RYOUU TAKAHASHI

Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Associate Professor
E-mail
rytakahahiroshima-u.ac.jp
Self-introduction
I am engaged in pharmaceutical research based on molecular biology. One of the major concerns in cancer biology is how cancer cells acquire therapeutic resistance to radiation and chemotherapy. Recently, accumulating the lines of evidence revealed that heterogeneity of cancer cells is associated with therapy resistance in various types of tumors. Therefore, I am struggling every day to elucidate the molecular mechanisms underlying the acquisition of therapeutic resistance at single cell level and identify promising targets for cancer therapy.

Basic Information

Academic Degrees

  • Tokyo Institute of Technology
  • Tokyo Institute of Technology

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Biological pharmacy

Research Keywords

  • microRNA, Cancer Stem Cell, Drug Resistance, Cellular Senescence

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 3Term, Biochemistry V
  2. 2024, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
  3. 2024, Undergraduate Education, 4Term, Biochemistry VI
  4. 2024, Undergraduate Education, 4Term, Cell Biology
  5. 2024, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  6. 2024, Undergraduate Education, Second Semester, Experiments of Cellular and Molecular Biology
  7. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Cell Carcinogenesis
  8. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Cell Carcinogenesis

Research Activities

Academic Papers

  1. Microrna in body fluids-development of the novel plat form for cancer therapeutics and diagnosis, Japanese Journal of Cancer and Chemotherapy, 45((6)), 899-905, 201806
  2. ★, CD44 exerts a functional role during EMT induction in cisplatin-resistant head and neck cancer cells., Oncotarget, 9(11), 10029-10041, 201801
  3. Drug resistance driven by cancer stem cells and their niche, International Journal of Molecular Sciences, 18(12), 201712
    Link to Paper Search Results by DOI
  4. A tissue microRNA signature that predicts the prognosis of breast cancer in young women, Plus ONE, 12(11), 201711
    Link to Paper Search Results by DOI
  5. The role of extracellular vesicle microRNAs in cancer biology, Clinical Chemistry and Laboratory Medicine, 55(5), 648-656, 201705
    Link to Paper Search Results by DOI
  6. Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity, Cell Stem Cell, 20(1), 41-55, 201701
    Link to Paper Search Results by DOI
  7. Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity., Cancer research, 76(1), 150-160, 201601
  8. The expression and clinical significance of ribophorin II (RPN2) in human breast cancer., Pathology international, 65(6), 301-308, 201506
  9. ★, Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1., Nature communications, 6, 7318, 201506
  10. ★, Development of miRNA-based therapeutic approaches for cancer patients, CANCER SCIENCE, 110(4), 1140-1147, 201904
    Link to Paper Search Results by DOI
  11. Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts, ONCOGENE, 38(28), 5566-5579, 20190711
    Link to Paper Search Results by DOI
  12. ★, Single-Cell Analysis Reveals a Preexisting Drug-Resistant Subpopulation in the Luminal Breast Cancer Subtype, CANCER RESEARCH, 79(17), 4412-4425, 20190901
    Link to Paper Search Results by DOI
  13. Recent Advances in Liquid Biopsy Based on Circulating Tumor DNA, JOURNAL OF CLINICAL MEDICINE, 2019
    Link to Paper Search Results by DOI

Publications such as books

  1. 2019/02/26, Nucleic Acid Nanotheranostics 1st Edition, ELSEVIER, 2019, 2, Scholarly Book, Joint work, 英語, Ryou-u Takahashi & Takahiro Ochiya, 9780128144701, 473, 27-41

Patented

  1. Patent, 5812491, 2015/10/02