Hiroki Nikawa

Last Updated :2025/06/11

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
Self-introduction
All work and no play makes Jack a dull boy.

Basic Information

Major Professional Backgrounds

  • 1999/04/01, 1998/06/30, Hiroshima University, Faculty of Dentistry, Research Associate
  • 1992/07/01, 1992/12/30, Hong Kong University, Faculty of Dentistry, Reseach Fellow
  • 1998/07/01, 2005/03/31, Hiroshima University, Hospital, Lecturer
  • 2005/04/01, 2006/03/31, Hiroshima University, Faculty of Dentistry, Professor
  • 2006/04/01, 2014/03/31, Graduate School of Hiroshima University, Institute of Biomedical Sciences, Professor
  • 2014/04/01, 2019/03/31, Graduate School of Hiroshima University, Institute of Biomedical and Health Sciences, Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Dental Research, Japan, 1986/04, 1990/03
  • Hiroshima University, Faculty of Dentistry, Japan, 1980/04, 1986/03

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Oral Health Sciences : Oral Engineering
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Health Sciences

In Charge of Primary Major Programs

  • Oral Health Science
  • Oral Engineering
  • Dentistry

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Prosthodontics / Dental materials science and

Research Keywords

  • biofilm|thigmotropism
  • serum|Candida albicans
  • probiotics
  • bacteria|Candida albicans
  • proliferation|antibacterial peptide
  • Candida albicans
  • caries
  • dental caries
  • adhesin expression
  • stem cell

Affiliated Academic Societies

  • Janan Society of Education for Dental Technology
  • Hiroshima University Dental Society
  • The Japan Society for Dental Materials and Devices
  • Nippon Academy of Dental Technology
  • Japan Prosthodontic Society
  • Japan Stomatological Society
  • The Scociety for Antibacterial and Antifungal Agents, 1986
  • Japan Academy of Digital dentistry, 1998
  • Japan Tissue Culture Association
  • Japan Society for Bacteriology
  • Japanese Association for Infectious Disease
  • Japanese Society for Periodontology
  • International Association for Dental Research
  • International Society for Human and Animal Mycology

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 4Term, General Health and Oral Sciences II
  2. 2025, Undergraduate Education, 4Term, Overview of Dentistry
  3. 2025, Undergraduate Education, 2Term, Technical Training for Tooth Carving
  4. 2025, Undergraduate Education, 4Term, Special Subject
  5. 2025, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  6. 2025, Undergraduate Education, 4Term, Introduction to Dental Science
  7. 2025, Undergraduate Education, 2Term, Technical Training for Tooth Carving
  8. 2025, Undergraduate Education, 3Term, Crown Restoration and Health Engineering I
  9. 2025, Undergraduate Education, 2Term, Crown Restoration and Health Engineering II
  10. 2025, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  11. 2025, Undergraduate Education, 1Term, Oral Health Management A
  12. 2025, Undergraduate Education, 1Term, Health Science on Sports Dentistry and Temporomandibular
  13. 2025, Undergraduate Education, 1Term, Introductory Course for Oral Engineering
  14. 2025, Undergraduate Education, 3Term, Crown Restoration and Health Engineering I
  15. 2025, Undergraduate Education, 3Term, Removable Denture and Health Engineering (Complete Denture)
  16. 2025, Undergraduate Education, 1Term, Stmatognathic System and Function
  17. 2025, Undergraduate Education, 2Term, Crown Restoration and Health Engineering II
  18. 2025, Undergraduate Education, 4Term, Crown Restoration and Health Engineering III
  19. 2025, Undergraduate Education, 3Term, Esthetic Dentistry
  20. 2025, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  21. 2025, Undergraduate Education, 1Term, Health Science on Sports Dentistry and Temporomandibular
  22. 2025, Undergraduate Education, First Semester, Overview of Oral Engineering
  23. 2025, Undergraduate Education, OutOfTerm(1st), Special Course in Rehabilitation Make Up
  24. 2025, Undergraduate Education, Second Semester, Clinical Practice in Oral Health Engineering
  25. 2025, Undergraduate Education, 3Term, Medical Design Engineering I
  26. 2025, Undergraduate Education, 4Term, Medical Design Engineering II
  27. 2025, Undergraduate Education, Second Semester, Special Study for Graduation
  28. 2025, Undergraduate Education, First Semester, Clinical Practice in Oral Health Engineering
  29. 2025, Undergraduate Education, First Semester, Special Study for Graduation
  30. 2025, Undergraduate Education, Second Semester, Clinical Practice in Oral Health Engineering
  31. 2025, Undergraduate Education, Second Semester, Special Study for Graduation
  32. 2025, Graduate Education (Master's Program) , 3Term, Dietetics
  33. 2025, Graduate Education (Master's Program) , First Semester, Advanced Lecture on Health Science 3(Experiment Research)
  34. 2025, Graduate Education (Master's Program) , First Semester, Lecture on Oral Health Sciences
  35. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Oral Health Sciences 1
  36. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Oral Health Sciences 2
  37. 2025, Graduate Education (Master's Program) , First Semester, Lecture on Oral Implantology
  38. 2025, Graduate Education (Master's Program) , First Semester, Lecture on Oral Engineering
  39. 2025, Graduate Education (Master's Program) , First Semester, Seminar on Oral Engineering (A)
  40. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Oral Engineering (A)
  41. 2025, Graduate Education (Master's Program) , First Semester, Seminar on Oral Engineering (B)
  42. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Oral Engineering (B)
  43. 2025, Graduate Education (Master's Program) , Year, Research on Oral Engineering
  44. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Applied Oral Biology and Engineering
  45. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Applied Oral Biology and Engineering
  46. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Oral Rehabilitation and Engineering
  47. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Oral Rehabilitation and Engineering
  48. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Applied Oral Biology, Oral Rehabilitation and Engineering
  49. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Applied Oral Biology, Oral Rehabilitation and Engineering
  50. 2025, Graduate Education (Master's Program) , First Semester, Research on Oral Engineering
  51. 2025, Graduate Education (Master's Program) , Second Semester, Research on Oral Engineering

Research Activities

Academic Papers

  1. Analysis of Risedronate Analog on Extraction Socket Healing in Mice, IN VIVO, 39(2), 648-655, 2025
    Link to Paper Search Results by DOI
  2. Activation of platelet-derived growth factor receptors regulate connective tissue growth factor protein levels via the AKT pathway in malignant mesothelioma cells, JOURNAL OF BIOCHEMISTRY, 176(6), 460-471, 20241023
    Link to Paper Search Results by DOI
  3. Influence of handheld nonthermal plasma on shear bond strength of polyaryletherketone to resin-matrix cement, JOURNAL OF DENTAL SCIENCES, 19(4), 2057-2064, 202410
    Link to Paper Search Results by DOI
  4. In vitro study of optimal removable partial denture clasp design made from novel high-performance polyetherketoneketone, JOURNAL OF PROSTHODONTIC RESEARCH, 68(3), 466-473, 2024
    Link to Paper Search Results by DOI
  5. Wisdom Tooth Autotransplantation for the Missing Maxillary Central Incisors Using a 3D-Printed Replica: A Case Report, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(5), 20240529
    Link to Paper Search Results by DOI
  6. Wisdom Tooth Autotransplantation for the Missing Maxillary Central Incisors Using a 3D-Printed Replica: A Case Report, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(5), 20240529
    Link to Paper Search Results by DOI
  7. Trisomy 12 compromises the mesendodermal differentiation propensity of human pluripotent stem cells, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 60(5), 521-534, 202405
    Link to Paper Search Results by DOI
  8. RESEARCH AND EDUCATION Comparative analysis of the retention force and deformation of PEEK and PEKK removable partial denture clasps with different thicknesses and undercut depths, JOURNAL OF PROSTHETIC DENTISTRY, 131(2), 202402
    Link to Paper Search Results by DOI
  9. Entire Dental Arch Mesial Movement after Extraction of Maxillary Right Central Incisor due to Root Fracture Treated with Temporary Anchorage Devices, BULLETIN OF TOKYO DENTAL COLLEGE, 65(1), 19-27, 2024
    Link to Paper Search Results by DOI
  10. Effects of various functional monomers' reaction on the surface characteristics and bonding performance of polyetheretherketone, JOURNAL OF PROSTHODONTIC RESEARCH, 68(2), 319-325, 2024
    Link to Paper Search Results by DOI
  11. Comparison of dental plaque flora between intellectually disabled patients and healthy individuals: a cross-sectional study, ODONTOLOGY, 112(2), 588-600, 202404
    Link to Paper Search Results by DOI
  12. Effect of Lacticaseibacillus rhamnosus L8020 on the abundance of periodontal pathogens in individuals with intellectual disability: a randomized clinical trial, QUINTESSENCE INTERNATIONAL, 54(5), 372-383, 202305
    Link to Paper Search Results by DOI
  13. Comparison of the accuracy of different handheld-type scanners in three-dimensional facial image recognition, JOURNAL OF PROSTHODONTIC RESEARCH, 67(2), 222-230, 2023
    Link to Paper Search Results by DOI
  14. Establishment of indicator for screening of child abuse and neglect in primary school-age children, EUROPEAN JOURNAL OF PAEDIATRIC DENTISTRY, 23(4), 315-320, 2022
    Link to Paper Search Results by DOI
  15. Effect of CD146(+) SHED on bone regeneration in a mouse calvaria defect model, ORAL DISEASES, 29(2), 725-734, 202303
    Link to Paper Search Results by DOI
  16. Combination of Carbonate Hydroxyapatite and Stem Cells from Human Deciduous Teeth Promotes Bone Regeneration by Enhancing BMP-2, VEGF and CD31 Expression in Immunodeficient Mice, CELLS, 11(12), 202206
    Link to Paper Search Results by DOI
  17. Lansoprazole and zoledronate delays hard tissue healing of tooth extraction sockets in dexamethasone-treated mice, BIOMEDICINE & PHARMACOTHERAPY, 150, 202206
    Link to Paper Search Results by DOI
  18. Occlusal Trauma and Bisphosphonate-Related Osteonecrosis of the Jaw in Mice, CALCIFIED TISSUE INTERNATIONAL, 110(3), 380-392, 202203
    Link to Paper Search Results by DOI
  19. Alterations to Titanium Surface Depending on the Fluorides and Abrasives in Toothpaste, MATERIALS, 15(1), 202201
    Link to Paper Search Results by DOI
  20. Alterations to Titanium Surface Depending on the Fluorides and Abrasives in Toothpaste, MATERIALS, 15(1), 202201
    Link to Paper Search Results by DOI
  21. Growth factor-defined culture medium for human mesenchymal stem cells, INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 55(2), 181-187, 2011
    Link to Paper Search Results by DOI
  22. Blocking of sodium and potassium ion-dependent adenosine triphosphatase-alpha 1 with ouabain and vanadate suppresses cell-cell fusion during RANKL-mediated osteoclastogenesis, EUROPEAN JOURNAL OF PHARMACOLOGY, 670(2-3), 409-418, 20111130
    Link to Paper Search Results by DOI
  23. Evaluation of trabecular bone formation in a canine model surrounding a dental implant fixture immobilized with an antimicrobial peptide derived from histatin, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 22(12), 2765-2772, 201112
    Link to Paper Search Results by DOI
  24. Clinical application of "Rebase H", The journal of dental engineering, 114, 12-16, 19950401
  25. Effects of Various Mixing Ratio on the Stress Relaxation and the Setting Time of Elastomeric Impression Materials, The Journal of Hiroshima University Dental Society, 23(2), 308-312, 19910401
  26. Denture cleanser, The journal of dental engineering, 114, 19-30, 19950401
  27. Non-Specific adherence of Candidaspecies of surfaee-modified glass, J. Med. Vet. Mycol., 19890401
  28. Binding of salirary of serum proteins to Candida albicans in vitro, Arch. Oral Biol., 35, 19900401
  29. Denture stomatitis and ABO blood types, J. Prosthet. Dent., 66, 19910401
  30. Factors involved in the adherence of Candida albicans and Candida tropicalis to protein-adsorbed surface, An invitro study using immobilized protein., Mycopathologia, 19920401
  31. An in vitro evaluation of sensitivity and ability of quantitative detection for Candida albicans of simplified diagnostic aid, J. Prosthet. Dent., 19920401
  32. In vitro analysis of Candida albicans adherence to soft denture lining materials., J. Prosthet. Dent., 19920401
  33. Clinical survey on Denture stomatitis PartI The relation between denture plaque and denture stomatitis, The Journal of the Japan Prosthodontic Society, 208-214, 19890401
  34. Clinical survey on denture stomatitis Part2 The relation between the maintenance of denture and denture stomatitis, The Journal of the Japan Prosthodontic Society, 202-207, 19900401
  35. Effects of various mixing ratio on the stress relaxation and the setting time of elastomeric impression materials, The Journal of Hiroshima University Dental Society, 308-312, 19910401
  36. The possible mechanisms of adherence of Candida albicans and Candida tropicalis to solid surfaces, The Journal of the Japan Prosthodontic Society, 980-987, 19920401
  37. Interactions between denture lining material, protein pellicles and Candida albicans., Archives of Oral biology, 38(7), 631-634, 19930401
  38. The fungicidal effect of human lactoferrin on Candida albicans and Candida krusei, Archives of Oral biology, 38(12), 1057-1063, 19930401
  39. Infection control in prosthetic dentistry, The Journal of Hiroshima University Dental Society, 365-366, 19930401
  40. A survey on perforation and proteinaceous contamination of plastic gloves during prosthodontic treatment, 738-745, 19930401
  41. The effects of antifungal agents on the in vitro susceptibility of Candida albicans to apo-lactoferrin., Arch. Oral Biol., 39, 921-923, 19940401
  42. Growth and/or acid production of Candida albicans on soft lining materials in vitro., J Oral Rehabil, 21, 585-594, 19940401
  43. Perforation and proteinaceous contamination of dental gloves during prosthodontic treatments., Int. J. Prosthodont., 7, 559-566, 19940401
  44. Effects of denture cleansers on direct soft lining materials., J. Prosthet. Dent., 72, 657-662, 19940401
  45. Characteristics and clinical use of denture cleansers., 19940401
  46. Denture eleanser containing propolis., 19940401
  47. Deterioration of tissue conditioners caused by denture clensers-Effect of peroxide, pH and plasticizer-, 19940401
  48. A novel method to study the hyphal phase of Candida albicans and to evaluate its hydrophobicity., Oral Microbiol Immnol., 10, 110-114, 19950401
  49. Modulation of the anti-Candida activity of apo-lactoferrin by dietary sugar and tunicamycin., Archs oral Biol, 40, 581-584, 19950401
  50. Commercial denture cleansers-Cleansing efficacy against Candida albicans biofilm and compatibility with soft denture lining materials-., Int. J. Prosthodont., 8, 434-444, 19950401
  51. Cleansing efficacy of commercial denture cleansers. -Removal ability of denture cleansers on Candida albicans biofilm., Int. J. Prosthodont., 8, 527-534, 19950401
  52. Effect of components of resilient denture lining materials on the growth, acid production and colonization of Candida albicans., J Oral Rehabil, 22, 817-824, 19950401
  53. The material and antifungal properties of antibiotic zeolite incorporated acrylic resin, The Journal of the Japan Prosthodontic Society, 39, 919-926, 19950401
  54. Inflamatory mucosa beneath denture., Dental Diamond, 20, 19-20, 19950401
  55. Clinical application of a relining material, Rebase H., Journal of Dental Engineering, 114, 12-16, 19950401
  56. Denture cleansers, Journal of Dental Engineering, 114, 19-30, 19950401
  57. The role of salivary or serum pellicle in the colonization process of Candida albicans on denture acrylic in vitro., 9, 35-48, 19960401
  58. Non-Specific adherence of Candida species to modified-glasses., Journal of Dental Research, 67(SI), 723, 19880401
  59. The effect of human lactoferrin on Candida albicans and Candida krusei., Journal of Dental Research, 73(SI), 391, 19940401
  60. A novel method for determining hydropholicity of Candida albicans hyphae., Journal of Dental Research, 73(SI), 392, 19940401
  61. Adherence of Candida albicans and Candida tropicalis to immobilized protein and/or sugar., Proceedings of Bacterial adherence meeting, 4, 93-102, 19900401
  62. The role of pellicles in Candida albicans colonization to denture acrylic surface., Proceedings of Bacterial adherence meeting, 8, 25-31, 19940401
  63. Composition and effect of denture base resin surface primer for reline acrylic resin., J. Prosthet. Dent., 75, 457-462, 19960401
  64. Perforation of dental gloves during prosthodontic treatments as assessed by conductivity test and water inflation technique., Int. J. Prosthodont., 9, 362-366, 19960401
  65. Antifungal effect of zeolite incorporated tissue conditioner against candida albicans growth and/or acid production, J Oral Rehabil, 24, 350-357, 19970401
  66. Effects of dietary sugars and, saliva and serum on Candida biofilm formation on acrylic surfaces., Mycopathologia, 139, 87-91, 19970401
  67. Effects of salivary or serum pellicles on the Candida albicans growth and biofilm formation on soft lining materials in vitro., J. Oral Rehabilitation, 24, 594-604, 19970401
  68. Quantification of thigmotropism (contact sensing) of Candida albicans and Candida tropicalis., Mycopathologia, 138, 13-19, 19970401
  69. Denture plaque -past and recent concerns-., J Dentistry, 26, 299-304, 19980401
  70. Rheology of tissue conditioners., J Prosthetic Dentistry, 79, 188-199, 19980401
  71. Viscoelastic properties of tissue conditioners-influence of molecular weight of polymer powders and powder/liquid ratio, and clinical implication, J Oral Rehabil, 25, 621-629, 19980401
  72. In vitro susceptibility of candida species to lactoferrin, Medical Mycol, 37, 35-41, 19990401
  73. Effects of modified pellicles on Candida biofilm formation, Mycoses, 42, 37-40, 19990401
  74. Incidence of occlusal contacts with complete dentures during mastication in 6-channel telemetry system : preliminary measurements., J Oral Rehabil, 26, 918-922, 19990401
  75. Efficacy of Commercial Denture Cleansers, Dental Journal, 31, 177-182, 19980401
  76. The effect of saliva or serum on Candida albicans colonization of denture acrylic and composite resin surfaces, Dental Journal, 31, 27-31, 19980401
  77. Interactions between thermal cycled resilient denture lining materials,salivary and serum pellicles and Candida albicans on in vitro.Part (]G0001[).Effects on fungal growth., J Oral Rehabil, 27, 41-51, 20000401
  78. Interactions between thermal cycled resilient denture lining materials,salivary and serum pellicles and Candida albicans on in vitro.Part (]G0002[).Effects on fungal colonozation., J Oral Rehabil, 27, 124-130, 20000401
  79. Effect of serum concentration on Candida biofilm formation on acrylic., Mycoses, 43, 139-143, 20000401
  80. Sub-therapeuic exposure to polyene antimycotics elicts a post-antifungal effect (PAFE) and depresses the cell surface hydrophobicity of oral Candida albicans isolates., J Oral Pathol Med, 29, 206-213, 20000401
  81. Exposure to sub-therapeutic concentrations of polyene antifungals suppressess the adherence of Candida species to denture acrylic., Chemother, 46, 267-274, 20000401
  82. Role of denture pellicles in Candida albicans biofilm development in vitro., J. Dent. Res., 74(SI/), 447#371, 19950401
  83. Interactions between denture pellicles,soft liners and Candida albicans., J. Dent. Res., 75(SI/), 206#1508, 19960401
  84. Streptococcus and Candida colonization on protein-coated hydroxylapatite., J. Dent. Res., 76(SI/), 106#742, 19970401
  85. Quantification of thigmotropism of Candida albicans and Candida tropicalis., J. Dent. Res., 76(SI/), 439#3401, 19970401
  86. Interactions between Candida albicans,pellicles and thermocycled semipermanent soft liners., J. Dent. Res., 77, 677#360, 19980401
  87. Effects of endogenous proteins on Candida biofilm formation on acrylic., J. Dent. Res., 77, 988#2855, 19980401
  88. Factors involved in Candida biofilm formation on acrylic surfaces, J. Dent. Res., 77, 988#2856, 19980401
  89. Bacterial and Candida colonization of protein coated type (]G0001[) collagen., J. Dent. Res., 78(SI/), 107#16, 19990401
  90. Effect of addition of ethyl alcohol on gelation and viscoelasticity of tissue conditioners., J Oral Rehabil, 28, 48-54, 20010401
  91. Growth of Candida species on commercial denture adhesives in vitro., Int. J. Prosthodont., 14, 48-52, 20010401
  92. Antifungal activity of Histatin-5 against non-albicans Candida species., Oral Microbiol Immunol, 16, 250-252, 20010401
  93. Potent role of histatin in nartural defence system against oral candidiasis., Dental Journal, 34, 47-51, 20010401
  94. Growth and/or acid production of Candida albicans on soft liners., J. Dent. Res., 73(SI/), 898#20, 19940401
  95. Composition of soft liners on Candida growth and acid production, J. Dent. Res., 73(SI/), 898#21, 19940401
  96. Impacts of PAFE on the relative CSH of Candida albicans., J. Dent. Res., 79(SI/), 151#64, 20000401
  97. Candida albicans colonization on thermalcycled maxillofacial polymeric materials., J. Dent. Res., 79(SI/), 478#2676, 20000401
  98. Adhesion of Candida albicans to intact and denatured collagen, J. Dent. Res., 79(SI/), 522#3030, 20000401
  99. Antifungal effect of zeolite-incorporated tissue conditioner against Candida albicans growth and/or acid production, J Oral Rehabil, 24, 350-357, 19970401
  100. Effects of salivary or serum pellicles on the Candida albicans growth and biofilm formation on soft lining materials in vitro, J Oral Rehabil, 24, 594-604, 19970401
  101. Quantification of thigmotropism (contact sensing) of Candida albicans and Candida tropicalis, Mycopathologia, 138, 13-19, 19970101
  102. Effects of dietary sugars and, saliva and serum on Candida biofilm formation on acrylic surfaces, Mycopathologia, 139, 87-91, 19970401
  103. The role of saliva and serum in Candida albicans biofilm formation on denture acrylic surfaces, Microbial Ecology in Health and Disease, 9, 35-48, 19960401
  104. Perforation of dental gloves during prosthodontic treatments as assessed by the conductivity and water inflation tests, Int. J. Prosthodont., 9(4), 362-366, 19960401
  105. Composition and effect of denture base resin surface primers for reline acrylic resins, J. Prosthet. Dent., 75, 457-462, 19960401
  106. Effect of addition of ethyl alcohol on gelation and viscoelasticity of tissue conditioners, J Oral Rehabil, 28, 48-54, 20010401
  107. Growth of Candida species on commercial denture adhesives in vitro, Int. J. Prosthodont., 14, 48-52, 20010401
  108. Candida albicans growth on thermal cycled materials for maxillofacial prostheses in vitro, J Oral Rehabil, 28, 526-533, 20010401
  109. Candida albicans colonization on thermal cycled maxillofacial polymeric materials in vitro, J Oral Rehabil, 28, 755-765, 20010401
  110. Antifungal activity of Histatin-5 against non-albicans Candida species, Oral Microbiol Immunol, 16, 250-252, 20010401
  111. Alteration of the coadherence of Candida albicans with oral bacteria by dietary sugars, Oral Microbiol Immunol, 16, 279-283, 20010401
  112. Sub-therapeutic exposure to polyene antimycotics elicits a post-antifungal effect (PAFE) and depresses the cell surface hydrophobicity of oral Candida albicans isolates, 29, 206-213, 20000401
  113. Exposure to subtherapeutic concentrations of polyene antifungals suppresses the adherence of Candida species to denture acrylic, Chemotherapy, 46(4), 267-274, 20000401
  114. Effect of serum concentration on Candida biofilm formation on acrylic surfaces, Mycoses, 43, 139-143, 20000401
  115. A review of in vitro and in vivo methods to evaluate the efficacy of denture cleansers, Int. J. Prosthodont., 12(2), 153-159, 19990201
  116. Effects of modified pellicles on Candida biofilm formation on acrylic surfaces, Mycoses, 42, 37-40, 19990401
  117. Relationship between thigmotropism and Candida biofilm formation in vitro, Mycopathologia, 144, 125-129, 19990401
  118. Incidence of occlusal contacts with complete dentures during mastication using a 6-channel telemetry system: preliminary measurements, J Oral Rehabil, 26, 918-922, 19990401
  119. Occlusal force distribution on the dental arch during various levels of clenching, J Oral Rehabil, 26, 932-935, 19990401
  120. Rheology of tissue conditioners, J. Prosthet. Dent., 79(1), 188-199, 19980101
  121. Viscoelastic properties of tissue conditioners ﾐinfluence of molecular weight of polymer powders and powder/liquid ratio and the clinical implications, J Oral Rehabil, 25, 621-629, 19980401
  122. The effect of saliva or serum on Streptococcus mutans and Candida albicans colonization of hydroxylapatite beads, Journal of Dentistry, 26(1), 31-37, 19980101
  123. Denture plaque -past and recent concerns-, Journal of Dentistry, 26(4), 299-304, 19980401
  124. Commercial denture cleansers?Cleansing efficacy against Candida albicans biofilm and compatibility with soft denture lining materials?, Int. J. Prosthodont., 8(5), 434-444, 19950501
  125. Cleansing efficacy of commercial denture cleansers : Ability to reduce Candida albicans biofilm activity, Int. J. Prosthodont., 8(6), 527-534, 19950601
  126. Effect of components of resilient denture-lining materials on the growth, acid production and colonization of Candida albicans, J Oral Rehabil, 22, 817-824, 19950401
  127. Modulation of the anti-Candida activity of apo-lactoferrin by dietary sugar and tunicamycin in vitro, Archs oral Biol, 40(6), 581-584, 19950601
  128. The effects of of antifungal agents on the in vitro susceptibility of Candida albicans to apo lactoferrin, Archs oral Biol, 39, 921-923, 19940401
  129. Growth and/or acid production of Candida albicans on soft lining materials in vitro, J Oral Rehabil, 21, 585-594, 19940401
  130. Effects of denture cleansers on direct soft denture lining materials, J. Prosthet. Dent., 72(6), 657-662, 19941201
  131. Perforation and proteinaceous contamination of dental gloves during prosthodontic treatments, Int. J. Prosthodont., 7(6), 559-566, 19940601
  132. Interactions between denture-lining material, protein pellicles and Candida albicans, Archs oral Biol, 38(7), 631-634, 19930701
  133. The fungicidal effect of human lactoferrin on Candida albicans and Candida krusei, Archs oral Biol, 38(12), 1057-1063, 19931201
  134. An in vitro evaluation of simplified quantitative diagnostic aids for detection of Candida albicans, J. Prosthet. Dent., 68(4), 629-633, 19920101
  135. In vitro evaluation of Candida albicans adherence to soft denture lining materials, J. Prosthet. Dent., 68(5), 804-808, 19921101
  136. Factors involved in the adherence of Candida albicans and Candida tropicalis to protein-absorbed surfaces. An in vitro study using immobilized protein, Mycopathologia, 118, 139-145, 19920401
  137. Denture stomatitis and ABO blood types, J. Prosthet. Dent., 66(3), 391-394, 19910901
  138. Binding of salivary or serum proteins to Candida albicans in vitro, Archs oral Biol, 35(7), 571-573, 19900701
  139. Non-specific adherence of Candida species to surface modified glass, J. Med. Vet. Mycol., 27, 269-271, 19890401
  140. Non-specific adherence of Candida species to modified glasses, 12th EPA proceeding, 19890401
  141. Non-specific adherence of Candida species to surface-modified glass., J. Med. Vet. Mycol(Sabouraudia), 27, 269-271, 19890401
  142. Denture stomatitis and ABO blood types., J. Prosthet. Dent., 66, 391-394, 19910401
  143. Factors involved in the adherence of Candida albicans and Candida tropicalis to protein-absorbed surfaces. An in vitro study using immobilized protein., Mycopathologia, 118, 139-145, 19920401
  144. Cleaning efficiency of commercial denture cleansers: Ability to reduce Candida albicans biofilm activity., Int. J. Prosthodont., 527-534, 19950401
  145. Effect of addition of ethyl alcohol on gelation and viscoelasticity of tissue conditioners, J Oral Rehabil, 28, 48-54, 20010401
  146. Growth of Candida species on commercial denture adhesives in vitro, Int. J. Prosthodont., 14, 48-52, 20010401
  147. Candida albicans growth on thermal cycled materials for maxillofacial prostheses in vitro, J Oral Rehabil, 28, 526-533, 20010401
  148. Candida albicans colonization on thermal cycled maxillofacial polymeric materials in vitro, J Oral Rehabil, 28, 755-765, 20010401
  149. Antifungal activity of Histatin-5 against non-albicans Candida species, Oral Microbiol Immunol, 16, 250-252, 20010401
  150. Alteration of the coadherence of Candida albicans with oral bacteria by dietary sugars, Oral Microbiol Immunol, 16, 279-283, 20010401
  151. Sub-therapeutic exposure to polyene antimycotics elicits a post-antifungal effect (PAFE) and depresses the cell surface hydrophobicity of oral Candida albicans isolates, 29, 206-213, 20000401
  152. Exposure to subtherapeutic concentrations of polyene antifungals suppresses the adherence of Candida species to denture acrylic, Chemotherapy, 46(4), 267-274, 20000401
  153. Effect of serum concentration on Candida biofilm formation on acrylic surfaces, Mycoses, 43, 139-143, 20000401
  154. A review of in vitro and in vivo methods to evaluate the efficacy of denture cleansers, Int. J. Prosthodont., 12(2), 153-159, 19990201
  155. Effects of modified pellicles on Candida biofilm formation on acrylic surfaces, Mycoses, 42, 37-40, 19990401
  156. Relationship between thigmotropism and Candida biofilm formation in vitro, Mycopathologia, 144, 125-129, 19990401
  157. Incidence of occlusal contacts with complete dentures during mastication using a 6-channel telemetry system: preliminary measurements, J Oral Rehabil, 26, 918-922, 19990401
  158. Occlusal force distribution on the dental arch during various levels of clenching, J Oral Rehabil, 26, 932-935, 19990401
  159. In vitro susceptibility of Candida species to lactoferrin., Medical Mycol, 37, 35-41, 19990401
  160. Rheology of tissue conditioners, J. Prosthet. Dent., 79(1), 188-199, 19980101
  161. Viscoelastic properties of tissue conditioners ﾐinfluence of molecular weight of polymer powders and powder/liquid ratio and the clinical implications, J Oral Rehabil, 25, 621-629, 19980401
  162. The effect of saliva or serum on Streptococcus mutans and Candida albicans colonization on hydroxylapatite beads., Journal of Dentistry, 26(4), 31-37, 19980401
  163. Denture plaque - past and recent concerns -., Journal of Dentistry, 26, 299-304, 19980401
  164. Perforation of dental gloves during prosthodontic treatments as assessed by the conductivity and water inflation tests, Int. J. Prosthodont., 9(4), 362-366, 19960401
  165. Perforation and proteinaceous contamination of dental bloves during prosthodontic treatmentsof dental gloves during prosthodontic treatments, Int. J. Prosthodont., 7(6), 559-566, 19940401
  166. Effect of addition of ethyl alcohol on gelation and viscoelasticity of tissue conditioners, Journal of Oral Rehabilitation, 28, 48-54, 20010401
  167. Interactions between thermal cycled resilient denture lining materials, salivary and serum pellicles and Candida albicans in vitro. Part I. Effects on fungal colonization, Journal of Oral Rehabilitation, 27, 124-130, 20000401
  168. Rheology of tissue conditioners, The Journal of Prosthetic Dentistry, 79, 188-199, 19980101
  169. Viscoelastic properties of tissue conditioners -influence of molecular weight of polymer powders and powder/liquid ratio and the clinical implications, Journal of Oral Rehabilitation, 25, 621-629, 19980401
  170. The effect of saliva or serum on Streptococcus mutans and Candida albicans colonization of hydroxylapatite beads, Journal of Dentistry, 26(1), 31-37, 19980101
  171. Antifungal effect of zeolite-incorporated tissue conditioner against Candida albicans growth and/or acid production, Journal of Oral Rehabilitation, 24, 350-357, 19970401
  172. Candida albicans colonization on thermal cycled maxillofacial polymeric materials in vitro, J Oral Rehabil, 28, 755-765, 20010401
  173. Alteration of the coadherence of Candida albicans with oral bacteria by dietary sugars, Oral Microbiol Immunol, 16, 279-283, 20010401
  174. Effect of eluates of denture adhesives on human gingival fibroblasts., 45, 403-411, 20010401
  175. Growth of Candida species on commercial denture adhesives in vitro, Int. J. Prosthodont., 14, 48-52, 20010401
  176. Candida albicans colonization on thermal cycled maxillofacial polymeric materials in vitro, J Oral Rehabil, 28, 755-765, 20010401
  177. Antifungal activity of Histatin-5 against non-albicans Candida species, Oral Microbiol Immunol, 16, 250-252, 20010401
  178. Alteration of the coadherence of Candida albicans with oral bacteria by dietary sugars, Oral Microbiol Immunol, 16, 279-283, 20010401
  179. Effect of serum concentration on Candida biofilm formation on acrylic surfaces, Mycoses, 43, 139-143, 20000401
  180. Adhesion of Candida albicans to Intact and Denatured Collagen., J. Dent. Res., 79(special issue), 522, 20000401
  181. Candida albicans colonization on thermocycled maxillofacial polymeric materials.?, J. Dental Research, 79(special issue), 478, 20000401
  182. A review of in vitro and in vivo methods to evaluate the efficacy of denture cleansers., Int. J. Prosthodont., 153-159, 20010401
  183. Denture plaque - past and recent concerns -., Journal of Dentistry, 299-304, 19980401
  184. Changes in surface roughness and colour stability of soft denture lining materials caused by denture cleansers, Journal of Oral Rehabiliation, 30(3), 125-130, 20031101
  185. A novel technique to evaluate the adhesion of Candida species to gingival epithelial cells., Mycoses, 46, 384-389, 20030401
  186. In vitro cariogenic potential of Candida albicans, Mycoses, 46, 471-478, 20030401
  187. Compatibility with Dental Stones and Changes in Surface Roughness with Time of Tissue Conditioners, J. Prosthet. Dent., 93, 274-281, 20050401
  188. Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage., Endocrinology, 144(6), 2480-2488, 20030401
  189. Physical properties and compatibility with dental stones of current alginate impression materials, J Oral Rehabil, 31, 1115-1122, 20040401
  190. Integrin and cancer metastasis, Surabaya Dental Journal, 34, 32-34, 20010401
  191. Potent role of histatin in natural defense system against oral candidiasis, Surabaya Dental Journal, 34, 47-51,, 20010401
  192. Impact of components of denture acrylic resin on gingival cell growth and sensitivity to Candida albicans adhesion, Mycoses, 45(8), 300-5, 20020401
  193. Susceptibility of Candida albicans isolates from the oral cavities of HIV-positive patients to histatin-5, J. Prosthet. Dent., 88(3), 263-7., 20020401
  194. Bacterial and Candida adhesion to intact and denatured collagen in vitro, Mycoses, 45(9-10), 389-92, 20020401
  195. Cell-associated collagenolytic activity by Candida albicans., Mycopathologia, 153(3), 125-8., 20020401
  196. Differences in Candida albicans adhesion to intact and denatured type I collagen in vitro., Microbiol. Immunol., 17(2), 129-31, 20020401
  197. Biofilm formation of Candida albicans on the surfaces of deteriorated soft denture lining materials caused by denture cleansers in vitro., J Oral Rehabil, 30(3), 243-50, 20030401
  198. Changes in surface roughness and colour stability of soft denture lining materials caused by denture cleansers., J Oral Rehabil, 30(2), 125-30, 20030401
  199. A novel technique to evaluate the adhesion of Candida species to gingival epithelial cells., Mycoses, 46(9-10), 384-9, 20030401
  200. In vitro cariogenic potential of Candida albicans., Mycoses, 46(11-12), 471-8, 20030401
  201. Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage., Endocrinology, 144(6), 2480-8, 20030401
  202. Correlation between maximum bite force and craniofacial morphology of young adults in Indonesia., J Oral Rehabil, 30, 1109-17, 20030401
  203. Lactobacillus reuteri in bovine milk fermented decreases the oral carriage of mutans streptococci., nternational Journal of Food Microbiology, 195(2), 219-223, 20041101
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  205. Physical properties and compatibility with dental stones of current alginate impression materials., J Oral Rehabil, 31(11), 1115-22, 20040401
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  208. Bacterial and Candida adhesion to intact and denatured collagen in vitro., Mycoses, 45, 389-392, 20020401
  209. Cell-associated collagenolytic activity by Candida albicans., Mycopathologia, 153, 125-128, 20010401
  210. Comprehensive analysis of chemotactic factors for bone marrow mesenchymal stem cells, Stem Cells Develop, 16, 119-129, 20070401
  211. The effect of saliva or serum on bacterial and Candida albicans colonization on type I collagen., J Oral Rehabil, 33, 767-774, 20060401
  212. Comprehensive analysis of chemotactic factors for bone marrow mesenchymal stem cells., Stem Cells and Developmen, 16(1), 119-29, 20070201
  213. Impact of components of denture acrylic resin on the gingival cells growth and sensitivity to Candida albicans adhesion., Mycoses, 45(8), 300-305, 20020401
  214. Susceptibility of Candida albicans isolates from oral cavities of HIV positive patients to Histatin-5., Journal of Prosthetic Dentistry, 88(3), 263-267, 20020901
  215. Immobilization of Octadecyl Ammonium Chloride on the Surface of Titan and Its Effects on Microbial Biofilm Formation In Vitro., Dental Materials Journal, 24(4), 570-582, 20051101
  216. Surface Roughness Accelerates RANKL-dependent Differentiation in the Osteoclast Precursor Cell Line, RAW264.7, Dental Materials Journal, 26, 739-745, 20071101
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  218. Susceptibility of Candida albicans isolates from oral cavities of HIV positive patients to Histatin-5., Journal of Prosthetic Dentistry, 88(3), 263-267, 20020901
  219. An in vitro evaluation of the adhesion of Candida species to oral and lung tissue cells., Mycoses, 49(1), 14-17, 20060101
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  275. Comprehensive analysis of chemotactic factors for bone marrow mesenchymal stem cells, STEM CELLS AND DEVELOPMENT, 16(1), 119-129, 200702
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  276. Titanium surface roughness accelerates RANKL-dependent differentiation in the osteoclast precursor cell line, RAW264.7, DENTAL MATERIALS JOURNAL, 26(5), 739-745, 200709
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  277. Impact of the microgravity environment in a 3-dimensional clinostat on osteoblast- and osteoclast-like cells, CELL BIOLOGY INTERNATIONAL, 32(9), 1176-1181, 200809
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  280. Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 11(4), 1458-1470, 201004
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Invited Lecture, Oral Presentation, Poster Presentation

  1. Application of Probiotics strain Lactobacillus rhamnosus L8020 to oral health, Hiroki Nikawa, Taiwan Lactic Acid Bacteria Association 2024 Annual Meeting & Conference, 2024/12/20, With Invitation, English, Taiwan Lactic Acid Bacteria Association
  2. Characterization and antibacterial or antiviral effects of immobilizing antimicrobial agents, Hiroki NIKAWA, 2015/05/14, With Invitation, Japanese
  3. A novel strategies for oral health., Hiroki NIKAWA, Citizen open lecture, Hiroshima City Dental Association, 2015/04/05, With Invitation, Japanese, Hiroshima City Dental Association, Hiroshima
  4. Gene Expression of Candida albicans during Biofilm Formation, Kazuki Sanetoshi, Tatsumi Hashida, Sumiyo Mimura, Tsuyoshi Taji, Hiroki Nikawa, The 6th International Congress of Dental Technology / The 39th Meeting of the Nippon Academy of Dental Technology, 2017/05/27, Without Invitation, English
  5. Flow Analysis with an Aortic Aneurysm Silicone Model through Collaboration with Medicine, Yurina Akita, Takuya Kihara, Tatsuya Kurosaki, Shinji Ninomiya, Tsuyoshi Taji, Taijirou Sueda, Hiroki Nikawa, he 6th International Congress of Dental Technology / The 39th Meeting of the Nippon Academy of Dental Technology, 2017/05/27, Without Invitation, English, other
  6. Investigation of Manufacturing Surgery Support Solid Model (3D model) made in Central-Dental-Laboratory of Hiroshima University Hospital, Yukihiro Takayama, Saiji Shimoe, Shogo Iwaguro, Takeshi Murayama, Ryoji Kato, Hiroki Nikawa, The 6th International Congress of Dental Technology / The 39th Meeting of the Nippon Academy of Dental Technology, Without Invitation, English, other
  7. A novel product for the general or oral health derived from biofilm study, Hiroki NIKAWA, 8th Internet of Things Expo, 2017/11/01, Without Invitation, English
  8. Introduction of Course for Oral Engineering in Hiroshima University, Memorandum of consortium for universities having 4-year education system for oral health engineering, 2018/09/24, With Invitation, English

Patented

  1. Patent, 7445910, 2024/02/29
  2. Patent, ZL201611048813.3, 2023/01/03
  3. Patent, 6912051, 2021/07/12
  4. Patent, 10143712, 2018/12/04
  5. Patent, 6371611, 2018/07/20
  6. Patent, 6395200, 2018/09/07
  7. Patent, 6432892, 2018/11/16
  8. Patent, 2682463, 2018/08/29
  9. Patent, ZL201280008481.X, 2020/06/12
  10. Patent, 6746091, 2020/08/07
  11. Patent, 6744542, 2020/08/04

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2023, 2025
  2. KAKENHI, 2015, 2017
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  3. KAKENHI, 2015, 2017
  4. KAKENHI, 2014, 2016
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  5. KAKENHI, 2012, 2014
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  6. KAKENHI, A fabrication of epithesis based on motion tracking analysis, 2011, 2013
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  7. KAKENHI, Study on control effect of the lifestyle-related disease through the BDNF factor by the chewing stimulation, 2010, 2012
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  8. 2009
  9. 2009
  10. 2009
  11. KAKENHI, Studies on inhibitory effects of the monoclonal antibodies to NHA2 on alveolar bone resorption, 2009, 2011
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  12. KAKENHI, Evaluation of potential to promote the differentiation of osteoblastic cells by immobilized cationic antimicrobial peptide, JH8194 which promotes the proliferation of mesenchymal stem cells, 2008, 2010
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  13. 2007
  14. 2006
  15. KAKENHI, Reduction of oral carriage of periodontal bacteria by the use of the induction of beta defensin through molecular pattern recognition into saliva, 2006, 2007
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  16. 2004
  17. KAKENHI, Development of a moisturized soft denture liner for a patient having dry mouth, 2004, 2005
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  18. KAKENHI, Influence of denture wearing of elderly with dementia on the state of dementia, general health, and QOL, 2004, 2007
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  19. KAKENHI, 2002, 2004
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  20. KAKENHI, Molecular pattern recognition of oral epithelial cells against pathogenic organisms, 2002, 2003
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  21. 2001
  22. KAKENHI, Antifungal activity of Lactoferricins and their derivatives, 2001, 2002
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  23. KAKENHI, Cariogenicity of Denture Plaque, 1999, 2000
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  24. KAKENHI, Factors involved in the interactions of Candida albicans and oral bacteria, 1999, 2000
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  25. KAKENHI, Establishment of Prosthodontic Treatment System of Traveling Dental Clinic in Solitary Islands, 1999, 2001
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  26. KAKENHI, Development of functional soft denture liners, 1998, 2001
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  27. KAKENHI, Development of the three-dimensional evaluation method for alveolar ridge and denture of elderly people and its application, 1998, 1999
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  28. KAKENHI, Factors involved in the interactions, of Candida albicans and oral bacteria, 1998, 1999
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  29. KAKENHI, 1997, 1998
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  30. KAKENHI, 1996, 1998
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  31. KAKENHI, 1996, 1997
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  32. KAKENHI, 1995, 1995
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  33. KAKENHI, 1994, 1994
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  34. KAKENHI, 1993, 1993
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  35. KAKENHI, Evaluation of trial denture cleansers with berberine hydrochloride, 1991, 1992
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  36. KAKENHI, Mechanisms of Adherence of Candida Albicans to Denture Pellicle., 1989, 1990
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  37. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2020, 2022

Social Activities

History as Peer Reviews of Academic Papers

  1. 2007, Prosthodontic Research and Practice, Editor