RYUJI TERAYAMA

Last Updated :2024/05/15

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
Web Site
https://www.hiroshima-u.ac.jp/en/dent/research/lab/dentistry/Maxillofacial_Anatomy_and_Neuroscience
E-mail
ryujithiroshima-u.ac.jp
Self-introduction
I am primarily involved in gross anatomy, particularly focused on the orofacial structures. We are trying to clarify the mechanisms underlying the development of neuropathic pain and to find appropriate treatments.

Basic Information

Academic Degrees

  • Ph.D (Medical Sciences), Miyazaki Medical College

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

In Charge of Primary Major Programs

  • Dentistry

Research Fields

  • Medicine,dentistry, and pharmacy;Boundary medicine;Pain science
  • Biological Sciences;Neuroscience;Nerve anatomy / Neuropathology
  • Medicine,dentistry, and pharmacy;Basic medicine;General anatomy (including histology / embryology)

Research Keywords

  • Glial cells
  • Central nervous system
  • Neuropathic pain

Affiliated Academic Societies

  • Japanese Association for Oral Biology
  • The Japanese Association of Anatomists
  • The Japan Neuroscience Society
  • Society for Neuroscience

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 2Term, Gross Anatomy
  2. 2024, Undergraduate Education, 4Term, Life Science
  3. 2024, Undergraduate Education, 3Term, Topographic Anatomy I
  4. 2024, Undergraduate Education, 4Term, Topographic Anatomy II
  5. 2024, Undergraduate Education, 3Term, Basic Practice of Anatomy I
  6. 2024, Undergraduate Education, 4Term, Basic Practice of Anatomy II
  7. 2024, Undergraduate Education, 2Term, Embryology
  8. 2024, Undergraduate Education, 1Term, Histology and Oral Histology
  9. 2024, Undergraduate Education, 1Term, Basic Practice of Histology I
  10. 2024, Undergraduate Education, 2Term, Basic Practice of Histology II
  11. 2024, Undergraduate Education, 2Term, Topics in Dental Research II
  12. 2024, Undergraduate Education, 3Term, Stomatognathic Function
  13. 2024, Undergraduate Education, First Semester, Dental Research Practices I
  14. 2024, Undergraduate Education, 3Term, Clinical Anatomy for Dentistry I
  15. 2024, Undergraduate Education, 4Term, Clinical Anatomy for Dentistry II
  16. 2024, Undergraduate Education, 3Term, Practice of Clinical Anatomy for Dentistry I
  17. 2024, Undergraduate Education, 4Term, Practice of Clinical Anatomy for Dentistry II
  18. 2024, Undergraduate Education, Second Semester, Dental Research Practices II
  19. 2024, Undergraduate Education, 2Term, Basic and clinical integrated theory
  20. 2024, Undergraduate Education, First Semester, Dental Research Practices III
  21. 2024, Undergraduate Education, 2Term, Anatomy and Oral Anatomy
  22. 2024, Undergraduate Education, 2Term, Anatomy and Oral Anatomy
  23. 2024, Graduate Education (Master's Program) , First Semester, Seminar
  24. 2024, Graduate Education (Master's Program) , Second Semester, Seminar
  25. 2024, Graduate Education (Master's Program) , First Semester, Research
  26. 2024, Graduate Education (Master's Program) , Second Semester, Research
  27. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  28. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  29. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  30. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  31. 2024, Graduate Education (Master's Program) , First Semester, Human Anatomy
  32. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Oral Biology
  33. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Oral Biology
  34. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Oral Biology
  35. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Oral Biology

Research Activities

Academic Papers

  1. Effects of Peripheral Nerve Injury on the Induction of c-Fos and Phosphorylated ERK in the Brainstem Trigeminal Sensory Nuclear Complex, Annals of Neurosciences, 30(3), 177-187, 202307
    Link to Paper Search Results by DOI
  2. Mouse maternal odontogenic infection with Porphyromonas gingivalis induces cognitive decline in offspring, FRONTIERS IN PEDIATRICS, 11, 20230811
    Link to Paper Search Results by DOI
  3. High-frequency near-infrared semiconductor laser irradiation suppressed experimental tooth movement-induced inflammatory pain markers in the periodontal ligament tissues of rats, LASERS IN MEDICAL SCIENCE, 38(1), 20230420
    Link to Paper Search Results by DOI
  4. Reorganization of synaptic inputs to spinal dorsal horn neurons in neuropathic pain, INTERNATIONAL JOURNAL OF NEUROSCIENCE, 132(12), 1210-1216, 20221202
    Link to Paper Search Results by DOI
  5. Effects of high-frequency near infrared laser irradiation on experimental tooth movement-induced pain in rats, LASERS IN MEDICAL SCIENCE, 37(6), 2697-2706, 202208
    Link to Paper Search Results by DOI
  6. Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins., The Journal of biological chemistry, 282(8), 2007
  7. Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue., Brain research, 1129(1), 2007
  8. Implications of protease M/neurosin in myelination during experimental demyelination and remyelination., Neuroscience letters, 405(3), 2006
  9. Aspartate-immunoreactive primary sensory neurons in the mouse trigeminal ganglion., Brain research, 1082(1), 2006
  10. ASIC3-immunoreactive neurons in the rat vagal and glossopharyngeal sensory ganglia., Brain research, 1081(1), 2006
  11. Brain-derived neurotrophic factor-immunoreactive primary sensory neurons in the rat trigeminal ganglion and trigeminal sensory nuclei., Brain research, 1081(1), 2006
  12. Activation of the caspase cascade underlies the rat trigeminal primary neuronal apoptosis induced by neonatal capsaicin administration., Archives of histology and cytology, 68(4), 2005
  13. Regeneration of the abdominal postganglionic sympathetic system., Neuroscience research, 54(4), 2006
  14. Immunohistochemical localization of gamma and beta subunits of epithelial Na+ channel in the rat molar tooth pulp., Brain research, 1065(1-2), 2005
  15. Calretinin-containing neurons which co-express parvalbumin and calbindin D-28k in the rat spinal and cranial sensory ganglia; triple immunofluorescence study., Brain research, 1061(2), 2005
  16. Involvement of neuropsin in the pathogenesis of experimental autoimmune encephalomyelitis., Glia, 52(2), 2005
  17. Differential expression of protease M/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis., Neuroscience letters, 382(1-2), 82-87, 20050411
  18. Differential expression of neuropsin and protease M/neurosin in oligodendrocytes after injury to the spinal cord., Glia, 48(2), 2004
  19. Local infusion of nerve growth factor attenuates myelinated nerve fiber sprouting into lamina II of the spinal dorsal horn and reduces the increased responsiveness to mechanical stimuli in rats with chronic constriction nerve injury., Journal of anesthesia, 15(4), 2001
  20. Differential rostral projections of caudal brainstem neurons receiving trigeminal input after masseter inflammation., The Journal of comparative neurology, 465(2), 2003
  21. Differential effects of NMDA and AMPA/KA receptor antagonists on c-Fos or Zif/268 expression in the rat spinal dorsal horn induced by noxious thermal or mechanical stimulation, or formalin injection., Neuroscience research, 43(4), 2002
  22. Brain-derived neurotrophic factor-immunoreactive neurons in the rat vagal and glossopharyngeal sensory ganglia; co-expression with other neurochemical substances., Brain research, 1155, 2007
  23. Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury., Neuroscience, 148(1), 2007
  24. ★, Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury., Neuroscience, 153(4), 2008
  25. The number of nociceptors in the trigeminal ganglion but not proprioceptors in the mesencephalic trigeminal tract nucleus is reduced in dystonin deficient dystonia musculorum mice., Brain research, 1226, 2008
  26. Differential changes in axonal conduction following CNS demyelination in two mouse models., The European journal of neuroscience, 28(9), 2008
  27. Brn-3a deficiency transiently increases expression of calbindin D-28 k and calretinin in the trigeminal ganglion during embryonic development., Cellular and molecular neurobiology, 29(5), 2009
  28. Peptide 19 in the rat superior cervical ganglion., Neuroscience, 161(1), 2009
  29. Persistent hypoglossal artery with hypoplasia of the vertebral and posterior communicating arteries., Anatomical science international, 86(1), 2011
  30. Differential activation of mitogen-activated protein kinases and glial cells in the trigeminal sensory nuclear complex following lingual nerve injury., Neuroscience research, 69(2), 2011
  31. Fos protein-like immunoreactive neurons induced by electrical stimulation in the trigeminal sensory nuclear complex of rats with chronically injured peripheral nerve., Experimental brain research, 219(2), 2012
  32. Effect of adenosine A1 receptor agonist on the enhanced excitability of spinal dorsal horn neurons after peripheral nerve injury., The International journal of neuroscience, 124(3), 2014
  33. Assessment of intraoral mucosal pain induced by the application of capsaicin., Archives of oral biology, 59(12), 2014
  34. Possible involvement of convergent nociceptive input to medullary dorsal horn neurons in intraoral hyperalgesia following peripheral nerve injury., Cellular and molecular neurobiology, 35(3), 2015
  35. Convergent nociceptive input to spinal dorsal horn neurons after peripheral nerve injury., Neurochemical research, 40(3), 2015
  36. Peripheral nerve injury activates convergent nociceptive input to dorsal horn neurons from neighboring intact nerve., Experimental brain research, 233(4), 2015
  37. Activated microglia contribute to convergent nociceptive inputs to spinal dorsal horn neurons and the development of neuropathic pain., Neurochemical research, 40(5), 2015
  38. Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission., Toxins, 7(8), 2015
  39. Differential Changes in Neuronal Excitability in the Spinal Dorsal Horn After Spinal Nerve Ligation in Rats., Neurochemical research, 41(11), 2016
  40. Differential induction of c-Fos and phosphorylated ERK by a noxious stimulus after peripheral nerve injury., The International journal of neuroscience, 128(3), 2018
  41. Basic research and clinical investigations of the neural basis of orofacial pain, JOURNAL OF ORAL BIOSCIENCES, 57(1), 27-36, 2015
  42. Tunicamycin-Induced Cell Death in the Trigeminal Ganglion is Suppressed by Nerve Growth Factor in the Mouse Embryo, CELLULAR AND MOLECULAR NEUROBIOLOGY, 30(3), 461-467, 2010
  43. Effect of ionotropic glutamate receptor antagonists on Fos-like immunoreactivity in the dorsal horn following transection of the rat sciatic nerve., Brain research, 934(1), 2002
  44. Age-dependency of analgesia elicited by intraoral sucrose in acute and persistent pain models., Pain, 97(1-2), 2002
  45. Differential expression of Fos protein after transection of the rat infraorbital nerve in the trigeminal nucleus caudalis., Brain research, 768(1-2), 1997
  46. Changes in gene expression and neuronal phenotype in brain stem pain modulatory circuitry after inflammation, JOURNAL OF NEUROPHYSIOLOGY, 87(2), 750-760, 2002
  47. ★, The roles of NMDA receptor activation and nucleus reticularis gigantocellularis in the time-dependent changes in descending inhibition after inflammation, PAIN, 97(1-2), 171-181, 2002
  48. Destruction of dorsal root ganglion neurons by isolectin B4-conjugated saporin (IB4-sap), NEUROSCIENCE RESEARCH, 55, S191-S191, 2006
  49. Activation of caspase cascade underlies the sensory primary neuronal apoptosis induced by neonatal capsaicin and peripheral nerve injury in rats, INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 24(8), 554-554, 2006
  50. Activation p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury, NEUROSCIENCE RESEARCH, 65, S178-S179, 2009
  51. A(3) adenosine receptor agonist attenuates neuropathic pain by suppressing activation of microglia and convergence of nociceptive inputs in the spinal dorsal horn, EXPERIMENTAL BRAIN RESEARCH, 236(12), 3203-3213, 201812
    Link to Paper Search Results by DOI
  52. Osteoclastogenesis from bone marrow cells during estrogen-induced medullary bone formation in Japanese quails, JOURNAL OF MOLECULAR HISTOLOGY, 50(4), 389-404, 201908
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Retinoid-loaded nanoparticles enable targeted bone growth by modulating function of the growth plate, Uchibe K, Terayama R, The 64th Annual Meeting of Japanese Association for Oral Biology, 2022/09/18, Without Invitation, English
  2. Effect of peripheral nerve injury on the induction of c-Fos and phosphorylated ERK in the trigeminal sensory nuclear complex, Terayama R, Uchibe K, The 64th Annual Meeting of Japanese Association for Oral Biology, 2022/09/18, Without Invitation, English
  3. Adenosine A3 receptor activation attenuates abnormal pain sensations after peripheral nerve injury, Terayama R, Uchibe K, The 44th Annual Meeting of the Japan Neuroscience Society The 1st CJK International Meeting, 2021/07/28, Without Invitation, English
  4. Effects of microglial inhibition on neuropathic pain, Terayama R, Uchibe K, The 63rd Annual Meeting of Japanese Association for Oral Biology, 2021/10/10, Without Invitation, English, Japanese Association for Oral Biology, Yokosuka
  5. Roles of retinoic acid signaling in chondrocytes, Uchibe K, Terayama R, The 62nd Annual Meeting of Japanese Association for Oral Biology, 2020/09/11, Without Invitation, English, Japanese Association for Oral Biology, Kagoshima (WEB)
  6. Possible mechanisms for the effects of A3 adenosine receptor agonist on neuropathic pain, Ryuji Terayama, Kenta Uchibe, The 62nd Annual Meeting of Japanese Association for Oral Biology, 2020/09/11, Without Invitation, English, Japanese Association for Oral Biology, Kagoshima (WEB)
  7. Abnormal pain sensation and changes in the spinal dorsal horn after peripheral nerve injury, Ryuji Terayama, The 24th Annual Meeting of Japanese Association for Orofacial Pain, 2019/09/29, With Invitation, Japanese, Japanese Association for Orofacial Pain, Kawasaki
  8. Effect of A3 adenosine receptor agonist on neuropathic pain, Ryuji Terayama, The 74th Annual Meeting of the Japanese Association of Anatomists Chugoku-Shikoku Chapter, 2019/10/26, Without Invitation, Japanese, Japanese Association of Anatomists Chugoku-Shikoku Chapter, Izumo
  9. A3 adenosine receptor agonist attenuates neuropathic pain by suppressing activation of microglia and convergence of nociceptive inputs in the spinal dorsal horn, Ryuji Terayama, The 61st Annual Meeting of Japanese Association for Oral Biology, 2019/10/12, Without Invitation, English, apanese Association for Oral Biology, Tokyo
    Related URL
  10. Differential Changes in Neuronal Excitability in the Spinal Dorsal Horn After Spinal Nerve Ligation in Rats., Ryuji Terayama, The 43rd Seminer of Okayama Brain Research, 2017/01/29, Without Invitation, Japanese, Seminer of Okayama Brain Research, Okayama
  11. Changes in the spinal dorsal horn involved in neuropathic pain., Ryuji Terayama, The 44th Okayama Brain Research Seminar, 2017/10/14, With Invitation, Japanese, Okayama Brain Research Seminar, Okayama
  12. Differential induction of c-Fos and phosphorylated ERK by a noxious stimulus after peripheral nerve injury., Tabata M, Terayama R, Maruhama K, Iida S, Sugimoto T., 2017/10/28, Without Invitation, Japanese, The Japanese Association of Anatomist, Hiroshima
  13. Differential induction of c-Fos and phosphorylated ERK after peripheral nerve injury, Ryuji Terayama, Kotaro Maruhama, The 60th Annual Meeting of Japanese Association for Oral Biology, 2018/09/06, Without Invitation, English, Japanese Association for Oral Biology, Fukuoka
  14. Basic Research for Neropathic Pain, Ryuji Terayama, With Invitation, Japanese, Hiroshima
  15. Memory of Pain -Chrinic Pain andNeurnal Plasticity-, Ryuji Terayama, 2018/10/24, With Invitation, Japanese, Hiroshima

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2019, 2021

Social Activities

History as Peer Reviews of Academic Papers

  1. 2021, The Anatomical Record, Others, Reviewer, 1
  2. 2020, Journal of Pain Research, Others, Reviewer, 1
  3. 2019, International Journal of Neuroscience, Others, Reviewer, 1
  4. 2018, Journal of Receptors and Signal Transduction, Others, Reviewer, 1
  5. 2018, Cell Tissue Organs, Others, Reviewer, 2