TOMOHISA NEZU

Last Updated :2019/11/08

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), ., Assistant Professor

Basic Information

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Neurology

Research Keywords

  • Neurology, Stroke Medicine

Educational Activity

Course in Charge

  1. 2019, Undergraduate Education, Intensive, Clinical diagnosis and treatment I
  2. 2019, Undergraduate Education, Intensive, Introduction to clinical clerkship

Research Activities

Academic Papers

  1. Preserved acetazolamide reactivity in lacunar patients with severe white-matter lesions: O-15-labeled gas and H2O positron emission tomography studies, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 32(5), 844-850, 2012
  2. Association of Serum Anti-Periodontal Pathogen Antibody with Ischemic Stroke, CEREBROVASCULAR DISEASES, 34(5-6), 385-392, 2012
  3. Alpha2-macroglobulin as a promising biomarker for cerebral small vessel disease in acute ischemic stroke patients, JOURNAL OF NEUROLOGY, 260(10), 2642-2649, 2013
  4. The Association between Hyperintense Vessel Sign and Final Ischemic Lesion Differ in Its Location, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 23(6), 1337-1343, 2014
  5. Safety Evaluation of Substituting Clopidogrel for Ticlopidine in Japanese Patients with Ischemic Stroke-Hiroshima Ticlopidine, Clopidogrel Safe Exchange Trial, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 23(6), 1485-1490, 2014
  6. CD34+/CD144+Circulating Endothelial Cells as an Indicator of Carotid Atherosclerosis, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(3), 583-590, 2015
  7. Endothelial dysfunction is associated with the severity of cerebral small vessel disease, HYPERTENSION RESEARCH, 38(4), 291-297, 2015
  8. A Case of Recurrent Ischemic Stroke Involving Subacute, Progressive Intracranial Cerebral Arterial Sclerosis Prior to Diagnosis with JAK2-mutated Polycythemia Vera, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 24(12), E4-E6, 2015
  9. Greater Severity of Neurological Defects in Women Admitted With Atrial Fibrillation-Related Stroke, CIRCULATION JOURNAL, 80(1), 250-+, 2015
  10. Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study., EBioMedicine, 2(8), 2015
  11. Carotid Intima-Media Thickness for Atherosclerosis., Journal of atherosclerosis and thrombosis, 23(1), 2016
  12. The Japan Statin Treatment Against Recurrent Stroke (J-STARS): A Multicenter, Randomized, Open-label, Parallel-group Study., EBioMedicine, 2(9), 2015
  13. Changes over Time in Intracranial Air in Patients with Cerebral Air Embolism: Radiological Study in Two Cases., Case reports in neurological medicine, 2015, 2015
  14. Intravenous alteplase at 0.6 mg/kg for acute stroke patients with basilar artery occlusion: the stroke acute management with urgent risk factor assessment and improvement (SAMURAI) Recombinant tissue plasminogen activator registry., Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 22(7), 2013
  15. CHADS2 score is associated with 3-month clinical outcomes after intravenous rt-PA therapy in stroke patients with atrial fibrillation: SAMURAI rt-PA Registry., Journal of the neurological sciences, 306(1-2), 2011
  16. Intravenous recombinant tissue plasminogen activator therapy for stroke patients receiving maintenance hemodialysis: the Stroke Acute Management with Urgent Risk-Factor Assessment and Improvement (SAMURAI) rt-PA registry., European neurology, 66(1), 2011
  17. Early ischemic change on CT versus diffusion-weighted imaging for patients with stroke receiving intravenous recombinant tissue-type plasminogen activator therapy: stroke acute management with urgent risk-factor assessment and improvement (SAMURAI) rt-PA registry., Stroke; a journal of cerebral circulation, 42(8), 2011
  18. Small-vessel disease in the basal ganglia: lacune or microbleed?, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 21(8), 2012
  19. Effects of hyperacute blood pressure and heart rate on stroke outcomes after intravenous tissue plasminogen activator., Journal of hypertension, 29(10), 2011
  20. Nationwide survey of neuro-specialists' opinions on anticoagulant therapy after intracerebral hemorrhage in patients with atrial fibrillation., Journal of the neurological sciences, 312(1-2), 2012
  21. Pre-treatment ASPECTS-DWI score has a relation with functional outcome at 3 months following intravenous rt-PA therapy, 31(5), 366-373, 20090925
  22. Central apnoea associated with subcortical haemorrhage in the left temporal lobe, J Neurol Neurosurg Psychiatry, 81, 299-301, 2010
  23. Pretreatment ASPECTS on DWI predicts 3-month outcome following rt-PA: SAMURAI rt-PA Registry., Neurology, 75, 555-561
  24. The Multidisciplinary Swallowing Team Approach Decreases Pneumonia Onset in Acute Stroke Patients, PLOS ONE, 11(5), MAY 3 2016
  25. Carotid Intima-Media Thickness for Atherosclerosis, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 23(1), 18-31, 2016
  26. Temporal Trends in Stroke Severity and Prior Antithrombotic Use Among Acute Ischemic Stroke Patients in Japan, CIRCULATION JOURNAL, 80(9), 2033-2036, SEP 2016
  27. Multiple Infarcts Are Associated With Long-Term Stroke Recurrence and All-Cause Mortality in Cryptogenic Stroke Patients, STROKE, 47(9), 2209-2215, SEP 2016
  28. Association Between Absolute Eosinophil Count and Complex Aortic Arch Plaque in Patients With Acute Ischemic Stroke, STROKE, 48(4), 1074-1076, APR 2017
  29. Blood pressure control with cilnidipine treatment in Japanese post-stroke hypertensive patients: The CA-ATTEND study, CLINICAL AND EXPERIMENTAL HYPERTENSION, 39(3), 225-234, 2017
  30. Various meteorological conditions exhibit both immediate and delayed influences on the risk of stroke events: The HEWS-stroke study, PLOS ONE, 12(5), JUN 2 2017
  31. A case of hypertensive encephalopathy with enlarged optic nerve sheath measured by transorbital sonography., J Stroke Cerebrovasc Dis, 26, e20-e21
  32. Long-Term Effect of Pravastatin on Carotid Intima-Media Complex Thickness The J-STARS Echo Study (Japan Statin Treatment Against Recurrent Stroke), STROKE, 49(1), 107-+, JAN 2018
  33. Pravastatin Reduces the Risk of Atherothrombotic Stroke when Administered within Six Months of an Initial Stroke Event, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(3), 262-268, 2018
  34. Impact of D-dimer levels for short-term or long-term outcomes in cryptogenic stroke patients, JOURNAL OF NEUROLOGY, 265(3), 628-636, MAR 2018
  35. Blood Pressure Variability in Acute Ischemic Stroke: Influence of Infarct Location in the Insular Cortex, EUROPEAN NEUROLOGY, 79(1-2), 90-99, 2018
  36. Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(4), 350-358, 2018
  37. Factors Associated with Intima-Media Complex Thickness of the Common Carotid Artery in Japanese Noncardioembolic Stroke Patients with Hyperlipidemia: The J-STARS Echo Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(4), 359-373, 2018
  38. Desirable Low-Density Lipoprotein Cholesterol Levels for Preventing Stroke Recurrence A Post Hoc Analysis of the J-STARS Study (Japan Statin Treatment Against Recurrent Stroke), STROKE, 49(4), 865-+, APR 2018
  39. Changes over Time in Intracranial Air in Patients with Cerebral Air Embolism: Radiological Study in Two Cases, CASE REPORTS IN NEUROLOGICAL MEDICINE, 2015
  40. Effects of Cilnidipine, an L/N-Type Calcium Channel Blocker, on Carotid Atherosclerosis in Japanese Post-Stroke Hypertensive Patients: Results from the CA-ATTEND Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 25(6), 490-504, 2018
  41. Antithrombotic Therapy Strategy for Cancer-Associated Ischemic Stroke: A Case Series of 26 Patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 27(9), E206-E211, SEP 2018
  42. Controlling nutritional status score for predicting 3-mo functional outcome in acute ischemic stroke, NUTRITION, 55-56, 1-6, 2018
  43. Screening for Fabry Disease in Japanese Patients with Young-Onset Stroke by Measuring alpha-Galactosidase A and Globotriaosylsphingosine, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 27(12), 3563-3569, 201812
  44. Warm Front Passage on the Previous Day Increased Ischemic Stroke Events, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 28(7), 1873-1878, 201907

Publications such as books

  1. 2017, Treatment of Non-vitamin K Antagonist Oral Anticoagulants, New Approaches for the Secondary Prevention of Cryptogenic Stroke Using Non-vitamin K Antagonist Oral Anticoagulants., Springer, 2017, Tomohisa Nezu, Yoshiki Yagita
  2. Stroke Revisited: Diagnosis and Treatment of Ischemic Stroke, Selections of Antithrombotic Agents During Acute Stage., Springer, 2017, Tomohisa Nezu, Naohisa Hosomi, Masayasu Matsumoto, 135-143

Invited Lecture, Oral Presentation, Poster Presentation

  1. Relationships between telomere G-tail lengths, inflammation, oxidative stress and endothelial function in the patients with carotid atherosclerosis, 2015/02/12, Without Invitation
  2. Endothelial dysfunction is associated with the severity of white matter lesions in patients with chronic cerebrovascular disease and comorbidity., Asia Pacific Stroke Conference 2014, 2014, Without Invitation, Taipei
  3. Relationships between endothelial function, biological markers and cerebral small vessel disease in patients with chronic cerebrovascular disease and comorbidity, International Stroke Conference 2014, 2014, Without Invitation, San Diego, USA
  4. Telomere G-tail length shortening is associated with endothelial dysfunction in patients with chronic cerebrovascular disease and comorbidity, International Stroke Conference 2014, 2014, Without Invitation
  5. High levels of serum alpha2-macroglobulin are associated with white matter lesions but not with IL-6 in acute ischemic stroke patients, Asia Pacific Stroke Conference2013, 2013, Without Invitation
  6. Association of alpha2-macroglobulin as a novel biomarker with acute ischemic stroke, International Stroke Conference 2013, 2013, Without Invitation, Honolulu, USA
  7. Acetazolamide reactivity and oxygen metabolism in lacunar patients with white matter lesions, International Symposium on Cerebral flow, Metabolism, and Function., 2011, Without Invitation, Barcelona, Spain
  8. Female sex is associated with unfavorable outcomes following low-dose intravenous rt-PA therapy: the SAMURAI rt-PA Registry, International Stroke Conference 2011, 2011, Without Invitation
  9. Pre-treatment DWI-ASPECTS is superior to CT-ASPECTS in detecting excellent to fairly good outcome after intravenous rt-PA therapy, International Stroke Conference 2010, 2010, Without Invitation, San Antonio, USA
  10. Pre-treatment DWI-ASPECTS has a relation with functional outcome at 3 months following intravenous rt-PA therapy, International Stroke Conference 2010, 2010, Without Invitation
  11. Microbleeds evaluation study for prevention of brain hemorrhage in ischemic stroke (MB-evidence): pilot analysis for multicenter longitudinal study., Nezu T, Naka H, Hosomi N, Takamatsu K, Nomura E, Kitamura T, Torii T, Oshita T, Nakamori M, Imamura E, shimomura R, Aoki S, Maruyama H, Matsumoto M., XXIII World Congress of Neurology, 2017/09/18, Without Invitation