TadashiShimamoto

Last Updated :2019/08/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, ., Professor
E-mail
tadashishiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy, Okayama University
  • Master of Pharmaceutical Science, Okayama University

Research Fields

  • Agricultural sciences;Animal life science;Veterinary medical science
  • Medicine,dentistry, and pharmacy;Basic medicine;Bacteriology (including mycology)

Research Keywords

  • DNA aptamer|Norovirus
  • pathogenic bacteria|drug resistance
  • SRSV
  • pathogenic bacteria
  • reverse transcriptase
  • retron
  • Caco-2
  • integron
  • antisense DNA
  • reverse transcriptase

Educational Activity

Course in Charge

  1. 2019, Liberal Arts Education Program1, 1Term, Life, food, and environmental sciences
  2. 2019, Liberal Arts Education Program1, 3Term, Food safety and health science
  3. 2019, Undergraduate Education, Intensive, Laboratory Work in General Biology I
  4. 2019, Undergraduate Education, 1Term, Introduction to Applied Biological Sciences
  5. 2019, Undergraduate Education, 2Term, Reading of Foreign Literature
  6. 2019, Undergraduate Education, 2Term, Introduction to Microbiology
  7. 2019, Undergraduate Education, 3Term, Public Health
  8. 2019, Undergraduate Education, Intensive, Laboratory Work in Food Hygiene
  9. 2019, Undergraduate Education, Academic Year, Graduation Thesis
  10. 2019, Undergraduate Education, 1Term, Food Microbiology
  11. 2019, Undergraduate Education, 3Term, Modern Food Science
  12. 2019, Graduate Education (Doctoral Program) , First Semester, Exercises in Food Science and Biofunctions (B)
  13. 2019, Graduate Education (Doctoral Program) , Second Semester, Exercises in Food Science and Biofunctions (B)
  14. 2019, Graduate Education (Master's Program) , First Semester, Practice in Food Science and Biofunctions
  15. 2019, Graduate Education (Master's Program) , 3Term, foodborne pathogenic genetics
  16. 2019, Graduate Education (Master's Program) , 4Term, exercises in foodborne pathogenic genetics
  17. 2019, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  18. 2019, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  19. 2019, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  20. 2019, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  21. 2019, Graduate Education (Master's Program) , 1Term, Microbiology for Food Safety I
  22. 2019, Graduate Education (Master's Program) , 3Term, Microbiology for Food Safety II

Research Activities

Academic Papers

  1. Genetic characterization of multidrug resistance in Shigella spp. from Japan, Journal of Medical Microbiology, 55(12), 1685-1691, 20061201
  2. Proteus mirabilis clinical isolate harboring a new variant of Salmonella genomic island 1 containing the multiple antibiotic resistance region, Journal of Antimicrobial Chemotherapy, 59(2), 184-190, 20070201
  3. Zoo animals as resorvoirs of gram-negative bacteria harboring integrons and antimicrobial resistance genes, Applied and Environmental Microbiology, 73(20), 6686-6690, 20071015
  4. Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC β-lactamase, CMY-37, INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 32(3), 256-261, 20080901
  5. Molecular characterization of multidrug-resistant avian pathogenic Escherichia coli isolated from septicemic broilers, INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 303(8), 475-483, 20131201
  6. Isolation and molecular characterization of Salmonella enterica, Escherichia coli O157:H7 and Shigella spp. from meat and dairy products in Egypt, INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 168, 57-62, 20140103
  7. Genetic characterization of antibiotic resistance and virulence factors in Enterococcus spp. from Japanese retail ready-to-eat raw fish, FOOD MICROBIOLOGY, 38, 62-66, 20140401
  8. Genetic basis of multidrug resistance in Salmonella enterica serovars Enteritidis and Typhimurium isolated from diarrheic calves in Egypt, ACTA TROPICA, 111(2), 144-149, 20090801
  9. Isolation and molecular characterization of multidrug-resistant strains of Escherichia coli and Salmonella from retail chicken meat in Japan, JOURNAL OF FOOD SCIENCE, 74(7), M405-M410, 20090901
  10. Characterization of integrons and antimicrobial resistance genes in clinical isolates of Gram-negative bacteria from Palestinian hospitals, MICROBIOLOGY AND IMMUNOLOGY, 53(11), 595-602, 20091101
  11. Nucleotide sequence of the melB gene and characteristics of deduced amino acid sequence of the melibiose carrier in Escherichia coli, The Journal of Biological Chemistry, 259(7), 4320-4326, 19840401
  12. Nucleotide sequence of the promoter region of the melibiose operon of Escherichia coli, Biochemical and Biophysical Research Communications, 121(1), 41-46, 19840501
  13. Value of heptyl-β-D-thioglucoside, a new nonionic detergent, in studies on membrane proteins, Journal of Biochemistry, 97(6), 1807-1810, 19850601
  14. Properties of a Na+-coupled serine-threonine transport system in Escherichia coli, Biochimica et Biophysica Acta, 905(1), 231-239, 19870701
  15. Purification and analysis of the structure of α-galactosidase from Escherichia coli, Biochemical and Biophysical Research Communications, 151(1), 236-241, 19880201
  16. Characterization of a novel L-serine transport system in Escherichia coli, JOURNAL OF BACTERIOLOGY, 170(5), 2236-2239, 19880501
  17. Amino acid substitutions and alteration in cation specificity in the melibiose carrier of Escherichia coli, Journal of Biological Chemistry, 263(28), 14276-14280, 19881001
  18. Cloning and expression of the 5’-nucleotidase gene of Vibrio parahaemolyticus in Escherichia coli and overproduction of the enzyme, Journal of Biochemistry, 105(5), 841-846, 19890301
  19. Purification and characterization of membrane-bound 5’-nucleotidase of Vibrio parahaemolyticus, Journal of Biochemistry, 105(5), 785-789, 19890301
  20. Sequence analysis of nutA gene encoding membrane-bound Cl--dependent 5’-nucleotidase of Vibrio parahaemolyticus, Journal of Biochemistry, 109(1), 24-29, 19910101
  21. Cloning and nucleotide sequence of the gene (citA) encoding a citrate carrier from Salmonella typhimurium, Journal of Biochemistry, 110(1), 22-28, 19910701
  22. Cloning and nucleotide sequence of the gene (citC) encoding a citrate carrier from several Salmonella serovars, Journal of Biological Chemistry, 267(14), 9559-9564, 19920501
  23. Reverse transcriptase from bacterial retrons require specific secondary structures at the 5’-end of the template for the cDNA priming reaction, Journal of Biological Chemistry, 268(4), 2684-2692, 19930201
  24. Transcriptional attenuation and differential mRNA stability in the regulation of the Escherichia coli melibiose operon, Journal of Biochemistry, 115(6), 1185-1189, 19940601
  25. The formation of the 2’, 5’-phosphodiester linkage in the cDNA priming reaction by bacterial reverse transcriptase in a cell-free system, Journal of Biological Chemistry, 270(2), 581-588, 19950101
  26. The role of ribonuclease H in multicopy single-stranded DNA synthesis in retron-Ec73 and retron-Ec107 of Escherichia coli, JOURNAL OF BACTERIOLOGY, 177(1), 264-267, 19950101
  27. Mutational analysis of the CitA citrate transporter from Salmonella typhimurium: Altered substrate specificity, Biochemical and Biophysical Research Communications, 226(2), 481-487, 19960101
  28. Primary structure and properties of the Na+/glucose symporter (SglS) of Vibrio parahaemolyticus, JOURNAL OF BACTERIOLOGY, 179(5), 1805-1808, 19970301
  29. Inhibition of melibiose transporter by amiloride in Escherichia coli, Biochemical and Biophysical Research Communications, 233(1), 147-149, 19970601
  30. A melibiose transporter and an operon containing its gene in Enterobacter cloacae, JOURNAL OF BACTERIOLOGY, 179(13), 4443-4445, 19970701
  31. Characteristics of the melibiose transporter and its primary structure in Enterobacter aerogenes, Biochimica et Biophysica Acta, 1326(1), 83-91, 19970701
  32. Sequence of a melibiose transporter gene of Enterobacter cloacae, Biochimica et Biophysica Acta, 1354(1), 7-12, 19970901
  33. In vitro synthesis of multicopy single-stranded DNA, using separate primer and template RNAs, by Escherichia coli reverse transcriptase, JOURNAL OF BACTERIOLOGY, 180(11), 2999-3002, 19980601
  34. Conversion of temperature-sensitive to -resistant gene expresssion due to mutations in the promoter region of the melibiose operon in Escherichia coli, Journal of Biological Chemistry, 273(27), 16860-16864, 19980701
  35. A retroelement in Vibrio cholerae, Molecular Microbiology, 34(3), 631-632, 19990201
  36. A cryptic melibiose transporter gene possessing a frameshift from Citrobacter freundii, JOURNAL OF BIOCHEMISTRY, 129(4), 607-613, 20010401
  37. msDNA-St85, a multicopy single-stranded DNA isolated from Salmonella enterica serovar Typhimurium LT2 with the genomic analysis of its retron, FEMS Microbiology Letters, 224(2), 291-297, 20030701
  38. New aminoglycoside acetyltransferase gene, aac(3)-Id, in a class 1 integron from a multiresistant strain of Vibrio fluvialis isolated from an infant aged 6 months, Journal of Antimicrobial Chemothrapy, 53(6), 947-951, 20040601
  39. A plasmid-encoded class 1 integron carrying sat, a putative phosphoserine phosphatase gene and aadA2 from enterotoxigenic Escherichia coli O159 isolated in Japan, FEMS Microbiology Letters, 235(2), 243-248, 20040601
  40. The first characterization of extended-spectrum β-lactamase-producing Salmonella in Japan, Journal of Antimicrobial Chemotherapy, 54(1), 283-284, 20040701
  41. Complex formation between a putative 66-residue thumb domain of bacterial reverse transcriptase RT-Ec86 and the primer recognition RNA, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(49), 50735-50742, 20041203
  42. A variant type of Vibrio cholerae SXT element in a multidrug-resistant strain of Vibrio fluvialis, FEMS Microbiology Letters, 242(2), 241-247, 20050101
  43. Molecular characterization of integrons in non-typhoid Salmonella serovars isolated in Japan: description of an unusual class 2 integron, Journal of Antimicrobial Chemotherapy, 55(3), 371-374, 20050301
  44. Molecular characterization of a multidrug-resistant strain of enteroinvasive Escherichia coli O164 isolated in Japan, Journal of Medical Microbiology, 54(3), 273-278, 20050301
  45. Characterization of a multidrug-resistant isolate of Salmonella Paratyphi B from Japan, Journal of Antimicrobial Chemotherapy, 56(1), 250-250A, 20050701
  46. Genomic analysis of a multidrug-resistant strain of enterohaemorrhagic Escherichia coli O157:H7 causing a family outbreak in Japan, Journal of Medical Microbiology, 54(9), 867-872, 20050901
  47. Class 2 integrons in Vibrio cholerae, Journal of Medical Microbiology, 55(5), 643-644, 20060501
  48. First characterization and Emergence of SHV-60 in raw milk of a healthy cow in Japan, JOURNAL OF VETERINARY MEDICAL SCIENCE, 70(11), 1269-1272, 20081101
  49. Molecular characterization of antimicrobial resistance in Salmonella isolated from animals in Japan, JOURNAL OF APPLIED MICROBIOLOGY, 106(2), 402-409, 20090201
  50. Prevalence and molecular characterization of ampicillin resistant Enterobacteriaceae isolated from traditional Egyptian Domiati cheese, JOURNAL OF FOOD PROTECTION, 72(3), 624-630, 20090301
  51. Genetic analysis of antimicrobial resistance in Escherichia coli isolated from diarrheic neonatal calves, VETERINARY MICROBIOLOGY, 136(42798), 397-402, 20090512
  52. Isolation and molecular characterization of multidrug-resistant Gram-negative bacteria from imported flamingos in Japan, ACTA VETERINARIA SCANDINAVICA, 51(1), 46, 20091124
  53. Molecular analysis of antimicrobial resistance in Gram-negative bacteria isolated from fish farms in Egypt, JOURNAL OF VETERINARY MEDICAL SCIENCE, 72(6), 727-734, 20100601
  54. Towards a compatible probiotic-antibiotic combination therapy: assessement of antimicrobial resistance in the Japanese probiotics, Journal of Applied Microbiology, 109(4), 1349-1360, 20101001
  55. Molecular characterization of antimicrobial resistance in Gram-negative bacteria isolated from bovine mastitis in Egypt, MICROBIOLOGY AND IMMUNOLOGY, 55(5), 318-327, 20110501
  56. Two novel retron elements are replaced with retron-Vc95 in Vibrio cholerae, MICROBIOLOGY AND IMMUNOLOGY, 55(7), 510-513, 20110701
  57. Asymptomatic intramammary infection with multidrug-resistant Gram-negative bacteria in a research dairy farm: Incidence and genetic basis of resistance, JOURNAL OF VETERINARY MEDICAL SCIENCE, 73(8), 1089-1092, 20110801
  58. Comparative study of different msDNA (multicopy single-stranded DNA) structures and phylogenetic comparison of reverse taranscriptases (RTs): evidence for vertical inheritance, Bioinformation, 7(4), 176-179, 20111014
  59. A novel msDNA (multi-copy single-stranded DNA) strain present in Yersinia frederiksenii ATCC 33641 cintig01029 enteropathogenic bacteria with the genomic analysis of its retron, Journal of Pathogens, 2011, 693769, 20111117
  60. Genetic analysis of multiple antimicrobial resistance in Salmonella isolated from diseased broilers in Egypt, MICROBIOLOGY AND IMMUNOLOGY, 56(4), 254-261, 20120401
  61. Occurrence and characteristics of methicillin-resistant and -susceptible Staphylococcus aureus and methicillin-resistant coagulase-negative staphylococci from Japanese retail ready-to-eat raw fish, INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 156(3), 286-289, 20120701
  62. A novel retron of Vibrio parahaemolyticus is closely related to retron-Vc95 of Vibrio cholerae, JOURNAL OF MICROBIOLOGY, 51(3), 323-328, 20130601
  63. Antiviral Effects of Persimmon Extract on Human Norovirus and Its Surrogate, Bacteriophage MS2, JOURNAL OF FOOD SCIENCE, 79(5), M941-M946, 20140501
  64. Characterization of integrons and resistance genes in multidrug-resistant Salmonella enterica isolated from meat and dairy products in Egypt, INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 189, 39-44, 20141017
  65. Molecular analysis of multidrug resistance in Shiga toxin-producing Escherichia coli O157:H7 isolated from meat and dairy products, INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 193, 68-73, 20150116
  66. Molecular characterization of multidrug-resistant Shigella spp. of food origin, INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 194, 78-82, 20150202
  67. Prevalence, antibiotic resistance and virulence of Enterococcus spp. in Egyptian fresh raw milk cheese, FOOD CONTROL, 50, 815-820, 20150401
  68. Antimicrobial effects of blueberry, raspberry, and strawberry aqueous extracts and their effects on virulence gene expression in Vibrio cholerae, PHYTOTHERAPY RESEARCH, 29(11), 1791-1797, 20151101
  69. Seafood as a reservoir of Gram-negative bacteria carrying integrons and antimicrobial resistance genes in Japan, Biomedical and Environmental Science, 28(12), 924-927, 20151201
  70. Emergence of plasmid-mediated colistin resistance gene mcr-1 in a clinical Escherichia coli isolate from Egypt, Antimicrobial Agents and Chemotherapy, 60(5), 3249-3250, 20160501
  71. Characterisation of the plasmid-mediated colistin resistance gene mcr-1 in Escherichia coli isolated from animals in Egypt, International Journal of Antimicrobial Agents, 47(5), 413-414, 20160501
  72. Emergence of an NDM-5-producing clinical Escherichia coli isolate in Egypt, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 48, 46-48, 20160701
  73. NDM-4 and NDM-5-producing Klebsiella pneumoniae coinfection in a 6-month-old infant, Antimicrobial Agents and Chemotherapy, 60(7), 4416-4417, 20160701
  74. Emergence of a novel β-lactamase in food of animal origin: Characterisation of SHV-111, from a cheese isolate of Klebsiella pneumoniae with an amino acid substitution in a strictly conserved position (P174S) in the Ω-loop, Journal of Medical Microbiology, 66(1), 96-97, 20170101
  75. First report in Africa of two clinical isolates of Proteus mirabilis carrying Salmonella genomic island (SGI1) variants, SGI1-PmABB and SGI1-W, Infection, Genetics and Evolution, 51, 132-137, 20170701
  76. Molecular and Phenotypic Analysis of Hemolytic Aeromonas Strains Isolated from Food in Egypt Revealed Clinically Important Multidrug Resistance and Virulence Profiles, Journal of Food Protection, 81(6), 1015-1021, 20180601
  77. Molecular and Phenotypic Analysis of Hemolytic Aeromonas Strains Isolated from Food in Egypt Revealed Clinically Important Multidrug Resistance and Virulence Profiles, JOURNAL OF FOOD PROTECTION, 81(6), 1015-1021, 20180601
  78. Occurrence of Salmonella genomic island 1 (SGI1) in two African Proteus mirabilis strains isolated from diseased chicken flocks, INFECTION GENETICS AND EVOLUTION, 62, 8-10, 201808
  79. Emergence of Salmonella Genomic Island 1 Variant SGI1-W in a Clinical Isolate of Providencia stuartii form Egypt, Antimicrobial Agents and Chemotherapy, 63(1), e01793-18, 20190101
  80. Full genome sequence of a polyvalent bacteriophage infecting strains of Shigella, Salmonella, and Escherichia., Achives of Virology, 163(11), 3211-3211, 20181101
  81. Systemic method to isolate large bacteriophages for use in biocontrol of a wide-range of pathogenic bacteria, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 127(1), 73-78, 20190101
  82. High Prevalence of Antimicrobial Resistance in Gram-Negative Bacteria Isolated from Clinical Settings in Egypt: Recalling for Judicious Use of Conventional Antimicrobials in Developing Nations, MICROBIAL DRUG RESISTANCE, 25(3), 371-385, 20190401

Publications such as books

  1. 1997/06/00, In vivo production of oligodeoxyribonucleotides of specific sequences: application to antisense DNA, Oligonucleotides as Therapeutic Agents (John Wiley & Sons Ltd), 1997, 6, 英語, Masayori Inouye, J-R Mao, Tadashi Shimaototo, Sumiko Inouye, 224-234
  2. 1998/07/00, Role of ribonuclease H in the biosynthesis of msDNA in Escherichia coli, The Physiological Functions of Escherichia coli RNase HI (INSERM Editions), 1998, 7, 英語, Masayori Inouye, Tadashi Shimamoto, Masamitsu Shimada, Sumiko Inouye, 67-78
  3. 2001/03/25, 海と大地の恵みのサイエンス, 2001, 3, 日本語, 201, 116-119
  4. 2001/03/25, 海と大地の恵みのサイエンス, 2001, 3, 日本語, 201, 82-85
  5. 2002/03/00, Retrons, Mobile DNA II (ASM Press), 2002, 3, 英語, Kunitoshi Yamanaka, Tadashi Shimaoto, Sumiko Inouye, Masayori Inouye, 784-795
  6. 2003/06/00, 医薬バイオテクノロジー事典, 2003, 6, 日本語, 526
  7. 2010/04/01, 食品微生物学辞典, 2010, 4, 日本語, 341
  8. 2011/11/25, 生命・食・環境のサイエンス, 2011, 11, 日本語, 228, 1月4日
  9. 2011/11/25, 生命・食・環境のサイエンス, 2011, 11, 日本語, 228, 172-174
  10. 2013/06/01, 腸炎ビブリオ〈第Ⅳ集〉, 2013, 6, 日本語, 362, 338-345
  11. 2013/07/25, Bacterial Satellite DNA: A Novel Dimension in Bacterial Pathogenicity, LAP LAMBERT Academic Publishing, 2013, 7, 英語, Rasel Das, Tadashi Shimamoto, Mohammad Arifuzzaman, 74, 74

Invited Lecture, Oral Presentation, Poster Presentation

  1. First report of Klebsiella pneumoniae co-producing NDM-1 and VIM-1 carbapenemases from a meat sample in Japan, Tadashi Shimamoto, Tadashi Shimamoto, Joint Event on 4th International Conference on APPLIED MICROBIOLOGY, ANTIBIOTICS, ANTIMICROBIALS AND BENEFICIAL MICROBES, 2019/05/20, With Invitation, CONFERENCE SERIES LLC LTD, Tokyo, Japan