Silvia NatsukoAkutsu

Last Updated :2019/10/06

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, ., Assistant Professor
E-mail
silvia-akutsuhiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2018/03/01, Hiroshima University, Research Institute for Radiation Biology and Medicine, Assistant Professor
  • 2013/10/01, 2014/03/31, Hiroshima University, RIRBM, Department of Genetics and Cell Biology, Visiting Researcher
  • 2017/09/25, 2017/10/27, University of Sussex, UK, Genome Damage and Stability Centre School of Life Sciences, Visiting Research

Educational Backgrounds

  • Hiroshima University, Phoenix Leader Education Program Hiroshima Initiative for Renaissance from Radiation Disaster, Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, PhD, Japan, 2014/10, 2018/03
  • Universidade Federal de São Paulo, Department of Experimental Clinical Oncology- Haematology and Hemotherapy, Master in Sciences, Brazil, 2012/08, 2014/10
  • Universidade Federal de São Paulo, Department of Experimental Clinical Oncology- Haematology and Hemotherapy, Specialization in Hematological Cytogenetics, Brazil, 2011/03, 2012/02
  • Universidade Estadual Paulista Júlio de Mesquita Filho, Department of Biology Sciences, Brazil, 2007/02, 2010/12

Academic Degrees

  • Ph.D (Science), Hiroshima University

Research Fields

  • Biology;Basic biology;Genetics / Chromosome dynamics
  • Biological Sciences;Genome science;Medical genome science

Research Keywords

  • Chromosome Genome Instability iPS technology Genome Editing

Research Activities

Academic Papers

  1. Analysis of individual differences in radiosensitivity using genome editing., Ann ICRP, 45(1), 290-296, 2016
  2. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells., Scientific Reports, 7(1), 5996, 20170720
  3. PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation., Human Molecular Genetics, 26(22), 4429-4440, 2017
  4. Update summary of genome editing technology in human cultured cells linked to human genetics studies., Journal of Human Genetics, 63, 133-143, 2018
  5. Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology., Journal of Radiation Research, 59(suppl_2), 75-82, 20180401
  6. Experimental trials for the chromosome aneuploidy correction in Down syndrome cell lines, 93(1), 286-290, 20180603

Invited Lecture, Oral Presentation, Poster Presentation

  1. Experimental Strategies for the Chromosome therapy in Down syndrome cell, The 61th Annual Meeting of the Japanese Radiation Research Society (JRRS), 2018/11/07, Without Invitation
  2. Experimental trials for the chromosome aneuploidy correction in Down syndrome cell lines., 2018/06/03, Without Invitation
  3. Development of chromosomal Therapies to rescue trisomy 21 to normal karyotype, 2018/07/31, Without Invitation
  4. Unravelling the pathological mechanisms of structure-chromosomal instability post IR in PCS (MVA) syndrome, 2018/01/27, Without Invitation
  5. CRISPR-ObLiGaRe法を用いたiPS細胞における蛍光核標識によるモザイク・トリソミー21のモデル細胞系の開発, The 4th Annual Meeting of the Japanese Society for Genome Editing, 2019/06/03, Without Invitation
  6. The generation of mosaic trisomy 21 model cells using patient cells with full trisomy 21 by trisomy rescue during cell reprogramming and their modification with fluorescent nuclear markers by genome editing technique, The 65th Brazilian International Congress of Genetics, 2019/08/20, With Invitation

Awards

  1. 2018年01月27日, Excellent Poster Presentation, The 7th International Symposium of Phoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster, Unravelling the pathological mechanisms of structure-chromosomal instability post IR in PCS (MVA) syndrome
  2. 2017年02月11日, Excellent Poster Presentation, The 6th International Symposium of Phoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster, The insufficiency of BUB1B gene increases structural-chromosomal instability post ionizing radiation
  3. Excellent Poster Award, The 4th International Symposium of Phoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster, Chromosomal analysis in myelodysplastic syndrome and acute myeloid leukemia cell lines through the cytokinesis-­block micronucleus assay (CBMN) and cytogenetic study.
  4. 2019年07月29日, 医学研究実習2019年度配属, 医学研究実習2019年度配属, Chromosomal analysis of Down Syndrome patient cells by reprograming