
Major Professional Backgrounds
- 1990/04/01, 1998/03/31, Hiroshima University, School of Pharmaceutical Sciences, Research Associate
- 1998/04/01, 2001/07/31, Hiroshima University Hospital, Lecturer
- 2001/08/01, 2007/03/31, Hiroshima University, School of Pharmaceutical Sciences, Associate Professor
- 2007/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor
- 2012/04, 2017/06, Nippon Kokan Fukuyama Hospital
- 2017/07/01, Hiroshima University Hospital, Professor
Educational Backgrounds
- Hiroshima University, Japan, 1986/04, 1990/03
- Hiroshima University, Faculty of Dentistry, Japan, 1980/04, 1986/03
Academic Degrees
Educational Activity
- [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences
Research Fields
- Medicine,dentistry, and pharmacy;Dentistry;Periodontology
Research Keywords
- general dentistry
- dental education
- clinical research
- periodontal treatment
Affiliated Academic Societies
- Japanese Society for Quality and Safety in Healthcare, 2021/08
- Japanese Society of Oral & Maxillofacial Surgeons, 2021/08
- Japanese Association of Health Communication
- Japanese Society of Periodontology
- Japan Endodontic Association
- Japanese Society for Regenerative Medicine
- The Japanese Society of Conservative Dentistry
- Japanese Society for Evidence and the Dental Professional
- Japanese Dental Education Association
- Japanese Society of the General Dentistry
Educational Activity
Course in Charge
- 2023, Liberal Arts Education Program1, 2Term, General Health and Oral Sciences I
- 2023, Undergraduate Education, 4Term, Overview of Dentistry
- 2023, Undergraduate Education, First Semester, Early Clinical Exposure I
- 2023, Undergraduate Education, 3Term, Interpersonal Communication
- 2023, Undergraduate Education, 3Term, Health and Medical Communication
- 2023, Undergraduate Education, Second Semester, Early Clinical Exposure II
- 2023, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
- 2023, Undergraduate Education, First Semester, Dental Research Practices I
- 2023, Undergraduate Education, 3Term, Disaster Dentistry and Forensic Odontology
- 2023, Undergraduate Education, 4Term, General Dentistry I
- 2023, Undergraduate Education, Second Semester, Early Clinical Exposure III
- 2023, Undergraduate Education, Second Semester, Dental Research Practices II
- 2023, Undergraduate Education, 2Term, General Dentistry II
- 2023, Undergraduate Education, 2Term, General Dentistry III
- 2023, Undergraduate Education, 1Term, Early Clinical Exposure III
- 2023, Undergraduate Education, First Semester, Dental Research Practices III
- 2023, Undergraduate Education, 3Term, Interpersonal Communication
- 2023, Undergraduate Education, 3Term, Health & Medical Communication
- 2023, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
- 2023, Undergraduate Education, 3Term, Disaster Dentistry and Forensic Odontology
- 2023, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
- 2023, Undergraduate Education, 3Term, Disaster Dentistry and Forensic Odontology
- 2023, Graduate Education (Master's Program) , First Semester, Seminar
- 2023, Graduate Education (Master's Program) , Second Semester, Seminar
- 2023, Graduate Education (Master's Program) , First Semester, Research
- 2023, Graduate Education (Master's Program) , Second Semester, Research
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on General Dentistry
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on General Dentistry
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on General Dentistry
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on General Dentistry
Research Activities
Academic Papers
- Improved ultrastructural preservation of epiphyseal chondrocytes by the freeze-substitution method., Anat.Rec., 219, 347-355, 1987
- Ultrastructure of matrix vesicles in chick growth plate as revealed by quick freezing and freeze substitution. Calcif.Tissue, Calcif.Tissue Int., 42, 383-393, 1988
- Different tartrate sensitivity and pH optimum for two isoenzymes of acid phosphatase in osteoclasts. An electron-microscopic enzyme-cytochemical study., Cell Tissue Res., 255, 69-76, 1989
- Ultrastructural and ultracytochemical characteristics of multinucleated cells after hydroxyapatite implantation into rat periodontal tissue., J.Periodont.Res., 27, 48-54, 1992
- Immunocytochemical and lectin-gold characterization of the interface between alveolar bone and implanted hydroxyapatite in the rat., Cells and Materials, 3, 337-350, 1993
- Ultrastructural studies and immunolocalization of enamel proteins in rodent secretory stage ameloblasts processed by various cryofixation methods., Anat.Rec., 238, 425-436, 1994
- New attachment to periodontally diseased root surfaces treated with hydrochloric acid., Oral Med.Pathol., 1, 23-28, 1996
- Ultrastructural and immunocytochemical characterization of the bone-single crystal sapphire implant interface in the rat maxilla., Oral Med.Pathol., 1, 84-89, 1996
- Cellular immuno-competence of infected root canal contents in pathogenesis of periapical lesions., J.Endodontics, 23, 213-216, 1997
- ★, Immunodetection of noncollagenous bone matrix proteins during periodontal tissue regeneration., J. Periodont.Res., 36, 205-213, 2001
- Expression of IL-1beta and IL-8 by human gingival epithelial cells in response to actinobacillus actinomycetemcomitans., Cytokine, 14, 152-161, 2001
- Osteoprotegerin levels increased by interleukin-1beta in human periodontal ligament cells are suppressed through prostaglandin E2 synthesized de novo., Cytokine, 18, 133-139, 2002
- The effect of extracellular calcium ion on gene expression of bone-related proteins in human pulp cells., J.Endod., 29, 104-107, 2003
- Immunohistochemical characteristics of epithelial cell rests of Malassez during cementum repair., J.Periodont.Res., 38, 51-56, 2003
- Expression of endothelins and thir receptors in cells from human periodontal tissues., J.Periodont.Res., 38, 269-275, 2003
- Syntheses of prostaglandin E2 and E-Cadherin and gene expression of beta-defensin-2 by human gingival epithelial cells in response to actinobacillus actinomycetemcomitans., Inflammation, 27, 341-349, 2003
- ★, Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells., J.Periodontol., 75, 1281-1287, 2004
- Effect of bone morphogenetic proteins-4, -5 and –6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells., Cell Bio.Int., 28, 675-682, 2004
- Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts., Biochem.Biophys.Res.Commun., 332, 297-303, 2005
- Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins., Cell Biol.Int., 29, 111-117, 2005
- Brain-derived neurotrophic factor enhanced periodontal tissue regeneration., Tissue Engineering, 11, 1618-1629, 2005
- ★, Behavior of transplanted bone marrow-derived mesenchymal stem cells in periodontal defects., J.Periodontol., 77, 1003-1007, 2006
- Human autologous serum obtained using a completely closed bag system as a substitute for foetal calf serum in human mesenchymal stem cell cultures., Cell Biol.Int., 30, 521-524, 2006
- Regulation of IL-8 by Irsogladine maleate is involved in abolishment of Actinobacillus actinomycetemcomitans-induced reduction of gap-junctional intercellular communication., Cytokine, 34, 271-277, 2006
- Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts., J.Periodont.Res., 42, 283-286, 2007
- Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells., Cell Biol.Int., 31, 1462-1469, 2007
- Irsogladine maleate counters the IL-1-induced suppression in gap-junctional intercellular communication without affecting increased ZO-1 levels by IL-1b in human gingival epithelial cells., J.Periodont.Res., 43, 96-102, 2008
- Brain-derived neurotrophic factor stimulates bone/cementum related protein gene expression in cementoblasts., J.Biol.Chem., 283, 16259-16267, 2008
- Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells., J.Periodontol., 79, 2182-2189, 2008
- Humoral factors released from human periodontal ligament cells influence calcification and proliferation in human bone marrow mesenchymal stem cells., J.Periodontol., 79, 2361-2370, 2008
- Brain-derived neurotrophic factor protects cementoblasts from serum starvation-Iinduced cell death., J.Cell Physiol., 221, 696-706, 2009
- Neodymium-dosed yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells., J.Endo., 35, 373-376, 2009
- Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans., Biochemical Pharmacolgy, 79, 1496-1505, 2010
- The expressions of claudin-1 and E-cadherin in junctional epithelium, J. Periodontal Res., 45(4), 579-582, 2010
- The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics., ; J Endod., 36(6), 1009-1013, 2010
- Characteristics of High-Molecular-Weight Hyaluronic Acid as a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration., Tissue Eng Part A., 17(7-8), 955-967, 2011
- Proteome analysis of proteins related to aggressive periodontitis combined with neutrophil chemotaxis dysfunction., J Clin Periodontol., 38(4), 310-317, 2011
- Brain-derived neurotrophic factor induces migration of endothelial cells through a TrkB-ERK-integrin alphaVbeta3-FAK cascade, J Cell Physiol., 227(5), 2123-2129, 2012
- Irsogladine maleate regulates epithelial barrier function in tumor necrosis factor-alpha-stimulated human gingival epithelial cells., J. Periodontal Res., 47, 55-61, 2012
- Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells., J Periodontal Res., 48, 228-234, 2013
- ★, Introduction of beta-tricalcium phosphate into a complex of bone marrow mesenchymal stem cells and type I collagen can augment the volume of alveolar bone without impairing cementum regeneration., J Periodontol., 86, 456-464, 2015
- Removal of mutans Streptococci from saliva to establish non-cariogenic oral flora. -A first step on exploring a new method using flow cytometry and cell sorting, International Journal of Research in Engineering and Science, 5, 41-54, 2017
- Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis-A Cross-Sectional Study in Japan, JOURNAL OF CLINICAL MEDICINE, 8(10), 201910
Publications such as books
- 2020/03, Clinical Periodontology 3rd., 2020, 2, Joint work
Invited Lecture, Oral Presentation, Poster Presentation
- Periodontal Tissue Engineering -An overview and new vista for regeneration therapies-., Hiroyuki Kawaguchi, Dental Education Committee of the Hawaii Dental Association,, 2003, With Invitation, English
- Immunodetection of Non-collagenous Bone Proteins at Sites of Root Repair., Hiroyuki Kawaguchi, Antonio Nanci, 13th International Conference on Oral Biology, 1994., 1994, Without Invitation, English
- Structural and Cytochemical Studies on the Response to Hydroxyapatite in Alveolar Bone., Hiroyuki Kawaguchi, Antonio Nanci, Scanning Microscopy 1993 Meeting, 1993, Without Invitation, English