Yoshiki Kudo

Last Updated :2020/12/01

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
E-mail
yoshkudohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • D.Phil, University of Oxford
  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Obstetrics and gynecology

Research Keywords

  • placenta
  • trophoblast
  • syncytialisation
  • placenta
  • trophoblast
  • pre-eclampsia

Educational Activity

Course in Charge

  1. 2020, Undergraduate Education, Year, Systemic Disease Control
  2. 2020, Undergraduate Education, Intensive, Practice for medical research
  3. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced course of biomedical ethics
  4. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Obstetrics and Gynecology
  5. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Obstetrics and Gynecology
  6. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Gynecologic cancer treatment
  7. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Gynecologic cancer treatment
  8. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced research on Obstetrics and Gynecology
  9. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Obstetrics and Gynecology
  10. 2020, Graduate Education (Master's Program) , 1Term, Medical Ethics A
  11. 2020, Graduate Education (Doctoral Program) , 1Term, Medical Ethics B
  12. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Obstetrics and Gynecology
  13. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Obstetrics and Gynecology
  14. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Obstetrics and Gynecology
  15. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Obstetrics and Gynecology
  16. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Gynecologic Cancer Treatment
  17. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Gynecologic Cancer Treatment

Research Activities

Academic Papers

  1. ATP-Induced Currents Carried Through P2X7 Receptor in Rat Myometrial Cells, REPRODUCTIVE SCIENCES, 19(12), 1285-1291, DEC 2012
  2. TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS ( MVA) syndrome, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(4), 1461-1466, JAN 28 2014
  3. Diagnostic efficacy of alveolar bone loss of the mandible for identifying postmenopausal women with femoral osteoporosis, Dentomaxillofacial Radiology, 36(1), 28-33, 20070101
  4. Identification of postmenopausal women at risk of osteoporosis by trained general dental practitioners using panoramic radiographs, Dentomaxillofacial Radiology, 36(3), 149-54, 20070301
  5. Risk for vertebral osteoporosis in postmenopausal women with alterations of the mandible, Dentomaxillofacial Radiology, 36(3), 143-8, 20070301
  6. Interaction of obesity and skeletal bone mineral density on tooth retention in Japanese postmenopausal women, Menopause-Journal of the North America Menopause Society, 14, 500-4, 20070501
  7. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas., Oncol Rep., 17(4), 871-874, 20070401
  8. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, Oncol. Rep., 17(4), 871-878, 20070401
  9. Interaction of obesity and skeletal bone mineral density on tooth retention in Japanese postmenopausal women, Menopause-Journal of the North America Menopause Society, 14, 500-4, 20070501
  10. Risk for vertebral osteoporosis in postmenopausal women with alterations of the mandible, Dentomaxillofacial Radiology, 36(3), 143-8, 20070301
  11. Identification of postmenopausal women at risk of osteoporosis by trained general dental practitioners using panoramic radiographs, Dentomaxillofacial Radiology, 36(3), 149-54, 20070301
  12. Diagnostic efficacy of alveolar bone loss of the mandible for identifying postmenopausal women with femoral osteoporosis, Dentomaxillofacial Radiology, 36(1), 28-33, 20070101
  13. Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers2, Molecular Cancer Research, 5, 767-775, 20060101
  14. Cyclic and characteristic expression of phosphorylated Akt in human endometrium and decidual cells in vivo and in vitro1, Human Reproduction, 21, 1122-1128, 20060102
  15. Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cell-missing 1 (GCM1) in mothers with pre-eclampsia1, Hiroshima Journal of Medical Science, 9-15, 20060601
  16. No correlation between the number of fetal nucleated cells and the amount of cell-free fetal DNA in maternal circulation either before or after delivery, Prenatal Diagnosis, 27(8), 717-721, 20070801
  17. Epithelioid Trophoblastic Tumor of the Lung, The Journal of Obstetrics and Gynaecology Research, 33(3), 397-401, 20070601
  18. THE ROLE OF STROMAL REACTION OF ADENOMYOSIS IN ENDOMETRIAL CANCER INVASION TO MYOMETRIUM, The XXth Asian and Oceanic Congress of Obstetrics and Gynecology, 228, 20070901
  19. SUCCESSFUL OUTCOME OF CAESAREAN SCAR ECTOPIC PREGNANCY: A CASE REPORT, The XXth Asian and Oceanic Congress of Obstetrics and Gynecology, 263, 20070901
  20. THE MOLECULAR GENETIC ANALYSIS OF EPITHELIOID TROPHOBLASTIC TUMOR BY USING SHORT TANDEM REPEAT SEQUANCES, The XXth Asian and Oceanic Congress of Obstetrics and Gynecology, 279, 20070901
  21. Stromal reaction of adenomyosis protects from uterine endometrial cancer invasion to myometrium, Supplement to Journal of Clinical Oncology, 25(18S), 667S, 20070620
  22. THE ROLE OF ADENOMYOSIS IN UTERINE ENDOMETRIAL CANCER INVASION TO MYOMETRIUM, Sixteenth International Symposium of the Hiroshima Cancer Seminar, 43, 20061022
  23. Blue rubber bleb nevus syndrome: Report of a patient with hemangiomas of the vaginal portion of the cervix appearing during pregnancy, J. Obstet. Gynaecol. Res., 33(4), 546-548, 20070801
  24. Diagnostic efficacy of alveolar bone loss of the mandible for identifying postmenopausal women with femoral osteoporosis, Dentomaxillofacial Radiology, 36(1), 28-33, 20070401
  25. Risk for vertebral osteoporosis in postmenopausal women with alterations of the mandible, Dentomaxillofacial Radiology, 36(3), 143-8, 20070401
  26. Identification of postmenopausal women at risk of osteoporosis by trained general dental practitioners using panoramic radiographs, Dentomaxillofacial Radiology, 36(3), 149-54, 20070401
  27. Effects of menopause and hormone therapy on erythrocyt deformability, Menopause, 16(3), 555-558, 20090501
  28. Intra-arterial infusion chemotherapy using cisplatin with radiotherapy for Stage III squamous cell carcinoma of the cervix., Int J Radiat Oncol Biol Phys, 75(2), 369-377, 20091001
  29. Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis, Cancer Science, 16, 1186-1192, 20090301
  30. Enhanced expression of P2X4 and P2X7 purinergic receptors in the myometrium of pregnant rats in preterm delivery models, Reproductive Science, 16, 1186-1192, 20090601
  31. ★, Functional expression of purinergic P2X7 receptors in pregnant rat myometrium, Am J Physiol Regul Integr Comp Physiol, 298, 1117-1124, 20100401
  32. ★, CD133+ cells from human umbilical cord blood reduce cortical damage and promote axonal growth in neonatal rat organ co-cultures exposed to hypoxia., Internatonal journal of developmental neuroscience, 28(7), 581-587,, 20101101
  33. Intergender differences in histological architecture of the fascia pelvis parietalis: A cadaveric study, Clinical Anatomy, 24, 469-477, 20110301
  34. Comparative histological study of levels 1-3 supportive tissues using pelvic floor semiserial sections from elderly nulliparous and multiparous women, The journal of obstetrics and gynaecology research, 37(1), 13-23, 20110101
  35. Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1638(1), 63-71, MAY 20 2003
  36. Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 61(2), 87-98, APR 2004
  37. Mechanisms regulating the expression of indoleamine 2,3-dioxygenase during decidualization of human endometrium, HUMAN REPRODUCTION, 19(5), 1222-1230, MAY 2004
  38. An analysis using DNA microarray of the time course of gene expression during syncytialization of a human placental cell line (BeWo), PLACENTA, 25(6), 479-488, JUL 2004
  39. RNA interference-induced reduction in CD98 expression suppresses cell fusion during syncytialization of human placental BeWo cells, FEBS LETTERS, 577(3), 473-477, NOV 19 2004
  40. Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers, MOLECULAR CANCER THERAPEUTICS, 5(3), 767-775, MAR 2006
  41. Cyclic and characteristic expression of phosphorylated Akt in human endometrium and decidual cells in vivo and in vitro, HUMAN REPRODUCTION, 21(5), 1122-1128, MAY 2006
  42. Expression of tumor-associated differentially expressed gene-14 (TADG-14/KLK8) and its protein hK8 in uterine endometria and endometrial carcinomas, TUMOR BIOLOGY, 27(5), 274-282, 2006
  43. Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas, ONCOLOGY REPORTS, 17(4), 871-878, APR 2007
  44. Diagnostic efficacy of alveolar bone loss of the mandible for identifying postmenopausal women with femoral osteoporosis, DENTOMAXILLOFACIAL RADIOLOGY, 36(1), 28-33, JAN 2007
  45. Heterodimeric amino acid transporters in the placenta - A workshop report, PLACENTA, 28, S103-S106, APR 2007
  46. Growth factors and trophoblast differentiation - Workshop report, PLACENTA, 28, S121-S124, APR 2007
  47. Risk of vertebral osteoporosis in post-menopausal women with alterations of the mandible, DENTOMAXILLOFACIAL RADIOLOGY, 36(3), 143-148, MAR 2007
  48. Identification of post-menopausal women at risk of osteoporosis by trained general dental practitioners using panoramic radiographs, DENTOMAXILLOFACIAL RADIOLOGY, 36(3), 149-154, MAR 2007
  49. P57kip2 immunohistochemical expression and ultrastructural findings of gestational trophoblastic disease and related disorders, MEDICAL MOLECULAR MORPHOLOGY, 40(2), 95-102, JUN 2007
  50. Blue rubber bleb nevus syndrome: Report of a patient with hemangiomas of the vaginal portion of the cervix appearing during pregnancy, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 33(4), 546-548, AUG 2007
  51. No correlation between the number of fetal nucleated cells and the amount of cell-free fetal DNA in maternal circulation either before or after delivery, PRENATAL DIAGNOSIS, 27(8), 717-721, AUG 2007
  52. A computer-aided diagnosis system to screen for osteoporosis using dental panoramic radiographs, DENTOMAXILLOFACIAL RADIOLOGY, 37(5), 274-281, JUL 2008
  53. Morphologic effects of epithelial ion channels on the mouse uterus: differences between raloxifene analog (LY117018) and estradiol treatments, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 199(4), OCT 2008
  54. Effects of menopause and hormone therapy on erythrocyte deformability, MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 16(3), 555-558, MAY-JUN 2009
  55. Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis, CANCER SCIENCE, 100(8), 1421-1428, AUG 2009
  56. INTRA-ARTERIAL INFUSION CHEMOTHERAPY USING CISPLATIN WITH RADIOTHERAPY FOR STAGE III SQUAMOUS CELL CARCINOMA OF THE CERVIX, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75(2), 369-377, OCT 1 2009
  57. Enhanced Expression of P2X4 and P2X7 Purinergic Receptors in the Myometrium of Pregnant Rats in Preterm Delivery Models, REPRODUCTIVE SCIENCES, 16(12), 1186-1192, DEC 2009
  58. Gene Expression Profile for Predicting Survival in Advanced-Stage Serous Ovarian Cancer Across Two Independent Datasets, PLOS ONE, 5(3), MAR 12 2010
  59. CD133(+) cells from human umbilical cord blood reduce cortical damage and promote axonal growth in neonatal rat organ co-cultures exposed to hypoxia, INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 28(7), 581-587, NOV 2010
  60. Comparative histological study of levels 1-3 supportive tissues using pelvic floor semiserial sections from elderly nulliparous and multiparous women, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 37(1), 13-23, JAN 2011
  61. Intergender Differences in Histological Architecture of the Fascia Pelvis Parietalis: A Cadaveric Study, CLINICAL ANATOMY, 24(4), 469-477, MAY 2011
  62. Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 40(6), 1469-1499, JUN 2014
  63. Functional expression of purinergic P2X7 receptors in pregnant rat myometrium, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 298(4), R1117-R1124, APR 2010
  64. Circulating endothelial progenitor cells and placental abruption in women with preeclampsia, PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, 4(3), 203-208, JUL 2014
  65. Urinary protein-to-creatinine ratio in pregnant women after dipstick testing: prospective observational study, BMC PREGNANCY AND CHILDBIRTH, 15, DEC 14 2015
  66. Influenza 2014-2015 among pregnant Japanese women: primiparous vs multiparous women, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 35(4), 665-671, APR 2016
  67. Survey of prenatal testing for genetic disorders in Japan: Recent report, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 42(4), 375-379, APR 2016
  68. Enhanced Expression of Contractile-Associated Proteins and Ion Channels in Preterm Delivery Model Mice With Chronic Odontogenic Porphyromonas Gingivalis Infection, REPRODUCTIVE SCIENCES, 23(7), 838-846, JUL 2016
  69. Regulation of multidrug resistance 1 expression by CDX2 in ovarian mucinous adenocarcinoma, CANCER MEDICINE, 5(7), 1546-1555, JUL 2016
  70. The therapeutic effect of CD133(+) cells derived from human umbilical cord blood on neonatal mouse hypoxic-ischemic encephalopathy model, LIFE SCIENCES, 157, 108-115, JUL 15 2016
  71. Isolated gestational proteinuria preceding the diagnosis of preeclampsia - an observational study., Acta Obstet Gynecol Scand, 95, 1048-1054
  72. Isolated gestational proteinuria preceding the diagnosis of preeclampsia - an observational study, ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 95(9), 1048-1054, SEP 2016
  73. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells, SCIENTIFIC REPORTS, 7, JUL 20 2017
  74. The role of placental indoleamine 2,3-dioxygenase in human pregnancy., Obstet. Gynecol. Sci., 56, 209-216, 2013
  75. Analysis of individual differences in radiosensitivity using genome editing., Ann ICRP, 45, 290-296
  76. Prenatal and peripartum management of patients with hypofibrinogenemia resulted in two successful deliveries, Case Reports in Obstetrics and Gynecology
  77. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells., Sci Rep, 7, 5996
  78. Reduced prevalence of hepatitis B surface antigen positivity among pregnant women born after the national implementation of immunoprophylaxis for babies born to hepatitis B virus-carrier mothers in Japan, HEPATOLOGY RESEARCH, 47(12), 1329-1334, NOV 2017
  79. 'Isolated gestational proteinuria preceding the diagnosis of preeclampsia -an observational study -, 'Acta Obstetricia et Gynecologica Scandinavica, 95, 1048-1054
  80. 'Urinary protein-to-creatinine ratio in pregnant women after dipstick testing: prospective observational study, 'BMC Pregnancy and Children, 15(331)
  81. 'Regulation of multidrug resistance 1 expression by CDX2 in ovarian mucinous adenocarcinoma., 'Cancer Medicine, 5(5), 1546-1555
  82. 'Survey of prenatal testing for genetic disorders in Japan: Recent report, 'J Obstet Gynaecol Res, 42(4), 375-379
  83. Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology, JOURNAL OF RADIATION RESEARCH, 59, APR 2018
  84. Two Case Reports of Intravenous Leiomyomatosis with Hyaluronan Expression., Case Rep Obstet Gynecol., 4039183
  85. Fetal Membrane Inflammation Induces Preterm Birth Via Toll-Like Receptor 2 in Mice With Chronic Gingivitis., Reprod Sci.
  86. Intramural florid cysticendosalpingiosis of the uterus after menopause. Pol J Pathol. 2018; 69:205-208., Pol J Pathol, 69, 205
  87. Concurrent chemoradiotherapy for locally advanced squamous cell carcinoma of the cervix in a uterus didelphys with vaginal septum, JOURNAL OF CONTEMPORARY BRACHYTHERAPY, 11(2), 180-188, 2019
  88. Fetal Membrane Inflammation Induces Preterm Birth Via Toll-Like Receptor 2 in Mice With Chronic Gingivitis, REPRODUCTIVE SCIENCES, 26(7), 869-878, 201907
  89. Regulation of REG4 Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma, CANCER GENOMICS & PROTEOMICS, 16(6), 481-490, 2019
  90. Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation, SCIENTIFIC REPORTS, 9, 20191220
  91. Indoleamine 2,3-dioxygenase and trophoblast invasion in caesarean scar pregnancy: Implications for the aetiopathogenesis of placenta accreta spectrum, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 138, 202004