HIROYUKI KAWAGUCHI

Last Updated :2024/03/04

Affiliations, Positions
Hiroshima University Hospital, Professor
E-mail
hkawarphiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan, Japan
TEL : (+81)82-257-5748 FAX : (+81)82-257-5717

Basic Information

Major Professional Backgrounds

  • 1990/04/01, 1998/03/31, Hiroshima University, School of Pharmaceutical Sciences, Research Associate
  • 1998/04/01, 2001/07/31, Hiroshima University Hospital, Lecturer
  • 2001/08/01, 2007/03/31, Hiroshima University, School of Pharmaceutical Sciences, Associate Professor
  • 2007/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor
  • 2012/04, 2017/06, Nippon Kokan Fukuyama Hospital
  • 2017/07/01, Hiroshima University Hospital, Professor

Educational Backgrounds

  • Hiroshima University, Japan, 1986/04, 1990/03
  • Hiroshima University, Faculty of Dentistry, Japan, 1980/04, 1986/03

Academic Degrees

  • Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Periodontology

Research Keywords

  • general dentistry
  • dental education
  • clinical research
  • periodontal treatment

Affiliated Academic Societies

  • Japanese Society for Quality and Safety in Healthcare, 2021/08
  • Japanese Society of Oral & Maxillofacial Surgeons, 2021/08
  • Japanese Association of Health Communication
  • Japanese Society of Periodontology
  • Japan Endodontic Association
  • Japanese Society for Regenerative Medicine
  • The Japanese Society of Conservative Dentistry
  • Japanese Society for Evidence and the Dental Professional
  • Japanese Dental Education Association
  • Japanese Society of the General Dentistry

Educational Activity

Course in Charge

  1. 2023, Liberal Arts Education Program1, 2Term, General Health and Oral Sciences I
  2. 2023, Undergraduate Education, 4Term, Overview of Dentistry
  3. 2023, Undergraduate Education, First Semester, Early Clinical Exposure I
  4. 2023, Undergraduate Education, 3Term, Interpersonal Communication
  5. 2023, Undergraduate Education, 3Term, Health and Medical Communication
  6. 2023, Undergraduate Education, Second Semester, Early Clinical Exposure II
  7. 2023, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  8. 2023, Undergraduate Education, First Semester, Dental Research Practices I
  9. 2023, Undergraduate Education, 3Term, Disaster Dentistry and Forensic Odontology
  10. 2023, Undergraduate Education, 4Term, General Dentistry I
  11. 2023, Undergraduate Education, Second Semester, Early Clinical Exposure III
  12. 2023, Undergraduate Education, Second Semester, Dental Research Practices II
  13. 2023, Undergraduate Education, 2Term, General Dentistry II
  14. 2023, Undergraduate Education, 2Term, General Dentistry III
  15. 2023, Undergraduate Education, 1Term, Early Clinical Exposure III
  16. 2023, Undergraduate Education, First Semester, Dental Research Practices III
  17. 2023, Undergraduate Education, 3Term, Interpersonal Communication
  18. 2023, Undergraduate Education, 3Term, Health & Medical Communication
  19. 2023, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  20. 2023, Undergraduate Education, 3Term, Disaster Dentistry and Forensic Odontology
  21. 2023, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  22. 2023, Undergraduate Education, 3Term, Disaster Dentistry and Forensic Odontology
  23. 2023, Graduate Education (Master's Program) , First Semester, Seminar
  24. 2023, Graduate Education (Master's Program) , Second Semester, Seminar
  25. 2023, Graduate Education (Master's Program) , First Semester, Research
  26. 2023, Graduate Education (Master's Program) , Second Semester, Research
  27. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  28. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  29. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  30. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  31. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on General Dentistry
  32. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on General Dentistry
  33. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on General Dentistry
  34. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on General Dentistry

Research Activities

Academic Papers

  1. Improved ultrastructural preservation of epiphyseal chondrocytes by the freeze-substitution method., Anat.Rec., 219, 347-355, 1987
  2. Ultrastructure of matrix vesicles in chick growth plate as revealed by quick freezing and freeze substitution. Calcif.Tissue, Calcif.Tissue Int., 42, 383-393, 1988
  3. Different tartrate sensitivity and pH optimum for two isoenzymes of acid phosphatase in osteoclasts. An electron-microscopic enzyme-cytochemical study., Cell Tissue Res., 255, 69-76, 1989
  4. Ultrastructural and ultracytochemical characteristics of multinucleated cells after hydroxyapatite implantation into rat periodontal tissue., J.Periodont.Res., 27, 48-54, 1992
  5. Immunocytochemical and lectin-gold characterization of the interface between alveolar bone and implanted hydroxyapatite in the rat., Cells and Materials, 3, 337-350, 1993
  6. Ultrastructural studies and immunolocalization of enamel proteins in rodent secretory stage ameloblasts processed by various cryofixation methods., Anat.Rec., 238, 425-436, 1994
  7. New attachment to periodontally diseased root surfaces treated with hydrochloric acid., Oral Med.Pathol., 1, 23-28, 1996
  8. Ultrastructural and immunocytochemical characterization of the bone-single crystal sapphire implant interface in the rat maxilla., Oral Med.Pathol., 1, 84-89, 1996
  9. Cellular immuno-competence of infected root canal contents in pathogenesis of periapical lesions., J.Endodontics, 23, 213-216, 1997
  10. ★, Immunodetection of noncollagenous bone matrix proteins during periodontal tissue regeneration., J. Periodont.Res., 36, 205-213, 2001
  11. Expression of IL-1beta and IL-8 by human gingival epithelial cells in response to actinobacillus actinomycetemcomitans., Cytokine, 14, 152-161, 2001
  12. Osteoprotegerin levels increased by interleukin-1beta in human periodontal ligament cells are suppressed through prostaglandin E2 synthesized de novo., Cytokine, 18, 133-139, 2002
  13. The effect of extracellular calcium ion on gene expression of bone-related proteins in human pulp cells., J.Endod., 29, 104-107, 2003
  14. Immunohistochemical characteristics of epithelial cell rests of Malassez during cementum repair., J.Periodont.Res., 38, 51-56, 2003
  15. Expression of endothelins and thir receptors in cells from human periodontal tissues., J.Periodont.Res., 38, 269-275, 2003
  16. Syntheses of prostaglandin E2 and E-Cadherin and gene expression of beta-defensin-2 by human gingival epithelial cells in response to actinobacillus actinomycetemcomitans., Inflammation, 27, 341-349, 2003
  17. ★, Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells., J.Periodontol., 75, 1281-1287, 2004
  18. Effect of bone morphogenetic proteins-4, -5 and –6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells., Cell Bio.Int., 28, 675-682, 2004
  19. Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts., Biochem.Biophys.Res.Commun., 332, 297-303, 2005
  20. Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins., Cell Biol.Int., 29, 111-117, 2005
  21. Brain-derived neurotrophic factor enhanced periodontal tissue regeneration., Tissue Engineering, 11, 1618-1629, 2005
  22. ★, Behavior of transplanted bone marrow-derived mesenchymal stem cells in periodontal defects., J.Periodontol., 77, 1003-1007, 2006
  23. Human autologous serum obtained using a completely closed bag system as a substitute for foetal calf serum in human mesenchymal stem cell cultures., Cell Biol.Int., 30, 521-524, 2006
  24. Regulation of IL-8 by Irsogladine maleate is involved in abolishment of Actinobacillus actinomycetemcomitans-induced reduction of gap-junctional intercellular communication., Cytokine, 34, 271-277, 2006
  25. Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts., J.Periodont.Res., 42, 283-286, 2007
  26. Effect of neurotrophins on differentiation, calcification and proliferation in cultures of human pulp cells., Cell Biol.Int., 31, 1462-1469, 2007
  27. Irsogladine maleate counters the IL-1-induced suppression in gap-junctional intercellular communication without affecting increased ZO-1 levels by IL-1b in human gingival epithelial cells., J.Periodont.Res., 43, 96-102, 2008
  28. Brain-derived neurotrophic factor stimulates bone/cementum related protein gene expression in cementoblasts., J.Biol.Chem., 283, 16259-16267, 2008
  29. Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells., J.Periodontol., 79, 2182-2189, 2008
  30. Humoral factors released from human periodontal ligament cells influence calcification and proliferation in human bone marrow mesenchymal stem cells., J.Periodontol., 79, 2361-2370, 2008
  31. Brain-derived neurotrophic factor protects cementoblasts from serum starvation-Iinduced cell death., J.Cell Physiol., 221, 696-706, 2009
  32. Neodymium-dosed yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells., J.Endo., 35, 373-376, 2009
  33. Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans., Biochemical Pharmacolgy, 79, 1496-1505, 2010
  34. The expressions of claudin-1 and E-cadherin in junctional epithelium, J. Periodontal Res., 45(4), 579-582, 2010
  35. The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics., ; J Endod., 36(6), 1009-1013, 2010
  36. Characteristics of High-Molecular-Weight Hyaluronic Acid as a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration., Tissue Eng Part A., 17(7-8), 955-967, 2011
  37. Proteome analysis of proteins related to aggressive periodontitis combined with neutrophil chemotaxis dysfunction., J Clin Periodontol., 38(4), 310-317, 2011
  38. Brain-derived neurotrophic factor induces migration of endothelial cells through a TrkB-ERK-integrin alphaVbeta3-FAK cascade, J Cell Physiol., 227(5), 2123-2129, 2012
  39. Irsogladine maleate regulates epithelial barrier function in tumor necrosis factor-alpha-stimulated human gingival epithelial cells., J. Periodontal Res., 47, 55-61, 2012
  40. Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells., J Periodontal Res., 48, 228-234, 2013
  41. ★, Introduction of beta-tricalcium phosphate into a complex of bone marrow mesenchymal stem cells and type I collagen can augment the volume of alveolar bone without impairing cementum regeneration., J Periodontol., 86, 456-464, 2015
  42. Removal of mutans Streptococci from saliva to establish non-cariogenic oral flora. -A first step on exploring a new method using flow cytometry and cell sorting, International Journal of Research in Engineering and Science, 5, 41-54, 2017
  43. Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis-A Cross-Sectional Study in Japan, JOURNAL OF CLINICAL MEDICINE, 8(10), 201910

Publications such as books

  1. 2020/03, Clinical Periodontology 3rd., 2020, 2, Joint work

Invited Lecture, Oral Presentation, Poster Presentation

  1. Periodontal Tissue Engineering -An overview and new vista for regeneration therapies-., Hiroyuki Kawaguchi, Dental Education Committee of the Hawaii Dental Association,, 2003, With Invitation, English
  2. Immunodetection of Non-collagenous Bone Proteins at Sites of Root Repair., Hiroyuki Kawaguchi, Antonio Nanci, 13th International Conference on Oral Biology, 1994., 1994, Without Invitation, English
  3. Structural and Cytochemical Studies on the Response to Hydroxyapatite in Alveolar Bone., Hiroyuki Kawaguchi, Antonio Nanci, Scanning Microscopy 1993 Meeting, 1993, Without Invitation, English